JP2020523000A5 - - Google Patents
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- JP2020523000A5 JP2020523000A5 JP2019564915A JP2019564915A JP2020523000A5 JP 2020523000 A5 JP2020523000 A5 JP 2020523000A5 JP 2019564915 A JP2019564915 A JP 2019564915A JP 2019564915 A JP2019564915 A JP 2019564915A JP 2020523000 A5 JP2020523000 A5 JP 2020523000A5
- Authority
- JP
- Japan
- Prior art keywords
- liver
- liver organoid
- organoid
- cells
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims description 38
- 210000004185 liver Anatomy 0.000 claims description 30
- 239000003814 drug Substances 0.000 claims description 7
- 210000003494 hepatocyte Anatomy 0.000 claims description 3
- 210000000130 stem cell Anatomy 0.000 claims description 3
- 231100000419 toxicity Toxicity 0.000 claims description 2
- 230000001988 toxicity Effects 0.000 claims description 2
- 210000002220 organoid Anatomy 0.000 claims 29
- 210000004027 cell Anatomy 0.000 claims 11
- 239000012190 activator Substances 0.000 claims 9
- 230000004156 Wnt signaling pathway Effects 0.000 claims 6
- -1 Wnt2b Proteins 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 5
- 102000009027 Albumins Human genes 0.000 claims 4
- 108010088751 Albumins Proteins 0.000 claims 4
- 210000002438 upper gastrointestinal tract Anatomy 0.000 claims 4
- 102000004328 Cytochrome P-450 CYP3A Human genes 0.000 claims 3
- 108010081668 Cytochrome P-450 CYP3A Proteins 0.000 claims 3
- 208000019423 liver disease Diseases 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000029752 retinol binding Human genes 0.000 claims 3
- 108091000053 retinol binding Proteins 0.000 claims 3
- 150000003384 small molecules Chemical group 0.000 claims 3
- CHADEQDQBURGHL-UHFFFAOYSA-N (6'-acetyloxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl) acetate Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(OC(C)=O)C=C1OC1=CC(OC(=O)C)=CC=C21 CHADEQDQBURGHL-UHFFFAOYSA-N 0.000 claims 2
- 102100023635 Alpha-fetoprotein Human genes 0.000 claims 2
- 208000008964 Chemical and Drug Induced Liver Injury Diseases 0.000 claims 2
- 102100035432 Complement factor H Human genes 0.000 claims 2
- 206010072268 Drug-induced liver injury Diseases 0.000 claims 2
- 102000001267 GSK3 Human genes 0.000 claims 2
- 108060006662 GSK3 Proteins 0.000 claims 2
- 102100033420 Keratin, type I cytoskeletal 19 Human genes 0.000 claims 2
- 108010066302 Keratin-19 Proteins 0.000 claims 2
- 230000002411 adverse Effects 0.000 claims 2
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 2
- 108010026331 alpha-Fetoproteins Proteins 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000029142 excretion Effects 0.000 claims 2
- 210000001654 germ layer Anatomy 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical group [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- NFVJNJQRWPQVOA-UHFFFAOYSA-N n-[2-chloro-5-(trifluoromethyl)phenyl]-2-[3-(4-ethyl-5-ethylsulfanyl-1,2,4-triazol-3-yl)piperidin-1-yl]acetamide Chemical group CCN1C(SCC)=NN=C1C1CN(CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)Cl)CCC1 NFVJNJQRWPQVOA-UHFFFAOYSA-N 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 229930002330 retinoic acid Natural products 0.000 claims 2
- 230000004083 survival effect Effects 0.000 claims 2
- 229960001727 tretinoin Drugs 0.000 claims 2
- IPICFSFUAKDZEI-UHFFFAOYSA-N 3-methyl-2-[2-[[3-methyl-2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyloxy]butanoyl]amino]propanoyloxy]butanoic acid Chemical compound CC(C)C(C(O)=O)OC(=O)C(C)NC(=O)C(C(C)C)OC(=O)C(C)NC(=O)OC(C)(C)C IPICFSFUAKDZEI-UHFFFAOYSA-N 0.000 claims 1
- 102100037129 ATP-binding cassette sub-family C member 11 Human genes 0.000 claims 1
- 108010075348 Activated-Leukocyte Cell Adhesion Molecule Proteins 0.000 claims 1
- 102000015735 Beta-catenin Human genes 0.000 claims 1
- 108060000903 Beta-catenin Proteins 0.000 claims 1
- 102100024210 CD166 antigen Human genes 0.000 claims 1
- AQGNHMOJWBZFQQ-UHFFFAOYSA-N CT 99021 Chemical group CC1=CNC(C=2C(=NC(NCCNC=3N=CC(=CC=3)C#N)=NC=2)C=2C(=CC(Cl)=CC=2)Cl)=N1 AQGNHMOJWBZFQQ-UHFFFAOYSA-N 0.000 claims 1
- 206010057573 Chronic hepatic failure Diseases 0.000 claims 1
- 108010053085 Complement Factor H Proteins 0.000 claims 1
- 102000003712 Complement factor B Human genes 0.000 claims 1
- 108090000056 Complement factor B Proteins 0.000 claims 1
- 108010000543 Cytochrome P-450 CYP2C9 Proteins 0.000 claims 1
- 102100029358 Cytochrome P450 2C9 Human genes 0.000 claims 1
- 102000018832 Cytochromes Human genes 0.000 claims 1
- 108010052832 Cytochromes Proteins 0.000 claims 1
- 208000010334 End Stage Liver Disease Diseases 0.000 claims 1
- 102000008946 Fibrinogen Human genes 0.000 claims 1
- 108010049003 Fibrinogen Proteins 0.000 claims 1
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 claims 1
- 102000003971 Fibroblast Growth Factor 1 Human genes 0.000 claims 1
- 102100028412 Fibroblast growth factor 10 Human genes 0.000 claims 1
- 102100028413 Fibroblast growth factor 11 Human genes 0.000 claims 1
- 102100028417 Fibroblast growth factor 12 Human genes 0.000 claims 1
- 102100035290 Fibroblast growth factor 13 Human genes 0.000 claims 1
- 102100035292 Fibroblast growth factor 14 Human genes 0.000 claims 1
- 102100035307 Fibroblast growth factor 16 Human genes 0.000 claims 1
- 108050002072 Fibroblast growth factor 16 Proteins 0.000 claims 1
- 102100035308 Fibroblast growth factor 17 Human genes 0.000 claims 1
- 102100035323 Fibroblast growth factor 18 Human genes 0.000 claims 1
- 102100031734 Fibroblast growth factor 19 Human genes 0.000 claims 1
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 1
- 102100031361 Fibroblast growth factor 20 Human genes 0.000 claims 1
- 108090000376 Fibroblast growth factor 21 Proteins 0.000 claims 1
- 102000003973 Fibroblast growth factor 21 Human genes 0.000 claims 1
- 102100024804 Fibroblast growth factor 22 Human genes 0.000 claims 1
- 102100024802 Fibroblast growth factor 23 Human genes 0.000 claims 1
- 102100028043 Fibroblast growth factor 3 Human genes 0.000 claims 1
- 102100028072 Fibroblast growth factor 4 Human genes 0.000 claims 1
- 102100037680 Fibroblast growth factor 8 Human genes 0.000 claims 1
- 102100037665 Fibroblast growth factor 9 Human genes 0.000 claims 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 206010019663 Hepatic failure Diseases 0.000 claims 1
- 102100029087 Hepatocyte nuclear factor 6 Human genes 0.000 claims 1
- 101001029057 Homo sapiens ATP-binding cassette sub-family C member 11 Proteins 0.000 claims 1
- 101000737574 Homo sapiens Complement factor H Proteins 0.000 claims 1
- 101000917237 Homo sapiens Fibroblast growth factor 10 Proteins 0.000 claims 1
- 101000917236 Homo sapiens Fibroblast growth factor 11 Proteins 0.000 claims 1
- 101000917234 Homo sapiens Fibroblast growth factor 12 Proteins 0.000 claims 1
- 101000878181 Homo sapiens Fibroblast growth factor 14 Proteins 0.000 claims 1
- 101000878124 Homo sapiens Fibroblast growth factor 17 Proteins 0.000 claims 1
- 101000878128 Homo sapiens Fibroblast growth factor 18 Proteins 0.000 claims 1
- 101000846394 Homo sapiens Fibroblast growth factor 19 Proteins 0.000 claims 1
- 101000846532 Homo sapiens Fibroblast growth factor 20 Proteins 0.000 claims 1
- 101001051971 Homo sapiens Fibroblast growth factor 22 Proteins 0.000 claims 1
- 101001051973 Homo sapiens Fibroblast growth factor 23 Proteins 0.000 claims 1
- 101001060280 Homo sapiens Fibroblast growth factor 3 Proteins 0.000 claims 1
- 101001060274 Homo sapiens Fibroblast growth factor 4 Proteins 0.000 claims 1
- 101001027382 Homo sapiens Fibroblast growth factor 8 Proteins 0.000 claims 1
- 101001027380 Homo sapiens Fibroblast growth factor 9 Proteins 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
- 101000988619 Homo sapiens Hepatocyte nuclear factor 6 Proteins 0.000 claims 1
- 101000934372 Homo sapiens Macrosialin Proteins 0.000 claims 1
- 101001069749 Homo sapiens Prospero homeobox protein 1 Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 102100025136 Macrosialin Human genes 0.000 claims 1
- 101100390675 Mus musculus Fgf15 gene Proteins 0.000 claims 1
- 108010072083 NSC 668036 Proteins 0.000 claims 1
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 claims 1
- 102100033880 Prospero homeobox protein 1 Human genes 0.000 claims 1
- 102000040739 Secretory proteins Human genes 0.000 claims 1
- 108091058545 Secretory proteins Proteins 0.000 claims 1
- 101150010310 WNT-4 gene Proteins 0.000 claims 1
- 101150109862 WNT-5A gene Proteins 0.000 claims 1
- 101150019524 WNT2 gene Proteins 0.000 claims 1
- 102000052547 Wnt-1 Human genes 0.000 claims 1
- 108700020987 Wnt-1 Proteins 0.000 claims 1
- 102000052556 Wnt-2 Human genes 0.000 claims 1
- 108700020986 Wnt-2 Proteins 0.000 claims 1
- 102000052549 Wnt-3 Human genes 0.000 claims 1
- 108700020985 Wnt-3 Proteins 0.000 claims 1
- 102000052548 Wnt-4 Human genes 0.000 claims 1
- 108700020984 Wnt-4 Proteins 0.000 claims 1
- 102000043366 Wnt-5a Human genes 0.000 claims 1
- 108700020483 Wnt-5a Proteins 0.000 claims 1
- 101100485097 Xenopus laevis wnt11b gene Proteins 0.000 claims 1
- 210000001130 astrocyte Anatomy 0.000 claims 1
- 210000002469 basement membrane Anatomy 0.000 claims 1
- 210000000941 bile Anatomy 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 208000011444 chronic liver failure Diseases 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000036267 drug metabolism Effects 0.000 claims 1
- 229940012952 fibrinogen Drugs 0.000 claims 1
- 102000003684 fibroblast growth factor 13 Human genes 0.000 claims 1
- 108090000047 fibroblast growth factor 13 Proteins 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 210000001865 kupffer cell Anatomy 0.000 claims 1
- 208000007903 liver failure Diseases 0.000 claims 1
- 231100000835 liver failure Toxicity 0.000 claims 1
- 210000002311 liver mitochondria Anatomy 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 108010082117 matrigel Proteins 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 210000004379 membrane Anatomy 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
- 210000000110 microvilli Anatomy 0.000 claims 1
- 210000003470 mitochondria Anatomy 0.000 claims 1
- 210000001700 mitochondrial membrane Anatomy 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 238000010428 oil painting Methods 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
- 230000008961 swelling Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 210000001778 pluripotent stem cell Anatomy 0.000 description 2
- 238000007877 drug screening Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022150773A JP7749290B2 (ja) | 2017-06-09 | 2022-09-22 | 肝臓オルガノイド組成物ならびにその作製および使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762517414P | 2017-06-09 | 2017-06-09 | |
| US62/517,414 | 2017-06-09 | ||
| PCT/US2018/018585 WO2018226267A1 (en) | 2017-06-09 | 2018-02-19 | Liver organoid compositions and methods of making and using same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022150773A Division JP7749290B2 (ja) | 2017-06-09 | 2022-09-22 | 肝臓オルガノイド組成物ならびにその作製および使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020523000A JP2020523000A (ja) | 2020-08-06 |
| JP2020523000A5 true JP2020523000A5 (https=) | 2021-04-01 |
| JP7148552B2 JP7148552B2 (ja) | 2022-10-05 |
Family
ID=64566329
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019564915A Active JP7148552B2 (ja) | 2017-06-09 | 2018-02-19 | 肝臓オルガノイド組成物ならびにその作製および使用方法 |
| JP2022150773A Active JP7749290B2 (ja) | 2017-06-09 | 2022-09-22 | 肝臓オルガノイド組成物ならびにその作製および使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022150773A Active JP7749290B2 (ja) | 2017-06-09 | 2022-09-22 | 肝臓オルガノイド組成物ならびにその作製および使用方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20200199537A1 (https=) |
| EP (1) | EP3635095A4 (https=) |
| JP (2) | JP7148552B2 (https=) |
| KR (2) | KR102781633B1 (https=) |
| CN (1) | CN110914408A (https=) |
| AU (2) | AU2018279790B2 (https=) |
| CA (1) | CA3065759A1 (https=) |
| IL (1) | IL270714B2 (https=) |
| NZ (1) | NZ759164A (https=) |
| WO (1) | WO2018226267A1 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| SG10201801654RA (en) | 2014-05-28 | 2018-04-27 | Childrens Hospital Med Ct | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| AU2015331848B2 (en) | 2014-10-17 | 2022-03-03 | Children's Hospital Medical Center, D/B/A Cincinnati Children's Hospital Medical Center | In vivo model of human small intestine using pluripotent stem cells and methods of making and using same |
| EP4553082A3 (en) * | 2016-11-04 | 2025-08-20 | Children's Hospital Medical Center | Liver organoid compositions and methods of making and using same |
| EP3548507A4 (en) | 2016-12-05 | 2020-07-15 | Children's Hospital Medical Center | COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF |
| JP7248586B2 (ja) | 2017-04-14 | 2023-03-29 | チルドレンズ ホスピタル メディカル センター | 複数ドナー幹細胞組成物およびそれを作製する方法 |
| WO2018226267A1 (en) * | 2017-06-09 | 2018-12-13 | Children's Hospital Medical Center | Liver organoid compositions and methods of making and using same |
| EP3694603B1 (en) | 2017-10-10 | 2026-04-08 | Children's Hospital Medical Center | Esophageal tissue and/or organoid compositions and methods of making same |
| EP3727394A4 (en) | 2017-12-21 | 2021-09-08 | Children's Hospital Medical Center | DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF |
| EP4678727A3 (en) | 2018-07-26 | 2026-03-11 | Children's Hospital Medical Center | Hepato-biliary-pancreatic tissues and methods of making same |
| CA3112026A1 (en) | 2018-09-12 | 2020-03-19 | Children's Hospital Medical Center | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| US12600943B2 (en) | 2019-02-01 | 2026-04-14 | The University Of Hong Kong | Innervated organoid compositions and methods of making same |
| AU2020283048A1 (en) | 2019-05-31 | 2021-12-23 | Children's Hospital Medical Center | Shaped organoid compositions and methods of making same |
| US12497597B2 (en) | 2019-05-31 | 2025-12-16 | Children's Hospital Medical Center | Methods of generating and expanding hematopoietic stem cells |
| US20230039816A1 (en) * | 2019-09-27 | 2023-02-09 | Public University Corporation Yokohama City University | Method for inducing hepatocyte plasticity |
| CA3175071A1 (en) | 2020-03-11 | 2021-09-16 | Bit Bio Limited | Method of generating hepatic cells |
| US20230399623A1 (en) * | 2020-11-13 | 2023-12-14 | Oslo Universitetssykehus Hf | Artifical liver organoids and methods of their production |
| CN112553339B (zh) * | 2020-12-29 | 2024-08-09 | 广东南芯医疗科技有限公司 | 伊立替康个体化用药基因的指导方法及试剂盒 |
| JP2024522642A (ja) * | 2021-06-11 | 2024-06-21 | チルドレンズ ホスピタル メディカル センター | 高ビリルビン血症のための肝臓オルガノイドモデル及びその作製方法及び使用方法 |
| JP2023020221A (ja) * | 2021-07-30 | 2023-02-09 | ウシオ電機株式会社 | 薬剤評価方法 |
| CN114317439B (zh) * | 2021-12-23 | 2024-04-16 | 北京基石生命科技有限公司 | 一种培养肿瘤类器官的方法 |
| CN114891831A (zh) * | 2022-01-14 | 2022-08-12 | 北京清华长庚医院 | 过表达wnt2基因的内皮细胞株及其构建方法和应用 |
| CN115386535B (zh) * | 2022-10-26 | 2023-02-03 | 天津外泌体科技有限公司 | 多谱系肝类器官模型及基于该模型的药物肝毒评价方法 |
| WO2024206911A2 (en) | 2023-03-30 | 2024-10-03 | Children's Hospital Medical Center | Clinical-grade organoids |
| WO2024238977A2 (en) | 2023-05-18 | 2024-11-21 | Children's Hospital Medical Center | Liver organoids with intrahepatic sympathetic nerves, and methods of use thereof |
| EP4731750A2 (en) | 2023-06-23 | 2026-04-29 | Children's Hospital Medical Center | Methods of matrix-free suspension culture |
| WO2025072803A1 (en) | 2023-09-29 | 2025-04-03 | Children's Hospital Medical Center | Ntrk2 signaling-mediated alveolar capillary injury and repair |
| CN117701492B (zh) * | 2023-12-14 | 2025-05-06 | 首都医科大学 | 肝类器官的构建方法及其应用 |
| WO2025212920A1 (en) | 2024-04-03 | 2025-10-09 | Children's Hospital Medical Center | Multi-zonal liver organoids |
| WO2025217202A1 (en) | 2024-04-08 | 2025-10-16 | Children's Hospital Medical Center | Bile duct organoid |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2412800A1 (en) * | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
| WO2011064309A1 (en) * | 2009-11-25 | 2011-06-03 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Method for hepatic differentiation of definitive endoderm cells |
| US9394522B2 (en) * | 2010-03-22 | 2016-07-19 | Takara Bio Europe Ab | Directed differentiation and maturation of pluripotent cells into hepatocyte like cells by modulation of Wnt-signalling pathway |
| TR201104076A1 (tr) * | 2011-04-26 | 2012-11-21 | Kordsa Global End�Str�Yel �Pl�K Ve Kord Bez� San. Ve T�C. A.�. | Araç lastiği üst kuşak şeridinin üretim yöntemi. |
| US20150329821A1 (en) * | 2012-10-19 | 2015-11-19 | Agency For Science, Technology And Research | Methods of differentiating stem cells into one or more cell lineages |
| US9442105B2 (en) * | 2013-03-15 | 2016-09-13 | Organovo, Inc. | Engineered liver tissues, arrays thereof, and methods of making the same |
| SG10201801654RA (en) * | 2014-05-28 | 2018-04-27 | Childrens Hospital Med Ct | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| US20170304369A1 (en) * | 2014-10-08 | 2017-10-26 | Agency For Science, Technology And Research | Methods of differentiating stem cells into liver cell lineages |
| US9324528B1 (en) * | 2014-11-17 | 2016-04-26 | General Electric Company | Magnetic trip mechanism for circuit breaker |
| CN107427537A (zh) * | 2015-03-03 | 2017-12-01 | 哈佛学院院长及董事 | 产生功能性人体组织的方法 |
| EP3350313B1 (en) * | 2015-09-15 | 2025-11-26 | Agency For Science, Technology And Research (A*star) | Derivation of liver organoids from human pluripotent stem cells |
| US20190086391A1 (en) * | 2016-03-08 | 2019-03-21 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method and system for continuous biosensing |
| EP4553082A3 (en) * | 2016-11-04 | 2025-08-20 | Children's Hospital Medical Center | Liver organoid compositions and methods of making and using same |
| WO2018226267A1 (en) * | 2017-06-09 | 2018-12-13 | Children's Hospital Medical Center | Liver organoid compositions and methods of making and using same |
-
2018
- 2018-02-19 WO PCT/US2018/018585 patent/WO2018226267A1/en not_active Ceased
- 2018-02-19 KR KR1020247000992A patent/KR102781633B1/ko active Active
- 2018-02-19 CA CA3065759A patent/CA3065759A1/en active Pending
- 2018-02-19 KR KR1020197034531A patent/KR102625361B1/ko active Active
- 2018-02-19 US US16/611,998 patent/US20200199537A1/en active Pending
- 2018-02-19 AU AU2018279790A patent/AU2018279790B2/en active Active
- 2018-02-19 NZ NZ759164A patent/NZ759164A/en not_active IP Right Cessation
- 2018-02-19 CN CN201880033510.5A patent/CN110914408A/zh active Pending
- 2018-02-19 JP JP2019564915A patent/JP7148552B2/ja active Active
- 2018-02-19 EP EP18813104.9A patent/EP3635095A4/en not_active Withdrawn
- 2018-02-19 IL IL270714A patent/IL270714B2/en unknown
-
2022
- 2022-07-05 AU AU2022204804A patent/AU2022204804A1/en active Pending
- 2022-09-22 JP JP2022150773A patent/JP7749290B2/ja active Active
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