JP2020520905A5 - - Google Patents
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- Publication number
- JP2020520905A5 JP2020520905A5 JP2019563123A JP2019563123A JP2020520905A5 JP 2020520905 A5 JP2020520905 A5 JP 2020520905A5 JP 2019563123 A JP2019563123 A JP 2019563123A JP 2019563123 A JP2019563123 A JP 2019563123A JP 2020520905 A5 JP2020520905 A5 JP 2020520905A5
- Authority
- JP
- Japan
- Prior art keywords
- weeks
- antigen
- antibody
- binding fragment
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims description 73
- 102000036639 antigens Human genes 0.000 claims description 73
- 108091007433 antigens Proteins 0.000 claims description 73
- 239000012634 fragment Substances 0.000 claims description 73
- 238000005303 weighing Methods 0.000 claims description 41
- 238000000034 method Methods 0.000 claims description 32
- 210000002966 serum Anatomy 0.000 claims description 14
- 201000010434 protein-losing enteropathy Diseases 0.000 claims description 8
- 102000004169 proteins and genes Human genes 0.000 claims description 8
- 108090000623 proteins and genes Proteins 0.000 claims description 8
- 206010025210 Lymphangiectasia Diseases 0.000 claims description 7
- 102000007562 Serum Albumin Human genes 0.000 claims description 6
- 108010071390 Serum Albumin Proteins 0.000 claims description 6
- 102100033732 Tumor necrosis factor receptor superfamily member 1A Human genes 0.000 claims description 4
- 101710187743 Tumor necrosis factor receptor superfamily member 1A Proteins 0.000 claims description 4
- 230000002163 immunogen Effects 0.000 claims description 4
- 208000004998 Abdominal Pain Diseases 0.000 claims description 2
- 206010003445 Ascites Diseases 0.000 claims description 2
- 208000000412 Avitaminosis Diseases 0.000 claims description 2
- 206010012735 Diarrhoea Diseases 0.000 claims description 2
- 206010021135 Hypovitaminosis Diseases 0.000 claims description 2
- 206010025282 Lymphoedema Diseases 0.000 claims description 2
- 206010030113 Oedema Diseases 0.000 claims description 2
- 208000002151 Pleural effusion Diseases 0.000 claims description 2
- 206010016256 fatigue Diseases 0.000 claims description 2
- 238000001990 intravenous administration Methods 0.000 claims description 2
- 208000002502 lymphedema Diseases 0.000 claims description 2
- 208000008494 pericarditis Diseases 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 208000030401 vitamin deficiency disease Diseases 0.000 claims description 2
- 230000004580 weight loss Effects 0.000 claims description 2
- 208000016261 weight loss Diseases 0.000 claims description 2
- 230000007423 decrease Effects 0.000 claims 2
- 208000037016 Lymphangiopathies Diseases 0.000 claims 1
- 208000018555 lymphatic system disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762509576P | 2017-05-22 | 2017-05-22 | |
| US62/509,576 | 2017-05-22 | ||
| PCT/US2018/033678 WO2018217638A1 (en) | 2017-05-22 | 2018-05-21 | Dosage and administration of anti-c5 antibodies for treatment of protein-losing enteropathy in patients |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020520905A JP2020520905A (ja) | 2020-07-16 |
| JP2020520905A5 true JP2020520905A5 (https=) | 2021-07-26 |
| JP7194698B2 JP7194698B2 (ja) | 2022-12-22 |
Family
ID=62620989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019563123A Active JP7194698B2 (ja) | 2017-05-22 | 2018-05-21 | 患者においてタンパク質漏出性腸症を処置するための抗ｃ５抗体の投薬量および投与 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11459382B2 (https=) |
| EP (1) | EP3630819B1 (https=) |
| JP (1) | JP7194698B2 (https=) |
| ES (1) | ES2967965T3 (https=) |
| WO (1) | WO2018217638A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7194698B2 (ja) | 2017-05-22 | 2022-12-22 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 患者においてタンパク質漏出性腸症を処置するための抗ｃ５抗体の投薬量および投与 |
| JP7798763B2 (ja) * | 2019-10-25 | 2026-01-14 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｃ５関連疾患の治療または予防のための投与レジメン |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6074642A (en) | 1994-05-02 | 2000-06-13 | Alexion Pharmaceuticals, Inc. | Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis |
| PL3167888T3 (pl) | 2006-03-15 | 2024-08-26 | Alexion Pharmaceuticals, Inc. | Leczenie pacjentów z napadową nocną hemoglobinurią za pomocą inhibitora dopełniacza |
| PY09026846A (es) | 2008-08-05 | 2015-09-01 | Novartis Ag | Composiciones y métodos para anticuerpos que se dirigen a la proteína de complemento c5 |
| LT2894165T (lt) * | 2008-11-10 | 2023-03-10 | Alexion Pharmaceuticals, Inc. | Būdai ir kompozicijos, skirti su komplementu susijusių sutrikimų gydymui |
| CN107207607B (zh) | 2014-12-19 | 2021-05-04 | 中外制药株式会社 | 抗-c5抗体及使用方法 |
| US20190256915A1 (en) * | 2016-09-14 | 2019-08-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv | Methods of diagnosing and treating cd55 deficiency, hyperactivation of complement, angiopathic thrombosis and protein losing enteropathy (chaple), a newly identified orphan disease |
| JP7194698B2 (ja) | 2017-05-22 | 2022-12-22 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 患者においてタンパク質漏出性腸症を処置するための抗ｃ５抗体の投薬量および投与 |
-
2018
- 2018-05-21 JP JP2019563123A patent/JP7194698B2/ja active Active
- 2018-05-21 US US16/614,582 patent/US11459382B2/en active Active
- 2018-05-21 ES ES18731616T patent/ES2967965T3/es active Active
- 2018-05-21 WO PCT/US2018/033678 patent/WO2018217638A1/en not_active Ceased
- 2018-05-21 EP EP18731616.1A patent/EP3630819B1/en active Active
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