JP2020515247A5 - - Google Patents
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- JP2020515247A5 JP2020515247A5 JP2019551983A JP2019551983A JP2020515247A5 JP 2020515247 A5 JP2020515247 A5 JP 2020515247A5 JP 2019551983 A JP2019551983 A JP 2019551983A JP 2019551983 A JP2019551983 A JP 2019551983A JP 2020515247 A5 JP2020515247 A5 JP 2020515247A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antigen
- binding fragment
- cancer
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710185400.8A CN108623686A (zh) | 2017-03-25 | 2017-03-25 | 抗ox40抗体及其用途 |
| CN201710185400.8 | 2017-03-25 | ||
| PCT/CN2018/080315 WO2018177220A1 (zh) | 2017-03-25 | 2018-03-23 | 抗ox40抗体及其用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020515247A JP2020515247A (ja) | 2020-05-28 |
| JP2020515247A5 true JP2020515247A5 (https=) | 2021-08-19 |
| JP7046973B2 JP7046973B2 (ja) | 2022-04-04 |
Family
ID=63674253
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019551983A Expired - Fee Related JP7046973B2 (ja) | 2017-03-25 | 2018-03-23 | 抗ｏｘ４０抗体およびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11498972B2 (https=) |
| EP (1) | EP3604338A4 (https=) |
| JP (1) | JP7046973B2 (https=) |
| CN (2) | CN108623686A (https=) |
| CA (1) | CA3056972A1 (https=) |
| WO (1) | WO2018177220A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3470424B1 (en) | 2016-06-08 | 2025-04-23 | Shanghai Jiao Tong University School of Medicine | Sequence of antibody heavy chain constant region for enhancing agonist antibody activity |
| CN107815465B (zh) | 2016-08-31 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化基因改造动物模型的制备方法及应用 |
| US11279948B2 (en) | 2016-08-31 | 2022-03-22 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal with human or chimeric OX40 |
| WO2019032628A1 (en) | 2017-08-07 | 2019-02-14 | The Regents Of The University Of California | GENERATING PLATFORM FOR SAFE CELLULAR THERAPEUTIC AGENTS |
| CN110305210B (zh) * | 2018-03-27 | 2023-02-28 | 信达生物制药(苏州)有限公司 | 新型抗体分子、其制备方法及其用途 |
| CN113166248B (zh) * | 2018-11-26 | 2022-05-27 | 南京金斯瑞生物科技有限公司 | 人源化抗人ox40单克隆抗体及其制备方法和用途 |
| CA3120474A1 (en) * | 2018-12-21 | 2020-06-25 | 23Andme, Inc. | Anti-il-36 antibodies and methods of use thereof |
| CN111363040B (zh) * | 2018-12-25 | 2023-07-14 | 杭州翰思生物医药有限公司 | 抗ox40的单克隆抗体及其应用 |
| TWI793395B (zh) * | 2019-01-25 | 2023-02-21 | 大陸商信達生物製藥（蘇州）有限公司 | 結合ｐｄ-ｌ１和ｏｘ４０的雙特異性抗體 |
| CN110003338B (zh) * | 2019-04-16 | 2021-04-23 | 北京免疫方舟医药科技有限公司 | 抗ox40抗体及其应用 |
| CN110004177A (zh) * | 2019-04-22 | 2019-07-12 | 中国食品药品检定研究院 | 一种检测抗ox40抗体的方法及其应用 |
| CN113045654A (zh) * | 2019-12-27 | 2021-06-29 | 南开大学 | 抗ox40抗体及其用途 |
| CN113045655A (zh) * | 2019-12-27 | 2021-06-29 | 高诚生物医药(香港)有限公司 | 抗ox40抗体及其用途 |
| CN113429483A (zh) * | 2020-03-23 | 2021-09-24 | 百奥泰生物制药股份有限公司 | 一种免疫细胞激活剂的开发及应用 |
| CN114014906B (zh) * | 2020-06-24 | 2024-01-12 | 夏尔巴生物技术(苏州)有限公司 | 一种利用阳离子交换层析纯化疏水性蛋白的方法 |
| CN111704671B (zh) * | 2020-08-19 | 2020-11-24 | 广东赛尔生物科技有限公司 | Ox40抗体及其在治疗癌症中的应用 |
| WO2023060244A1 (en) * | 2021-10-07 | 2023-04-13 | Lankenau Institute For Medical Research | Methods and compositions including novel antibodies for diagnosing covid-19 variants |
| KR20240122784A (ko) | 2021-12-17 | 2024-08-13 | 상하이 헨리우스 바이오테크, 인크. | 항-ox40 항체 및 사용 방법 |
| KR20240116755A (ko) | 2021-12-17 | 2024-07-30 | 상하이 헨리우스 바이오테크, 인크. | 항-ox40 항체, 다중 특이적 항체 및 이의 사용 방법 |
| CN114478789B (zh) * | 2021-12-20 | 2024-06-14 | 安徽安科生物工程（集团）股份有限公司 | 抗pd-l1与ox40双特异性抗体及其用途 |
| CN114966061B (zh) * | 2022-07-28 | 2022-10-21 | 中国食品药品检定研究院 | 一种抗ox40抗体的生物活性检测方法 |
| CN120476146A (zh) * | 2022-12-30 | 2025-08-12 | 甘李药业股份有限公司 | 抗ox40抗体及其应用 |
| TW202521577A (zh) * | 2023-08-04 | 2025-06-01 | 大陸商信達生物製藥（蘇州）有限公司 | 抗ｏｘ４０ｌ抗體以及其用途 |
Family Cites Families (39)
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| US4737456A (en) | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| GB9114948D0 (en) | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline intermediates |
| US7018809B1 (en) | 1991-09-19 | 2006-03-28 | Genentech, Inc. | Expression of functional antibody fragments |
| US5789199A (en) | 1994-11-03 | 1998-08-04 | Genentech, Inc. | Process for bacterial production of polypeptides |
| US5840523A (en) | 1995-03-01 | 1998-11-24 | Genetech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
| US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| US6171586B1 (en) | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| AP1261A (en) | 1998-02-24 | 2004-03-19 | Sisters Of Providence In Oregon | Composition containing an OX-40 receptor binding agent or a nucleic acid encoding the same and methods for enhancing antigen-specific immune response. |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| US7850962B2 (en) | 2004-04-20 | 2010-12-14 | Genmab A/S | Human monoclonal antibodies against CD20 |
| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| DK2439273T3 (da) | 2005-05-09 | 2019-06-03 | Ono Pharmaceutical Co | Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika |
| US7862235B2 (en) | 2005-05-12 | 2011-01-04 | Nsk Ltd. | Linear guide device |
| PT1907424E (pt) | 2005-07-01 | 2015-10-09 | Squibb & Sons Llc | Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1) |
| TWI461436B (zh) * | 2005-11-25 | 2014-11-21 | Kyowa Hakko Kirin Co Ltd | 人類ｃｄ１３４（ｏｘ４０）之人類單株抗體及其製造及使用方法 |
| KR20100014588A (ko) * | 2007-02-27 | 2010-02-10 | 제넨테크, 인크. | 길항제 ｏｘ40 항체 및 염증성 및 자가면역 질환의 치료에서의 이의 용도 |
| US8877688B2 (en) | 2007-09-14 | 2014-11-04 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
| EP3124497B1 (en) | 2007-09-14 | 2020-04-15 | Adimab, LLC | Rationally designed, synthetic antibody libraries and uses therefor |
| PT2594590E (pt) | 2007-12-14 | 2015-01-14 | Bristol Myers Squibb Co | Moléculas de ligação ao recetor humano ox40 |
| CN101970499B (zh) | 2008-02-11 | 2014-12-31 | 治疗科技公司 | 用于肿瘤治疗的单克隆抗体 |
| EP2262837A4 (en) | 2008-03-12 | 2011-04-06 | Merck Sharp & Dohme | PD-1 BINDING PROTEINS |
| JP2012500855A (ja) | 2008-08-25 | 2012-01-12 | アンプリミューン、インコーポレーテッド | Ｐｄ−１アンタゴニストおよび感染性疾患を処置するための方法 |
| EP3255060A1 (en) | 2008-12-09 | 2017-12-13 | F. Hoffmann-La Roche AG | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| WO2011066342A2 (en) | 2009-11-24 | 2011-06-03 | Amplimmune, Inc. | Simultaneous inhibition of pd-l1/pd-l2 |
| WO2012009567A2 (en) | 2010-07-15 | 2012-01-19 | The Regents Of The University Of California | Biomarkers for diagnosis of stroke and its causes |
| KR102318383B1 (ko) | 2010-07-16 | 2021-10-27 | 아디맵 엘엘씨 | 항체 라이브러리 |
| CA2809089C (en) | 2010-08-23 | 2018-12-18 | Board Of Regents, The University Of Texas System | Anti-ox40 antibodies and methods of using the same |
| SG10201708048XA (en) | 2013-03-18 | 2017-10-30 | Biocerox Prod Bv | Humanized anti-cd134 (ox40) antibodies and uses thereof |
| WO2015095423A2 (en) * | 2013-12-17 | 2015-06-25 | Genentech, Inc. | Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists |
| SG11201607969XA (en) | 2014-03-31 | 2016-10-28 | Genentech Inc | Anti-ox40 antibodies and methods of use |
| SG10201807625PA (en) * | 2014-11-17 | 2018-10-30 | Genentech Inc | Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists |
| SG11201708804WA (en) * | 2015-05-07 | 2017-11-29 | Agenus Inc | Anti-ox40 antibodies and methods of use thereof |
| DK3303396T5 (da) | 2015-05-29 | 2024-10-07 | Bristol Myers Squibb Co | Antistoffer mod ox40 og anvendelser deraf |
| MX2017015937A (es) * | 2015-06-08 | 2018-12-11 | Genentech Inc | Métodos de tratamiento del cáncer con anticuerpos anti-ox40 y antagonistas de unión al eje de pd-1. |
| JP2018521019A (ja) * | 2015-06-08 | 2018-08-02 | ジェネンテック， インコーポレイテッド | 抗ｏｘ４０抗体を使用して癌を治療する方法 |
| US11574747B2 (en) | 2017-04-20 | 2023-02-07 | The University Of Chicago | Methods of treating cancer with placenta growth factor peptide linked to immunotherapeutic antibodies |
-
2017
- 2017-03-25 CN CN201710185400.8A patent/CN108623686A/zh active Pending
-
2018
- 2018-03-23 WO PCT/CN2018/080315 patent/WO2018177220A1/zh not_active Ceased
- 2018-03-23 EP EP18776775.1A patent/EP3604338A4/en not_active Withdrawn
- 2018-03-23 US US16/496,019 patent/US11498972B2/en active Active
- 2018-03-23 JP JP2019551983A patent/JP7046973B2/ja not_active Expired - Fee Related
- 2018-03-23 CN CN201880020043.2A patent/CN110536903B/zh active Active
- 2018-03-23 CA CA3056972A patent/CA3056972A1/en active Pending
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