JP2020513844A5 - - Google Patents

Info

Publication number

JP2020513844A5

JP2020513844A5 JP2019565052A JP2019565052A JP2020513844A5 JP 2020513844 A5 JP2020513844 A5 JP 2020513844A5 JP 2019565052 A JP2019565052 A JP 2019565052A JP 2019565052 A JP2019565052 A JP 2019565052A JP 2020513844 A5 JP2020513844 A5 JP 2020513844A5

Authority

JP

Japan

Prior art keywords

cells

vitro

cell precursors

population

pharmaceutical composition

Prior art date

2018-02-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 238000000034 method Methods 0.000 claims 16
• 210000004027 cell Anatomy 0.000 claims 13
• 210000000173 T-lymphoid precursor cell Anatomy 0.000 claims 10
• 238000000338 in vitro Methods 0.000 claims 10
• 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 8
• 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 8
• 239000003446 ligand Substances 0.000 claims 6
• 239000008194 pharmaceutical composition Substances 0.000 claims 5
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 4
• 102000003984 Aryl Hydrocarbon Receptors Human genes 0.000 claims 4
• 108090000448 Aryl Hydrocarbon Receptors Proteins 0.000 claims 4
• 210000001744 T-lymphocyte Anatomy 0.000 claims 4
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 4
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 4
• 239000005557 antagonist Substances 0.000 claims 4
• 150000004945 aromatic hydrocarbons Chemical class 0.000 claims 4
• 239000012634 fragment Substances 0.000 claims 4
• 239000002609 medium Substances 0.000 claims 4
• 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 3
• 239000001963 growth medium Substances 0.000 claims 3
• 239000002243 precursor Substances 0.000 claims 3
• 238000010361 transduction Methods 0.000 claims 3
• 230000026683 transduction Effects 0.000 claims 3
• 238000001890 transfection Methods 0.000 claims 3
• 102100037362 Fibronectin Human genes 0.000 claims 2
• 108010067306 Fibronectins Proteins 0.000 claims 2
• 206010025327 Lymphopenia Diseases 0.000 claims 2
• 238000012258 culturing Methods 0.000 claims 2
• 210000002865 immune cell Anatomy 0.000 claims 2
• 238000002054 transplantation Methods 0.000 claims 2
• NNRFRJQMBSBXGO-CIUDSAMLSA-N (3s)-3-[[2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-4-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-oxobutanoic acid Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(O)=O NNRFRJQMBSBXGO-CIUDSAMLSA-N 0.000 claims 1
• BGFHMYJZJZLMHW-UHFFFAOYSA-N 4-[2-[[2-(1-benzothiophen-3-yl)-9-propan-2-ylpurin-6-yl]amino]ethyl]phenol Chemical group N1=C(C=2C3=CC=CC=C3SC=2)N=C2N(C(C)C)C=NC2=C1NCCC1=CC=C(O)C=C1 BGFHMYJZJZLMHW-UHFFFAOYSA-N 0.000 claims 1
• 208000023275 Autoimmune disease Diseases 0.000 claims 1
• 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
• 208000031886 HIV Infections Diseases 0.000 claims 1
• 208000037357 HIV infectious disease Diseases 0.000 claims 1
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
• 101000829980 Homo sapiens Ral guanine nucleotide dissociation stimulator Proteins 0.000 claims 1
• 206010061598 Immunodeficiency Diseases 0.000 claims 1
• 208000029462 Immunodeficiency disease Diseases 0.000 claims 1
• 125000002066 L-histidyl group Chemical group [H]N1C([H])=NC(C([H])([H])[C@](C(=O)[*])([H])N([H])[H])=C1[H] 0.000 claims 1
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
• 102100023320 Ral guanine nucleotide dissociation stimulator Human genes 0.000 claims 1
• 108700019146 Transgenes Proteins 0.000 claims 1
• 108010031318 Vitronectin Proteins 0.000 claims 1
• 102100035140 Vitronectin Human genes 0.000 claims 1
• 238000002512 chemotherapy Methods 0.000 claims 1
• 239000011248 coating agent Substances 0.000 claims 1
• 238000000576 coating method Methods 0.000 claims 1
• 230000003750 conditioning effect Effects 0.000 claims 1
• 238000010362 genome editing Methods 0.000 claims 1
• 208000024908 graft versus host disease Diseases 0.000 claims 1
• 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
• 229960002897 heparin Drugs 0.000 claims 1
• 229920000669 heparin Polymers 0.000 claims 1
• 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
• 230000007813 immunodeficiency Effects 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 238000002347 injection Methods 0.000 claims 1
• 239000007924 injection Substances 0.000 claims 1
• 238000010253 intravenous injection Methods 0.000 claims 1
• 208000032839 leukemia Diseases 0.000 claims 1
• 231100001023 lymphopenia Toxicity 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 150000007523 nucleic acids Chemical group 0.000 claims 1
• 210000000056 organ Anatomy 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 108010056030 retronectin Proteins 0.000 claims 1