MA47541A - Procédé permettant de produire des progéniteurs de lymphocytes t - Google Patents

Procédé permettant de produire des progéniteurs de lymphocytes t

Info

Publication number
MA47541A
MA47541A MA047541A MA47541A MA47541A MA 47541 A MA47541 A MA 47541A MA 047541 A MA047541 A MA 047541A MA 47541 A MA47541 A MA 47541A MA 47541 A MA47541 A MA 47541A
Authority
MA
Morocco
Prior art keywords
producing
lymphocyte progenitors
progenitors
lymphocyte
Prior art date
Application number
MA047541A
Other languages
English (en)
Inventor
Isabelle Andre
Marina Cavazzana
Kuiying Ma
John Tchen
Original Assignee
Hopitaux Paris Assist Publique
Fondation Imagine Inst Des Maladies Genetiques
Inst Nat Sante Rech Med
Univ Paris Descartes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hopitaux Paris Assist Publique, Fondation Imagine Inst Des Maladies Genetiques, Inst Nat Sante Rech Med, Univ Paris Descartes filed Critical Hopitaux Paris Assist Publique
Publication of MA47541A publication Critical patent/MA47541A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/145—Thrombopoietin [TPO]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2307—Interleukin-7 (IL-7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/25—Tumour necrosing factors [TNF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/42—Notch; Delta; Jagged; Serrate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
MA047541A 2017-02-13 2018-02-12 Procédé permettant de produire des progéniteurs de lymphocytes t MA47541A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17305161 2017-02-13

Publications (1)

Publication Number Publication Date
MA47541A true MA47541A (fr) 2019-12-18

Family

ID=58185453

Family Applications (1)

Application Number Title Priority Date Filing Date
MA047541A MA47541A (fr) 2017-02-13 2018-02-12 Procédé permettant de produire des progéniteurs de lymphocytes t

Country Status (16)

Country Link
US (5) US20200046767A1 (fr)
EP (2) EP3580330B1 (fr)
JP (2) JP7164798B2 (fr)
KR (1) KR102666158B1 (fr)
CN (1) CN110506110A (fr)
AU (1) AU2018217404B2 (fr)
BR (1) BR112019016672A8 (fr)
CA (1) CA3053294A1 (fr)
DK (1) DK3580330T3 (fr)
ES (1) ES2931530T3 (fr)
HU (1) HUE060548T2 (fr)
IL (1) IL268641B1 (fr)
MA (1) MA47541A (fr)
PL (1) PL3580330T3 (fr)
PT (1) PT3580330T (fr)
WO (1) WO2018146297A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3580330B1 (fr) * 2017-02-13 2022-08-31 Assistance Publique - Hôpitaux de Paris Methode de generation de progeniteurs de cellules t
CA3077344A1 (fr) * 2017-09-29 2019-04-04 Regents Of The University Of Minnesota Procedes de fabrication, d'expansion et d'utilisation d'une cellule t progenitrice humaine
JP2021535747A (ja) * 2018-09-07 2021-12-23 ウィスコンシン アラムニ リサーチ ファンデーション ヒト多能性幹細胞からの造血前駆細胞の生成
JP2023502965A (ja) * 2019-11-14 2023-01-26 ウィリアム ザンドストラ，ピーター 前駆ｔ細胞を製造するための培地処方および方法
JPWO2021200901A1 (fr) * 2020-03-31 2021-10-07
WO2022248354A1 (fr) * 2021-05-25 2022-12-01 Universiteit Gent Génération de précurseurs de lymphocytes t par agonisation du récepteur 2 du facteur de nécrose tumorale
WO2023079082A1 (fr) 2021-11-04 2023-05-11 Aphp (Assistance Publique - Hôpitaux De Paris) Méthode de génération de cellules nk
FR3130843A1 (fr) * 2021-12-21 2023-06-23 Universite Claude Bernard Lyon 1 Cellule progéniteur des lymphocytes T exprimant de manière régulée un transgène d’intérêt

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6093531A (en) 1997-09-29 2000-07-25 Neurospheres Holdings Ltd. Generation of hematopoietic cells from multipotent neural stem cells
CA2313250A1 (fr) 1997-12-04 1999-06-10 Duke University Procedes d'isolation et d'utilisation des cellules hematopoietiques cd7+cd34-lin-
WO2009097140A1 (fr) 2008-01-30 2009-08-06 Memorial Sloan-Kettering Cancer Center Procédés d'immunothérapie tumorale prête à l'emploi utilisant des précurseurs de lymphocytes t allogéniques
RU2535966C2 (ru) 2008-09-12 2014-12-20 Криопрашис Криобиоложия Лтда. Клеточная терапия ишемической ткани
US8772028B2 (en) * 2008-11-07 2014-07-08 Sunnybrook Health Sciences Centre CD34+CD7+CD5+CD1a-human progenitor T-cells produced in vitro and methods of using
WO2011068962A1 (fr) 2009-12-03 2011-06-09 The University Of Utah Research Foundation Procédés de génération de lymphocytes t à partir de cellules souches hématopoïétiques
EP2555782A1 (fr) 2010-04-09 2013-02-13 Fred Hutchinson Cancer Research Center Compositions et procédés pour fournir une fonction hématopoïétique sans correspondance hla
WO2013074916A1 (fr) 2011-11-18 2013-05-23 Board Of Regents, The University Of Texas System Lymphocytes t car+ génétiquement modifiés pour éliminer l'expression du récepteur des lymphocytes t et/ou le système hla
US9834755B2 (en) * 2011-12-08 2017-12-05 Fred Hutchinson Cancer Research Center Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells
US20150352180A1 (en) 2013-01-11 2015-12-10 The Trustee Of The University Of Pennsylvania Notch Ligand Bound Biocompatible Substrates And Their Use In Bone Formation
EP3027755B1 (fr) 2013-08-02 2019-10-09 The Regents of The University of California Modification d'une immunité antivirale médiée par les cellules t par des cellules souches et des récepteurs d'antigène chimériques
WO2015099134A1 (fr) 2013-12-26 2015-07-02 アストリム株式会社 Immunothérapie utilisant des cellules t précurseurs dérivées de cellules souches pluripotentes portant un gène du récepteur t réarrangé
CA2945388A1 (fr) 2014-04-23 2015-10-29 Board Of Regents, The University Of Texas System Recepteurs d'antigenes chimeres (car) utilises dans un traitement et methodes de fabrication associees
EP3134512B1 (fr) * 2014-04-24 2019-01-02 Miltenyi Biotec GmbH Procédé de production automatisée de cellules t génétiquement modifiées
WO2016039933A1 (fr) 2014-09-11 2016-03-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Vecteur lentiviral pour le traitement de troubles de l'hémoglobine
FR3026744B1 (fr) * 2014-10-06 2024-04-19 Hopitaux Paris Assist Publique Methode de generation de progeniteurs de cellules t
JP2018518181A (ja) * 2015-06-17 2018-07-12 ザ ユーエービー リサーチ ファンデーション 血液細胞系列の細胞に機能的ポリペプチドを導入するためのＣＲＩＳＰＲ／Ｃａｓ９複合体
CN109312307A (zh) 2016-04-08 2019-02-05 多伦多大学管理委员会 用于从干细胞和/或祖细胞生成祖t细胞的方法及其用途
EP3580330B1 (fr) * 2017-02-13 2022-08-31 Assistance Publique - Hôpitaux de Paris Methode de generation de progeniteurs de cellules t

Also Published As

Publication number Publication date
US20210169934A1 (en) 2021-06-10
CA3053294A1 (fr) 2018-08-16
US11638723B2 (en) 2023-05-02
PL3580330T3 (pl) 2023-01-16
CN110506110A (zh) 2019-11-26
AU2018217404B2 (en) 2024-03-28
HUE060548T2 (hu) 2023-03-28
AU2018217404A1 (en) 2019-09-05
DK3580330T3 (da) 2022-12-05
RU2019125600A3 (fr) 2021-11-03
BR112019016672A2 (pt) 2020-04-14
ES2931530T3 (es) 2022-12-30
US20210169935A1 (en) 2021-06-10
RU2019125600A (ru) 2021-03-15
IL268641B1 (en) 2024-06-01
JP7164798B2 (ja) 2022-11-02
EP3580330A1 (fr) 2019-12-18
KR102666158B1 (ko) 2024-05-16
US20230293586A1 (en) 2023-09-21
US11426430B2 (en) 2022-08-30
AU2018217404A2 (en) 2019-09-19
US11642376B2 (en) 2023-05-09
WO2018146297A1 (fr) 2018-08-16
EP3580330B1 (fr) 2022-08-31
EP4067482A1 (fr) 2022-10-05
KR20190117550A (ko) 2019-10-16
US20200046767A1 (en) 2020-02-13
JP2022185024A (ja) 2022-12-13
JP2020513844A (ja) 2020-05-21
PT3580330T (pt) 2022-12-06
IL268641A (en) 2019-10-31
US20200390817A1 (en) 2020-12-17
BR112019016672A8 (pt) 2022-11-22

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