CN110520424B - 用于疗法的杂芳族化合物 - Google Patents

用于疗法的杂芳族化合物 Download PDF

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Publication number
CN110520424B
CN110520424B CN201880023679.2A CN201880023679A CN110520424B CN 110520424 B CN110520424 B CN 110520424B CN 201880023679 A CN201880023679 A CN 201880023679A CN 110520424 B CN110520424 B CN 110520424B
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dimethyl
indazol
compound
amine
pharmaceutically acceptable
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CN201880023679.2A
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Chinese (zh)
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CN110520424A (zh
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J.韦斯特曼
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Curovir AB
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Curovir AB
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201880023679.2A 2017-04-05 2018-04-04 用于疗法的杂芳族化合物 Active CN110520424B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17165082.3 2017-04-05
EP17165082 2017-04-05
PCT/EP2018/058522 WO2018185120A1 (en) 2017-04-05 2018-04-04 Heteroaromatic compounds useful in therapy

Publications (2)

Publication Number Publication Date
CN110520424A CN110520424A (zh) 2019-11-29
CN110520424B true CN110520424B (zh) 2022-06-21

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ID=58489645

Family Applications (1)

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CN201880023679.2A Active CN110520424B (zh) 2017-04-05 2018-04-04 用于疗法的杂芳族化合物

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US (1) US11001587B2 (https=)
EP (1) EP3606926B1 (https=)
JP (1) JP7200126B2 (https=)
CN (1) CN110520424B (https=)
AU (1) AU2018248581B2 (https=)
CA (1) CA3057408A1 (https=)
DK (1) DK3606926T3 (https=)
ES (1) ES2880327T3 (https=)
NZ (1) NZ758449A (https=)
PL (1) PL3606926T3 (https=)
RU (1) RU2770363C2 (https=)
WO (1) WO2018185120A1 (https=)
ZA (1) ZA201907303B (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017147526A1 (en) 2016-02-26 2017-08-31 The Board Of Trustees Of The Leland Stanford Junior University Pi-kinase inhibitors with anti-infective activity
AU2018248581B2 (en) * 2017-04-05 2022-05-26 Curovir Ab Heteroaromatic compounds useful in therapy
WO2020074160A1 (en) 2018-10-10 2020-04-16 Curovir Ab Condensed pyrimidine or pyridazine derivatives as antiviral agents
MX2021003915A (es) 2018-10-10 2021-06-04 Curovir Ab Derivados de 2,6-dimetilo-n-((piridina-4ilo-metilo) imidazol[1,2-b]piridazina-8-amina y 2,5-dimetilo-n-[(piridina-4-il o)metilo]pirazolo(1,5-a)pirimidina-7-amina para tratar infecciones virales.
CA3126143A1 (en) * 2019-01-11 2020-07-16 The Board Of Trustees Of The Leland Stanford Junior University Pi4-kinase inhibitors with anti-cancer activity
US12415788B2 (en) 2019-03-21 2025-09-16 The Board Of Trustees Of The Leland Stanford Junior University PI4-kinase inhibitors and methods of using the same
EP4028131B1 (en) 2019-08-20 2023-11-22 Curovir Ab Heteroaromatic compounds useful in therapy
WO2024184442A1 (en) 2023-03-09 2024-09-12 Curovir Ab Compound and formulation for systemic therapy by oral transmucosal administration

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015110491A2 (en) * 2014-01-22 2015-07-30 Apodemus Ab Pyrazolo[1,5-a]pyrimidin-7-amine derivatives useful in therapy
WO2016206999A1 (en) * 2015-06-24 2016-12-29 Apodemus Ab Pyrazolo[1,5-a]triazin-4-amine derivatives useful in therapy

Family Cites Families (11)

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US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
US6191131B1 (en) * 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
CA2379585C (en) * 1999-09-30 2006-06-20 James W. Darrow Certain alkylene diamine-substituted pyrazolo[1,5,-a]-1,5-pyrimidines and pyrazolo[1,5-a]-1,3,5-triazines
RU2340611C2 (ru) * 2000-09-15 2008-12-10 Вертекс Фармасьютикалз Инкорпорейтед Производные пиразола, используемые в качестве ингибиторов протеинкиназы
US20070078136A1 (en) 2005-09-22 2007-04-05 Bristol-Myers Squibb Company Fused heterocyclic compounds useful as kinase modulators
WO2010086040A1 (en) 2009-01-29 2010-08-05 Biomarin Iga, Ltd. Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy
FR2943058B1 (fr) 2009-03-11 2011-06-03 Centre Nat Rech Scient Derives de pyrazolo°1,5-a!-1,3,5-triazines, leur preparation et leur application en therapeutique.
PH12013502240B1 (en) * 2011-05-04 2018-06-27 Rhizen Pharmaceuticals Sa Novel compounds as modulators of protein kinase
EP2634189A1 (en) 2012-03-01 2013-09-04 Lead Discovery Center GmbH Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhibitors
WO2015140491A1 (en) * 2014-03-18 2015-09-24 Micromass Uk Limited Liquid extraction matrix assisted laser desorption ionisation ion source
AU2018248581B2 (en) * 2017-04-05 2022-05-26 Curovir Ab Heteroaromatic compounds useful in therapy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015110491A2 (en) * 2014-01-22 2015-07-30 Apodemus Ab Pyrazolo[1,5-a]pyrimidin-7-amine derivatives useful in therapy
WO2016206999A1 (en) * 2015-06-24 2016-12-29 Apodemus Ab Pyrazolo[1,5-a]triazin-4-amine derivatives useful in therapy

Also Published As

Publication number Publication date
BR112019019796A2 (pt) 2020-04-22
WO2018185120A1 (en) 2018-10-11
JP7200126B2 (ja) 2023-01-06
ES2880327T3 (es) 2021-11-24
PL3606926T3 (pl) 2021-11-02
AU2018248581B2 (en) 2022-05-26
US11001587B2 (en) 2021-05-11
DK3606926T3 (da) 2021-07-05
CN110520424A (zh) 2019-11-29
RU2770363C2 (ru) 2022-04-15
JP2020516599A (ja) 2020-06-11
RU2019133777A3 (https=) 2021-04-23
ZA201907303B (en) 2022-07-27
RU2019133777A (ru) 2021-04-23
US20200031833A1 (en) 2020-01-30
NZ758449A (en) 2026-03-27
AU2018248581A1 (en) 2019-11-07
EP3606926A1 (en) 2020-02-12
EP3606926B1 (en) 2021-05-26
CA3057408A1 (en) 2018-10-11

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