CA3061412A1 - Bi- or multi-differentiated organoid - Google Patents
Bi- or multi-differentiated organoid Download PDFInfo
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- CA3061412A1 CA3061412A1 CA3061412A CA3061412A CA3061412A1 CA 3061412 A1 CA3061412 A1 CA 3061412A1 CA 3061412 A CA3061412 A CA 3061412A CA 3061412 A CA3061412 A CA 3061412A CA 3061412 A1 CA3061412 A1 CA 3061412A1
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| PCT/EP2018/060559 WO2018197544A1 (en) | 2017-04-25 | 2018-04-25 | Bi- or multi-differentiated organoid |
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| WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| ES2860423T3 (es) | 2014-05-28 | 2021-10-05 | Childrens Hospital Med Ct | Métodos y sistemas para convertir células precursoras en tejidos gástricos mediante diferenciación dirigida |
| WO2016061464A1 (en) | 2014-10-17 | 2016-04-21 | Children's Hospital Center, D/B/A Cincinnati Children's Hospital Medical Center | In vivo model of human small intetine using pluripotent stem cells and methods of making and using same |
| JP6963882B2 (ja) | 2016-05-05 | 2021-11-10 | チルドレンズ ホスピタル メディカル センター | 胃底部組織のインビトロでの製造のための方法及び当該方法と関連した組成物 |
| EP3534907A4 (en) | 2016-11-04 | 2020-06-24 | Children's Hospital Medical Center | COMPOSITIONS AND METHODS FOR TREATING HEPATIC DISEASE |
| EP3548507A4 (en) | 2016-12-05 | 2020-07-15 | Children's Hospital Medical Center | COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF |
| EP3609997A4 (en) | 2017-04-14 | 2021-03-03 | Children's Hospital Medical Center | COMPOSITIONS OF STEM CELLS FROM MULTIPLE DONOR CELLS AND THEIR PREPARATION PROCEDURES |
| CA3071454A1 (en) * | 2017-07-28 | 2019-01-31 | Memorial Sloan-Kettering Cancer Center | Establishing topographic organization in three-dimensional tissue culture |
| CA3077442A1 (en) | 2017-10-10 | 2019-04-18 | Children's Hospital Medical Center | Esophageal tissue and/or organoid compositions and methods of making same |
| US20200386742A1 (en) * | 2017-12-04 | 2020-12-10 | The Administrators Of The Tulane Educational Fund | Cell systems using spheroids and methods of making and using the same |
| WO2019126626A1 (en) | 2017-12-21 | 2019-06-27 | Children's Hospital Medical Center | Digitalized human organoids and methods of using same |
| SG11202100533VA (en) | 2018-07-26 | 2021-02-25 | Childrens Hospital Med Ct | Hepato-biliary-pancreatic tissues and methods of making same |
| CA3112026A1 (en) | 2018-09-12 | 2020-03-19 | Children's Hospital Medical Center | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| US12497597B2 (en) | 2019-05-31 | 2025-12-16 | Children's Hospital Medical Center | Methods of generating and expanding hematopoietic stem cells |
| WO2022010901A2 (en) * | 2020-07-06 | 2022-01-13 | President And Fellows Of Harvard College | Programmable organoids and methods of producing the same via orthogonal differentiation and bioprinting |
| WO2022154080A1 (ja) * | 2021-01-15 | 2022-07-21 | 国立大学法人東京大学 | 複雑な活動と可塑性を示すインビトロ神経回路組織、その神経活動の観察装置およびこれを用いた物質のスクリーニング方法 |
| DE102021132190A1 (de) * | 2021-12-07 | 2023-06-22 | Eberhard Karls Universität Tübingen, Körperschaft des öffentlichen Rechts | Biokompatible Strukturen zur Verbindung und Kultivierung von biologischem Material |
| HUP2200189A2 (hu) * | 2022-05-30 | 2023-12-28 | Biotalentum Tudasfejlesztoe Kft | Új, riportert stabilan expresszáló humán indukált pluripotens õssejt |
| EP4286513A1 (en) | 2022-06-03 | 2023-12-06 | IMBA-Institut für Molekulare Biotechnologie GmbH | Triple tissue culture fusion |
| CN116129193B (zh) * | 2023-02-27 | 2024-06-11 | 重庆大学附属肿瘤医院 | 一种类器官生长预测方法、系统及设备 |
| CN118530833B (zh) * | 2024-04-02 | 2024-11-29 | 武汉大学 | 一种同步共分化的多组织或多类器官模型及其构建方法 |
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| US4829000A (en) | 1985-08-30 | 1989-05-09 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Reconstituted basement membrane complex with biological activity |
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| US8021876B2 (en) | 2001-11-15 | 2011-09-20 | Children's Medical Center Corporation | Methods of isolation, expansion and differentiation of fetal stem cells from chorionic villus, amniotic fluid, and placenta and therapeutic uses thereof |
| WO2004084950A2 (en) | 2003-03-24 | 2004-10-07 | Case Western Reserve University | Cell targeting methods and compositions |
| WO2009023246A2 (en) | 2007-08-14 | 2009-02-19 | Wake Forest University Health Sciences | Pluripotent adult stem cells |
| EP2028268A1 (en) * | 2007-08-20 | 2009-02-25 | Université Libre De Bruxelles | Generation of neuronal cells from pluripotent stem cells |
| US20110143433A1 (en) | 2008-03-17 | 2011-06-16 | Agency For Science, Technology And Research | Microcarriers for Stem Cell Culture |
| DK2496688T3 (en) * | 2009-11-05 | 2017-04-03 | Riken | Method of Inducing Differentiation in Cultured Stem Cells |
| CN103052707A (zh) * | 2010-07-30 | 2013-04-17 | 剑桥实业有限公司 | 人类多能细胞的皮层生成 |
| WO2014033322A1 (en) * | 2012-09-03 | 2014-03-06 | Novo Nordisk A/S | Generation of pancreatic endoderm from pluripotent stem cells using small molecules |
| EP2743345A1 (en) * | 2012-12-13 | 2014-06-18 | IMBA-Institut für Molekulare Biotechnologie GmbH | Three dimensional heterogeneously differentiated tissue culture |
| KR101381798B1 (ko) * | 2013-02-27 | 2014-04-07 | 씨제이제일제당 (주) | 신규 박테리오파지 및 이를 포함하는 항균 조성물 |
| WO2014153346A1 (en) * | 2013-03-18 | 2014-09-25 | Massachusetts Institute Of Technology | Engineering a heterogeneous tissue pluripotent stem cells |
| AU2014256876B2 (en) * | 2013-04-26 | 2020-11-12 | Cornell, University | Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells |
| US10794802B2 (en) * | 2013-09-20 | 2020-10-06 | California Institute Of Technology | Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high resolution intact circuit mapping and phenotyping |
| US11767507B2 (en) * | 2013-11-08 | 2023-09-26 | The Mclean Hospital Corporation | Methods for efficient generation of GABAergic interneurons from pluripotent stem cells |
| AU2014353973B2 (en) * | 2013-11-22 | 2021-01-28 | Riken | Method for manufacturing telencephalon or progenitor tissue thereof |
| US10081792B2 (en) * | 2014-12-31 | 2018-09-25 | Wisconsin Alumni Research Foundation | Derivation of human microglia from pluripotent stem cells |
| JP6807853B2 (ja) * | 2015-03-03 | 2021-01-06 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 機能的ヒト組織の作製方法 |
| US10087417B2 (en) * | 2015-04-22 | 2018-10-02 | William J. Freed | Three-dimensional model of human cortex |
| US10081791B2 (en) * | 2015-05-07 | 2018-09-25 | William J. Freed | Modeling connections between dopaminergic neurons and the cerebral cortex |
| LU92845B1 (en) * | 2015-10-08 | 2017-05-02 | Univ Du Luxembourg Campus Belval | Means and methods for generating midbrain organoids |
| WO2017083705A1 (en) * | 2015-11-13 | 2017-05-18 | The Johns Hopkins University | Cell culture system and method of use thereof |
| WO2017117547A1 (en) * | 2015-12-31 | 2017-07-06 | President And Fellows Of Harvard College | Methods for generating neural tissue and uses thereof |
| US12428623B2 (en) * | 2016-03-14 | 2025-09-30 | Agency For Science, Technology And Research | Generation of midbrain-specific organoids from human pluripotent stem cells |
| FR3058892B1 (fr) * | 2016-11-23 | 2021-04-09 | Univ Bordeaux | Unite de tissu neural et utilisation d'une telle unite pour l'implantation dans le systeme nerveux d'un mammifere |
| US10676715B2 (en) * | 2017-03-28 | 2020-06-09 | The Board Of Trustees Of The Leland Stanford Junior University | Assembly of functionally integrated human forebrain spheroids and methods of use thereof |
| JP2020515689A (ja) * | 2017-03-29 | 2020-05-28 | イーストマン ケミカル カンパニー | 位置選択的に置換されたセルロースエステル |
| GB201900930D0 (en) * | 2019-01-23 | 2019-03-13 | Res & Innovation Uk | Choroid plexus organoids and methods for productions thereof |
| WO2020247336A1 (en) * | 2019-06-03 | 2020-12-10 | The Regents Of The University Of California | Pifithrin analogues and methods of treating rett syndrome |
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| US20210095260A1 (en) | 2021-04-01 |
| AU2018260183B2 (en) | 2024-09-19 |
| CN119101651A (zh) | 2024-12-10 |
| WO2018197544A1 (en) | 2018-11-01 |
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