KR102666158B1 - T 세포 전구체(progenitor)의 생성 방법 - Google Patents

T 세포 전구체(progenitor)의 생성 방법 Download PDF

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KR102666158B1
KR102666158B1 KR1020197024529A KR20197024529A KR102666158B1 KR 102666158 B1 KR102666158 B1 KR 102666158B1 KR 1020197024529 A KR1020197024529 A KR 1020197024529A KR 20197024529 A KR20197024529 A KR 20197024529A KR 102666158 B1 KR102666158 B1 KR 102666158B1
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KR20190117550A (ko
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이자벨 안드레
마리나 카바자나
쿠이잉 마
존 첸
타예베흐-샤비 소헬리
모이랑뎀 란지타 데비
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아시스땅스 퍼블리끄-오삐또 드 빠리
폰데이션 이메진 - 인스티튜트 데스 말라다이스 제네티크
인스티튜트 내셔널 드 라 싼테 에 드 라 리셰르셰 메디칼르 (인 썸)
유니베르시떼 파리 시테
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    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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    • C12N2533/50—Proteins
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  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
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  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
KR1020197024529A 2017-02-13 2018-02-12 T 세포 전구체(progenitor)의 생성 방법 Active KR102666158B1 (ko)

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Application Number Priority Date Filing Date Title
EP17305161.6 2017-02-13
EP17305161 2017-02-13
PCT/EP2018/053406 WO2018146297A1 (en) 2017-02-13 2018-02-12 Method for generating t cells progenitors

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KR20190117550A KR20190117550A (ko) 2019-10-16
KR102666158B1 true KR102666158B1 (ko) 2024-05-16

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US (5) US20200046767A1 (enExample)
EP (2) EP3580330B1 (enExample)
JP (2) JP7164798B2 (enExample)
KR (1) KR102666158B1 (enExample)
CN (1) CN110506110B (enExample)
AU (1) AU2018217404B2 (enExample)
BR (1) BR112019016672A8 (enExample)
CA (1) CA3053294A1 (enExample)
DK (1) DK3580330T3 (enExample)
ES (1) ES2931530T3 (enExample)
HU (1) HUE060548T2 (enExample)
IL (1) IL268641B2 (enExample)
MA (1) MA47541A (enExample)
PL (1) PL3580330T3 (enExample)
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Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL268641B2 (en) * 2017-02-13 2024-10-01 Assist Publique Hopitaux Paris Aphp Method for generating t cells progenitors
US20200308540A1 (en) * 2017-09-29 2020-10-01 Regents Of The University Of Minnesota Methods of making, expanding, and using a human progenitor t cell
CN112041431A (zh) 2018-02-14 2020-12-04 桑尼布鲁克研究所 产生t细胞谱系细胞的方法
CA3109546A1 (en) * 2018-09-07 2020-03-12 Wisconsin Alumni Research Foundation Generation of hematopoietic progenitor cells from human pluripotent stem cells
US20220315895A1 (en) * 2019-05-01 2022-10-06 Transfusion Health, Llc Methods of making oligopotent and unipotent precursors
CA3144640A1 (en) * 2019-06-24 2020-12-30 Children's Hospital Los Angeles Bcl11b overexpression to enhance human thymopoiesis and t cell function
CA3159629A1 (en) * 2019-11-14 2021-05-20 Peter William ZANDSTRA Media formulations and methods for producing progenitor t cells
US20230159891A1 (en) * 2020-03-31 2023-05-25 Kyoto University T cell progenitor production method
JP2023553313A (ja) 2020-11-30 2023-12-21 チョ ファーマ インコーポレイテッド 細胞を富化するための抗体
CA3213581A1 (en) * 2021-05-25 2022-12-01 Kai Ling LIANG Generating t cell precursors via agonizing tumor necrosis factor receptor 2
EP4426319A1 (en) 2021-11-04 2024-09-11 APHP (Assistance Publique - Hôpitaux de Paris) Method for generating nk cells
FR3130843A1 (fr) * 2021-12-21 2023-06-23 Universite Claude Bernard Lyon 1 Cellule progéniteur des lymphocytes T exprimant de manière régulée un transgène d’intérêt
AU2024211048A1 (en) 2023-01-27 2025-08-07 Notch Therapeutics (Canada), Inc. Method for generating t cell lineage populations from stem/progenitor cells
WO2024175738A1 (en) * 2023-02-22 2024-08-29 Smart Immune Method for thymus regeneration
US20250332260A1 (en) 2024-04-10 2025-10-30 Garuda Therapeutics, Inc. Immune compatible cells for allogeneic cell therapies to cover global, ethnic, or disease-specific populations
WO2025219552A1 (en) 2024-04-17 2025-10-23 Assitance Publique Hopitaux De Paris Method for producing t cell progenitors from human pluripotent stem cells
CN119709836B (zh) * 2024-12-21 2025-08-08 湖南农业大学 OsProT2基因在调控水稻镉含量、镉耐受性及产量中的应用和方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016055396A1 (fr) * 2014-10-06 2016-04-14 Assistance Publique - Hopitaux De Paris Méthode de génération de progéniteurs de cellules t

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6093531A (en) 1997-09-29 2000-07-25 Neurospheres Holdings Ltd. Generation of hematopoietic cells from multipotent neural stem cells
JP2001525176A (ja) 1997-12-04 2001-12-11 デューク・ユニバーシティー Ｃｄ７＋ｃｄ３４−ｌｉｎ−造血細胞を単離し、使用する方法
US10059923B2 (en) 2008-01-30 2018-08-28 Memorial Sloan Kettering Cancer Center Methods for off-the-shelf tumor immunotherapy using allogeneic T-cell precursors
RU2535966C2 (ru) 2008-09-12 2014-12-20 Криопрашис Криобиоложия Лтда. Клеточная терапия ишемической ткани
US8772028B2 (en) * 2008-11-07 2014-07-08 Sunnybrook Health Sciences Centre CD34+CD7+CD5+CD1a-human progenitor T-cells produced in vitro and methods of using
WO2011068962A1 (en) 2009-12-03 2011-06-09 The University Of Utah Research Foundation Methods for generating t lymphocytes from hematopoietic stem cells
US20130095079A1 (en) 2010-04-09 2013-04-18 Fred Hutchinson Cancer Research Center Compositions and methods for providing hematopoietic function without hla matching
WO2013074916A1 (en) 2011-11-18 2013-05-23 Board Of Regents, The University Of Texas System Car+ t cells genetically modified to eliminate expression of t- cell receptor and/or hla
US9834755B2 (en) * 2011-12-08 2017-12-05 Fred Hutchinson Cancer Research Center Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells
WO2014110353A1 (en) 2013-01-11 2014-07-17 The Trustees Of The University Of Pennsylvania Notch ligand bound bicompatible substrates and their use in bone formation
EP3027755B1 (en) * 2013-08-02 2019-10-09 The Regents of The University of California Engineering antiviral t cell immunity through stem cells and chimeric antigen receptors
US20170128556A1 (en) 2013-12-26 2017-05-11 Thyas Co. Ltd. Immunotherapy using t precursor cells derived from pluripotent stem cells having rearranged t cell receptor genes
KR20160145802A (ko) 2014-04-23 2016-12-20 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 요법에 사용하기 위한 키메라 항원 수용체 (car) 및 이의 제조 방법
US10131876B2 (en) * 2014-04-24 2018-11-20 Miltenyi Biotec Gmbh Method for automated generation of genetically modified T cells
WO2016039933A1 (en) 2014-09-11 2016-03-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Lentiviral vector for treating hemoglobin disorders
WO2016205680A1 (en) * 2015-06-17 2016-12-22 The Uab Research Foundation Crispr/cas9 complex for introducing a functional polypeptide into cells of blood cell lineage
EP3440198A4 (en) 2016-04-08 2019-11-06 The Governing Council of the Universtiy of Toronto PROCESS FOR THE PRODUCTION OF PRE-TREATMENT T CELLS FROM TRUNK AND / OR PRECURSOR CELLS AND USE THEREOF
IL268641B2 (en) * 2017-02-13 2024-10-01 Assist Publique Hopitaux Paris Aphp Method for generating t cells progenitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016055396A1 (fr) * 2014-10-06 2016-04-14 Assistance Publique - Hopitaux De Paris Méthode de génération de progéniteurs de cellules t

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Blood. 2001,98:1402-1407.

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US11426430B2 (en) 2022-08-30
JP7164798B2 (ja) 2022-11-02
US20210169934A1 (en) 2021-06-10
HUE060548T2 (hu) 2023-03-28
US11638723B2 (en) 2023-05-02
ES2931530T3 (es) 2022-12-30
KR20190117550A (ko) 2019-10-16
JP2022185024A (ja) 2022-12-13
AU2018217404A1 (en) 2019-09-05
AU2018217404A2 (en) 2019-09-19
US20210169935A1 (en) 2021-06-10
MA47541A (fr) 2019-12-18
US20230293586A1 (en) 2023-09-21
CN110506110B (zh) 2024-09-06
IL268641B2 (en) 2024-10-01
IL268641A (en) 2019-10-31
RU2019125600A3 (enExample) 2021-11-03
CA3053294A1 (en) 2018-08-16
CN110506110A (zh) 2019-11-26
AU2018217404B2 (en) 2024-03-28
PT3580330T (pt) 2022-12-06
IL268641B1 (en) 2024-06-01
RU2019125600A (ru) 2021-03-15
US11642376B2 (en) 2023-05-09
JP2020513844A (ja) 2020-05-21
BR112019016672A2 (pt) 2020-04-14
PL3580330T3 (pl) 2023-01-16
EP3580330A1 (en) 2019-12-18
DK3580330T3 (da) 2022-12-05
ZA201905470B (en) 2024-12-18
BR112019016672A8 (pt) 2022-11-22
US20200046767A1 (en) 2020-02-13
EP4067482A1 (en) 2022-10-05
WO2018146297A1 (en) 2018-08-16
EP3580330B1 (en) 2022-08-31
US20200390817A1 (en) 2020-12-17

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