JP2020522549A5 - - Google Patents
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- JP2020522549A5 JP2020522549A5 JP2019567641A JP2019567641A JP2020522549A5 JP 2020522549 A5 JP2020522549 A5 JP 2020522549A5 JP 2019567641 A JP2019567641 A JP 2019567641A JP 2019567641 A JP2019567641 A JP 2019567641A JP 2020522549 A5 JP2020522549 A5 JP 2020522549A5
- Authority
- JP
- Japan
- Prior art keywords
- apo
- rtx
- cells
- survival
- synergistic effect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000004027 cell Anatomy 0.000 description 9
- 229960004641 rituximab Drugs 0.000 description 9
- 230000002195 synergetic effect Effects 0.000 description 7
- 230000004083 survival effect Effects 0.000 description 6
- 230000009286 beneficial effect Effects 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 239000006146 Roswell Park Memorial Institute medium Substances 0.000 description 2
- 210000001185 bone marrow Anatomy 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 206010061818 Disease progression Diseases 0.000 description 1
- 238000010824 Kaplan-Meier survival analysis Methods 0.000 description 1
- 206010024264 Lethargy Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 206010033892 Paraplegia Diseases 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762516714P | 2017-06-08 | 2017-06-08 | |
| US62/516,714 | 2017-06-08 | ||
| US201762549465P | 2017-08-24 | 2017-08-24 | |
| US62/549,465 | 2017-08-24 | ||
| PCT/IL2018/050621 WO2018225072A1 (en) | 2017-06-08 | 2018-06-07 | Therapeutic apoptotic cells for cancer therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020522549A JP2020522549A (ja) | 2020-07-30 |
| JP2020522549A5 true JP2020522549A5 (https=) | 2021-08-26 |
| JP7321101B2 JP7321101B2 (ja) | 2023-08-04 |
Family
ID=64566093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019567641A Active JP7321101B2 (ja) | 2017-06-08 | 2018-06-07 | 癌治療のための治療的アポトーシス細胞 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11951126B2 (https=) |
| EP (1) | EP3612192A4 (https=) |
| JP (1) | JP7321101B2 (https=) |
| KR (1) | KR20200014418A (https=) |
| CN (1) | CN110996972A (https=) |
| AU (1) | AU2018282127B2 (https=) |
| CA (1) | CA3064893A1 (https=) |
| IL (1) | IL270697A (https=) |
| WO (1) | WO2018225072A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11318163B2 (en) | 2015-02-18 | 2022-05-03 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| EP3865139B1 (en) | 2015-02-18 | 2023-05-03 | Enlivex Therapeutics Rdo Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11304976B2 (en) | 2015-02-18 | 2022-04-19 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| WO2016170541A1 (en) | 2015-04-21 | 2016-10-27 | Enlivex Therapeutics Ltd. | Therapeutic pooled blood apoptotic cell preparations and uses thereof |
| US11596652B2 (en) | 2015-02-18 | 2023-03-07 | Enlivex Therapeutics R&D Ltd | Early apoptotic cells for use in treating sepsis |
| US11000548B2 (en) | 2015-02-18 | 2021-05-11 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11497767B2 (en) | 2015-02-18 | 2022-11-15 | Enlivex Therapeutics R&D Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| CN109069539A (zh) | 2016-02-18 | 2018-12-21 | 恩立夫克治疗有限责任公司 | 用于癌症治疗的联合免疫疗法和细胞因子控制疗法 |
| CN117015387A (zh) * | 2020-10-20 | 2023-11-07 | 加利福尼亚大学董事会 | 减毒的癌细胞及其相关方法 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4036945A (en) | 1976-05-03 | 1977-07-19 | The Massachusetts General Hospital | Composition and method for determining the size and location of myocardial infarcts |
| US4331647A (en) | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| ATE158021T1 (de) | 1990-08-29 | 1997-09-15 | Genpharm Int | Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US6489311B1 (en) | 2000-05-02 | 2002-12-03 | Charlotte-Mecklenburg Hospital Authoirty | Method for the prevention of apoptosis |
| US9944713B2 (en) * | 2004-11-24 | 2018-04-17 | Medicinal Bioconvergence Research Center | Antibody specific to the AIMP2-DX2 |
| EP2566954B2 (en) | 2010-05-04 | 2022-11-02 | Yeda Research and Development Co. Ltd. | Immunotherapy using redirected allogeneic cells |
| HRP20230297T1 (hr) * | 2012-07-13 | 2023-05-12 | The Trustees Of The University Of Pennsylvania | UPRAVLJANJE TOKSIČNOŠĆU ZA ANTI-TUMORSKO DJELOVANJE CAR-a |
| US20140127179A1 (en) * | 2012-11-02 | 2014-05-08 | Scientific Formulations, Llc | Natural Killer Cell Formulations |
| AU2013353573B2 (en) | 2012-12-06 | 2019-01-17 | Enlivex Therapeutics R&D Ltd | Therapeutic apoptotic cell preparations, method for producing same and uses thereof |
| US20160032404A1 (en) * | 2014-08-01 | 2016-02-04 | Pharmacyclics Llc | Biomarkers for predicting response of dlbcl to treatment with a btk inhibitor |
| EP3865139B1 (en) * | 2015-02-18 | 2023-05-03 | Enlivex Therapeutics Rdo Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11318163B2 (en) * | 2015-02-18 | 2022-05-03 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11000548B2 (en) * | 2015-02-18 | 2021-05-11 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11596652B2 (en) * | 2015-02-18 | 2023-03-07 | Enlivex Therapeutics R&D Ltd | Early apoptotic cells for use in treating sepsis |
| US11497767B2 (en) * | 2015-02-18 | 2022-11-15 | Enlivex Therapeutics R&D Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| WO2016170541A1 (en) * | 2015-04-21 | 2016-10-27 | Enlivex Therapeutics Ltd. | Therapeutic pooled blood apoptotic cell preparations and uses thereof |
| US11304976B2 (en) * | 2015-02-18 | 2022-04-19 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| CN109069539A (zh) | 2016-02-18 | 2018-12-21 | 恩立夫克治疗有限责任公司 | 用于癌症治疗的联合免疫疗法和细胞因子控制疗法 |
-
2018
- 2018-06-07 WO PCT/IL2018/050621 patent/WO2018225072A1/en not_active Ceased
- 2018-06-07 KR KR1020207000485A patent/KR20200014418A/ko not_active Ceased
- 2018-06-07 AU AU2018282127A patent/AU2018282127B2/en not_active Expired - Fee Related
- 2018-06-07 CN CN201880051674.0A patent/CN110996972A/zh active Pending
- 2018-06-07 JP JP2019567641A patent/JP7321101B2/ja active Active
- 2018-06-07 CA CA3064893A patent/CA3064893A1/en active Pending
- 2018-06-07 EP EP18812666.8A patent/EP3612192A4/en not_active Withdrawn
-
2019
- 2019-09-19 US US16/576,734 patent/US11951126B2/en active Active
- 2019-11-17 IL IL270697A patent/IL270697A/en unknown
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