JP2020514363A - 腫瘍特異的細胞枯渇のためのＦｃ最適化抗ＣＤ２５ - Google Patents

腫瘍特異的細胞枯渇のためのＦｃ最適化抗ＣＤ２５ Download PDF

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JP2020514363A
JP2020514363A JP2019550705A JP2019550705A JP2020514363A JP 2020514363 A JP2020514363 A JP 2020514363A JP 2019550705 A JP2019550705 A JP 2019550705A JP 2019550705 A JP2019550705 A JP 2019550705A JP 2020514363 A JP2020514363 A JP 2020514363A
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antibody
seq
cells
amino acid
acid sequence
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JP2020514363A5 (https=
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アンヌ グビエ
アンヌ グビエ
パスカル メルヒールス
パスカル メルヒールス
ジョセフィン サリム
ジョセフィン サリム
コルソ ベアトリス ゴイエンチェア
コルソ ベアトリス ゴイエンチェア
ケヴィン モウルダー
ケヴィン モウルダー
セルジオ ケサダ
セルジオ ケサダ
カール ペッグス
カール ペッグス
バルガス フレデリック アルセ
バルガス フレデリック アルセ
イザベル ソロモン
イザベル ソロモン
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Cancer Research Technology Ltd
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Cancer Research Technology Ltd
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=61655786&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2020514363(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB1710879.6A external-priority patent/GB201710879D0/en
Priority claimed from GBGB1714429.6A external-priority patent/GB201714429D0/en
Application filed by Cancer Research Technology Ltd filed Critical Cancer Research Technology Ltd
Publication of JP2020514363A publication Critical patent/JP2020514363A/ja
Publication of JP2020514363A5 publication Critical patent/JP2020514363A5/ja
Priority to JP2024009215A priority Critical patent/JP2024050684A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2019550705A 2017-03-17 2018-03-13 腫瘍特異的細胞枯渇のためのＦｃ最適化抗ＣＤ２５ Pending JP2020514363A (ja)

Priority Applications (1)

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JP2024009215A JP2024050684A (ja) 2017-03-17 2024-01-25 腫瘍特異的細胞枯渇のためのＦｃ最適化抗ＣＤ２５

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP17161717 2017-03-17
EP17161717.8 2017-03-17
GBGB1710879.6A GB201710879D0 (en) 2017-07-06 2017-07-06 Methods and compounds for tumour-specific cell depletion
GB1710879.6 2017-07-06
GBGB1714429.6A GB201714429D0 (en) 2017-09-07 2017-09-07 Compounds and methods for tumour-specific cell depletion
GB1714429.6 2017-09-07
PCT/EP2018/056312 WO2018167104A1 (en) 2017-03-17 2018-03-13 Fc-optimized anti-cd25 for tumour specific cell depletion

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JP2024009215A Division JP2024050684A (ja) 2017-03-17 2024-01-25 腫瘍特異的細胞枯渇のためのＦｃ最適化抗ＣＤ２５

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JP2020514363A true JP2020514363A (ja) 2020-05-21
JP2020514363A5 JP2020514363A5 (https=) 2021-04-30

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JP2019550705A Pending JP2020514363A (ja) 2017-03-17 2018-03-13 腫瘍特異的細胞枯渇のためのＦｃ最適化抗ＣＤ２５
JP2024009215A Pending JP2024050684A (ja) 2017-03-17 2024-01-25 腫瘍特異的細胞枯渇のためのＦｃ最適化抗ＣＤ２５

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US (1) US11879014B2 (https=)
EP (1) EP3596123B1 (https=)
JP (2) JP2020514363A (https=)
KR (1) KR20190130137A (https=)
CN (1) CN110869388B (https=)
AU (1) AU2018233976B2 (https=)
BR (1) BR112019017017A2 (https=)
CA (1) CA3056506A1 (https=)
CL (1) CL2019002624A1 (https=)
CR (1) CR20190477A (https=)
DK (1) DK3596123T3 (https=)
ES (1) ES2975063T3 (https=)
FI (1) FI3596123T3 (https=)
HR (1) HRP20240469T1 (https=)
HU (1) HUE065999T2 (https=)
IL (1) IL269081B1 (https=)
LT (1) LT3596123T (https=)
MX (1) MX2019010974A (https=)
MY (1) MY208220A (https=)
PE (1) PE20191812A1 (https=)
PL (1) PL3596123T3 (https=)
RS (1) RS65351B1 (https=)
SG (1) SG11201908578YA (https=)
SI (1) SI3596123T1 (https=)
WO (1) WO2018167104A1 (https=)
ZA (1) ZA201904980B (https=)

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JP2023550446A (ja) * 2020-11-20 2023-12-01 インセルム（インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル） 抗ｃｄ２５抗体
JP2024505556A (ja) * 2021-02-02 2024-02-06 ラクテン・メディカル，インコーポレイテッド がん、腫瘍および腫瘍細胞の局所および全身処置のための方法

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EP3880698A4 (en) 2018-11-14 2022-11-30 RubrYc Therapeutics, Inc. MANIPULATED CD25 POLYPEPTIDES AND USES THEREOF
EP3972997A1 (en) * 2019-05-20 2022-03-30 Institut National de la Santé et de la Recherche Médicale (INSERM) Novel anti-cd25 antibodies
PL3932949T3 (pl) * 2019-06-10 2025-11-24 Shandong Boan Biotechnology Co., Ltd. Przeciwciało anty-cd25 i jego zastosowanie
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KR20230154012A (ko) 2021-03-01 2023-11-07 에프. 호프만-라 로슈 아게 신규 바이오마커 및 이의 용도
TW202319400A (zh) 2021-09-02 2023-05-16 瑞士商赫孚孟拉羅股份公司 用於治療aml之抗體
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CN115181182B (zh) * 2022-06-13 2024-03-29 南京融捷康生物科技有限公司 一种人源化的抗cd25的单域抗体及其应用
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CN119451978A (zh) 2022-07-01 2025-02-14 神经基因治疗公司 Neo-2/15变体及其用于优先刺激T调节细胞的用途
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CN120314588B (zh) * 2025-05-21 2025-10-17 成都蓉生药业有限责任公司 一种人免疫球蛋白抗体依赖性细胞介导的吞噬作用生物学活性的检测方法和检测试剂盒

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JP2021533726A (ja) * 2018-03-13 2021-12-09 タスク セラピューティクス リミテッド 腫瘍特異的細胞枯渇のための抗ｃｄ２５
JP7451415B2 (ja) 2018-03-13 2024-03-18 タスク セラピューティクス リミテッド 腫瘍特異的細胞枯渇のための抗ｃｄ２５
JP2021516974A (ja) * 2018-03-13 2021-07-15 タスク セラピューティクス リミテッド 腫瘍特異的細胞枯渇のための抗ｃｄ２５
JP2021516976A (ja) * 2018-03-13 2021-07-15 タスク セラピューティクス リミテッド 腫瘍特異的細胞枯渇のための抗ｃｄ２５
JP2021516973A (ja) * 2018-03-13 2021-07-15 タスク セラピューティクス リミテッド 腫瘍特異的細胞枯渇のための抗ｃｄ２５
JP2021516975A (ja) * 2018-03-13 2021-07-15 タスク セラピューティクス リミテッド 抗ｃｄ２５抗体剤
JP2021515565A (ja) * 2018-03-13 2021-06-24 タスク セラピューティクス リミテッド 腫瘍特異的細胞枯渇のための抗ｃｄ２５
JP7565797B2 (ja) 2018-03-13 2024-10-11 タスク セラピューティクス リミテッド 腫瘍特異的細胞枯渇のための抗ｃｄ２５
JP2021515566A (ja) * 2018-03-13 2021-06-24 タスク セラピューティクス リミテッド 腫瘍特異的細胞枯渇のための抗ｃｄ２５
JP7451414B2 (ja) 2018-03-13 2024-03-18 タスク セラピューティクス リミテッド 抗ｃｄ２５抗体剤
JP7563979B2 (ja) 2018-03-13 2024-10-08 タスク セラピューティクス リミテッド 腫瘍特異的細胞枯渇のための抗ｃｄ２５
JP7474701B2 (ja) 2018-03-13 2024-04-25 タスク セラピューティクス リミテッド 腫瘍特異的細胞枯渇のための抗ｃｄ２５抗体
JP7563978B2 (ja) 2018-03-13 2024-10-08 タスク セラピューティクス リミテッド 腫瘍特異的細胞枯渇のための抗ｃｄ２５
JP2023550446A (ja) * 2020-11-20 2023-12-01 インセルム（インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル） 抗ｃｄ２５抗体
JP2024505556A (ja) * 2021-02-02 2024-02-06 ラクテン・メディカル，インコーポレイテッド がん、腫瘍および腫瘍細胞の局所および全身処置のための方法

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