JP2016503304A5 - - Google Patents

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Publication number
JP2016503304A5
JP2016503304A5 JP2015544465A JP2015544465A JP2016503304A5 JP 2016503304 A5 JP2016503304 A5 JP 2016503304A5 JP 2015544465 A JP2015544465 A JP 2015544465A JP 2015544465 A JP2015544465 A JP 2015544465A JP 2016503304 A5 JP2016503304 A5 JP 2016503304A5
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JP
Japan
Prior art keywords
cells
retinoic acid
hepatocyte
inhibitor
receptor activator
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JP2015544465A
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English (en)
Japanese (ja)
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JP2016503304A (ja
JP6476127B2 (ja
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Priority claimed from PCT/EP2013/075017 external-priority patent/WO2014083132A1/en
Publication of JP2016503304A publication Critical patent/JP2016503304A/ja
Publication of JP2016503304A5 publication Critical patent/JP2016503304A5/ja
Application granted granted Critical
Publication of JP6476127B2 publication Critical patent/JP6476127B2/ja
Expired - Fee Related legal-status Critical Current
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JP2015544465A 2012-11-29 2013-11-28 ヒト多能性幹細胞由来肝細胞様細胞の成熟 Expired - Fee Related JP6476127B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201261731281P 2012-11-29 2012-11-29
US201261731266P 2012-11-29 2012-11-29
US61/731,281 2012-11-29
US61/731,266 2012-11-29
DKPA201270740 2012-11-29
DKPA201270741 2012-11-29
DKPA201270740 2012-11-29
DKPA201270741 2012-11-29
PCT/EP2013/075017 WO2014083132A1 (en) 2012-11-29 2013-11-28 Maturation of hepatocyte-like cells derived from human pluripotent stem cells

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019017638A Division JP6780216B2 (ja) 2012-11-29 2019-02-04 ヒト多能性幹細胞由来肝細胞様細胞の成熟

Publications (3)

Publication Number Publication Date
JP2016503304A JP2016503304A (ja) 2016-02-04
JP2016503304A5 true JP2016503304A5 (https=) 2016-12-22
JP6476127B2 JP6476127B2 (ja) 2019-02-27

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JP2015544465A Expired - Fee Related JP6476127B2 (ja) 2012-11-29 2013-11-28 ヒト多能性幹細胞由来肝細胞様細胞の成熟
JP2019017638A Expired - Fee Related JP6780216B2 (ja) 2012-11-29 2019-02-04 ヒト多能性幹細胞由来肝細胞様細胞の成熟

Family Applications After (1)

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JP2019017638A Expired - Fee Related JP6780216B2 (ja) 2012-11-29 2019-02-04 ヒト多能性幹細胞由来肝細胞様細胞の成熟

Country Status (5)

Country Link
US (2) US10294457B2 (https=)
EP (2) EP3401391A1 (https=)
JP (2) JP6476127B2 (https=)
CN (1) CN105143445B (https=)
WO (1) WO2014083132A1 (https=)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
PL2970890T3 (pl) 2013-03-14 2020-11-16 The Brigham And Women's Hospital, Inc. Kompozycje i sposoby ekspansji i hodowli nabłonkowych komórek macierzystych
WO2015069736A1 (en) 2013-11-08 2015-05-14 The Mclean Hospital Corporation METHODS FOR EFFICIENT GENERATION OF GABAergic INTERNEURONS FROM PLURIPOTENT STEM CELLS
SG10201801654RA (en) 2014-05-28 2018-04-27 Childrens Hospital Med Ct Methods and systems for converting precursor cells into gastric tissues through directed differentiation
EP3189134A1 (en) 2014-09-03 2017-07-12 The Brigham and Women's Hospital, Inc. Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss
US10711249B2 (en) 2014-12-26 2020-07-14 Kyoto University Method for inducing hepatocytes
EP3303566B1 (en) 2015-06-03 2020-10-14 Takara Bio Europe AB Maturation of mammalian hepatocytes
US20180161340A1 (en) * 2015-06-18 2018-06-14 St. Jude Children's Research Hospital Methods and compositions for the prevention and treatment of hearing loss
CN106554936B (zh) * 2015-09-30 2020-05-05 海门雨霖细胞科技有限责任公司 诱导人干细胞向肝细胞定向分化的新方法
GB201521179D0 (en) 2015-12-01 2016-01-13 Univ Leuven Kath Methods for differentiating cells into hepatic stellate cells
US11021687B2 (en) 2016-01-08 2021-06-01 The Brigham And Women's Hospital, Inc. Production of differentiated enteroendocrine cells and insulin producing cells
RU2018128598A (ru) * 2016-01-08 2020-02-11 Кинити Ко., Лтд. Способ продуцирования стволовых клеток/клеток-предшественников печени из зрелых клеток печени с использованием низкомолекулярного соединения
US10213511B2 (en) 2016-03-02 2019-02-26 Frequency Therapeutics, Inc. Thermoreversible compositions for administration of therapeutic agents
US11260130B2 (en) 2016-03-02 2022-03-01 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV
US10201540B2 (en) 2016-03-02 2019-02-12 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I
KR101918817B1 (ko) * 2016-10-06 2018-11-14 (주) 넥셀 인간 줄기세포 유래 간세포 분화 방법 및 간세포
EP4553082A3 (en) 2016-11-04 2025-08-20 Children's Hospital Medical Center Liver organoid compositions and methods of making and using same
EP3562827A1 (en) 2016-12-30 2019-11-06 Frequency Therapeutics, Inc. 1h-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells
JP7248586B2 (ja) 2017-04-14 2023-03-29 チルドレンズ ホスピタル メディカル センター 複数ドナー幹細胞組成物およびそれを作製する方法
JP6954531B2 (ja) * 2017-09-15 2021-10-27 国立大学法人大阪大学 高機能分化誘導細胞の濃縮方法及び高機能分化誘導細胞集団
EP3694603B1 (en) 2017-10-10 2026-04-08 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
EP3727394A4 (en) 2017-12-21 2021-09-08 Children's Hospital Medical Center DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF
CN108588008A (zh) * 2018-04-18 2018-09-28 广西壮族自治区畜牧研究所 一种德保黑猪手工克隆重构胚胎体外发育的药物及应用
EP4678727A3 (en) 2018-07-26 2026-03-11 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
JP2021533788A (ja) 2018-08-17 2021-12-09 フリークエンシー セラピューティクス インコーポレイテッド Jag−1を上方制御することにより有毛細胞を生成するための組成物及び方法
US11617745B2 (en) 2018-08-17 2023-04-04 Frequency Therapeutics, Inc. Compositions and methods for generating hair cells by downregulating FOXO
CA3112026A1 (en) 2018-09-12 2020-03-19 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
US20210340502A1 (en) * 2018-09-28 2021-11-04 The Mclean Hospital Corporation Generation of Post-Mitotic Migratory Cortical Interneurons
US12600943B2 (en) 2019-02-01 2026-04-14 The University Of Hong Kong Innervated organoid compositions and methods of making same
EP3920885A1 (en) 2019-02-08 2021-12-15 Frequency Therapeutics, Inc. Valproic acid compounds and wnt agonists for treating ear disorders
JP7556502B2 (ja) * 2019-05-09 2024-09-26 フジフィルム セルラー ダイナミクス,インコーポレイテッド ヘパトサイトの作製方法
US12497597B2 (en) 2019-05-31 2025-12-16 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
AU2020283048A1 (en) 2019-05-31 2021-12-23 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
CA3175071A1 (en) 2020-03-11 2021-09-16 Bit Bio Limited Method of generating hepatic cells
WO2025117474A1 (en) * 2023-11-30 2025-06-05 Immorta Bio, Inc. Treatment of liver failure using personalized progenitor cells and derivatives thereof

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU621972B2 (en) * 1988-12-14 1992-03-26 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Cell culture medium for human liver epithelial cell line
DK0859608T3 (da) * 1995-09-18 2004-06-14 Ligand Pharm Inc Behandling af NIDDM med RXR-agonister
US8579966B2 (en) 1999-11-17 2013-11-12 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US7732199B2 (en) 2001-07-12 2010-06-08 Geron Corporation Process for making transplantable cardiomyocytes from human embryonic stem cells
MXPA04005010A (es) * 2001-11-26 2005-04-08 Advanced Cell Tech Inc METODO PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS METODOS PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS HUMANOS REPROGRAMADOS Y CELULAS DEL TALLO HUMANAS AUTOLOGAS E ISOGENICAS.
JP2005512593A (ja) 2001-12-28 2005-05-12 セルアーティス アーベー 多能性のヒト胚盤胞由来幹細胞株の樹立方法
US20060003446A1 (en) 2002-05-17 2006-01-05 Gordon Keller Mesoderm and definitive endoderm cell populations
WO2004099394A2 (en) 2003-05-08 2004-11-18 Cellartis Ab A method for efficient transfer of human blastocyst-derived stem cells (hbs cells) from a feeder-supported to a feeder-free culture system
WO2005017131A2 (en) * 2003-08-14 2005-02-24 THE GOUVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT F HEALTH AND HUMAN SERVICES Methods for the differentiation of human stem cells
JP2005095138A (ja) * 2003-08-19 2005-04-14 Effector Cell Institute Inc 多分化能を有する細胞の分化誘導方法
US20080207594A1 (en) 2005-05-04 2008-08-28 Davelogen Aktiengesellschaft Use of Gsk-3 Inhibitors for Preventing and Treating Pancreatic Autoimmune Disorders
GB2445338A (en) 2005-10-07 2008-07-02 Cellartis Ab A method for obtaining a xeno-free HBS cell line
US8460928B2 (en) 2005-10-24 2013-06-11 Agency For Science, Technology And Research Methods of specifying mesodermal, endodermal and mesoendodermal cell fates
US20070196514A1 (en) * 2006-02-21 2007-08-23 Benyi Li Prostate cancer treatment with glycogen synthase kinase-3beta inhibitors
US8741643B2 (en) 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
US8148151B2 (en) 2006-06-02 2012-04-03 Geron Corporation Differentiation of primate pluripotent cells to hepatocyte-lineage cells
AU2007256393A1 (en) 2006-06-04 2007-12-13 Cellartis Ab Novel hepatocyte-like cells and hepatoblast-like cells derived from hBS cells
CA2676044C (en) 2007-01-30 2019-10-22 University Of Georgia Research Foundation, Inc. Early mesoderm cells, a stable population of mesendoderm cells that has utility for generation of endoderm and mesoderm lineages and multipotent migratory cells (mmc)
US20090053182A1 (en) * 2007-05-25 2009-02-26 Medistem Laboratories, Inc. Endometrial stem cells and methods of making and using same
JP2010534065A (ja) 2007-07-20 2010-11-04 セルアーティス アーベー ヒト胚盤胞幹細胞に、胚体内胚葉(DE‐hep)を介して由来する新規な肝細胞の集団
EP2195417A1 (en) 2007-08-24 2010-06-16 University Court of the University of Edinburgh Regionalised endoderm cells and uses thereof
JP5694946B2 (ja) 2008-12-03 2015-04-01 インターナショナル ステム セル コーポレイション 幹細胞から分化細胞を得る方法
US20100143313A1 (en) * 2008-12-10 2010-06-10 The General Hospital Corporation Homogeneous differentiation of hepatocyte-like cells from embryonic stem cells
EP2393915A4 (en) * 2009-02-05 2012-12-26 Regenertech Pty Ltd PROCESS FOR THE PREPARATION OF PRECURSOR CELLS FROM DIFFERENTIATED CELLS
US20120142005A1 (en) 2009-05-26 2012-06-07 Takeda Pharmaceutical Company Limited Method for screening of regenerative medicine
KR101874463B1 (ko) 2009-10-31 2018-08-02 뉴 월드 레보러토리즈 인코포레이티드. 세포의 재프로그램화 방법 및 이의 용도
WO2011060342A2 (en) 2009-11-13 2011-05-19 Wisconsin Alumni Research Foundation Cardiac differentiation of human pluripotent stem cells under defined conditions using matrix overlay methods
US9394522B2 (en) * 2010-03-22 2016-07-19 Takara Bio Europe Ab Directed differentiation and maturation of pluripotent cells into hepatocyte like cells by modulation of Wnt-signalling pathway
KR101877077B1 (ko) * 2010-08-09 2018-07-10 다케다 야쿠힌 고교 가부시키가이샤 췌호르몬-생성 세포의 제조 방법

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