|
US3710795A
(en)
|
1970-09-29 |
1973-01-16 |
Alza Corp |
Drug-delivery device with stretched, rate-controlling membrane
|
|
US4485045A
(en)
|
1981-07-06 |
1984-11-27 |
Research Corporation |
Synthetic phosphatidyl cholines useful in forming liposomes
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4544545A
(en)
|
1983-06-20 |
1985-10-01 |
Trustees University Of Massachusetts |
Liposomes containing modified cholesterol for organ targeting
|
|
WO1987000201A1
(en)
|
1985-07-05 |
1987-01-15 |
Whitehead Institute For Biomedical Research |
Epithelial cells expressing foreign genetic material
|
|
US4980286A
(en)
|
1985-07-05 |
1990-12-25 |
Whitehead Institute For Biomedical Research |
In vivo introduction and expression of foreign genetic material in epithelial cells
|
|
US4863457A
(en)
|
1986-11-24 |
1989-09-05 |
Lee David A |
Drug delivery device
|
|
WO1988007089A1
(en)
|
1987-03-18 |
1988-09-22 |
Medical Research Council |
Altered antibodies
|
|
EP0378576B1
(en)
|
1987-09-11 |
1995-01-18 |
Whitehead Institute For Biomedical Research |
Transduced fibroblasts and uses therefor
|
|
WO1989005345A1
(en)
|
1987-12-11 |
1989-06-15 |
Whitehead Institute For Biomedical Research |
Genetic modification of endothelial cells
|
|
JP2917998B2
(ja)
|
1988-02-05 |
1999-07-12 |
ホワイトヘッド・インスティチュート・フォー・バイオメディカル・リサーチ |
修飾された肝細胞およびその用途
|
|
US5013556A
(en)
|
1989-10-20 |
1991-05-07 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5164188A
(en)
|
1989-11-22 |
1992-11-17 |
Visionex, Inc. |
Biodegradable ocular implants
|
|
JP3249516B2
(ja)
|
1990-10-31 |
2002-01-21 |
ソマティクス セラピー コーポレイション |
遺伝子治療のためのレトロウイルスのベクター
|
|
KR0185215B1
(ko)
|
1990-11-30 |
1999-05-01 |
요시다 쇼오지 |
서방성 안구삽입용 약제
|
|
US5714350A
(en)
|
1992-03-09 |
1998-02-03 |
Protein Design Labs, Inc. |
Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
|
|
BR9306765A
(pt)
|
1992-07-23 |
1998-12-08 |
Minnesota Mining & Mfg |
Processo para a preparação de uma partícula abrasiva e artigo abrasivo
|
|
AU701578B2
(en)
|
1992-08-21 |
1999-02-04 |
Vrije Universiteit Brussel |
Immunoglobulins devoid of light chains
|
|
US6005079A
(en)
|
1992-08-21 |
1999-12-21 |
Vrije Universiteit Brussels |
Immunoglobulins devoid of light chains
|
|
US5885573A
(en)
|
1993-06-01 |
1999-03-23 |
Arch Development Corporation |
Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies
|
|
IT1265573B1
(it)
|
1993-09-17 |
1996-11-22 |
Zanussi Grandi Impianti Spa |
Forno di cottura di alimenti con porta perfezionata
|
|
US5308341A
(en)
|
1993-09-28 |
1994-05-03 |
Becton, Dickinson And Company |
Method of testing the dose accuracy of a medication delivery device
|
|
US5443505A
(en)
|
1993-11-15 |
1995-08-22 |
Oculex Pharmaceuticals, Inc. |
Biocompatible ocular implants
|
|
NZ281112A
(en)
|
1994-03-07 |
1998-04-27 |
Inhale Therapeutic Syst |
Powdered insulin delivered as an aerosol
|
|
US6074642A
(en)
|
1994-05-02 |
2000-06-13 |
Alexion Pharmaceuticals, Inc. |
Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis
|
|
US6019968A
(en)
|
1995-04-14 |
2000-02-01 |
Inhale Therapeutic Systems, Inc. |
Dispersible antibody compositions and methods for their preparation and use
|
|
AU725609C
(en)
|
1995-08-18 |
2002-01-03 |
Morphosys Ag |
Protein/(poly)peptide libraries
|
|
US5773019A
(en)
|
1995-09-27 |
1998-06-30 |
The University Of Kentucky Research Foundation |
Implantable controlled release device to deliver drugs directly to an internal portion of the body
|
|
JP4046354B2
(ja)
|
1996-03-18 |
2008-02-13 |
ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム |
増大した半減期を有する免疫グロブリン様ドメイン
|
|
US6001329A
(en)
|
1996-05-06 |
1999-12-14 |
Uab Research Foundation |
Radiolabeled fusion toxins for cancer therapy
|
|
US6146361A
(en)
|
1996-09-26 |
2000-11-14 |
Becton Dickinson And Company |
Medication delivery pen having a 31 gauge needle
|
|
WO1998023289A1
(en)
|
1996-11-27 |
1998-06-04 |
The General Hospital Corporation |
MODULATION OF IgG BINDING TO FcRn
|
|
GB9626960D0
(en)
|
1996-12-27 |
1997-02-12 |
Glaxo Group Ltd |
Valve for aerosol container
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
WO1998047531A2
(en)
|
1997-04-21 |
1998-10-29 |
Arch Development Corporation |
Fc receptor non-binding anti-cd3 monoclonal antibodies deliver a partial tcr signal and induce clonal anergy
|
|
US5954047A
(en)
|
1997-10-17 |
1999-09-21 |
Systemic Pulmonary Development, Ltd. |
Methods and apparatus for delivering aerosolized medication
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
US6302855B1
(en)
|
1998-05-20 |
2001-10-16 |
Novo Nordisk A/S |
Medical apparatus for use by a patient for medical self treatment of diabetes
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
HU230769B1
(hu)
|
1999-01-15 |
2018-03-28 |
Genentech Inc. |
Módosított effektor-funkciójú polipeptid-változatok
|
|
EP1169053A1
(en)
|
1999-04-13 |
2002-01-09 |
Inhale Therapeutic Systems, Inc. |
Pulmonary administration of dry powder formulations for treating infertility
|
|
WO2000061178A1
(en)
|
1999-04-13 |
2000-10-19 |
Inhale Therapeutics Systems, Inc. |
Pulmonary administration of dry powder formulations for treating infertility
|
|
US6192891B1
(en)
|
1999-04-26 |
2001-02-27 |
Becton Dickinson And Company |
Integrated system including medication delivery pen, blood monitoring device, and lancer
|
|
GB9910975D0
(en)
|
1999-05-13 |
1999-07-14 |
Univ Strathclyde |
Rapid dehydration of proteins
|
|
US6277099B1
(en)
|
1999-08-06 |
2001-08-21 |
Becton, Dickinson And Company |
Medication delivery pen
|
|
PE20011227A1
(es)
|
2000-04-17 |
2002-01-07 |
Chiesi Farma Spa |
Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros
|
|
ATE547080T1
(de)
|
2000-08-30 |
2012-03-15 |
Univ Johns Hopkins |
Vorrichtungen zur intraokularen arzneimittelabgabe
|
|
PT1355919E
(pt)
|
2000-12-12 |
2011-03-02 |
Medimmune Llc |
Moléculas com semivida longa, composições que as contêm e suas utilizações
|
|
AU2002333554C1
(en)
|
2001-09-12 |
2008-12-11 |
Becton, Dickinson And Company |
Microneedle-based pen device for drug delivery and method for using same
|
|
AU2003217912A1
(en)
|
2002-03-01 |
2003-09-16 |
Xencor |
Antibody optimization
|
|
AU2003256266A1
(en)
|
2002-06-12 |
2003-12-31 |
Genencor International, Inc. |
Methods and compositions for milieu-dependent binding of a targeted agent to a target
|
|
US9415102B2
(en)
|
2002-09-06 |
2016-08-16 |
Alexion Pharmaceuticals, Inc. |
High concentration formulations of anti-C5 antibodies
|
|
US20050271660A1
(en)
|
2002-09-06 |
2005-12-08 |
Alexion Pharmaceuticals, Inc. |
Nebulization of monoclonal antibodies for treating pulmonary diseases
|
|
US20040102469A1
(en)
|
2002-09-13 |
2004-05-27 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Method for reducing the mortality rate
|
|
GB0222023D0
(en)
|
2002-09-21 |
2002-10-30 |
Aventis Pharma Ltd |
Inhaler
|
|
WO2004029207A2
(en)
|
2002-09-27 |
2004-04-08 |
Xencor Inc. |
Optimized fc variants and methods for their generation
|
|
FR2849436B1
(fr)
|
2002-12-27 |
2007-01-05 |
Patrick Frayssinet |
Particules et ceramiques de phosphates de calcium pour transfection in vivo et in vitro
|
|
WO2004073551A2
(en)
|
2003-02-18 |
2004-09-02 |
Massachusetts Eye And Ear Infirmary |
Transscleral drug delivery device and related methods
|
|
AU2004261229A1
(en)
|
2003-07-29 |
2005-02-10 |
Eisai, Inc. |
Antibodies and methods for generating genetically altered antibodies with enhanced effector function
|
|
GB0324368D0
(en)
|
2003-10-17 |
2003-11-19 |
Univ Cambridge Tech |
Polypeptides including modified constant regions
|
|
US20050249723A1
(en)
|
2003-12-22 |
2005-11-10 |
Xencor, Inc. |
Fc polypeptides with novel Fc ligand binding sites
|
|
EP1737890A2
(en)
|
2004-03-24 |
2007-01-03 |
Xencor, Inc. |
Immunoglobulin variants outside the fc region
|
|
US8685435B2
(en)
|
2004-04-30 |
2014-04-01 |
Allergan, Inc. |
Extended release biodegradable ocular implants
|
|
US7919094B2
(en)
|
2004-06-10 |
2011-04-05 |
Omeros Corporation |
Methods for treating conditions associated with MASP-2 dependent complement activation
|
|
GB0416328D0
(en)
|
2004-07-21 |
2004-08-25 |
Univ Cardiff |
Use of dry powder compositions for pulmonary delivery
|
|
US20060074225A1
(en)
|
2004-09-14 |
2006-04-06 |
Xencor, Inc. |
Monomeric immunoglobulin Fc domains
|
|
US8367805B2
(en)
|
2004-11-12 |
2013-02-05 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
US8802820B2
(en)
|
2004-11-12 |
2014-08-12 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
DK1817340T3
(da)
|
2004-11-12 |
2012-08-13 |
Xencor Inc |
Fc-varianter med ændret binding til fcrn
|
|
WO2006094234A1
(en)
|
2005-03-03 |
2006-09-08 |
Xencor, Inc. |
Methods for the design of libraries of protein variants
|
|
CA2602663A1
(en)
|
2005-03-31 |
2006-10-05 |
Xencor, Inc. |
Fc variants with optimized properties
|
|
WO2007041635A2
(en)
|
2005-10-03 |
2007-04-12 |
Xencor, Inc. |
Fc variants with optimized fc receptor binding properties
|
|
BRPI0620316A2
(pt)
|
2005-12-21 |
2011-11-08 |
Wyeth Corp |
formulações de proteìnas com viscosidades reduzida e seus usos
|
|
RS53864B1
(sr)
|
2006-03-02 |
2015-08-31 |
Alexion Pharmaceuticals, Inc. |
Produžavanje preživljavanja alografta inhibiranjem aktivnosti komplementa
|
|
PL3167888T3
(pl)
|
2006-03-15 |
2024-08-26 |
Alexion Pharmaceuticals, Inc. |
Leczenie pacjentów z napadową nocną hemoglobinurią za pomocą inhibitora dopełniacza
|
|
ES2892925T3
(es)
|
2006-03-31 |
2022-02-07 |
Chugai Pharmaceutical Co Ltd |
Métodos para controlar la farmacocinética en sangre de anticuerpos
|
|
US8037880B2
(en)
|
2006-04-07 |
2011-10-18 |
The University Of Western Ontario |
Dry powder inhaler
|
|
US20100034194A1
(en)
|
2006-10-11 |
2010-02-11 |
Siemens Communications Inc. |
Eliminating unreachable subscribers in voice-over-ip networks
|
|
AU2007313300A1
(en)
|
2006-10-16 |
2008-04-24 |
Medimmune, Llc. |
Molecules with reduced half-lives, compositions and uses thereof
|
|
WO2008092117A2
(en)
|
2007-01-25 |
2008-07-31 |
Xencor, Inc. |
Immunoglobulins with modifications in the fcr binding region
|
|
US20090110679A1
(en)
|
2007-07-13 |
2009-04-30 |
Luk-Chiu Li |
Methods and compositions for pulmonary administration of a TNFa inhibitor
|
|
CN101874042B9
(zh)
|
2007-09-26 |
2019-01-01 |
中外制药株式会社 |
利用cdr的氨基酸取代来改变抗体等电点的方法
|
|
RU2529951C2
(ru)
|
2007-12-26 |
2014-10-10 |
Ксенкор, Инк. |
ВАРИАНТЫ Fc С ИЗМЕНЕННЫМ СВЯЗЫВАНИЕМ C FcRn
|
|
KR102057826B1
(ko)
|
2008-04-11 |
2019-12-20 |
추가이 세이야쿠 가부시키가이샤 |
복수 분자의 항원에 반복 결합하는 항원 결합 분자
|
|
PY09026846A
(es)
|
2008-08-05 |
2015-09-01 |
Novartis Ag |
Composiciones y métodos para anticuerpos que se dirigen a la proteína de complemento c5
|
|
EP3524620A1
(en)
|
2008-10-14 |
2019-08-14 |
Genentech, Inc. |
Immunoglobulin variants and uses thereof
|
|
AU2015227544B2
(en)
|
2008-11-10 |
2017-05-25 |
Alexion Pharmaceuticals, Inc. |
Methods and compositions for treating complement-associated disorders
|
|
LT2894165T
(lt)
|
2008-11-10 |
2023-03-10 |
Alexion Pharmaceuticals, Inc. |
Būdai ir kompozicijos, skirti su komplementu susijusių sutrikimų gydymui
|
|
NZ597259A
(en)
|
2009-06-23 |
2014-04-30 |
Alexion Pharma Inc |
Bispecific antibodies that bind to complement proteins
|
|
SG183867A1
(en)
|
2010-03-11 |
2012-10-30 |
Rinat Neuroscience Corp |
ANTIBODIES WITH pH DEPENDENT ANTIGEN BINDING
|
|
TWI667346B
(zh)
|
2010-03-30 |
2019-08-01 |
中外製藥股份有限公司 |
促進抗原消失之具有經修飾的FcRn親和力之抗體
|
|
SG185107A1
(en)
|
2010-04-30 |
2012-12-28 |
Alexion Pharma Inc |
Antibodies having reduced immunogenicity in a human
|
|
TWI812066B
(zh)
|
2010-11-30 |
2023-08-11 |
日商中外製藥股份有限公司 |
具有鈣依存性的抗原結合能力之抗體
|
|
EP2698431B1
(en)
|
2011-03-30 |
2020-09-09 |
Chugai Seiyaku Kabushiki Kaisha |
Retention of antigen-binding molecules in blood plasma and method for modifying immunogenicity
|
|
TW201817744A
(zh)
|
2011-09-30 |
2018-05-16 |
日商中外製藥股份有限公司 |
具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子
|
|
JP6322411B2
(ja)
|
2011-09-30 |
2018-05-09 |
中外製薬株式会社 |
複数の生理活性を有する抗原の消失を促進する抗原結合分子
|
|
AU2014306002B2
(en)
|
2013-08-07 |
2017-05-25 |
Alexion Pharmaceuticals, Inc. |
Atypical hemolytic uremic syndrome (aHUS) biomarker proteins
|
|
NZ631007A
(en)
|
2014-03-07 |
2015-10-30 |
Alexion Pharma Inc |
Anti-c5 antibodies having improved pharmacokinetics
|
|
CN107207607B
(zh)
|
2014-12-19 |
2021-05-04 |
中外制药株式会社 |
抗-c5抗体及使用方法
|
|
US20190135903A1
(en)
|
2015-03-31 |
2019-05-09 |
Alexion Pharmaceuticals, Inc. |
Identifying and treating subpopulations of paroxysmal nocturnal hemoglobinuria (pnh) patients
|
|
US20180311299A1
(en)
|
2015-05-01 |
2018-11-01 |
Alexion Pharmaceuticals, Inc. |
Efficacy of an anti-c5 antibody in the prevention of antibody mediated rejection in sensitized recipients of a kidney transplant
|
|
EP3313437A1
(en)
|
2015-06-26 |
2018-05-02 |
Alexion Pharmaceuticals, Inc. |
A method for treating a patient in compliance with vaccination with eculizumab or an eculizumab variant
|
|
WO2017044811A1
(en)
|
2015-09-11 |
2017-03-16 |
Bruce Andrien |
Recombinant glycosylated eculizumab and eculizumab variants
|
|
US20180311345A1
(en)
|
2015-10-30 |
2018-11-01 |
Alexion Pharmaceuticals, Inc. |
A method of inhibiting exacerbations of t cell-mediated allograft vasculopathy
|
|
EP3402816A1
(en)
*
|
2016-01-11 |
2018-11-21 |
Alexion Pharmaceuticals, Inc. |
Dosage and administration of anti-c5 antibodies for treatment
|
|
ES2984352T3
(es)
|
2016-06-14 |
2024-10-29 |
Regeneron Pharma |
Anticuerpos anti-C5 y usos de los mismos
|
|
EP3526250A1
(en)
|
2016-10-12 |
2019-08-21 |
Alexion Pharmaceuticals, Inc. |
Efficacy of an anti-c5 antibody in the prevention of antibody mediated rejection in sensitized recipients of a kidney transplant
|
|
CA3080187A1
(en)
|
2017-10-26 |
2019-05-02 |
Alexion Pharmaceuticals, Inc. |
Dosage and administration of anti-c5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (pnh) and atypical hemolytic uremic syndrome (ahus)
|
|
US12404320B2
(en)
|
2018-05-31 |
2025-09-02 |
Alexion Pharmaceuticals, Inc. |
Dosage and administration of anti-C5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (PNH) in pediatric patients
|
|
JP7577542B2
(ja)
|
2018-06-04 |
2024-11-05 |
アレクシオン ファーマシューティカルズ， インコーポレイテッド |
小児患者における非典型溶血性尿毒症症候群（ａＨＵＳ）の治療のための抗Ｃ５抗体の用量および投与
|
|
CN112996561A
(zh)
|
2018-10-30 |
2021-06-18 |
亚力兄制药公司 |
用于治疗阵发性睡眠性血红蛋白尿症(pnh)的抗c5抗体的皮下剂量和施用
|
|
CA3127797A1
(en)
|
2019-01-25 |
2020-07-30 |
Alexion Pharmaceuticals, Inc. |
Dosage and administration of anti-c5 antibodies for treatment of atypical hemolytic uremic syndrome (ahus)
|
|
EP4054634A1
(en)
|
2019-11-08 |
2022-09-14 |
Alexion Pharmaceuticals, Inc. |
High concentration anti-c5 antibody formulations
|
|
JP2023533030A
(ja)
|
2020-07-09 |
2023-08-01 |
アレクシオン ファーマシューティカルズ， インコーポレイテッド |
小児患者において発作性夜間血色素尿症（ｐｎｈ）を治療するための抗ｃ５抗体の投薬量及び投与
|
|
CA3196434A1
(en)
|
2020-10-23 |
2022-04-28 |
Krista K. JOHNSON |
Methods of treating patients having complement disorders using anti-c5 antibodies
|