JP2020521117A - 診断用終末糖化産物抗体 - Google Patents

診断用終末糖化産物抗体 Download PDF

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JP2020521117A
JP2020521117A JP2019560086A JP2019560086A JP2020521117A JP 2020521117 A JP2020521117 A JP 2020521117A JP 2019560086 A JP2019560086 A JP 2019560086A JP 2019560086 A JP2019560086 A JP 2019560086A JP 2020521117 A JP2020521117 A JP 2020521117A
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age
cells
patient
sample
antibody
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JP2020521117A5 (https=
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ルイス エス. グルバー
ルイス エス. グルバー
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シワ コーポレーション
シワ コーポレーション
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Priority to JP2023064753A priority Critical patent/JP2023098996A/ja
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/0002General or multifunctional contrast agents, e.g. chelated agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/70Mechanisms involved in disease identification
    • G01N2800/7042Aging, e.g. cellular aging

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
JP2019560086A 2017-05-04 2018-05-03 診断用終末糖化産物抗体 Pending JP2020521117A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023064753A JP2023098996A (ja) 2017-05-04 2023-04-12 診断用終末糖化産物抗体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762501424P 2017-05-04 2017-05-04
US62/501,424 2017-05-04
US201762610003P 2017-12-22 2017-12-22
US62/610,003 2017-12-22
PCT/US2018/030931 WO2018204679A1 (en) 2017-05-04 2018-05-03 Diagnostic advanced glycation end-product antibodies

Related Child Applications (1)

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JP2023064753A Division JP2023098996A (ja) 2017-05-04 2023-04-12 診断用終末糖化産物抗体

Publications (2)

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JP2020521117A true JP2020521117A (ja) 2020-07-16
JP2020521117A5 JP2020521117A5 (https=) 2021-06-17

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JP2019560086A Pending JP2020521117A (ja) 2017-05-04 2018-05-03 診断用終末糖化産物抗体
JP2023064753A Pending JP2023098996A (ja) 2017-05-04 2023-04-12 診断用終末糖化産物抗体

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US (1) US20200150131A1 (https=)
EP (1) EP3619540A1 (https=)
JP (2) JP2020521117A (https=)
KR (2) KR20200003067A (https=)
CN (1) CN110832327A (https=)
AU (1) AU2018261622A1 (https=)
CA (1) CA3062082A1 (https=)
IL (1) IL270285B2 (https=)
WO (1) WO2018204679A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023538035A (ja) * 2020-08-11 2023-09-06 シェンチェン、プロトゲン、リミテッド 若い無傷ヒト血清アルブミンによる人類の寿命の延長
JP2024514580A (ja) * 2021-04-09 2024-04-02 カチョン ユニバーシティ オブ インダストリー-アカデミック コーオペレイション ファウンデイション グリコトキシン、グリコトキシンに結合した特定タンパク質、またはグリコトキシン-特定タンパク質複合体を含む神経変性疾患のバイオマーカー

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2553225C2 (ru) 2008-05-23 2015-06-10 Сива Корпорейшн Способ облегчения регенерации
US8721571B2 (en) 2010-11-22 2014-05-13 Siwa Corporation Selective removal of cells having accumulated agents
EP3194439B1 (en) 2014-09-19 2022-01-19 Siwa Corporation Anti-age antibodies for treating inflammation and auto-immune disorders
US10358502B2 (en) 2014-12-18 2019-07-23 Siwa Corporation Product and method for treating sarcopenia
US9993535B2 (en) 2014-12-18 2018-06-12 Siwa Corporation Method and composition for treating sarcopenia
HUE058854T2 (hu) 2016-02-19 2022-09-28 Siwa Corp Módszer és készítmény a rák kezelésére, az áttétes rákos sejtek elpusztítására és a rák áttétképzõdésének megelõzésére a fejlett glikációs végtermékek (AGE) elleni antitest alkalmazásával
KR20180133452A (ko) 2016-04-15 2018-12-14 시와 코퍼레이션 신경퇴행성 질환을 치료하기 위한 항-노화 항체
JP2019518763A (ja) 2016-06-23 2019-07-04 シワ コーポレーション 様々な疾患及び障害の治療において使用するためのワクチン
US10925937B1 (en) 2017-01-06 2021-02-23 Siwa Corporation Vaccines for use in treating juvenile disorders associated with inflammation
US10961321B1 (en) 2017-01-06 2021-03-30 Siwa Corporation Methods and compositions for treating pain associated with inflammation
US10995151B1 (en) 2017-01-06 2021-05-04 Siwa Corporation Methods and compositions for treating disease-related cachexia
US10858449B1 (en) 2017-01-06 2020-12-08 Siwa Corporation Methods and compositions for treating osteoarthritis
CA3059803A1 (en) 2017-04-13 2018-10-18 Siwa Corporation Humanized monoclonal advanced glycation end-product antibody
US11518801B1 (en) 2017-12-22 2022-12-06 Siwa Corporation Methods and compositions for treating diabetes and diabetic complications
EP3826670A1 (en) * 2018-07-23 2021-06-02 Siwa Corporation Methods and compositions for treating chronic effects of radiation and chemical exposure
US20220396841A1 (en) * 2019-12-02 2022-12-15 Viome Life Sciences, Inc. Detection and elimination of aberrant cells
KR20210101481A (ko) * 2020-02-10 2021-08-19 한국과학기술연구원 초음파 출력부를 포함하는 노화세포 제거 장치
US20230181730A1 (en) 2020-05-01 2023-06-15 Siwa Corporation Methods of treating infections
WO2022125776A2 (en) 2020-12-09 2022-06-16 Siwa Corporation Methods and compositions for treating kidney diseases
EP4388016A1 (en) 2021-08-20 2024-06-26 Siwa Corporation Methods and compositions for treating fibrotic diseases
CN114624362A (zh) * 2022-03-17 2022-06-14 广东省中医院(广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院) 一种检测血清中晚期糖基化终末产物的试剂盒及其应用
CN118562721A (zh) * 2024-06-27 2024-08-30 广州市华代生物科技有限公司 一种基于全皮模型的糖化衰老模型及抗糖效果测试评价方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003160599A (ja) * 2001-11-22 2003-06-03 Transgenic Inc カルボキシメチル化ペプチドに対する抗体
US20110319499A1 (en) * 2008-06-30 2011-12-29 The Johns Hopkins University Methods for the Detection of Advanced Glycation Endproducts and Markers for Disease
JP2013533766A (ja) * 2010-06-18 2013-08-29 ディアフノプティクス ホールディング ベー.フェー. 皮膚組織の自己蛍光値を求めるための方法および装置
WO2016040752A1 (en) * 2014-09-12 2016-03-17 The Procter & Gamble Company Anti-aging skin care compositions and regimens
US20160215043A1 (en) * 2014-12-18 2016-07-28 Siwa Corporation Product and method for treating sarcopenia

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5624804A (en) 1991-12-20 1997-04-29 The Rockefeller University Immunochemical detection of In vivo advanced glycosylation end products
US6380165B1 (en) 1997-09-19 2002-04-30 The Picower Institute For Medical Research Immunological advanced glycation endproduct crosslink
WO2009085216A2 (en) 2007-12-20 2009-07-09 Squicor Compositions and methods for detecting or elimninating senescent cells to diagnose or treat disease
RU2553225C2 (ru) 2008-05-23 2015-06-10 Сива Корпорейшн Способ облегчения регенерации
ES2725852T3 (es) * 2010-09-27 2019-09-27 Siwa Corp Eliminación selectiva de células modificadas por AGE para el tratamiento de la aterosclerosis
IL286427B2 (en) * 2014-01-28 2024-08-01 Mayo Found Medical Education & Res Inhibitors bcl-2 anti-apoptotic protein family members for treatment of non cancer pulmonary disease or an opthalmic disease
CN108431044A (zh) * 2015-10-13 2018-08-21 Siwa有限公司 抗age抗体及其使用方法
HUE058854T2 (hu) 2016-02-19 2022-09-28 Siwa Corp Módszer és készítmény a rák kezelésére, az áttétes rákos sejtek elpusztítására és a rák áttétképzõdésének megelõzésére a fejlett glikációs végtermékek (AGE) elleni antitest alkalmazásával

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003160599A (ja) * 2001-11-22 2003-06-03 Transgenic Inc カルボキシメチル化ペプチドに対する抗体
US20110319499A1 (en) * 2008-06-30 2011-12-29 The Johns Hopkins University Methods for the Detection of Advanced Glycation Endproducts and Markers for Disease
JP2013533766A (ja) * 2010-06-18 2013-08-29 ディアフノプティクス ホールディング ベー.フェー. 皮膚組織の自己蛍光値を求めるための方法および装置
WO2016040752A1 (en) * 2014-09-12 2016-03-17 The Procter & Gamble Company Anti-aging skin care compositions and regimens
US20160215043A1 (en) * 2014-12-18 2016-07-28 Siwa Corporation Product and method for treating sarcopenia

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
KRTOLICA, A. ET AL.: "Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and ag", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 98, no. 21, JPN6022051418, 9 October 2001 (2001-10-09), pages 12072 - 12077, ISSN: 0004941517 *
MEERWALDT, R. ET AL.: "Skin autofluorescence is a strong predictor of cardiac mortality in diabetes", DIABETES CARE, vol. 30, no. 1, JPN6022051419, January 2007 (2007-01-01), pages 107 - 112, ISSN: 0004941518 *
NI JIAQIAN ET AL.: "Plasma Protein Pentosidine and Carboxymethyllysine, Biomarkers for Age-related Macular Degeneration", MOLECULAR & CELLULAR PROTEOMICS, vol. 8, JPN6020015471, 2009, pages 1921 - 1933, ISSN: 0004731615 *
SCHALKWIJK CASPER G. ET AL.: "Increased accumulation of the glycoxidation product Nε-(carboxymethyl)lysine in hearts of diabetic", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1636, JPN6020015472, March 2004 (2004-03-01), pages 82 - 89, ISSN: 0004941515 *
SCHLEICHER ERWIN D. ET AL.: "Increased Accumulation of the Glycoxidation Product Nε-(carboxymethyl)lysine in Human Tissues in Di", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 99, no. 3, JPN6022010410, February 1997 (1997-02-01), pages 457 - 468, ISSN: 0004941516 *
VAN HEIJST, JEROEN W. J. ET AL., ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 1043, no. 1, JPN6020008356, June 2005 (2005-06-01), pages 725 - 733, ISSN: 0004731616 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023538035A (ja) * 2020-08-11 2023-09-06 シェンチェン、プロトゲン、リミテッド 若い無傷ヒト血清アルブミンによる人類の寿命の延長
JP2024514580A (ja) * 2021-04-09 2024-04-02 カチョン ユニバーシティ オブ インダストリー-アカデミック コーオペレイション ファウンデイション グリコトキシン、グリコトキシンに結合した特定タンパク質、またはグリコトキシン-特定タンパク質複合体を含む神経変性疾患のバイオマーカー
JP7607149B2 (ja) 2021-04-09 2024-12-26 カチョン ユニバーシティ オブ インダストリー-アカデミック コーオペレイション ファウンデイション グリコトキシン、グリコトキシンに結合した特定タンパク質、またはグリコトキシン-特定タンパク質複合体を含む神経変性疾患のバイオマーカー

Also Published As

Publication number Publication date
IL270285B1 (en) 2025-02-01
WO2018204679A1 (en) 2018-11-08
EP3619540A1 (en) 2020-03-11
KR20200003067A (ko) 2020-01-08
RU2019139256A3 (https=) 2022-01-18
IL270285A (en) 2019-12-31
US20200150131A1 (en) 2020-05-14
CA3062082A1 (en) 2018-11-08
AU2018261622A1 (en) 2019-12-12
KR20240006702A (ko) 2024-01-15
IL270285B2 (en) 2025-06-01
CN110832327A (zh) 2020-02-21
JP2023098996A (ja) 2023-07-11
RU2019139256A (ru) 2021-06-07

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