CN110799203A - 用于治疗痤疮的包含痤疮丙酸杆菌噬菌体的组合物 - Google Patents

用于治疗痤疮的包含痤疮丙酸杆菌噬菌体的组合物 Download PDF

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Publication number
CN110799203A
CN110799203A CN201880041505.9A CN201880041505A CN110799203A CN 110799203 A CN110799203 A CN 110799203A CN 201880041505 A CN201880041505 A CN 201880041505A CN 110799203 A CN110799203 A CN 110799203A
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composition
acnes
sequence
seq
rdna sequence
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Chinese (zh)
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Y·瓦尔马
N·万普鲁彦
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Phi Treatment Co Ltd
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Phi Treatment Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/327Peroxy compounds, e.g. hydroperoxides, peroxides, peroxyacids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/60Salicylic acid; Derivatives thereof
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/66Microorganisms or materials therefrom
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    • A61K35/76Viruses; Subviral particles; Bacteriophages
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    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44Oxidoreductases (1)
    • A61K38/446Superoxide dismutase (1.15)
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    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/47Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K8/04Dispersions; Emulsions
    • A61K8/06Emulsions
    • A61K8/062Oil-in-water emulsions
    • AHUMAN NECESSITIES
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    • A61K8/04Dispersions; Emulsions
    • A61K8/06Emulsions
    • A61K8/064Water-in-oil emulsions, e.g. Water-in-silicone emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/22Peroxides; Oxygen; Ozone
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/23Sulfur; Selenium; Tellurium; Compounds thereof
    • AHUMAN NECESSITIES
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    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/347Phenols
    • AHUMAN NECESSITIES
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    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
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    • A61K8/67Vitamins
    • A61K8/671Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
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    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
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    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01052Beta-N-acetylhexosaminidase (3.2.1.52)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C12N2795/00Bacteriophages
    • C12N2795/00011Details
    • C12N2795/10011Details dsDNA Bacteriophages
    • C12N2795/10311Siphoviridae
    • C12N2795/10321Viruses as such, e.g. new isolates, mutants or their genomic sequences
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    • C12N2795/00Bacteriophages
    • C12N2795/00011Details
    • C12N2795/10011Details dsDNA Bacteriophages
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    • C12N2795/10332Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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    • C12Y105/00Oxidoreductases acting on the CH-NH group of donors (1.5)
    • C12Y105/01Oxidoreductases acting on the CH-NH group of donors (1.5) with NAD+ or NADP+ as acceptor (1.5.1)
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    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
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CN201880041505.9A 2017-04-21 2018-04-20 用于治疗痤疮的包含痤疮丙酸杆菌噬菌体的组合物 Pending CN110799203A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762488326P 2017-04-21 2017-04-21
US62/488,326 2017-04-21
PCT/US2018/028556 WO2018195415A1 (en) 2017-04-21 2018-04-20 Compositions comprising propionibacterium acnes bacteriophages for treating acne

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CN110799203A true CN110799203A (zh) 2020-02-14

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US (3) US20210338569A1 (enExample)
EP (1) EP3612200A4 (enExample)
JP (2) JP7595459B2 (enExample)
KR (2) KR102799152B1 (enExample)
CN (1) CN110799203A (enExample)
AU (1) AU2018255972B2 (enExample)
CA (1) CA3060415A1 (enExample)
WO (1) WO2018195415A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115813869A (zh) * 2022-12-15 2023-03-21 深圳市奥极因科技有限公司 一种感知进食状态智能给药的重组菌含片

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017254684A1 (en) 2016-04-21 2018-12-06 Weiss Bioscience, Inc. Compositions and methods for treatment of skin disorders
JP7595459B2 (ja) 2017-04-21 2024-12-06 ピー・エイチ・アイ・セラピューティクス・インコーポレイテッド ざ瘡を治療するためのプロピオニバクテリウムアクネス(Propionibacterium acnes)バクテリオファージを含む組成物
US20210177920A1 (en) * 2017-12-05 2021-06-17 Biomx Ltd. Bacteriophage treatment for acne and biofilms
WO2020104216A1 (en) * 2018-11-19 2020-05-28 Unilever N.V. An antimicrobial composition for selectively inhibiting growth of p. acnes bacteria
KR20210033627A (ko) * 2019-09-19 2021-03-29 성균관대학교산학협력단 레조르시놀 또는 페닐에틸레조르시놀을 포함하는 공기오염물질에 의해 유발되는 피부 질환 예방, 치료, 또는 개선용 조성물
WO2025024918A1 (en) * 2023-07-28 2025-02-06 Kane Biotech Inc. Composition, methods, and uses thereof for acne prevention, reduction, and treatment
CO2023015253A1 (es) * 2023-11-10 2024-02-15 Univ Los Andes Fago funcionalizado para tratamiento de acné

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0817613B1 (en) * 1996-01-31 2005-03-30 Cosmoferm B.V. Use of compositions comprising stabilized enzymes
WO2007007055A1 (en) * 2005-07-12 2007-01-18 The University Of Leeds Bacteriophage and their uses
WO2015118150A2 (en) * 2014-02-07 2015-08-13 Fixed Phage Limited Treatment of topical and systemic bacterial infections
US9125919B2 (en) * 2008-12-17 2015-09-08 Ei Llc Acne treatment powder foundation
US20160338979A1 (en) * 2014-01-10 2016-11-24 The Regents Of The University Of California Skin probiotic
US9526738B2 (en) * 2009-08-21 2016-12-27 Novan, Inc. Topical gels and methods of using the same

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5235033A (en) 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US6034506A (en) 1998-01-16 2000-03-07 Space Systems/Loral, Inc. Lithium ion satellite battery charge control circuit
US6235033B1 (en) 2000-04-19 2001-05-22 Synthes (Usa) Bone fixation assembly
JP2008297241A (ja) * 2007-05-31 2008-12-11 Fujifilm Corp ニキビ用皮膚外用剤
KR20120115920A (ko) * 2011-04-11 2012-10-19 신라대학교 산학협력단 여드름 치료, 개선 또는 예방용 조성물
EP3692999A1 (en) 2012-03-17 2020-08-12 The Regents of the University of California Fast diagnosis and personalized treatments for acne
KR101689033B1 (ko) * 2014-06-10 2016-12-22 경북대학교 산학협력단 여드름균을 사멸시키는 여드름균 특이적 박테리오파지
WO2016130024A1 (en) * 2015-02-13 2016-08-18 Supreme Biotechnologies Limited Endolysin expression platform
US12043847B2 (en) * 2016-05-15 2024-07-23 The Regents Of The University Of California Compositions and methods for treating acne
JP7595459B2 (ja) 2017-04-21 2024-12-06 ピー・エイチ・アイ・セラピューティクス・インコーポレイテッド ざ瘡を治療するためのプロピオニバクテリウムアクネス(Propionibacterium acnes)バクテリオファージを含む組成物
US20210177920A1 (en) * 2017-12-05 2021-06-17 Biomx Ltd. Bacteriophage treatment for acne and biofilms

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0817613B1 (en) * 1996-01-31 2005-03-30 Cosmoferm B.V. Use of compositions comprising stabilized enzymes
WO2007007055A1 (en) * 2005-07-12 2007-01-18 The University Of Leeds Bacteriophage and their uses
US9125919B2 (en) * 2008-12-17 2015-09-08 Ei Llc Acne treatment powder foundation
US9526738B2 (en) * 2009-08-21 2016-12-27 Novan, Inc. Topical gels and methods of using the same
US20160338979A1 (en) * 2014-01-10 2016-11-24 The Regents Of The University Of California Skin probiotic
WO2015118150A2 (en) * 2014-02-07 2015-08-13 Fixed Phage Limited Treatment of topical and systemic bacterial infections

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115813869A (zh) * 2022-12-15 2023-03-21 深圳市奥极因科技有限公司 一种感知进食状态智能给药的重组菌含片

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US20210338569A1 (en) 2021-11-04
KR20250054134A (ko) 2025-04-22
KR102799152B1 (ko) 2025-04-23
WO2018195415A1 (en) 2018-10-25
KR20190135054A (ko) 2019-12-05
JP7801389B2 (ja) 2026-01-16
EP3612200A4 (en) 2020-12-30
JP2024099592A (ja) 2024-07-25
AU2018255972A1 (en) 2019-10-31
CA3060415A1 (en) 2018-10-25
JP2020517735A (ja) 2020-06-18
US11903984B1 (en) 2024-02-20
US20240189220A1 (en) 2024-06-13
EP3612200A1 (en) 2020-02-26
JP7595459B2 (ja) 2024-12-06
AU2018255972B2 (en) 2024-11-21
US20240066079A1 (en) 2024-02-29

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