JP7148552B2 - 肝臓オルガノイド組成物ならびにその作製および使用方法 - Google Patents

肝臓オルガノイド組成物ならびにその作製および使用方法 Download PDF

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JP7148552B2
JP7148552B2 JP2019564915A JP2019564915A JP7148552B2 JP 7148552 B2 JP7148552 B2 JP 7148552B2 JP 2019564915 A JP2019564915 A JP 2019564915A JP 2019564915 A JP2019564915 A JP 2019564915A JP 7148552 B2 JP7148552 B2 JP 7148552B2
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liver
organoids
cells
organoid
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貴則 武部
忠紘 篠澤
小池博之
昌樹 木村
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Cincinnati Childrens Hospital Medical Center
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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JP2022119862A (ja) * 2016-11-04 2022-08-17 チルドレンズ ホスピタル メディカル センター 肝臓オルガノイド組成物ならびにその作製および使用方法
JP2022191263A (ja) * 2017-06-09 2022-12-27 チルドレンズ ホスピタル メディカル センター 肝臓オルガノイド組成物ならびにその作製および使用方法
US12241090B2 (en) 2014-05-28 2025-03-04 Children's Hospital Medical Center Methods and systems for converting precursor cells into gastric tissues through directed differentiation
US12258584B2 (en) 2010-05-06 2025-03-25 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
US12281334B2 (en) 2017-04-14 2025-04-22 Children's Hospital Medical Center Multi donor stem cell compositions and methods of making same
US12297457B2 (en) 2017-10-10 2025-05-13 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
US12379372B2 (en) 2017-12-21 2025-08-05 Children's Hospital Medical Center Digitalized human organoids and methods of using same
US12421500B2 (en) 2018-07-26 2025-09-23 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
US12428622B2 (en) 2018-09-12 2025-09-30 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
US12497597B2 (en) 2019-05-31 2025-12-16 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
US12534709B2 (en) 2019-05-31 2026-01-27 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
US12600943B2 (en) 2019-02-01 2026-04-14 The University Of Hong Kong Innervated organoid compositions and methods of making same

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AU2015331848B2 (en) 2014-10-17 2022-03-03 Children's Hospital Medical Center, D/B/A Cincinnati Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
EP3548507A4 (en) 2016-12-05 2020-07-15 Children's Hospital Medical Center COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF
US20230039816A1 (en) * 2019-09-27 2023-02-09 Public University Corporation Yokohama City University Method for inducing hepatocyte plasticity
CA3175071A1 (en) 2020-03-11 2021-09-16 Bit Bio Limited Method of generating hepatic cells
US20230399623A1 (en) * 2020-11-13 2023-12-14 Oslo Universitetssykehus Hf Artifical liver organoids and methods of their production
CN112553339B (zh) * 2020-12-29 2024-08-09 广东南芯医疗科技有限公司 伊立替康个体化用药基因的指导方法及试剂盒
JP2024522642A (ja) * 2021-06-11 2024-06-21 チルドレンズ ホスピタル メディカル センター 高ビリルビン血症のための肝臓オルガノイドモデル及びその作製方法及び使用方法
JP2023020221A (ja) * 2021-07-30 2023-02-09 ウシオ電機株式会社 薬剤評価方法
CN114317439B (zh) * 2021-12-23 2024-04-16 北京基石生命科技有限公司 一种培养肿瘤类器官的方法
CN114891831A (zh) * 2022-01-14 2022-08-12 北京清华长庚医院 过表达wnt2基因的内皮细胞株及其构建方法和应用
CN115386535B (zh) * 2022-10-26 2023-02-03 天津外泌体科技有限公司 多谱系肝类器官模型及基于该模型的药物肝毒评价方法
WO2024206911A2 (en) 2023-03-30 2024-10-03 Children's Hospital Medical Center Clinical-grade organoids
WO2024238977A2 (en) 2023-05-18 2024-11-21 Children's Hospital Medical Center Liver organoids with intrahepatic sympathetic nerves, and methods of use thereof
EP4731750A2 (en) 2023-06-23 2026-04-29 Children's Hospital Medical Center Methods of matrix-free suspension culture
WO2025072803A1 (en) 2023-09-29 2025-04-03 Children's Hospital Medical Center Ntrk2 signaling-mediated alveolar capillary injury and repair
CN117701492B (zh) * 2023-12-14 2025-05-06 首都医科大学 肝类器官的构建方法及其应用
WO2025212920A1 (en) 2024-04-03 2025-10-09 Children's Hospital Medical Center Multi-zonal liver organoids
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JP2022119862A (ja) * 2016-11-04 2022-08-17 チルドレンズ ホスピタル メディカル センター 肝臓オルガノイド組成物ならびにその作製および使用方法
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