JP2020517735A5 - - Google Patents
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- JP2020517735A5 JP2020517735A5 JP2020507498A JP2020507498A JP2020517735A5 JP 2020517735 A5 JP2020517735 A5 JP 2020517735A5 JP 2020507498 A JP2020507498 A JP 2020507498A JP 2020507498 A JP2020507498 A JP 2020507498A JP 2020517735 A5 JP2020517735 A5 JP 2020517735A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- rdna sequence
- acnes
- composition according
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108020004465 16S ribosomal RNA Proteins 0.000 claims 28
- 239000000203 mixture Substances 0.000 claims 27
- 230000003255 anti-acne Effects 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 13
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 10
- 102000004190 Enzymes Human genes 0.000 claims 10
- 108090000790 Enzymes Proteins 0.000 claims 10
- 229940088598 enzyme Drugs 0.000 claims 10
- 230000035772 mutation Effects 0.000 claims 10
- 208000020154 Acnes Diseases 0.000 claims 8
- 241001515965 unidentified phage Species 0.000 claims 8
- 241000186427 Cutibacterium acnes Species 0.000 claims 6
- 241000894006 Bacteria Species 0.000 claims 5
- 239000004342 Benzoyl peroxide Substances 0.000 claims 5
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims 5
- 235000019400 benzoyl peroxide Nutrition 0.000 claims 5
- 239000006041 probiotic Substances 0.000 claims 5
- 230000000529 probiotic effect Effects 0.000 claims 5
- 235000018291 probiotics Nutrition 0.000 claims 5
- 229940055019 propionibacterium acne Drugs 0.000 claims 5
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 claims 4
- 208000002874 Acne Vulgaris Diseases 0.000 claims 3
- 108010031186 Glycoside Hydrolases Proteins 0.000 claims 3
- 102000005744 Glycoside Hydrolases Human genes 0.000 claims 3
- 239000004367 Lipase Substances 0.000 claims 3
- 102000004882 Lipase Human genes 0.000 claims 3
- 108090001060 Lipase Proteins 0.000 claims 3
- 206010000496 acne Diseases 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 235000019421 lipase Nutrition 0.000 claims 3
- 230000001717 pathogenic effect Effects 0.000 claims 3
- 239000013612 plasmid Substances 0.000 claims 3
- 108010067770 Endopeptidase K Proteins 0.000 claims 2
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 claims 2
- 241000186429 Propionibacterium Species 0.000 claims 2
- 239000004365 Protease Substances 0.000 claims 2
- 108090000787 Subtilisin Proteins 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 229950006780 n-acetylglucosamine Drugs 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 230000007918 pathogenicity Effects 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- ZZPKZRHERLGEKA-UHFFFAOYSA-N resorcinol monoacetate Chemical compound CC(=O)OC1=CC=CC(O)=C1 ZZPKZRHERLGEKA-UHFFFAOYSA-N 0.000 claims 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims 2
- 241000894007 species Species 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- 239000000304 virulence factor Substances 0.000 claims 2
- 230000007923 virulence factor Effects 0.000 claims 2
- 239000004382 Amylase Substances 0.000 claims 1
- 102000013142 Amylases Human genes 0.000 claims 1
- 108010065511 Amylases Proteins 0.000 claims 1
- 241001135755 Betaproteobacteria Species 0.000 claims 1
- 108010059892 Cellulase Proteins 0.000 claims 1
- 241000186216 Corynebacterium Species 0.000 claims 1
- 241001464974 Cutibacterium avidum Species 0.000 claims 1
- 241001464975 Cutibacterium granulosum Species 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 102000016911 Deoxyribonucleases Human genes 0.000 claims 1
- 108010053770 Deoxyribonucleases Proteins 0.000 claims 1
- DUKURNFHYQXCJG-UHFFFAOYSA-N Lewis A pentasaccharide Natural products OC1C(O)C(O)C(C)OC1OC1C(OC2C(C(O)C(O)C(CO)O2)O)C(NC(C)=O)C(OC2C(C(OC3C(OC(O)C(O)C3O)CO)OC(CO)C2O)O)OC1CO DUKURNFHYQXCJG-UHFFFAOYSA-N 0.000 claims 1
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 claims 1
- 108090000526 Papain Proteins 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 102000003992 Peroxidases Human genes 0.000 claims 1
- 241000982698 Prorodonopsis coli Species 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 102400000830 Saposin-B Human genes 0.000 claims 1
- 101800001697 Saposin-B Proteins 0.000 claims 1
- 241000702202 Siphoviridae Species 0.000 claims 1
- 241000191940 Staphylococcus Species 0.000 claims 1
- 102000019197 Superoxide Dismutase Human genes 0.000 claims 1
- 108010012715 Superoxide dismutase Proteins 0.000 claims 1
- 102000004142 Trypsin Human genes 0.000 claims 1
- 108090000631 Trypsin Proteins 0.000 claims 1
- 238000004115 adherent culture Methods 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 229940061720 alpha hydroxy acid Drugs 0.000 claims 1
- 150000001280 alpha hydroxy acids Chemical class 0.000 claims 1
- 235000019418 amylase Nutrition 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000003712 anti-aging effect Effects 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 102000007478 beta-N-Acetylhexosaminidases Human genes 0.000 claims 1
- 108010085377 beta-N-Acetylhexosaminidases Proteins 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- -1 bromeline Proteins 0.000 claims 1
- 229940106157 cellulase Drugs 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 210000002919 epithelial cell Anatomy 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 230000002101 lytic effect Effects 0.000 claims 1
- 239000007764 o/w emulsion Substances 0.000 claims 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 1
- 229940055729 papain Drugs 0.000 claims 1
- 235000019834 papain Nutrition 0.000 claims 1
- 108040007629 peroxidase activity proteins Proteins 0.000 claims 1
- 108010004131 poly(beta-D-mannuronate) lyase Proteins 0.000 claims 1
- 229940055009 propionibacterium avidum Drugs 0.000 claims 1
- 235000019419 proteases Nutrition 0.000 claims 1
- 108091008146 restriction endonucleases Proteins 0.000 claims 1
- 150000004492 retinoid derivatives Chemical class 0.000 claims 1
- 229960004889 salicylic acid Drugs 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 238000004114 suspension culture Methods 0.000 claims 1
- 239000012588 trypsin Substances 0.000 claims 1
- 239000007762 w/o emulsion Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024063779A JP7801389B2 (ja) | 2017-04-21 | 2024-04-11 | ざ瘡を治療するためのプロピオニバクテリウムアクネス（Ｐｒｏｐｉｏｎｉｂａｃｔｅｒｉｕｍ ａｃｎｅｓ）バクテリオファージを含む組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762488326P | 2017-04-21 | 2017-04-21 | |
| US62/488,326 | 2017-04-21 | ||
| PCT/US2018/028556 WO2018195415A1 (en) | 2017-04-21 | 2018-04-20 | Compositions comprising propionibacterium acnes bacteriophages for treating acne |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024063779A Division JP7801389B2 (ja) | 2017-04-21 | 2024-04-11 | ざ瘡を治療するためのプロピオニバクテリウムアクネス（Ｐｒｏｐｉｏｎｉｂａｃｔｅｒｉｕｍ ａｃｎｅｓ）バクテリオファージを含む組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020517735A JP2020517735A (ja) | 2020-06-18 |
| JP2020517735A5 true JP2020517735A5 (enExample) | 2021-05-27 |
| JP7595459B2 JP7595459B2 (ja) | 2024-12-06 |
Family
ID=63857016
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020507498A Active JP7595459B2 (ja) | 2017-04-21 | 2018-04-20 | ざ瘡を治療するためのプロピオニバクテリウムアクネス（Ｐｒｏｐｉｏｎｉｂａｃｔｅｒｉｕｍ ａｃｎｅｓ）バクテリオファージを含む組成物 |
| JP2024063779A Active JP7801389B2 (ja) | 2017-04-21 | 2024-04-11 | ざ瘡を治療するためのプロピオニバクテリウムアクネス（Ｐｒｏｐｉｏｎｉｂａｃｔｅｒｉｕｍ ａｃｎｅｓ）バクテリオファージを含む組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024063779A Active JP7801389B2 (ja) | 2017-04-21 | 2024-04-11 | ざ瘡を治療するためのプロピオニバクテリウムアクネス（Ｐｒｏｐｉｏｎｉｂａｃｔｅｒｉｕｍ ａｃｎｅｓ）バクテリオファージを含む組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20210338569A1 (enExample) |
| EP (1) | EP3612200A4 (enExample) |
| JP (2) | JP7595459B2 (enExample) |
| KR (2) | KR102799152B1 (enExample) |
| CN (1) | CN110799203A (enExample) |
| AU (1) | AU2018255972B2 (enExample) |
| CA (1) | CA3060415A1 (enExample) |
| WO (1) | WO2018195415A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017254684A1 (en) | 2016-04-21 | 2018-12-06 | Weiss Bioscience, Inc. | Compositions and methods for treatment of skin disorders |
| JP7595459B2 (ja) | 2017-04-21 | 2024-12-06 | ピー・エイチ・アイ・セラピューティクス・インコーポレイテッド | ざ瘡を治療するためのプロピオニバクテリウムアクネス（Ｐｒｏｐｉｏｎｉｂａｃｔｅｒｉｕｍ ａｃｎｅｓ）バクテリオファージを含む組成物 |
| US20210177920A1 (en) * | 2017-12-05 | 2021-06-17 | Biomx Ltd. | Bacteriophage treatment for acne and biofilms |
| WO2020104216A1 (en) * | 2018-11-19 | 2020-05-28 | Unilever N.V. | An antimicrobial composition for selectively inhibiting growth of p. acnes bacteria |
| KR20210033627A (ko) * | 2019-09-19 | 2021-03-29 | 성균관대학교산학협력단 | 레조르시놀 또는 페닐에틸레조르시놀을 포함하는 공기오염물질에 의해 유발되는 피부 질환 예방, 치료, 또는 개선용 조성물 |
| CN115813869A (zh) * | 2022-12-15 | 2023-03-21 | 深圳市奥极因科技有限公司 | 一种感知进食状态智能给药的重组菌含片 |
| WO2025024918A1 (en) * | 2023-07-28 | 2025-02-06 | Kane Biotech Inc. | Composition, methods, and uses thereof for acne prevention, reduction, and treatment |
| CO2023015253A1 (es) * | 2023-11-10 | 2024-02-15 | Univ Los Andes | Fago funcionalizado para tratamiento de acné |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5235033A (en) | 1985-03-15 | 1993-08-10 | Anti-Gene Development Group | Alpha-morpholino ribonucleoside derivatives and polymers thereof |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US6117433A (en) * | 1996-01-31 | 2000-09-12 | Dsm N.V. | Use of compositions comprising stabilized biologically effective compounds |
| US6034506A (en) | 1998-01-16 | 2000-03-07 | Space Systems/Loral, Inc. | Lithium ion satellite battery charge control circuit |
| US6235033B1 (en) | 2000-04-19 | 2001-05-22 | Synthes (Usa) | Bone fixation assembly |
| EP1907534B2 (en) | 2005-07-12 | 2024-04-10 | Micreos B.V. | Bacteriophage and their uses |
| JP2008297241A (ja) * | 2007-05-31 | 2008-12-11 | Fujifilm Corp | ニキビ用皮膚外用剤 |
| ES2569218T3 (es) * | 2008-12-17 | 2016-05-09 | Ei, Inc. | Base de polvo para tratamiento del acné |
| BR112012003792B1 (pt) * | 2009-08-21 | 2020-05-19 | Novan Inc | composição tópica, e, uso da composição tópica |
| KR20120115920A (ko) * | 2011-04-11 | 2012-10-19 | 신라대학교 산학협력단 | 여드름 치료, 개선 또는 예방용 조성물 |
| EP3692999A1 (en) | 2012-03-17 | 2020-08-12 | The Regents of the University of California | Fast diagnosis and personalized treatments for acne |
| US20160338979A1 (en) * | 2014-01-10 | 2016-11-24 | The Regents Of The University Of California | Skin probiotic |
| GB201402139D0 (en) * | 2014-02-07 | 2014-03-26 | Fixed Phage Ltd | Treatment of topical and systemic bacterial infections |
| KR101689033B1 (ko) * | 2014-06-10 | 2016-12-22 | 경북대학교 산학협력단 | 여드름균을 사멸시키는 여드름균 특이적 박테리오파지 |
| WO2016130024A1 (en) * | 2015-02-13 | 2016-08-18 | Supreme Biotechnologies Limited | Endolysin expression platform |
| US12043847B2 (en) * | 2016-05-15 | 2024-07-23 | The Regents Of The University Of California | Compositions and methods for treating acne |
| JP7595459B2 (ja) | 2017-04-21 | 2024-12-06 | ピー・エイチ・アイ・セラピューティクス・インコーポレイテッド | ざ瘡を治療するためのプロピオニバクテリウムアクネス（Ｐｒｏｐｉｏｎｉｂａｃｔｅｒｉｕｍ ａｃｎｅｓ）バクテリオファージを含む組成物 |
| US20210177920A1 (en) * | 2017-12-05 | 2021-06-17 | Biomx Ltd. | Bacteriophage treatment for acne and biofilms |
-
2018
- 2018-04-20 JP JP2020507498A patent/JP7595459B2/ja active Active
- 2018-04-20 CA CA3060415A patent/CA3060415A1/en active Pending
- 2018-04-20 KR KR1020197034011A patent/KR102799152B1/ko active Active
- 2018-04-20 US US16/606,158 patent/US20210338569A1/en not_active Abandoned
- 2018-04-20 KR KR1020257012416A patent/KR20250054134A/ko active Pending
- 2018-04-20 AU AU2018255972A patent/AU2018255972B2/en active Active
- 2018-04-20 EP EP18787737.8A patent/EP3612200A4/en active Pending
- 2018-04-20 CN CN201880041505.9A patent/CN110799203A/zh active Pending
- 2018-04-20 WO PCT/US2018/028556 patent/WO2018195415A1/en not_active Ceased
-
2022
- 2022-08-11 US US17/819,050 patent/US11903984B1/en active Active
-
2024
- 2024-01-16 US US18/413,988 patent/US20240189220A1/en active Pending
- 2024-04-11 JP JP2024063779A patent/JP7801389B2/ja active Active
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