JP2020513050A5 - - Google Patents
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- JP2020513050A5 JP2020513050A5 JP2019553932A JP2019553932A JP2020513050A5 JP 2020513050 A5 JP2020513050 A5 JP 2020513050A5 JP 2019553932 A JP2019553932 A JP 2019553932A JP 2019553932 A JP2019553932 A JP 2019553932A JP 2020513050 A5 JP2020513050 A5 JP 2020513050A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
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- composition
- alkyl
- quencher
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 *C(C(C(NCCO*)=O)NC(C(*)NC([U]*)=O)=O)I Chemical compound *C(C(C(NCCO*)=O)NC(C(*)NC([U]*)=O)=O)I 0.000 description 4
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762478639P | 2017-03-30 | 2017-03-30 | |
| US62/478,639 | 2017-03-30 | ||
| PCT/US2018/025567 WO2018183960A1 (en) | 2017-03-30 | 2018-03-30 | Protease-activated contrast agents for in vivo imaging |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020513050A JP2020513050A (ja) | 2020-04-30 |
| JP2020513050A5 true JP2020513050A5 (https=) | 2021-05-06 |
| JP7149614B2 JP7149614B2 (ja) | 2022-10-07 |
Family
ID=63678348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019553932A Active JP7149614B2 (ja) | 2017-03-30 | 2018-03-30 | ｉｎ ｖｉｖｏ画像化のためのプロテアーゼ活性化コントラスト剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11828752B2 (https=) |
| EP (1) | EP3601261A4 (https=) |
| JP (1) | JP7149614B2 (https=) |
| KR (1) | KR102669535B1 (https=) |
| CN (1) | CN110678460A (https=) |
| WO (1) | WO2018183960A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10570173B2 (en) * | 2015-01-22 | 2020-02-25 | The Board Of Trustees Of The Leland Stanford Junior University | Protease-activated contrast agents for in vivo imaging |
| WO2022203930A1 (en) * | 2021-03-24 | 2022-09-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Fluorogenic cyanine carbamates |
| CN116199662B (zh) * | 2021-11-30 | 2024-10-11 | 中国科学院大连化学物理研究所 | 一种可见光和近红外光罗丹明荧光淬灭剂及其合成和应用 |
| CN116199675B (zh) * | 2021-11-30 | 2024-08-20 | 中国科学院大连化学物理研究所 | 一类罗丹明荧光淬灭剂及其合成和应用 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL60888A (en) | 1978-06-16 | 1984-07-31 | Yeda Res & Dev | Substrates and process for the quantitative assay of enzymes |
| US5055451A (en) | 1986-12-22 | 1991-10-08 | Syntex Inc. | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors |
| WO1996041638A1 (en) | 1995-06-13 | 1996-12-27 | Sanofi Winthrop, Inc. | Calpain inhibitors for the treatment of neurodegenerative diseases |
| US6544951B2 (en) | 1998-07-02 | 2003-04-08 | Idun Pharmaceuticals, Inc. | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
| US20020052323A1 (en) | 2000-08-30 | 2002-05-02 | Jinhai Wang | Quinoline-(C=O)-(multiple amino acids)-leaving group compounds for pharmaceutical compositions and reagents |
| GB0112868D0 (en) | 2001-05-25 | 2001-07-18 | Secr Defence | Detection system |
| US7303741B2 (en) | 2002-09-23 | 2007-12-04 | General Electric Company | Systems and methods for high-resolution in vivo imaging of biochemical activity in a living organism |
| JP2008522624A (ja) | 2004-12-09 | 2008-07-03 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ヘミアスタリン（ｈｅｍｉａｓｔｅｒｌｉｎ）アナログを使用する癌治療におけるチューブリンのアイソタイプのスクリーニング |
| US8968700B2 (en) | 2005-08-11 | 2015-03-03 | The Board Of Trustees Of The Leland Stanford Junior University | Imaging of protease activity in live cells using activity based probes |
| WO2008104271A2 (en) | 2007-02-28 | 2008-09-04 | Sanofi-Aventis | Imaging probes |
| CN101652149B (zh) | 2007-02-28 | 2012-11-14 | 塞诺菲-安万特股份有限公司 | 成像探针 |
| CN101772577A (zh) | 2007-08-03 | 2010-07-07 | 塞诺菲-安万特股份有限公司 | 半胱天冬蛋白酶成像探针 |
| US20090214436A1 (en) * | 2008-02-18 | 2009-08-27 | Washington University | Dichromic fluorescent compounds |
| US8343458B2 (en) | 2008-04-03 | 2013-01-01 | The Board Of Trustees Of The Leland Stanford Junior University | Probes for in vivo targeting of active cysteine proteases |
| US9155471B2 (en) | 2009-05-27 | 2015-10-13 | Lumicell, Inc'. | Methods and systems for spatially identifying abnormal cells |
| WO2012021800A2 (en) | 2010-08-13 | 2012-02-16 | Banyan Biomarkers | Caspase inhibitors as therapeutics for neural and organ injury and imaging |
| WO2012118715A2 (en) | 2011-02-28 | 2012-09-07 | The Board Of Trustees Of Leland Stanford Junior University | Non-peptidic quenched fluorescent imaging probes |
| EP2686680B1 (en) | 2011-03-18 | 2018-06-13 | Biotium Inc. | Fluorescent dyes, fluorescent dye kits, and methods of preparing labeled molecules |
| US20140249468A1 (en) | 2011-09-09 | 2014-09-04 | The United States Of America,As Represented By The Secretary, Department Of Health And Human Service | Imaging agents for imaging protease activity and uses thereof |
| US20140180073A1 (en) | 2012-12-24 | 2014-06-26 | Anticancer, Inc. | Portable digital imaging system for fluorescence-guided surgery |
| US9763577B2 (en) | 2013-03-14 | 2017-09-19 | Lumicell, Inc. | Imaging agent for detection of diseased cells |
| EP4218829A3 (en) * | 2013-03-15 | 2023-08-16 | The Board of Trustees of the Leland Stanford Junior University | Activity-based probe compounds, compositions, and methods of use |
| SG11201508185YA (en) | 2013-04-19 | 2015-11-27 | Agency Science Tech & Res | Tunable fluorescence using cleavable linkers |
| WO2015075699A1 (en) * | 2013-11-25 | 2015-05-28 | Sanofi | Dotam derivatives for therapeutic use |
| US10570173B2 (en) * | 2015-01-22 | 2020-02-25 | The Board Of Trustees Of The Leland Stanford Junior University | Protease-activated contrast agents for in vivo imaging |
-
2018
- 2018-03-30 KR KR1020197032178A patent/KR102669535B1/ko active Active
- 2018-03-30 JP JP2019553932A patent/JP7149614B2/ja active Active
- 2018-03-30 CN CN201880035357.XA patent/CN110678460A/zh active Pending
- 2018-03-30 US US16/499,734 patent/US11828752B2/en active Active
- 2018-03-30 EP EP18777788.3A patent/EP3601261A4/en active Pending
- 2018-03-30 WO PCT/US2018/025567 patent/WO2018183960A1/en not_active Ceased
-
2023
- 2023-10-18 US US18/489,653 patent/US20240077475A1/en active Pending
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