CN105143445B - 衍生自人多能干细胞的肝细胞样细胞的成熟 - Google Patents
衍生自人多能干细胞的肝细胞样细胞的成熟 Download PDFInfo
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- CN105143445B CN105143445B CN201380062656.XA CN201380062656A CN105143445B CN 105143445 B CN105143445 B CN 105143445B CN 201380062656 A CN201380062656 A CN 201380062656A CN 105143445 B CN105143445 B CN 105143445B
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261731281P | 2012-11-29 | 2012-11-29 | |
| US201261731266P | 2012-11-29 | 2012-11-29 | |
| US61/731,281 | 2012-11-29 | ||
| US61/731,266 | 2012-11-29 | ||
| DKPA201270740 | 2012-11-29 | ||
| DKPA201270741 | 2012-11-29 | ||
| DKPA201270740 | 2012-11-29 | ||
| DKPA201270741 | 2012-11-29 | ||
| PCT/EP2013/075017 WO2014083132A1 (en) | 2012-11-29 | 2013-11-28 | Maturation of hepatocyte-like cells derived from human pluripotent stem cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105143445A CN105143445A (zh) | 2015-12-09 |
| CN105143445B true CN105143445B (zh) | 2020-07-07 |
Family
ID=50827209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380062656.XA Expired - Fee Related CN105143445B (zh) | 2012-11-29 | 2013-11-28 | 衍生自人多能干细胞的肝细胞样细胞的成熟 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10294457B2 (https=) |
| EP (2) | EP3401391A1 (https=) |
| JP (2) | JP6476127B2 (https=) |
| CN (1) | CN105143445B (https=) |
| WO (1) | WO2014083132A1 (https=) |
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| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| PL2970890T3 (pl) | 2013-03-14 | 2020-11-16 | The Brigham And Women's Hospital, Inc. | Kompozycje i sposoby ekspansji i hodowli nabłonkowych komórek macierzystych |
| WO2015069736A1 (en) | 2013-11-08 | 2015-05-14 | The Mclean Hospital Corporation | METHODS FOR EFFICIENT GENERATION OF GABAergic INTERNEURONS FROM PLURIPOTENT STEM CELLS |
| SG10201801654RA (en) | 2014-05-28 | 2018-04-27 | Childrens Hospital Med Ct | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| EP3189134A1 (en) | 2014-09-03 | 2017-07-12 | The Brigham and Women's Hospital, Inc. | Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss |
| US10711249B2 (en) | 2014-12-26 | 2020-07-14 | Kyoto University | Method for inducing hepatocytes |
| EP3303566B1 (en) | 2015-06-03 | 2020-10-14 | Takara Bio Europe AB | Maturation of mammalian hepatocytes |
| US20180161340A1 (en) * | 2015-06-18 | 2018-06-14 | St. Jude Children's Research Hospital | Methods and compositions for the prevention and treatment of hearing loss |
| CN106554936B (zh) * | 2015-09-30 | 2020-05-05 | 海门雨霖细胞科技有限责任公司 | 诱导人干细胞向肝细胞定向分化的新方法 |
| GB201521179D0 (en) | 2015-12-01 | 2016-01-13 | Univ Leuven Kath | Methods for differentiating cells into hepatic stellate cells |
| US11021687B2 (en) | 2016-01-08 | 2021-06-01 | The Brigham And Women's Hospital, Inc. | Production of differentiated enteroendocrine cells and insulin producing cells |
| RU2018128598A (ru) * | 2016-01-08 | 2020-02-11 | Кинити Ко., Лтд. | Способ продуцирования стволовых клеток/клеток-предшественников печени из зрелых клеток печени с использованием низкомолекулярного соединения |
| US10213511B2 (en) | 2016-03-02 | 2019-02-26 | Frequency Therapeutics, Inc. | Thermoreversible compositions for administration of therapeutic agents |
| US11260130B2 (en) | 2016-03-02 | 2022-03-01 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV |
| US10201540B2 (en) | 2016-03-02 | 2019-02-12 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I |
| KR101918817B1 (ko) * | 2016-10-06 | 2018-11-14 | (주) 넥셀 | 인간 줄기세포 유래 간세포 분화 방법 및 간세포 |
| EP4553082A3 (en) | 2016-11-04 | 2025-08-20 | Children's Hospital Medical Center | Liver organoid compositions and methods of making and using same |
| EP3562827A1 (en) | 2016-12-30 | 2019-11-06 | Frequency Therapeutics, Inc. | 1h-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells |
| JP7248586B2 (ja) | 2017-04-14 | 2023-03-29 | チルドレンズ ホスピタル メディカル センター | 複数ドナー幹細胞組成物およびそれを作製する方法 |
| JP6954531B2 (ja) * | 2017-09-15 | 2021-10-27 | 国立大学法人大阪大学 | 高機能分化誘導細胞の濃縮方法及び高機能分化誘導細胞集団 |
| EP3694603B1 (en) | 2017-10-10 | 2026-04-08 | Children's Hospital Medical Center | Esophageal tissue and/or organoid compositions and methods of making same |
| EP3727394A4 (en) | 2017-12-21 | 2021-09-08 | Children's Hospital Medical Center | DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF |
| CN108588008A (zh) * | 2018-04-18 | 2018-09-28 | 广西壮族自治区畜牧研究所 | 一种德保黑猪手工克隆重构胚胎体外发育的药物及应用 |
| EP4678727A3 (en) | 2018-07-26 | 2026-03-11 | Children's Hospital Medical Center | Hepato-biliary-pancreatic tissues and methods of making same |
| JP2021533788A (ja) | 2018-08-17 | 2021-12-09 | フリークエンシー セラピューティクス インコーポレイテッド | Jag−1を上方制御することにより有毛細胞を生成するための組成物及び方法 |
| US11617745B2 (en) | 2018-08-17 | 2023-04-04 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by downregulating FOXO |
| CA3112026A1 (en) | 2018-09-12 | 2020-03-19 | Children's Hospital Medical Center | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| US20210340502A1 (en) * | 2018-09-28 | 2021-11-04 | The Mclean Hospital Corporation | Generation of Post-Mitotic Migratory Cortical Interneurons |
| US12600943B2 (en) | 2019-02-01 | 2026-04-14 | The University Of Hong Kong | Innervated organoid compositions and methods of making same |
| EP3920885A1 (en) | 2019-02-08 | 2021-12-15 | Frequency Therapeutics, Inc. | Valproic acid compounds and wnt agonists for treating ear disorders |
| JP7556502B2 (ja) * | 2019-05-09 | 2024-09-26 | フジフィルム セルラー ダイナミクス,インコーポレイテッド | ヘパトサイトの作製方法 |
| US12497597B2 (en) | 2019-05-31 | 2025-12-16 | Children's Hospital Medical Center | Methods of generating and expanding hematopoietic stem cells |
| AU2020283048A1 (en) | 2019-05-31 | 2021-12-23 | Children's Hospital Medical Center | Shaped organoid compositions and methods of making same |
| CA3175071A1 (en) | 2020-03-11 | 2021-09-16 | Bit Bio Limited | Method of generating hepatic cells |
| WO2025117474A1 (en) * | 2023-11-30 | 2025-06-05 | Immorta Bio, Inc. | Treatment of liver failure using personalized progenitor cells and derivatives thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100173414A1 (en) * | 2008-12-03 | 2010-07-08 | International Stem Cell Corporation | Methods of Deriving Differentiated Cells from Stem Cells |
| WO2011116930A1 (en) * | 2010-03-22 | 2011-09-29 | Cellartis Ab | Directed differentiation and maturation of pluripotent cells into hepatocyte like cells by modulation of wnt-signalling pathway |
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| AU621972B2 (en) * | 1988-12-14 | 1992-03-26 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Cell culture medium for human liver epithelial cell line |
| DK0859608T3 (da) * | 1995-09-18 | 2004-06-14 | Ligand Pharm Inc | Behandling af NIDDM med RXR-agonister |
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| MXPA04005010A (es) * | 2001-11-26 | 2005-04-08 | Advanced Cell Tech Inc | METODO PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS METODOS PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS HUMANOS REPROGRAMADOS Y CELULAS DEL TALLO HUMANAS AUTOLOGAS E ISOGENICAS. |
| JP2005512593A (ja) | 2001-12-28 | 2005-05-12 | セルアーティス アーベー | 多能性のヒト胚盤胞由来幹細胞株の樹立方法 |
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| WO2004099394A2 (en) | 2003-05-08 | 2004-11-18 | Cellartis Ab | A method for efficient transfer of human blastocyst-derived stem cells (hbs cells) from a feeder-supported to a feeder-free culture system |
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| US20070196514A1 (en) * | 2006-02-21 | 2007-08-23 | Benyi Li | Prostate cancer treatment with glycogen synthase kinase-3beta inhibitors |
| US8741643B2 (en) | 2006-04-28 | 2014-06-03 | Lifescan, Inc. | Differentiation of pluripotent stem cells to definitive endoderm lineage |
| US8148151B2 (en) | 2006-06-02 | 2012-04-03 | Geron Corporation | Differentiation of primate pluripotent cells to hepatocyte-lineage cells |
| AU2007256393A1 (en) | 2006-06-04 | 2007-12-13 | Cellartis Ab | Novel hepatocyte-like cells and hepatoblast-like cells derived from hBS cells |
| CA2676044C (en) | 2007-01-30 | 2019-10-22 | University Of Georgia Research Foundation, Inc. | Early mesoderm cells, a stable population of mesendoderm cells that has utility for generation of endoderm and mesoderm lineages and multipotent migratory cells (mmc) |
| US20090053182A1 (en) * | 2007-05-25 | 2009-02-26 | Medistem Laboratories, Inc. | Endometrial stem cells and methods of making and using same |
| JP2010534065A (ja) | 2007-07-20 | 2010-11-04 | セルアーティス アーベー | ヒト胚盤胞幹細胞に、胚体内胚葉(DE‐hep)を介して由来する新規な肝細胞の集団 |
| EP2195417A1 (en) | 2007-08-24 | 2010-06-16 | University Court of the University of Edinburgh | Regionalised endoderm cells and uses thereof |
| US20100143313A1 (en) * | 2008-12-10 | 2010-06-10 | The General Hospital Corporation | Homogeneous differentiation of hepatocyte-like cells from embryonic stem cells |
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| US20120142005A1 (en) | 2009-05-26 | 2012-06-07 | Takeda Pharmaceutical Company Limited | Method for screening of regenerative medicine |
| KR101874463B1 (ko) | 2009-10-31 | 2018-08-02 | 뉴 월드 레보러토리즈 인코포레이티드. | 세포의 재프로그램화 방법 및 이의 용도 |
| WO2011060342A2 (en) | 2009-11-13 | 2011-05-19 | Wisconsin Alumni Research Foundation | Cardiac differentiation of human pluripotent stem cells under defined conditions using matrix overlay methods |
| KR101877077B1 (ko) * | 2010-08-09 | 2018-07-10 | 다케다 야쿠힌 고교 가부시키가이샤 | 췌호르몬-생성 세포의 제조 방법 |
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2013
- 2013-11-28 JP JP2015544465A patent/JP6476127B2/ja not_active Expired - Fee Related
- 2013-11-28 US US14/648,365 patent/US10294457B2/en not_active Expired - Fee Related
- 2013-11-28 EP EP18169827.5A patent/EP3401391A1/en not_active Withdrawn
- 2013-11-28 EP EP13805795.5A patent/EP2925859B1/en not_active Not-in-force
- 2013-11-28 WO PCT/EP2013/075017 patent/WO2014083132A1/en not_active Ceased
- 2013-11-28 CN CN201380062656.XA patent/CN105143445B/zh not_active Expired - Fee Related
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2018
- 2018-12-19 US US16/225,051 patent/US20190194609A1/en not_active Abandoned
-
2019
- 2019-02-04 JP JP2019017638A patent/JP6780216B2/ja not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100173414A1 (en) * | 2008-12-03 | 2010-07-08 | International Stem Cell Corporation | Methods of Deriving Differentiated Cells from Stem Cells |
| WO2011116930A1 (en) * | 2010-03-22 | 2011-09-29 | Cellartis Ab | Directed differentiation and maturation of pluripotent cells into hepatocyte like cells by modulation of wnt-signalling pathway |
Non-Patent Citations (2)
| Title |
|---|
| Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells;Si-Tayeb K等;《Hepatology》;20100131;第51卷(第1期);摘要、图2A * |
| Jiayi Huang等.Retinoic acid signalling induces the di¡erentiation of mouse fetal liver-derived hepatic progenitor cells.《Liver International》.2009,摘要、第1570页右栏第1段、第1571页左栏第1段、第1575页左栏第2段和图5、图6. * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6780216B2 (ja) | 2020-11-04 |
| EP2925859A1 (en) | 2015-10-07 |
| US20190194609A1 (en) | 2019-06-27 |
| JP2016503304A (ja) | 2016-02-04 |
| EP2925859B1 (en) | 2018-05-02 |
| JP6476127B2 (ja) | 2019-02-27 |
| JP2019088308A (ja) | 2019-06-13 |
| US20150307839A1 (en) | 2015-10-29 |
| EP3401391A1 (en) | 2018-11-14 |
| WO2014083132A1 (en) | 2014-06-05 |
| CN105143445A (zh) | 2015-12-09 |
| US10294457B2 (en) | 2019-05-21 |
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