JP7164798B2 - T細胞前駆体を産生させるための方法 - Google Patents

T細胞前駆体を産生させるための方法 Download PDF

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JP7164798B2
JP7164798B2 JP2019565052A JP2019565052A JP7164798B2 JP 7164798 B2 JP7164798 B2 JP 7164798B2 JP 2019565052 A JP2019565052 A JP 2019565052A JP 2019565052 A JP2019565052 A JP 2019565052A JP 7164798 B2 JP7164798 B2 JP 7164798B2
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アンドレ,イザベル
カヴァッザーナ,マリナ
マ,クーイン
チェン,ジョン
ソヘイリ,タイベ-シャビ
モイランテム,ランジタ デビ
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL268641B2 (en) * 2017-02-13 2024-10-01 Assist Publique Hopitaux Paris Aphp Method for generating t cells progenitors
US20200308540A1 (en) * 2017-09-29 2020-10-01 Regents Of The University Of Minnesota Methods of making, expanding, and using a human progenitor t cell
CN112041431A (zh) 2018-02-14 2020-12-04 桑尼布鲁克研究所 产生t细胞谱系细胞的方法
CA3109546A1 (en) * 2018-09-07 2020-03-12 Wisconsin Alumni Research Foundation Generation of hematopoietic progenitor cells from human pluripotent stem cells
US20220315895A1 (en) * 2019-05-01 2022-10-06 Transfusion Health, Llc Methods of making oligopotent and unipotent precursors
CA3144640A1 (en) * 2019-06-24 2020-12-30 Children's Hospital Los Angeles Bcl11b overexpression to enhance human thymopoiesis and t cell function
CA3159629A1 (en) * 2019-11-14 2021-05-20 Peter William ZANDSTRA Media formulations and methods for producing progenitor t cells
US20230159891A1 (en) * 2020-03-31 2023-05-25 Kyoto University T cell progenitor production method
JP2023553313A (ja) 2020-11-30 2023-12-21 チョ ファーマ インコーポレイテッド 細胞を富化するための抗体
CA3213581A1 (en) * 2021-05-25 2022-12-01 Kai Ling LIANG Generating t cell precursors via agonizing tumor necrosis factor receptor 2
EP4426319A1 (en) 2021-11-04 2024-09-11 APHP (Assistance Publique - Hôpitaux de Paris) Method for generating nk cells
FR3130843A1 (fr) * 2021-12-21 2023-06-23 Universite Claude Bernard Lyon 1 Cellule progéniteur des lymphocytes T exprimant de manière régulée un transgène d’intérêt
AU2024211048A1 (en) 2023-01-27 2025-08-07 Notch Therapeutics (Canada), Inc. Method for generating t cell lineage populations from stem/progenitor cells
WO2024175738A1 (en) * 2023-02-22 2024-08-29 Smart Immune Method for thymus regeneration
US20250332260A1 (en) 2024-04-10 2025-10-30 Garuda Therapeutics, Inc. Immune compatible cells for allogeneic cell therapies to cover global, ethnic, or disease-specific populations
WO2025219552A1 (en) 2024-04-17 2025-10-23 Assitance Publique Hopitaux De Paris Method for producing t cell progenitors from human pluripotent stem cells
CN119709836B (zh) * 2024-12-21 2025-08-08 湖南农业大学 OsProT2基因在调控水稻镉含量、镉耐受性及产量中的应用和方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012508188A (ja) 2008-11-07 2012-04-05 サニーブルック ヘルス サイエンシズ センター ヒト前駆t細胞
US20140369973A1 (en) 2011-12-08 2014-12-18 Fred Hutchinson Cancer Research Center Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells
WO2016055396A1 (fr) 2014-10-06 2016-04-14 Assistance Publique - Hopitaux De Paris Méthode de génération de progéniteurs de cellules t
JP2016526913A (ja) 2013-08-02 2016-09-08 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 幹細胞及びキメラ抗原受容体を介した抗腫瘍性t細胞免疫の改変
WO2016205680A1 (en) 2015-06-17 2016-12-22 The Uab Research Foundation Crispr/cas9 complex for introducing a functional polypeptide into cells of blood cell lineage

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6093531A (en) 1997-09-29 2000-07-25 Neurospheres Holdings Ltd. Generation of hematopoietic cells from multipotent neural stem cells
JP2001525176A (ja) 1997-12-04 2001-12-11 デューク・ユニバーシティー Cd7+cd34−lin−造血細胞を単離し、使用する方法
US10059923B2 (en) 2008-01-30 2018-08-28 Memorial Sloan Kettering Cancer Center Methods for off-the-shelf tumor immunotherapy using allogeneic T-cell precursors
RU2535966C2 (ru) 2008-09-12 2014-12-20 Криопрашис Криобиоложия Лтда. Клеточная терапия ишемической ткани
WO2011068962A1 (en) 2009-12-03 2011-06-09 The University Of Utah Research Foundation Methods for generating t lymphocytes from hematopoietic stem cells
US20130095079A1 (en) 2010-04-09 2013-04-18 Fred Hutchinson Cancer Research Center Compositions and methods for providing hematopoietic function without hla matching
WO2013074916A1 (en) 2011-11-18 2013-05-23 Board Of Regents, The University Of Texas System Car+ t cells genetically modified to eliminate expression of t- cell receptor and/or hla
WO2014110353A1 (en) 2013-01-11 2014-07-17 The Trustees Of The University Of Pennsylvania Notch ligand bound bicompatible substrates and their use in bone formation
US20170128556A1 (en) 2013-12-26 2017-05-11 Thyas Co. Ltd. Immunotherapy using t precursor cells derived from pluripotent stem cells having rearranged t cell receptor genes
KR20160145802A (ko) 2014-04-23 2016-12-20 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 요법에 사용하기 위한 키메라 항원 수용체 (car) 및 이의 제조 방법
US10131876B2 (en) * 2014-04-24 2018-11-20 Miltenyi Biotec Gmbh Method for automated generation of genetically modified T cells
WO2016039933A1 (en) 2014-09-11 2016-03-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Lentiviral vector for treating hemoglobin disorders
EP3440198A4 (en) 2016-04-08 2019-11-06 The Governing Council of the Universtiy of Toronto PROCESS FOR THE PRODUCTION OF PRE-TREATMENT T CELLS FROM TRUNK AND / OR PRECURSOR CELLS AND USE THEREOF
IL268641B2 (en) * 2017-02-13 2024-10-01 Assist Publique Hopitaux Paris Aphp Method for generating t cells progenitors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012508188A (ja) 2008-11-07 2012-04-05 サニーブルック ヘルス サイエンシズ センター ヒト前駆t細胞
US20140369973A1 (en) 2011-12-08 2014-12-18 Fred Hutchinson Cancer Research Center Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells
JP2016526913A (ja) 2013-08-02 2016-09-08 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 幹細胞及びキメラ抗原受容体を介した抗腫瘍性t細胞免疫の改変
WO2016055396A1 (fr) 2014-10-06 2016-04-14 Assistance Publique - Hopitaux De Paris Méthode de génération de progéniteurs de cellules t
WO2016205680A1 (en) 2015-06-17 2016-12-22 The Uab Research Foundation Crispr/cas9 complex for introducing a functional polypeptide into cells of blood cell lineage

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Blood, 2000, 95(9), pp.2806-2812
Stem Cells, 2012, 30(8), pp.1771-1780

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US11426430B2 (en) 2022-08-30
US20210169934A1 (en) 2021-06-10
HUE060548T2 (hu) 2023-03-28
US11638723B2 (en) 2023-05-02
ES2931530T3 (es) 2022-12-30
KR20190117550A (ko) 2019-10-16
JP2022185024A (ja) 2022-12-13
AU2018217404A1 (en) 2019-09-05
AU2018217404A2 (en) 2019-09-19
US20210169935A1 (en) 2021-06-10
MA47541A (fr) 2019-12-18
US20230293586A1 (en) 2023-09-21
CN110506110B (zh) 2024-09-06
IL268641B2 (en) 2024-10-01
KR102666158B1 (ko) 2024-05-16
IL268641A (en) 2019-10-31
RU2019125600A3 (enExample) 2021-11-03
CA3053294A1 (en) 2018-08-16
CN110506110A (zh) 2019-11-26
AU2018217404B2 (en) 2024-03-28
PT3580330T (pt) 2022-12-06
IL268641B1 (en) 2024-06-01
RU2019125600A (ru) 2021-03-15
US11642376B2 (en) 2023-05-09
JP2020513844A (ja) 2020-05-21
BR112019016672A2 (pt) 2020-04-14
PL3580330T3 (pl) 2023-01-16
EP3580330A1 (en) 2019-12-18
DK3580330T3 (da) 2022-12-05
ZA201905470B (en) 2024-12-18
BR112019016672A8 (pt) 2022-11-22
US20200046767A1 (en) 2020-02-13
EP4067482A1 (en) 2022-10-05
WO2018146297A1 (en) 2018-08-16
EP3580330B1 (en) 2022-08-31
US20200390817A1 (en) 2020-12-17

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