JP2020516599A5 - - Google Patents
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- Publication number
- JP2020516599A5 JP2020516599A5 JP2019554725A JP2019554725A JP2020516599A5 JP 2020516599 A5 JP2020516599 A5 JP 2020516599A5 JP 2019554725 A JP2019554725 A JP 2019554725A JP 2019554725 A JP2019554725 A JP 2019554725A JP 2020516599 A5 JP2020516599 A5 JP 2020516599A5
- Authority
- JP
- Japan
- Prior art keywords
- dimethyl
- indazole
- amine
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims description 57
- 150000001875 compounds Chemical class 0.000 claims description 47
- -1 (3- (1,3-dimethyl-1H-indazole-5-yl) -2,5-dimethylpyrazolo [1,5-a] pyrimidin-7-yl) amino Chemical group 0.000 claims description 22
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 14
- 206010033645 Pancreatitis Diseases 0.000 claims description 9
- 208000036142 Viral infection Diseases 0.000 claims description 8
- 201000010099 disease Diseases 0.000 claims description 8
- 230000009385 viral infection Effects 0.000 claims description 8
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 6
- 208000035475 disorder Diseases 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 208000024827 Alzheimer disease Diseases 0.000 claims description 5
- 206010006187 Breast cancer Diseases 0.000 claims description 5
- 208000026310 Breast neoplasm Diseases 0.000 claims description 5
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 claims description 5
- 206010009944 Colon cancer Diseases 0.000 claims description 5
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 5
- 206010010741 Conjunctivitis Diseases 0.000 claims description 5
- 206010012735 Diarrhoea Diseases 0.000 claims description 5
- 208000023105 Huntington disease Diseases 0.000 claims description 5
- 201000009906 Meningitis Diseases 0.000 claims description 5
- 208000003926 Myelitis Diseases 0.000 claims description 5
- 208000009525 Myocarditis Diseases 0.000 claims description 5
- 206010028980 Neoplasm Diseases 0.000 claims description 5
- 206010033128 Ovarian cancer Diseases 0.000 claims description 5
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 5
- 206010033799 Paralysis Diseases 0.000 claims description 5
- 208000018737 Parkinson disease Diseases 0.000 claims description 5
- 206010060862 Prostate cancer Diseases 0.000 claims description 5
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 5
- 206010040047 Sepsis Diseases 0.000 claims description 5
- 230000002159 abnormal effect Effects 0.000 claims description 5
- 230000004900 autophagic degradation Effects 0.000 claims description 5
- 201000011510 cancer Diseases 0.000 claims description 5
- 206010012601 diabetes mellitus Diseases 0.000 claims description 5
- 206010014599 encephalitis Diseases 0.000 claims description 5
- 208000019622 heart disease Diseases 0.000 claims description 5
- 230000001771 impaired effect Effects 0.000 claims description 5
- 208000027866 inflammatory disease Diseases 0.000 claims description 5
- 201000010901 lateral sclerosis Diseases 0.000 claims description 5
- 208000005264 motor neuron disease Diseases 0.000 claims description 5
- 208000030194 mouth disease Diseases 0.000 claims description 5
- 201000006417 multiple sclerosis Diseases 0.000 claims description 5
- 210000003205 muscle Anatomy 0.000 claims description 5
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims description 5
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 5
- 208000023504 respiratory system disease Diseases 0.000 claims description 5
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims description 4
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims description 4
- 206010035623 Pleuritic pain Diseases 0.000 claims description 4
- 125000004429 atom Chemical group 0.000 claims description 4
- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 125000001072 heteroaryl group Chemical group 0.000 claims description 4
- 230000003902 lesion Effects 0.000 claims description 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 4
- 229940127557 pharmaceutical product Drugs 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 4
- 208000005155 Picornaviridae Infections Diseases 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 150000002367 halogens Chemical class 0.000 claims description 3
- 230000004770 neurodegeneration Effects 0.000 claims description 3
- 208000013223 septicemia Diseases 0.000 claims description 3
- 206010040882 skin lesion Diseases 0.000 claims description 3
- 231100000444 skin lesion Toxicity 0.000 claims description 3
- WOFPLOFGYRLRJS-UHFFFAOYSA-N 3-(1,3-dimethylindazol-5-yl)-2,5-dimethyl-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine Chemical compound CN1N=C(C)C2=C1C=CC(=C2)C1=C2N=C(C)C=C(NCC3=CC=NC=C3)N2N=C1C WOFPLOFGYRLRJS-UHFFFAOYSA-N 0.000 claims description 2
- YJJRTYKINMSQQF-UHFFFAOYSA-N 3-(1,3-dimethylindazol-5-yl)-2,5-dimethyl-N-(thiophen-2-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine Chemical compound C=1C(=NC=2N(C=1NCC1=CC=CS1)N=C(C=2C1=CC=2C(=NN(C=2C=C1)C)C)C)C YJJRTYKINMSQQF-UHFFFAOYSA-N 0.000 claims description 2
- RZXUNLOIVLNMQA-UHFFFAOYSA-N 3-(1,3-dimethylindazol-5-yl)-2,5-dimethyl-N-[(4-methylsulfonylphenyl)methyl]pyrazolo[1,5-a]pyrimidin-7-amine Chemical compound CN1N=C(C)C2=C1C=CC(=C2)C1=C2N=C(C)C=C(NCC3=CC=C(C=C3)S(C)(=O)=O)N2N=C1C RZXUNLOIVLNMQA-UHFFFAOYSA-N 0.000 claims description 2
- YQTASBNNYQPVQL-UHFFFAOYSA-N 3-(1,3-dimethylindazol-5-yl)-2,5-dimethyl-N-[(6-methylpyridin-3-yl)methyl]pyrazolo[1,5-a]pyrimidin-7-amine Chemical compound CN1N=C(C)C2=C1C=CC(=C2)C1=C2N=C(C)C=C(NCC3=CC=C(C)N=C3)N2N=C1C YQTASBNNYQPVQL-UHFFFAOYSA-N 0.000 claims description 2
- KLHVRCVOQALCQV-UHFFFAOYSA-N 3-(1,3-dimethylindazol-5-yl)-2,5-dimethyl-N-[[6-(trifluoromethyl)pyridin-3-yl]methyl]pyrazolo[1,5-a]pyrimidin-7-amine Chemical compound CN1N=C(C)C2=C1C=CC(=C2)C1=C2N=C(C)C=C(NCC3=CC=C(N=C3)C(F)(F)F)N2N=C1C KLHVRCVOQALCQV-UHFFFAOYSA-N 0.000 claims description 2
- ULOZTIYXFDFIFX-UHFFFAOYSA-N 3-(1,3-dimethylindazol-5-yl)-N-[(4-fluorophenyl)methyl]-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amine Chemical compound FC1=CC=C(CNC2=CC(=NC=3N2N=C(C=3C2=CC=3C(C)=NN(C=3C=C2)C)C)C)C=C1 ULOZTIYXFDFIFX-UHFFFAOYSA-N 0.000 claims description 2
- JITYVOBUUFSWAW-UHFFFAOYSA-N 3-(1,3-dimethylindazol-5-yl)-N-[(4-methoxyphenyl)methyl]-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amine Chemical compound COC1=CC=C(CNC2=CC(C)=NC3=C(C(C)=NN23)C2=CC3=C(C=C2)N(C)N=C3C)C=C1 JITYVOBUUFSWAW-UHFFFAOYSA-N 0.000 claims description 2
- QGVAIRIHEYEWJS-UHFFFAOYSA-N 3-(1,3-dimethylindazol-5-yl)-N-[(6-methoxypyridin-3-yl)methyl]-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amine Chemical compound CN1N=C(C2=CC(=CC=C12)C=1C(=NN2C=1N=C(C=C2NCC=1C=NC(=CC=1)OC)C)C)C QGVAIRIHEYEWJS-UHFFFAOYSA-N 0.000 claims description 2
- 125000006283 4-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])* 0.000 claims description 2
- 125000004217 4-methoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])* 0.000 claims description 2
- KBRKERCJKFMZEM-UHFFFAOYSA-N 8-(1,3-dimethylindazol-5-yl)-2,7-dimethyl-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound N1=CC=C(C=C1)CNC1=NC(=NC=2N1N=C(C=2C1=CC=2C(=NN(C=2C=C1)C)C)C)C KBRKERCJKFMZEM-UHFFFAOYSA-N 0.000 claims description 2
- SIENVEHBXCWECI-UHFFFAOYSA-N 8-(1,3-dimethylindazol-5-yl)-2,7-dimethyl-N-(thiophen-2-ylmethyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound N=1C(=NC=2N(C=1NCC1=CC=CS1)N=C(C=2C1=CC=2C(=NN(C=2C=C1)C)C)C)C SIENVEHBXCWECI-UHFFFAOYSA-N 0.000 claims description 2
- NBLBPINRSZKXJF-UHFFFAOYSA-N 8-(1,3-dimethylindazol-5-yl)-2,7-dimethyl-N-[(4-methylsulfonylphenyl)methyl]pyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound S(=O)(=O)(C1=CC=C(CNC2=NC(=NC=3N2N=C(C=3C2=CC=3C(=NN(C=3C=C2)C)C)C)C)C=C1)C NBLBPINRSZKXJF-UHFFFAOYSA-N 0.000 claims description 2
- QXKBMTCFPXKHDN-UHFFFAOYSA-N 8-(1,3-dimethylindazol-5-yl)-2,7-dimethyl-N-[(6-methylpyridin-3-yl)methyl]pyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound Cc1nn2c(NCc3ccc(C)nc3)nc(C)nc2c1-c1ccc2n(C)nc(C)c2c1 QXKBMTCFPXKHDN-UHFFFAOYSA-N 0.000 claims description 2
- KPWFAUMDCXWFEX-UHFFFAOYSA-N 8-(1,3-dimethylindazol-5-yl)-N-[(4-methoxyphenyl)methyl]-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound COC1=CC=C(CNC2=NC(C)=NC3=C(C(C)=NN23)C2=CC3=C(C=C2)N(C)N=C3C)C=C1 KPWFAUMDCXWFEX-UHFFFAOYSA-N 0.000 claims description 2
- YEKJZRWQOMWPMI-UHFFFAOYSA-N 8-(1,3-dimethylindazol-5-yl)-N-[(6-methoxypyridin-3-yl)methyl]-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound COc1ccc(CNc2nc(C)nc3c(c(C)nn23)-c2ccc3n(C)nc(C)c3c2)cn1 YEKJZRWQOMWPMI-UHFFFAOYSA-N 0.000 claims description 2
- INIHKJIARHRCAP-UHFFFAOYSA-N N-[(4-chlorophenyl)methyl]-3-(1,3-dimethylindazol-5-yl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amine Chemical compound ClC1=CC=C(CNC=2N3C(N=C(C=2)C)=C(C2=CC4=C(C=C2)N(N=C4C)C)C(=N3)C)C=C1 INIHKJIARHRCAP-UHFFFAOYSA-N 0.000 claims description 2
- ICIHYCCESPOYJG-UHFFFAOYSA-N N-[(4-chlorophenyl)methyl]-8-(1,3-dimethylindazol-5-yl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound CN1N=C(C)C2=C1C=CC(=C2)C1=C2N=C(C)N=C(NCC3=CC=C(Cl)C=C3)N2N=C1C ICIHYCCESPOYJG-UHFFFAOYSA-N 0.000 claims description 2
- UQYGFIRDOHPVOD-UHFFFAOYSA-N N-[4-[[[3-(1,3-dimethylindazol-5-yl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-yl]amino]methyl]phenyl]methanesulfonamide Chemical compound CN1N=C(C)C2=C1C=CC(=C2)C1=C2N=C(C)C=C(NCC3=CC=C(NS(C)(=O)=O)C=C3)N2N=C1C UQYGFIRDOHPVOD-UHFFFAOYSA-N 0.000 claims description 2
- DZORMANSUVIHFZ-UHFFFAOYSA-N N-benzyl-3-(1,3-dimethylindazol-5-yl)-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amine Chemical compound C1=CC=C(C=C1)CNC1=CC(=NC=2N1N=C(C=2C1=CC=2C(C)=NN(C=2C=C1)C)C)C DZORMANSUVIHFZ-UHFFFAOYSA-N 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 125000002837 carbocyclic group Chemical group 0.000 claims description 2
- 125000005842 heteroatom Chemical group 0.000 claims description 2
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 2
- HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 claims description 2
- 229910052760 oxygen Inorganic materials 0.000 claims description 2
- 229910052717 sulfur Inorganic materials 0.000 claims description 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 241000124008 Mammalia Species 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 206010061218 Inflammation Diseases 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 241000700605 Viruses Species 0.000 description 3
- 210000003020 exocrine pancreas Anatomy 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 238000003752 polymerase chain reaction Methods 0.000 description 3
- 241000709675 Coxsackievirus B3 Species 0.000 description 2
- 238000003364 immunohistochemistry Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000010172 mouse model Methods 0.000 description 2
- 230000017074 necrotic cell death Effects 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 description 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000010460 detection of virus Effects 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17165082.3 | 2017-04-05 | ||
| EP17165082 | 2017-04-05 | ||
| PCT/EP2018/058522 WO2018185120A1 (en) | 2017-04-05 | 2018-04-04 | Heteroaromatic compounds useful in therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020516599A JP2020516599A (ja) | 2020-06-11 |
| JP2020516599A5 true JP2020516599A5 (https=) | 2021-05-13 |
| JP7200126B2 JP7200126B2 (ja) | 2023-01-06 |
Family
ID=58489645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019554725A Active JP7200126B2 (ja) | 2017-04-05 | 2018-04-04 | 療法において有用なヘテロ芳香族化合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11001587B2 (https=) |
| EP (1) | EP3606926B1 (https=) |
| JP (1) | JP7200126B2 (https=) |
| CN (1) | CN110520424B (https=) |
| AU (1) | AU2018248581B2 (https=) |
| CA (1) | CA3057408A1 (https=) |
| DK (1) | DK3606926T3 (https=) |
| ES (1) | ES2880327T3 (https=) |
| NZ (1) | NZ758449A (https=) |
| PL (1) | PL3606926T3 (https=) |
| RU (1) | RU2770363C2 (https=) |
| WO (1) | WO2018185120A1 (https=) |
| ZA (1) | ZA201907303B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017147526A1 (en) | 2016-02-26 | 2017-08-31 | The Board Of Trustees Of The Leland Stanford Junior University | Pi-kinase inhibitors with anti-infective activity |
| AU2018248581B2 (en) * | 2017-04-05 | 2022-05-26 | Curovir Ab | Heteroaromatic compounds useful in therapy |
| WO2020074160A1 (en) | 2018-10-10 | 2020-04-16 | Curovir Ab | Condensed pyrimidine or pyridazine derivatives as antiviral agents |
| MX2021003915A (es) | 2018-10-10 | 2021-06-04 | Curovir Ab | Derivados de 2,6-dimetilo-n-((piridina-4ilo-metilo) imidazol[1,2-b]piridazina-8-amina y 2,5-dimetilo-n-[(piridina-4-il o)metilo]pirazolo(1,5-a)pirimidina-7-amina para tratar infecciones virales. |
| CA3126143A1 (en) * | 2019-01-11 | 2020-07-16 | The Board Of Trustees Of The Leland Stanford Junior University | Pi4-kinase inhibitors with anti-cancer activity |
| US12415788B2 (en) | 2019-03-21 | 2025-09-16 | The Board Of Trustees Of The Leland Stanford Junior University | PI4-kinase inhibitors and methods of using the same |
| EP4028131B1 (en) | 2019-08-20 | 2023-11-22 | Curovir Ab | Heteroaromatic compounds useful in therapy |
| WO2024184442A1 (en) | 2023-03-09 | 2024-09-12 | Curovir Ab | Compound and formulation for systemic therapy by oral transmucosal administration |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6313124B1 (en) | 1997-07-23 | 2001-11-06 | Dupont Pharmaceuticals Company | Tetrazine bicyclic compounds |
| US6191131B1 (en) * | 1997-07-23 | 2001-02-20 | Dupont Pharmaceuticals Company | Azolo triazines and pyrimidines |
| CA2379585C (en) * | 1999-09-30 | 2006-06-20 | James W. Darrow | Certain alkylene diamine-substituted pyrazolo[1,5,-a]-1,5-pyrimidines and pyrazolo[1,5-a]-1,3,5-triazines |
| RU2340611C2 (ru) * | 2000-09-15 | 2008-12-10 | Вертекс Фармасьютикалз Инкорпорейтед | Производные пиразола, используемые в качестве ингибиторов протеинкиназы |
| US20070078136A1 (en) | 2005-09-22 | 2007-04-05 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
| WO2010086040A1 (en) | 2009-01-29 | 2010-08-05 | Biomarin Iga, Ltd. | Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy |
| FR2943058B1 (fr) | 2009-03-11 | 2011-06-03 | Centre Nat Rech Scient | Derives de pyrazolo°1,5-a!-1,3,5-triazines, leur preparation et leur application en therapeutique. |
| PH12013502240B1 (en) * | 2011-05-04 | 2018-06-27 | Rhizen Pharmaceuticals Sa | Novel compounds as modulators of protein kinase |
| EP2634189A1 (en) | 2012-03-01 | 2013-09-04 | Lead Discovery Center GmbH | Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhibitors |
| JP6509238B2 (ja) * | 2014-01-22 | 2019-05-08 | キュロヴィル・アクチボラグ | 治療に有用なピラゾロ［１，５−ａ］ピリミジン−７−アミン誘導体 |
| WO2015140491A1 (en) * | 2014-03-18 | 2015-09-24 | Micromass Uk Limited | Liquid extraction matrix assisted laser desorption ionisation ion source |
| AU2016284638B2 (en) * | 2015-06-24 | 2020-01-23 | Curovir Ab | Pyrazolo[1,5-a]triazin-4-amine derivatives useful in therapy |
| AU2018248581B2 (en) * | 2017-04-05 | 2022-05-26 | Curovir Ab | Heteroaromatic compounds useful in therapy |
-
2018
- 2018-04-04 AU AU2018248581A patent/AU2018248581B2/en active Active
- 2018-04-04 WO PCT/EP2018/058522 patent/WO2018185120A1/en not_active Ceased
- 2018-04-04 NZ NZ758449A patent/NZ758449A/en unknown
- 2018-04-04 RU RU2019133777A patent/RU2770363C2/ru not_active Application Discontinuation
- 2018-04-04 PL PL18716212T patent/PL3606926T3/pl unknown
- 2018-04-04 EP EP18716212.8A patent/EP3606926B1/en active Active
- 2018-04-04 CA CA3057408A patent/CA3057408A1/en active Pending
- 2018-04-04 ES ES18716212T patent/ES2880327T3/es active Active
- 2018-04-04 JP JP2019554725A patent/JP7200126B2/ja active Active
- 2018-04-04 DK DK18716212.8T patent/DK3606926T3/da active
- 2018-04-04 US US16/495,903 patent/US11001587B2/en active Active
- 2018-04-04 CN CN201880023679.2A patent/CN110520424B/zh active Active
-
2019
- 2019-11-04 ZA ZA2019/07303A patent/ZA201907303B/en unknown
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