JP2020517283A5 - - Google Patents

Download PDF

Info

Publication number
JP2020517283A5
JP2020517283A5 JP2019557794A JP2019557794A JP2020517283A5 JP 2020517283 A5 JP2020517283 A5 JP 2020517283A5 JP 2019557794 A JP2019557794 A JP 2019557794A JP 2019557794 A JP2019557794 A JP 2019557794A JP 2020517283 A5 JP2020517283 A5 JP 2020517283A5
Authority
JP
Japan
Prior art keywords
tissue
neural
differentiation
tissues
pluripotent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019557794A
Other languages
English (en)
Japanese (ja)
Other versions
JP7248590B2 (ja
JP2020517283A (ja
Filing date
Publication date
Priority claimed from EP17168051.5A external-priority patent/EP3395942A1/en
Application filed filed Critical
Publication of JP2020517283A publication Critical patent/JP2020517283A/ja
Publication of JP2020517283A5 publication Critical patent/JP2020517283A5/ja
Application granted granted Critical
Publication of JP7248590B2 publication Critical patent/JP7248590B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019557794A 2017-04-25 2018-04-25 二分化または多分化オルガノイド Active JP7248590B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17168051.5A EP3395942A1 (en) 2017-04-25 2017-04-25 Bi- or multi-differentiated organoid
EP17168051.5 2017-04-25
PCT/EP2018/060559 WO2018197544A1 (en) 2017-04-25 2018-04-25 Bi- or multi-differentiated organoid

Publications (3)

Publication Number Publication Date
JP2020517283A JP2020517283A (ja) 2020-06-18
JP2020517283A5 true JP2020517283A5 (cg-RX-API-DMAC7.html) 2021-04-30
JP7248590B2 JP7248590B2 (ja) 2023-03-29

Family

ID=58672346

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019557794A Active JP7248590B2 (ja) 2017-04-25 2018-04-25 二分化または多分化オルガノイド

Country Status (9)

Country Link
US (1) US20210095260A1 (cg-RX-API-DMAC7.html)
EP (2) EP3395942A1 (cg-RX-API-DMAC7.html)
JP (1) JP7248590B2 (cg-RX-API-DMAC7.html)
KR (1) KR102692498B1 (cg-RX-API-DMAC7.html)
CN (2) CN119101651A (cg-RX-API-DMAC7.html)
AU (1) AU2018260183B2 (cg-RX-API-DMAC7.html)
CA (1) CA3061412A1 (cg-RX-API-DMAC7.html)
SG (1) SG11201909470TA (cg-RX-API-DMAC7.html)
WO (1) WO2018197544A1 (cg-RX-API-DMAC7.html)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011140441A2 (en) 2010-05-06 2011-11-10 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
ES2860423T3 (es) 2014-05-28 2021-10-05 Childrens Hospital Med Ct Métodos y sistemas para convertir células precursoras en tejidos gástricos mediante diferenciación dirigida
WO2016061464A1 (en) 2014-10-17 2016-04-21 Children's Hospital Center, D/B/A Cincinnati Children's Hospital Medical Center In vivo model of human small intetine using pluripotent stem cells and methods of making and using same
JP6963882B2 (ja) 2016-05-05 2021-11-10 チルドレンズ ホスピタル メディカル センター 胃底部組織のインビトロでの製造のための方法及び当該方法と関連した組成物
EP3534907A4 (en) 2016-11-04 2020-06-24 Children's Hospital Medical Center COMPOSITIONS AND METHODS FOR TREATING HEPATIC DISEASE
EP3548507A4 (en) 2016-12-05 2020-07-15 Children's Hospital Medical Center COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF
EP3609997A4 (en) 2017-04-14 2021-03-03 Children's Hospital Medical Center COMPOSITIONS OF STEM CELLS FROM MULTIPLE DONOR CELLS AND THEIR PREPARATION PROCEDURES
CA3071454A1 (en) * 2017-07-28 2019-01-31 Memorial Sloan-Kettering Cancer Center Establishing topographic organization in three-dimensional tissue culture
CA3077442A1 (en) 2017-10-10 2019-04-18 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
US20200386742A1 (en) * 2017-12-04 2020-12-10 The Administrators Of The Tulane Educational Fund Cell systems using spheroids and methods of making and using the same
WO2019126626A1 (en) 2017-12-21 2019-06-27 Children's Hospital Medical Center Digitalized human organoids and methods of using same
SG11202100533VA (en) 2018-07-26 2021-02-25 Childrens Hospital Med Ct Hepato-biliary-pancreatic tissues and methods of making same
CA3112026A1 (en) 2018-09-12 2020-03-19 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
US12497597B2 (en) 2019-05-31 2025-12-16 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
WO2022010901A2 (en) * 2020-07-06 2022-01-13 President And Fellows Of Harvard College Programmable organoids and methods of producing the same via orthogonal differentiation and bioprinting
WO2022154080A1 (ja) * 2021-01-15 2022-07-21 国立大学法人東京大学 複雑な活動と可塑性を示すインビトロ神経回路組織、その神経活動の観察装置およびこれを用いた物質のスクリーニング方法
DE102021132190A1 (de) * 2021-12-07 2023-06-22 Eberhard Karls Universität Tübingen, Körperschaft des öffentlichen Rechts Biokompatible Strukturen zur Verbindung und Kultivierung von biologischem Material
HUP2200189A2 (hu) * 2022-05-30 2023-12-28 Biotalentum Tudasfejlesztoe Kft Új, riportert stabilan expresszáló humán indukált pluripotens õssejt
EP4286513A1 (en) 2022-06-03 2023-12-06 IMBA-Institut für Molekulare Biotechnologie GmbH Triple tissue culture fusion
CN116129193B (zh) * 2023-02-27 2024-06-11 重庆大学附属肿瘤医院 一种类器官生长预测方法、系统及设备
CN118530833B (zh) * 2024-04-02 2024-11-29 武汉大学 一种同步共分化的多组织或多类器官模型及其构建方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4829000A (en) 1985-08-30 1989-05-09 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Reconstituted basement membrane complex with biological activity
DE10003521A1 (de) 2000-01-27 2001-08-09 Medigene Ag Vorrichtung zum Herstellen eines dreidimensionalen Matrixkörpers, Multi-Well-Platte, Lösung zum Kultivieren von Säugerkardiomyocyten, Verfahren zum Kultivieren einer Zellkultur, Vorrichtung für die Messung isometrischer Kraftparameter von Zellkulturen sowie Verfahren zum meßbaren Verfolgen von Kontraktionen eines in eine Trägersubstanz eingelagerten Zellgewebes
US8021876B2 (en) 2001-11-15 2011-09-20 Children's Medical Center Corporation Methods of isolation, expansion and differentiation of fetal stem cells from chorionic villus, amniotic fluid, and placenta and therapeutic uses thereof
WO2004084950A2 (en) 2003-03-24 2004-10-07 Case Western Reserve University Cell targeting methods and compositions
WO2009023246A2 (en) 2007-08-14 2009-02-19 Wake Forest University Health Sciences Pluripotent adult stem cells
EP2028268A1 (en) * 2007-08-20 2009-02-25 Université Libre De Bruxelles Generation of neuronal cells from pluripotent stem cells
US20110143433A1 (en) 2008-03-17 2011-06-16 Agency For Science, Technology And Research Microcarriers for Stem Cell Culture
DK2496688T3 (en) * 2009-11-05 2017-04-03 Riken Method of Inducing Differentiation in Cultured Stem Cells
CN103052707A (zh) * 2010-07-30 2013-04-17 剑桥实业有限公司 人类多能细胞的皮层生成
WO2014033322A1 (en) * 2012-09-03 2014-03-06 Novo Nordisk A/S Generation of pancreatic endoderm from pluripotent stem cells using small molecules
EP2743345A1 (en) * 2012-12-13 2014-06-18 IMBA-Institut für Molekulare Biotechnologie GmbH Three dimensional heterogeneously differentiated tissue culture
KR101381798B1 (ko) * 2013-02-27 2014-04-07 씨제이제일제당 (주) 신규 박테리오파지 및 이를 포함하는 항균 조성물
WO2014153346A1 (en) * 2013-03-18 2014-09-25 Massachusetts Institute Of Technology Engineering a heterogeneous tissue pluripotent stem cells
AU2014256876B2 (en) * 2013-04-26 2020-11-12 Cornell, University Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells
US10794802B2 (en) * 2013-09-20 2020-10-06 California Institute Of Technology Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high resolution intact circuit mapping and phenotyping
US11767507B2 (en) * 2013-11-08 2023-09-26 The Mclean Hospital Corporation Methods for efficient generation of GABAergic interneurons from pluripotent stem cells
AU2014353973B2 (en) * 2013-11-22 2021-01-28 Riken Method for manufacturing telencephalon or progenitor tissue thereof
US10081792B2 (en) * 2014-12-31 2018-09-25 Wisconsin Alumni Research Foundation Derivation of human microglia from pluripotent stem cells
JP6807853B2 (ja) * 2015-03-03 2021-01-06 プレジデント アンド フェローズ オブ ハーバード カレッジ 機能的ヒト組織の作製方法
US10087417B2 (en) * 2015-04-22 2018-10-02 William J. Freed Three-dimensional model of human cortex
US10081791B2 (en) * 2015-05-07 2018-09-25 William J. Freed Modeling connections between dopaminergic neurons and the cerebral cortex
LU92845B1 (en) * 2015-10-08 2017-05-02 Univ Du Luxembourg Campus Belval Means and methods for generating midbrain organoids
WO2017083705A1 (en) * 2015-11-13 2017-05-18 The Johns Hopkins University Cell culture system and method of use thereof
WO2017117547A1 (en) * 2015-12-31 2017-07-06 President And Fellows Of Harvard College Methods for generating neural tissue and uses thereof
US12428623B2 (en) * 2016-03-14 2025-09-30 Agency For Science, Technology And Research Generation of midbrain-specific organoids from human pluripotent stem cells
FR3058892B1 (fr) * 2016-11-23 2021-04-09 Univ Bordeaux Unite de tissu neural et utilisation d'une telle unite pour l'implantation dans le systeme nerveux d'un mammifere
US10676715B2 (en) * 2017-03-28 2020-06-09 The Board Of Trustees Of The Leland Stanford Junior University Assembly of functionally integrated human forebrain spheroids and methods of use thereof
JP2020515689A (ja) * 2017-03-29 2020-05-28 イーストマン ケミカル カンパニー 位置選択的に置換されたセルロースエステル
GB201900930D0 (en) * 2019-01-23 2019-03-13 Res & Innovation Uk Choroid plexus organoids and methods for productions thereof
WO2020247336A1 (en) * 2019-06-03 2020-12-10 The Regents Of The University Of California Pifithrin analogues and methods of treating rett syndrome

Similar Documents

Publication Publication Date Title
JP2020517283A5 (cg-RX-API-DMAC7.html)
US20210403863A1 (en) Microglia derived from pluripotent stem cells and methods of making and using the same
Hill et al. Human embryonic stem cell− derived vascular progenitor cells capable of endothelial and smooth muscle cell function
JP7097814B2 (ja) ヒト心室前駆細胞の生着のための遺伝子マーカー
JP2020178713A (ja) 多分化能細胞および多能性細胞の分化を方向付けることによって発生させる皮質介在ニューロンおよびその他のニューロン細胞
CN104946590B (zh) 成人骨髓中Muse细胞诱导为神经前体细胞的方法
JP6824267B2 (ja) ヒト誘導多能性幹細胞からライディッヒ細胞への分化誘導方法及びその用途
CN111133099A (zh) 神经纤毛蛋白-1（nrp1）作为细胞表面标志物用于分离人心脏心室祖细胞的用途
Mathivanan et al. Retinal differentiation of human bone marrow-derived stem cells by co-culture with retinal pigment epithelium in vitro
Munoz et al. Feline bone marrow-derived mesenchymal stromal cells (MSCs) show similar phenotype and functions with regards to neuronal differentiation as human MSCs
TW201323610A (zh) 由萬能幹細胞所分化之神經上皮細胞及其所使用之培養基與其分化方法
JP2014508527A5 (cg-RX-API-DMAC7.html)
US20160251612A1 (en) Culture medium for establishing neuroepithelial stem cells, method for establishing neuroepithelial stem cells, and applications thereof
JP6786077B2 (ja) 胚様体の評価方法
JP6721868B2 (ja) スフェロイドの作製方法及び該方法に用いる培地
Liu et al. Pluripotent fates and tissue regenerative potential of adult olfactory bulb neural stem and progenitor cells
Qiu et al. A simplified and modified procedure to culture brain glioma stem cells from clinical specimens
Iachininoto et al. In vitro cardiomyocyte differentiation of umbilical cord blood cells: crucial role for c-kit+ cells
CN117089516A (zh) 骨肉瘤诱导多能干细胞平台的构建方法
JP7541748B2 (ja) 心筋細胞の富化方法
JP6478464B2 (ja) 多能性幹細胞から脳血管内皮細胞を製造する方法
Sathananthan Neural stem cells in neurospheres, embryoid bodies, and central nervous system of human embryos
KR101490867B1 (ko) 심장-얼굴-피부 증후군의 유도-만능 줄기세포 모델 및 이의 용도
JP2008278842A (ja) 脂肪組織間質細胞の神経細胞への分化誘導方法並びに分化誘導された該神経細胞
WO2010068946A1 (en) Methods of isolating and using stem cells