CN110914408A - 肝类器官组合物以及其制备和使用方法 - Google Patents

肝类器官组合物以及其制备和使用方法 Download PDF

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CN110914408A
CN110914408A CN201880033510.5A CN201880033510A CN110914408A CN 110914408 A CN110914408 A CN 110914408A CN 201880033510 A CN201880033510 A CN 201880033510A CN 110914408 A CN110914408 A CN 110914408A
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liver
cells
drug
organoids
organoid
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Chinese (zh)
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武部贵则
筱泽忠纮
小池博之
木村昌树
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Japan Science and Technology Agency
Cincinnati Childrens Hospital Medical Center
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Japan Science and Technology Agency
Cincinnati Childrens Hospital Medical Center
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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CN201880033510.5A 2017-06-09 2018-02-19 肝类器官组合物以及其制备和使用方法 Pending CN110914408A (zh)

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US201762517414P 2017-06-09 2017-06-09
US62/517,414 2017-06-09
PCT/US2018/018585 WO2018226267A1 (en) 2017-06-09 2018-02-19 Liver organoid compositions and methods of making and using same

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CN110914408A true CN110914408A (zh) 2020-03-24

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US (1) US20200199537A1 (https=)
EP (1) EP3635095A4 (https=)
JP (2) JP7148552B2 (https=)
KR (2) KR102781633B1 (https=)
CN (1) CN110914408A (https=)
AU (2) AU2018279790B2 (https=)
CA (1) CA3065759A1 (https=)
IL (1) IL270714B2 (https=)
NZ (1) NZ759164A (https=)
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CN114317439A (zh) * 2021-12-23 2022-04-12 北京基石生命科技有限公司 一种培养肿瘤类器官的方法
CN117701492A (zh) * 2023-12-14 2024-03-15 首都医科大学 肝类器官的构建方法及其应用

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EP4553082A3 (en) * 2016-11-04 2025-08-20 Children's Hospital Medical Center Liver organoid compositions and methods of making and using same
EP3548507A4 (en) 2016-12-05 2020-07-15 Children's Hospital Medical Center COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF
JP7248586B2 (ja) 2017-04-14 2023-03-29 チルドレンズ ホスピタル メディカル センター 複数ドナー幹細胞組成物およびそれを作製する方法
WO2018226267A1 (en) * 2017-06-09 2018-12-13 Children's Hospital Medical Center Liver organoid compositions and methods of making and using same
EP3694603B1 (en) 2017-10-10 2026-04-08 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
EP3727394A4 (en) 2017-12-21 2021-09-08 Children's Hospital Medical Center DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF
EP4678727A3 (en) 2018-07-26 2026-03-11 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
CA3112026A1 (en) 2018-09-12 2020-03-19 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
US12600943B2 (en) 2019-02-01 2026-04-14 The University Of Hong Kong Innervated organoid compositions and methods of making same
AU2020283048A1 (en) 2019-05-31 2021-12-23 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
US12497597B2 (en) 2019-05-31 2025-12-16 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
US20230039816A1 (en) * 2019-09-27 2023-02-09 Public University Corporation Yokohama City University Method for inducing hepatocyte plasticity
CA3175071A1 (en) 2020-03-11 2021-09-16 Bit Bio Limited Method of generating hepatic cells
US20230399623A1 (en) * 2020-11-13 2023-12-14 Oslo Universitetssykehus Hf Artifical liver organoids and methods of their production
CN112553339B (zh) * 2020-12-29 2024-08-09 广东南芯医疗科技有限公司 伊立替康个体化用药基因的指导方法及试剂盒
JP2024522642A (ja) * 2021-06-11 2024-06-21 チルドレンズ ホスピタル メディカル センター 高ビリルビン血症のための肝臓オルガノイドモデル及びその作製方法及び使用方法
JP2023020221A (ja) * 2021-07-30 2023-02-09 ウシオ電機株式会社 薬剤評価方法
CN114891831A (zh) * 2022-01-14 2022-08-12 北京清华长庚医院 过表达wnt2基因的内皮细胞株及其构建方法和应用
CN115386535B (zh) * 2022-10-26 2023-02-03 天津外泌体科技有限公司 多谱系肝类器官模型及基于该模型的药物肝毒评价方法
WO2024206911A2 (en) 2023-03-30 2024-10-03 Children's Hospital Medical Center Clinical-grade organoids
WO2024238977A2 (en) 2023-05-18 2024-11-21 Children's Hospital Medical Center Liver organoids with intrahepatic sympathetic nerves, and methods of use thereof
EP4731750A2 (en) 2023-06-23 2026-04-29 Children's Hospital Medical Center Methods of matrix-free suspension culture
WO2025072803A1 (en) 2023-09-29 2025-04-03 Children's Hospital Medical Center Ntrk2 signaling-mediated alveolar capillary injury and repair
WO2025212920A1 (en) 2024-04-03 2025-10-09 Children's Hospital Medical Center Multi-zonal liver organoids
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Publication number Priority date Publication date Assignee Title
CN114317439A (zh) * 2021-12-23 2022-04-12 北京基石生命科技有限公司 一种培养肿瘤类器官的方法
CN114317439B (zh) * 2021-12-23 2024-04-16 北京基石生命科技有限公司 一种培养肿瘤类器官的方法
CN117701492A (zh) * 2023-12-14 2024-03-15 首都医科大学 肝类器官的构建方法及其应用

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JP2022191263A (ja) 2022-12-27
KR102625361B1 (ko) 2024-01-18
CA3065759A1 (en) 2018-12-13
AU2022204804A1 (en) 2022-07-28
IL270714B1 (en) 2025-09-01
JP2020523000A (ja) 2020-08-06
KR102781633B1 (ko) 2025-03-18
KR20200015898A (ko) 2020-02-13
US20200199537A1 (en) 2020-06-25
NZ759164A (en) 2023-02-24
IL270714B2 (en) 2026-01-01
JP7749290B2 (ja) 2025-10-06
AU2018279790A1 (en) 2019-12-05
EP3635095A4 (en) 2021-12-01
KR20240010095A (ko) 2024-01-23
EP3635095A1 (en) 2020-04-15
IL270714A (en) 2020-01-30
WO2018226267A1 (en) 2018-12-13
JP7148552B2 (ja) 2022-10-05
AU2018279790B2 (en) 2022-04-07

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