JP2022191263A5 - - Google Patents
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- Publication number
- JP2022191263A5 JP2022191263A5 JP2022150773A JP2022150773A JP2022191263A5 JP 2022191263 A5 JP2022191263 A5 JP 2022191263A5 JP 2022150773 A JP2022150773 A JP 2022150773A JP 2022150773 A JP2022150773 A JP 2022150773A JP 2022191263 A5 JP2022191263 A5 JP 2022191263A5
- Authority
- JP
- Japan
- Prior art keywords
- liver
- organoid
- liver organoid
- pathway activator
- signaling pathway
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762517414P | 2017-06-09 | 2017-06-09 | |
| US62/517,414 | 2017-06-09 | ||
| JP2019564915A JP7148552B2 (ja) | 2017-06-09 | 2018-02-19 | 肝臓オルガノイド組成物ならびにその作製および使用方法 |
| PCT/US2018/018585 WO2018226267A1 (en) | 2017-06-09 | 2018-02-19 | Liver organoid compositions and methods of making and using same |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019564915A Division JP7148552B2 (ja) | 2017-06-09 | 2018-02-19 | 肝臓オルガノイド組成物ならびにその作製および使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022191263A JP2022191263A (ja) | 2022-12-27 |
| JP2022191263A5 true JP2022191263A5 (https=) | 2023-04-26 |
| JP7749290B2 JP7749290B2 (ja) | 2025-10-06 |
Family
ID=64566329
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019564915A Active JP7148552B2 (ja) | 2017-06-09 | 2018-02-19 | 肝臓オルガノイド組成物ならびにその作製および使用方法 |
| JP2022150773A Active JP7749290B2 (ja) | 2017-06-09 | 2022-09-22 | 肝臓オルガノイド組成物ならびにその作製および使用方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019564915A Active JP7148552B2 (ja) | 2017-06-09 | 2018-02-19 | 肝臓オルガノイド組成物ならびにその作製および使用方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20200199537A1 (https=) |
| EP (1) | EP3635095A4 (https=) |
| JP (2) | JP7148552B2 (https=) |
| KR (2) | KR102781633B1 (https=) |
| CN (1) | CN110914408A (https=) |
| AU (2) | AU2018279790B2 (https=) |
| CA (1) | CA3065759A1 (https=) |
| IL (1) | IL270714B2 (https=) |
| NZ (1) | NZ759164A (https=) |
| WO (1) | WO2018226267A1 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| SG10201801654RA (en) | 2014-05-28 | 2018-04-27 | Childrens Hospital Med Ct | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| AU2015331848B2 (en) | 2014-10-17 | 2022-03-03 | Children's Hospital Medical Center, D/B/A Cincinnati Children's Hospital Medical Center | In vivo model of human small intestine using pluripotent stem cells and methods of making and using same |
| EP4553082A3 (en) * | 2016-11-04 | 2025-08-20 | Children's Hospital Medical Center | Liver organoid compositions and methods of making and using same |
| EP3548507A4 (en) | 2016-12-05 | 2020-07-15 | Children's Hospital Medical Center | COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF |
| JP7248586B2 (ja) | 2017-04-14 | 2023-03-29 | チルドレンズ ホスピタル メディカル センター | 複数ドナー幹細胞組成物およびそれを作製する方法 |
| WO2018226267A1 (en) * | 2017-06-09 | 2018-12-13 | Children's Hospital Medical Center | Liver organoid compositions and methods of making and using same |
| EP3694603B1 (en) | 2017-10-10 | 2026-04-08 | Children's Hospital Medical Center | Esophageal tissue and/or organoid compositions and methods of making same |
| EP3727394A4 (en) | 2017-12-21 | 2021-09-08 | Children's Hospital Medical Center | DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF |
| EP4678727A3 (en) | 2018-07-26 | 2026-03-11 | Children's Hospital Medical Center | Hepato-biliary-pancreatic tissues and methods of making same |
| CA3112026A1 (en) | 2018-09-12 | 2020-03-19 | Children's Hospital Medical Center | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| US12600943B2 (en) | 2019-02-01 | 2026-04-14 | The University Of Hong Kong | Innervated organoid compositions and methods of making same |
| AU2020283048A1 (en) | 2019-05-31 | 2021-12-23 | Children's Hospital Medical Center | Shaped organoid compositions and methods of making same |
| US12497597B2 (en) | 2019-05-31 | 2025-12-16 | Children's Hospital Medical Center | Methods of generating and expanding hematopoietic stem cells |
| US20230039816A1 (en) * | 2019-09-27 | 2023-02-09 | Public University Corporation Yokohama City University | Method for inducing hepatocyte plasticity |
| CA3175071A1 (en) | 2020-03-11 | 2021-09-16 | Bit Bio Limited | Method of generating hepatic cells |
| US20230399623A1 (en) * | 2020-11-13 | 2023-12-14 | Oslo Universitetssykehus Hf | Artifical liver organoids and methods of their production |
| CN112553339B (zh) * | 2020-12-29 | 2024-08-09 | 广东南芯医疗科技有限公司 | 伊立替康个体化用药基因的指导方法及试剂盒 |
| JP2024522642A (ja) * | 2021-06-11 | 2024-06-21 | チルドレンズ ホスピタル メディカル センター | 高ビリルビン血症のための肝臓オルガノイドモデル及びその作製方法及び使用方法 |
| JP2023020221A (ja) * | 2021-07-30 | 2023-02-09 | ウシオ電機株式会社 | 薬剤評価方法 |
| CN114317439B (zh) * | 2021-12-23 | 2024-04-16 | 北京基石生命科技有限公司 | 一种培养肿瘤类器官的方法 |
| CN114891831A (zh) * | 2022-01-14 | 2022-08-12 | 北京清华长庚医院 | 过表达wnt2基因的内皮细胞株及其构建方法和应用 |
| CN115386535B (zh) * | 2022-10-26 | 2023-02-03 | 天津外泌体科技有限公司 | 多谱系肝类器官模型及基于该模型的药物肝毒评价方法 |
| WO2024206911A2 (en) | 2023-03-30 | 2024-10-03 | Children's Hospital Medical Center | Clinical-grade organoids |
| WO2024238977A2 (en) | 2023-05-18 | 2024-11-21 | Children's Hospital Medical Center | Liver organoids with intrahepatic sympathetic nerves, and methods of use thereof |
| EP4731750A2 (en) | 2023-06-23 | 2026-04-29 | Children's Hospital Medical Center | Methods of matrix-free suspension culture |
| WO2025072803A1 (en) | 2023-09-29 | 2025-04-03 | Children's Hospital Medical Center | Ntrk2 signaling-mediated alveolar capillary injury and repair |
| CN117701492B (zh) * | 2023-12-14 | 2025-05-06 | 首都医科大学 | 肝类器官的构建方法及其应用 |
| WO2025212920A1 (en) | 2024-04-03 | 2025-10-09 | Children's Hospital Medical Center | Multi-zonal liver organoids |
| WO2025217202A1 (en) | 2024-04-08 | 2025-10-16 | Children's Hospital Medical Center | Bile duct organoid |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2412800A1 (en) * | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
| WO2011064309A1 (en) * | 2009-11-25 | 2011-06-03 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Method for hepatic differentiation of definitive endoderm cells |
| US9394522B2 (en) * | 2010-03-22 | 2016-07-19 | Takara Bio Europe Ab | Directed differentiation and maturation of pluripotent cells into hepatocyte like cells by modulation of Wnt-signalling pathway |
| TR201104076A1 (tr) * | 2011-04-26 | 2012-11-21 | Kordsa Global End�Str�Yel �Pl�K Ve Kord Bez� San. Ve T�C. A.�. | Araç lastiği üst kuşak şeridinin üretim yöntemi. |
| US20150329821A1 (en) * | 2012-10-19 | 2015-11-19 | Agency For Science, Technology And Research | Methods of differentiating stem cells into one or more cell lineages |
| US9442105B2 (en) * | 2013-03-15 | 2016-09-13 | Organovo, Inc. | Engineered liver tissues, arrays thereof, and methods of making the same |
| SG10201801654RA (en) * | 2014-05-28 | 2018-04-27 | Childrens Hospital Med Ct | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| US20170304369A1 (en) * | 2014-10-08 | 2017-10-26 | Agency For Science, Technology And Research | Methods of differentiating stem cells into liver cell lineages |
| US9324528B1 (en) * | 2014-11-17 | 2016-04-26 | General Electric Company | Magnetic trip mechanism for circuit breaker |
| CN107427537A (zh) * | 2015-03-03 | 2017-12-01 | 哈佛学院院长及董事 | 产生功能性人体组织的方法 |
| EP3350313B1 (en) * | 2015-09-15 | 2025-11-26 | Agency For Science, Technology And Research (A*star) | Derivation of liver organoids from human pluripotent stem cells |
| US20190086391A1 (en) * | 2016-03-08 | 2019-03-21 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method and system for continuous biosensing |
| EP4553082A3 (en) * | 2016-11-04 | 2025-08-20 | Children's Hospital Medical Center | Liver organoid compositions and methods of making and using same |
| WO2018226267A1 (en) * | 2017-06-09 | 2018-12-13 | Children's Hospital Medical Center | Liver organoid compositions and methods of making and using same |
-
2018
- 2018-02-19 WO PCT/US2018/018585 patent/WO2018226267A1/en not_active Ceased
- 2018-02-19 KR KR1020247000992A patent/KR102781633B1/ko active Active
- 2018-02-19 CA CA3065759A patent/CA3065759A1/en active Pending
- 2018-02-19 KR KR1020197034531A patent/KR102625361B1/ko active Active
- 2018-02-19 US US16/611,998 patent/US20200199537A1/en active Pending
- 2018-02-19 AU AU2018279790A patent/AU2018279790B2/en active Active
- 2018-02-19 NZ NZ759164A patent/NZ759164A/en not_active IP Right Cessation
- 2018-02-19 CN CN201880033510.5A patent/CN110914408A/zh active Pending
- 2018-02-19 JP JP2019564915A patent/JP7148552B2/ja active Active
- 2018-02-19 EP EP18813104.9A patent/EP3635095A4/en not_active Withdrawn
- 2018-02-19 IL IL270714A patent/IL270714B2/en unknown
-
2022
- 2022-07-05 AU AU2022204804A patent/AU2022204804A1/en active Pending
- 2022-09-22 JP JP2022150773A patent/JP7749290B2/ja active Active
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