JP7321101B2 - 癌治療のための治療的アポトーシス細胞 - Google Patents
癌治療のための治療的アポトーシス細胞 Download PDFInfo
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Description
本出願は、その全体が参照により本明細書に組み込まれる、2017年6月8日に出願された米国仮出願第62/516,714号及び2016年8月24日に出願された米国仮出願第62/549,465号の優先権の利益を主張する。
Claims (7)
- 早期アポトーシス細胞集団を含む組成物であって、
前記組成物は、対象における癌または腫瘍の治療、増殖の抑制、疾患進行の遅延、腫瘍負荷の低減、または発生率の低減のための薬剤の調製に使用され、
前記癌または腫瘍は、白血病またはリンパ腫から選択される非固形癌または非固形腫瘍であり、
前記対象における癌または腫瘍の治療、増殖の抑制、疾患進行の遅延、腫瘍負荷の低減、または発生率の低減により、前記対象における腫瘍または癌の微小残存病変の低減、寛解の増加、寛解期間の増大、腫瘍再発率の低減、転移の防止、転移率の低減、またはそれらの任意の組み合わせをもたらし、
前記早期アポトーシス細胞集団が、
(a)単核濃縮早期アポトーシス細胞集団、または
(b)照射された単核濃縮早期アポトーシス細胞集団を含むか、
あるいは、
前記早期アポトーシス細胞集団が、
早期アポトーシス細胞のプールされた集団であって、
(d)単核濃縮早期アポトーシス細胞集団、または
(e)照射された単核濃縮早期アポトーシス細胞集団を含む、該早期アポトーシス細胞のプールされた集団、
を含み、
前記単核濃縮早期アポトーシス細胞集団を分析すると、少なくとも40%のアネキシンV陽性細胞、及び15%以下のヨウ化プロピジウム陽性細胞を含むことが示されることを特徴とする組成物。 - 請求項1に記載の組成物であって、
前記癌若しくは腫瘍の、サイズ、成長速度若しくはそれらの組み合わせの低下、前記対象の生存期間の延長、または、それらの組み合わせをもたらすことを特徴とする組成物。 - 請求項1または2に記載の組成物であって、
前記対象はヒト対象であることを特徴とする組成物。 - 請求項1~3のいずれか1項に記載の組成物であって、
前記早期アポトーシス細胞集団の単回投与のために製剤化されるか、または
前記早期アポトーシス細胞集団の複数回投与のために製剤化されることを特徴とする組成物。 - 請求項1~4のいずれか1項に記載の組成物であって、
抗体またはその機能的断片を含む、追加の免疫調節剤と共に投与するために製剤化され、
前記追加の免疫調節剤は、前記早期アポトーシス細胞の投与前、投与と同時、または投与後に、投与されることを特徴とする組成物。 - 請求項5に記載の組成物であって、
前記抗体またはその機能的断片は、抗CD20抗体またはその機能的断片を含むことを特徴とする組成物。 - 請求項1~6のいずれか1項に記載の組成物であって、
第一選択療法またはアジュバント療法に使用されることを特徴とする組成物。
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US11596652B2 (en) | 2015-02-18 | 2023-03-07 | Enlivex Therapeutics R&D Ltd | Early apoptotic cells for use in treating sepsis |
US11318163B2 (en) | 2015-02-18 | 2022-05-03 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
US11304976B2 (en) | 2015-02-18 | 2022-04-19 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
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