RU2770363C2 - Гетероароматические соединения, пригодные в терапии - Google Patents

Гетероароматические соединения, пригодные в терапии Download PDF

Info

Publication number
RU2770363C2
RU2770363C2 RU2019133777A RU2019133777A RU2770363C2 RU 2770363 C2 RU2770363 C2 RU 2770363C2 RU 2019133777 A RU2019133777 A RU 2019133777A RU 2019133777 A RU2019133777 A RU 2019133777A RU 2770363 C2 RU2770363 C2 RU 2770363C2
Authority
RU
Russia
Prior art keywords
dimethyl
indazol
compound
amine
pharmaceutically acceptable
Prior art date
Application number
RU2019133777A
Other languages
English (en)
Russian (ru)
Other versions
RU2019133777A3 (https=
RU2019133777A (ru
Inventor
Якоб Вестман
Original Assignee
Куровир Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Куровир Аб filed Critical Куровир Аб
Publication of RU2019133777A3 publication Critical patent/RU2019133777A3/ru
Publication of RU2019133777A publication Critical patent/RU2019133777A/ru
Application granted granted Critical
Publication of RU2770363C2 publication Critical patent/RU2770363C2/ru

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
RU2019133777A 2017-04-05 2018-04-04 Гетероароматические соединения, пригодные в терапии RU2770363C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17165082.3 2017-04-05
EP17165082 2017-04-05
PCT/EP2018/058522 WO2018185120A1 (en) 2017-04-05 2018-04-04 Heteroaromatic compounds useful in therapy

Publications (3)

Publication Number Publication Date
RU2019133777A3 RU2019133777A3 (https=) 2021-04-23
RU2019133777A RU2019133777A (ru) 2021-04-23
RU2770363C2 true RU2770363C2 (ru) 2022-04-15

Family

ID=58489645

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2019133777A RU2770363C2 (ru) 2017-04-05 2018-04-04 Гетероароматические соединения, пригодные в терапии

Country Status (13)

Country Link
US (1) US11001587B2 (https=)
EP (1) EP3606926B1 (https=)
JP (1) JP7200126B2 (https=)
CN (1) CN110520424B (https=)
AU (1) AU2018248581B2 (https=)
CA (1) CA3057408A1 (https=)
DK (1) DK3606926T3 (https=)
ES (1) ES2880327T3 (https=)
NZ (1) NZ758449A (https=)
PL (1) PL3606926T3 (https=)
RU (1) RU2770363C2 (https=)
WO (1) WO2018185120A1 (https=)
ZA (1) ZA201907303B (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017147526A1 (en) 2016-02-26 2017-08-31 The Board Of Trustees Of The Leland Stanford Junior University Pi-kinase inhibitors with anti-infective activity
AU2018248581B2 (en) * 2017-04-05 2022-05-26 Curovir Ab Heteroaromatic compounds useful in therapy
WO2020074160A1 (en) 2018-10-10 2020-04-16 Curovir Ab Condensed pyrimidine or pyridazine derivatives as antiviral agents
MX2021003915A (es) 2018-10-10 2021-06-04 Curovir Ab Derivados de 2,6-dimetilo-n-((piridina-4ilo-metilo) imidazol[1,2-b]piridazina-8-amina y 2,5-dimetilo-n-[(piridina-4-il o)metilo]pirazolo(1,5-a)pirimidina-7-amina para tratar infecciones virales.
CA3126143A1 (en) * 2019-01-11 2020-07-16 The Board Of Trustees Of The Leland Stanford Junior University Pi4-kinase inhibitors with anti-cancer activity
US12415788B2 (en) 2019-03-21 2025-09-16 The Board Of Trustees Of The Leland Stanford Junior University PI4-kinase inhibitors and methods of using the same
EP4028131B1 (en) 2019-08-20 2023-11-22 Curovir Ab Heteroaromatic compounds useful in therapy
WO2024184442A1 (en) 2023-03-09 2024-09-12 Curovir Ab Compound and formulation for systemic therapy by oral transmucosal administration

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6191131B1 (en) * 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
EA200200422A1 (ru) * 1999-09-30 2002-10-31 Ньюроджен Корпорейшн НЕКОТОРЫЕ АЛКИЛЕНДИАМИНОЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-а]-1,5-ПИРИМИДИНЫ И ПИРАЗОЛО[1,5-а]-1,3,5-ТРИАЗИНЫ
RU2340611C2 (ru) * 2000-09-15 2008-12-10 Вертекс Фармасьютикалз Инкорпорейтед Производные пиразола, используемые в качестве ингибиторов протеинкиназы
WO2015140491A1 (en) * 2014-03-18 2015-09-24 Micromass Uk Limited Liquid extraction matrix assisted laser desorption ionisation ion source
WO2016206999A1 (en) * 2015-06-24 2016-12-29 Apodemus Ab Pyrazolo[1,5-a]triazin-4-amine derivatives useful in therapy

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
US20070078136A1 (en) 2005-09-22 2007-04-05 Bristol-Myers Squibb Company Fused heterocyclic compounds useful as kinase modulators
WO2010086040A1 (en) 2009-01-29 2010-08-05 Biomarin Iga, Ltd. Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy
FR2943058B1 (fr) 2009-03-11 2011-06-03 Centre Nat Rech Scient Derives de pyrazolo°1,5-a!-1,3,5-triazines, leur preparation et leur application en therapeutique.
PH12013502240B1 (en) * 2011-05-04 2018-06-27 Rhizen Pharmaceuticals Sa Novel compounds as modulators of protein kinase
EP2634189A1 (en) 2012-03-01 2013-09-04 Lead Discovery Center GmbH Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhibitors
JP6509238B2 (ja) * 2014-01-22 2019-05-08 キュロヴィル・アクチボラグ 治療に有用なピラゾロ［１，５−ａ］ピリミジン−７−アミン誘導体
AU2018248581B2 (en) * 2017-04-05 2022-05-26 Curovir Ab Heteroaromatic compounds useful in therapy

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6191131B1 (en) * 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
EA200200422A1 (ru) * 1999-09-30 2002-10-31 Ньюроджен Корпорейшн НЕКОТОРЫЕ АЛКИЛЕНДИАМИНОЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-а]-1,5-ПИРИМИДИНЫ И ПИРАЗОЛО[1,5-а]-1,3,5-ТРИАЗИНЫ
RU2340611C2 (ru) * 2000-09-15 2008-12-10 Вертекс Фармасьютикалз Инкорпорейтед Производные пиразола, используемые в качестве ингибиторов протеинкиназы
WO2015140491A1 (en) * 2014-03-18 2015-09-24 Micromass Uk Limited Liquid extraction matrix assisted laser desorption ionisation ion source
WO2016206999A1 (en) * 2015-06-24 2016-12-29 Apodemus Ab Pyrazolo[1,5-a]triazin-4-amine derivatives useful in therapy

Also Published As

Publication number Publication date
BR112019019796A2 (pt) 2020-04-22
CN110520424B (zh) 2022-06-21
WO2018185120A1 (en) 2018-10-11
JP7200126B2 (ja) 2023-01-06
ES2880327T3 (es) 2021-11-24
PL3606926T3 (pl) 2021-11-02
AU2018248581B2 (en) 2022-05-26
US11001587B2 (en) 2021-05-11
DK3606926T3 (da) 2021-07-05
CN110520424A (zh) 2019-11-29
JP2020516599A (ja) 2020-06-11
RU2019133777A3 (https=) 2021-04-23
ZA201907303B (en) 2022-07-27
RU2019133777A (ru) 2021-04-23
US20200031833A1 (en) 2020-01-30
NZ758449A (en) 2026-03-27
AU2018248581A1 (en) 2019-11-07
EP3606926A1 (en) 2020-02-12
EP3606926B1 (en) 2021-05-26
CA3057408A1 (en) 2018-10-11

Similar Documents

Publication Publication Date Title
RU2770363C2 (ru) Гетероароматические соединения, пригодные в терапии
CN107949563B (zh) 治疗中有用的吡唑并[1,5-a]三嗪-4-胺衍生物
CA2935658C (en) Pyrazolo[1,5-a]pyrimidin-7-amine derivatives useful in therapy
US12319696B2 (en) 2,6-dimethyl-n-((pyridin-4-yl)methyl)imidazo[1,2-b]pyridazin-8-amine and 2,5-dimethyl-n-[(pyridin-4-yl)methyl]pyrazolo[1,5-a]pyrimidin-7-amine derivatives for treating viral infections
RU2798107C2 (ru) Производные 2,6-диметил-n-((пиридин-4-ил)метил)имидазо[1,2-b]пиридазин-8-амина и 2,5-диметил-n-[(пиридин-4-ил)метил]пиразоло[1,5-a]пиримидин-7-амина для лечения вирусных инфекций
HK40019049A (en) Heteroaromatic compounds useful in therapy
HK40019049B (en) Heteroaromatic compounds useful in therapy
BR112019019796B1 (pt) Composto, composição farmacêutica, e, uso de composto ou de sal farmaceuticamente aceitável
HK1254809B (en) Pyrazolo[1,5-a]triazin-4-amine derivatives useful in therapy

Legal Events

Date Code Title Description
FA92 Acknowledgement of application withdrawn (lack of supplementary materials submitted)

Effective date: 20220112

FZ9A Application not withdrawn (correction of the notice of withdrawal)

Effective date: 20220112