JP2020516309A5 - - Google Patents
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- JP2020516309A5 JP2020516309A5 JP2020503365A JP2020503365A JP2020516309A5 JP 2020516309 A5 JP2020516309 A5 JP 2020516309A5 JP 2020503365 A JP2020503365 A JP 2020503365A JP 2020503365 A JP2020503365 A JP 2020503365A JP 2020516309 A5 JP2020516309 A5 JP 2020516309A5
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- antibody
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- Prior art date
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- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims description 116
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims description 100
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims description 100
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims description 100
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims description 100
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 claims description 47
- 239000000427 antigen Substances 0.000 claims description 28
- 102000036639 antigens Human genes 0.000 claims description 28
- 108091007433 antigens Proteins 0.000 claims description 28
- 102100031586 Leukocyte antigen CD37 Human genes 0.000 claims description 24
- 102000048426 human CD37 Human genes 0.000 claims description 23
- 230000035772 mutation Effects 0.000 claims description 22
- 210000004027 cell Anatomy 0.000 claims description 16
- 239000003814 drug Substances 0.000 claims description 15
- 238000006467 substitution reaction Methods 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 229940124597 therapeutic agent Drugs 0.000 claims description 10
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims description 8
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims description 8
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims description 8
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 8
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims description 8
- 201000003444 follicular lymphoma Diseases 0.000 claims description 8
- 150000001413 amino acids Chemical class 0.000 claims description 7
- 201000011510 cancer Diseases 0.000 claims description 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 6
- 230000003993 interaction Effects 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 5
- 102000039446 nucleic acids Human genes 0.000 claims description 5
- 108020004707 nucleic acids Proteins 0.000 claims description 5
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims description 4
- 208000023275 Autoimmune disease Diseases 0.000 claims description 4
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims description 4
- 108010006654 Bleomycin Proteins 0.000 claims description 4
- DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 claims description 4
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims description 4
- 206010020751 Hypersensitivity Diseases 0.000 claims description 4
- 241000282567 Macaca fascicularis Species 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 206010052779 Transplant rejections Diseases 0.000 claims description 4
- 230000007815 allergy Effects 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- 229960001561 bleomycin Drugs 0.000 claims description 4
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 claims description 4
- 229960005243 carmustine Drugs 0.000 claims description 4
- JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 claims description 4
- 229960004630 chlorambucil Drugs 0.000 claims description 4
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims description 4
- 229960004316 cisplatin Drugs 0.000 claims description 4
- 229960004397 cyclophosphamide Drugs 0.000 claims description 4
- 229960004679 doxorubicin Drugs 0.000 claims description 4
- 239000013604 expression vector Substances 0.000 claims description 4
- 229960000390 fludarabine Drugs 0.000 claims description 4
- GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 claims description 4
- 208000032839 leukemia Diseases 0.000 claims description 4
- 229960002450 ofatumumab Drugs 0.000 claims description 4
- 229960004641 rituximab Drugs 0.000 claims description 4
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims description 4
- 229960004528 vincristine Drugs 0.000 claims description 4
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims description 4
- 208000037979 autoimmune inflammatory disease Diseases 0.000 claims description 3
- 101100495232 Homo sapiens MS4A1 gene Proteins 0.000 claims description 2
- 108060003951 Immunoglobulin Proteins 0.000 claims description 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000012636 effector Substances 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 claims description 2
- 210000003527 eukaryotic cell Anatomy 0.000 claims description 2
- 102000018358 immunoglobulin Human genes 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 230000000813 microbial effect Effects 0.000 claims description 2
- 239000004175 ponceau 4R Substances 0.000 claims description 2
- 210000001236 prokaryotic cell Anatomy 0.000 claims description 2
- YTKUWDBFDASYHO-UHFFFAOYSA-N bendamustine Chemical compound ClCCN(CCCl)C1=CC=C2N(C)C(CCCC(O)=O)=NC2=C1 YTKUWDBFDASYHO-UHFFFAOYSA-N 0.000 claims 1
- 229960002707 bendamustine Drugs 0.000 claims 1
- 230000036210 malignancy Effects 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 7
- 239000002177 L01XE27 - Ibrutinib Substances 0.000 description 3
- -1 bendamstin Chemical compound 0.000 description 3
- XYFPWWZEPKGCCK-GOSISDBHSA-N ibrutinib Chemical compound C1=2C(N)=NC=NC=2N([C@H]2CN(CCC2)C(=O)C=C)N=C1C(C=C1)=CC=C1OC1=CC=CC=C1 XYFPWWZEPKGCCK-GOSISDBHSA-N 0.000 description 3
- 229960001507 ibrutinib Drugs 0.000 description 3
- 241000282412 Homo Species 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 230000009918 complex formation Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023130372A JP7680501B2 (ja) | 2017-03-31 | 2023-08-09 | 二重特異性抗ｃｄ３７抗体、モノクローナル抗ｃｄ３７抗体、およびそれらの使用方法 |
| JP2025078106A JP2025121994A (ja) | 2017-03-31 | 2025-05-08 | 二重特異性抗ｃｄ３７抗体、モノクローナル抗ｃｄ３７抗体、およびそれらの使用方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762479712P | 2017-03-31 | 2017-03-31 | |
| US62/479,712 | 2017-03-31 | ||
| EP2018057836 | 2018-03-27 | ||
| EPPCT/EP2018/057836 | 2018-03-27 | ||
| PCT/EP2018/058479 WO2018178396A1 (en) | 2017-03-31 | 2018-04-03 | Bispecific anti-cd37 antibodies, monoclonal anti-cd37 antibodies and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023130372A Division JP7680501B2 (ja) | 2017-03-31 | 2023-08-09 | 二重特異性抗ｃｄ３７抗体、モノクローナル抗ｃｄ３７抗体、およびそれらの使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020516309A JP2020516309A (ja) | 2020-06-11 |
| JP2020516309A5 true JP2020516309A5 (enExample) | 2021-05-13 |
| JP7330942B2 JP7330942B2 (ja) | 2023-08-22 |
Family
ID=62044657
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020503365A Active JP7330942B2 (ja) | 2017-03-31 | 2018-04-03 | 二重特異性抗ｃｄ３７抗体、モノクローナル抗ｃｄ３７抗体、およびそれらの使用方法 |
| JP2023130372A Active JP7680501B2 (ja) | 2017-03-31 | 2023-08-09 | 二重特異性抗ｃｄ３７抗体、モノクローナル抗ｃｄ３７抗体、およびそれらの使用方法 |
| JP2025078106A Pending JP2025121994A (ja) | 2017-03-31 | 2025-05-08 | 二重特異性抗ｃｄ３７抗体、モノクローナル抗ｃｄ３７抗体、およびそれらの使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023130372A Active JP7680501B2 (ja) | 2017-03-31 | 2023-08-09 | 二重特異性抗ｃｄ３７抗体、モノクローナル抗ｃｄ３７抗体、およびそれらの使用方法 |
| JP2025078106A Pending JP2025121994A (ja) | 2017-03-31 | 2025-05-08 | 二重特異性抗ｃｄ３７抗体、モノクローナル抗ｃｄ３７抗体、およびそれらの使用方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (7) | US20200270359A1 (enExample) |
| EP (1) | EP3601354A1 (enExample) |
| JP (3) | JP7330942B2 (enExample) |
| KR (1) | KR102706161B1 (enExample) |
| CN (2) | CN119285787A (enExample) |
| AU (2) | AU2018242227B2 (enExample) |
| BR (1) | BR112019020219A2 (enExample) |
| CA (1) | CA3057907A1 (enExample) |
| IL (1) | IL269645B2 (enExample) |
| MX (2) | MX2019011520A (enExample) |
| SG (1) | SG11201908772TA (enExample) |
| UA (1) | UA127586C2 (enExample) |
| WO (1) | WO2018178396A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA117901C2 (uk) * | 2011-07-06 | 2018-10-25 | Ґенмаб Б.В. | Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування |
| CN119285787A (zh) | 2017-03-31 | 2025-01-10 | 健玛保控股有限公司 | 双特异性抗cd37抗体、单克隆抗cd37抗体及其使用方法 |
| CN111201030B (zh) | 2017-07-25 | 2024-11-01 | 真和制药有限公司 | 通过阻断tim-3和其配体的相互作用治疗癌症 |
| MX2020011552A (es) | 2018-05-03 | 2020-11-24 | Genmab Bv | Combinaciones de variantes de anticuerpos y usos de las mismas. |
| JP7513530B2 (ja) * | 2018-06-22 | 2024-07-09 | ジェンマブ ホールディング ビー．ブイ． | 抗ｃｄ３７抗体および抗ｃｄ２０抗体、組成物、ならびにそれらの使用方法 |
| AU2019354105A1 (en) * | 2018-10-04 | 2021-04-29 | Genmab Holding B.V. | Pharmaceutical compositions comprising bispecific anti-CD37 antibodies |
| CN113271965B (zh) * | 2019-01-11 | 2023-11-03 | 湖南远泰生物技术有限公司 | Cd37抗体和cd37-car-t细胞 |
| KR20210124308A (ko) | 2019-01-30 | 2021-10-14 | 트루바인딩 아이엔씨. | 항-gal3 항체 및 이의 용도 |
| JP7880817B2 (ja) | 2019-11-06 | 2026-06-26 | ジェンマブ ビー．ブイ． | 抗体変種の組み合わせおよびその使用 |
| MX2022014786A (es) | 2020-05-26 | 2023-01-16 | Truebinding Inc | Metodos para tratar enfermedades inflamatorias mediante el bloqueo de galectina-3. |
| CN113504371B (zh) * | 2021-07-09 | 2024-06-14 | 博以新(杭州)生物技术有限公司 | 基于环糊精包合的免分离化学发光免疫分析的方法 |
| JP7437558B1 (ja) | 2023-07-20 | 2024-02-22 | 株式会社ファーマフーズ | 情報処理装置、情報処理方法、およびプログラム |
| KR20260094403A (ko) | 2023-10-18 | 2026-06-22 | 데비오팜 인터내셔널 에스에이 | 항-cd37 항체 메이탄신 접합체와 bcl2 저해제 또는 p13k 저해제를 포함하는 약물 조합 |
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2018
- 2018-04-03 CN CN202411136586.4A patent/CN119285787A/zh active Pending
- 2018-04-03 KR KR1020197032125A patent/KR102706161B1/ko active Active
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- 2018-04-03 US US16/498,104 patent/US20200270359A1/en not_active Abandoned
- 2018-04-03 WO PCT/EP2018/058479 patent/WO2018178396A1/en not_active Ceased
- 2018-04-03 UA UAA201910706A patent/UA127586C2/uk unknown
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