JP2020512276A5 - - Google Patents
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- JP2020512276A5 JP2020512276A5 JP2019527831A JP2019527831A JP2020512276A5 JP 2020512276 A5 JP2020512276 A5 JP 2020512276A5 JP 2019527831 A JP2019527831 A JP 2019527831A JP 2019527831 A JP2019527831 A JP 2019527831A JP 2020512276 A5 JP2020512276 A5 JP 2020512276A5
- Authority
- JP
- Japan
- Prior art keywords
- carbon atoms
- branched
- substituted
- linear
- cyclic alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 *IN(C(C=C1)=O)C1=O Chemical compound *IN(C(C=C1)=O)C1=O 0.000 description 8
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022207896A JP2023036842A (ja) | 2016-11-23 | 2022-12-26 | ベンゾジアゼピン誘導体の選択的スルホン化 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662425761P | 2016-11-23 | 2016-11-23 | |
| US62/425,761 | 2016-11-23 | ||
| PCT/US2017/062989 WO2018098258A2 (en) | 2016-11-23 | 2017-11-22 | Selective sulfonation of benzodiazepine derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022207896A Division JP2023036842A (ja) | 2016-11-23 | 2022-12-26 | ベンゾジアゼピン誘導体の選択的スルホン化 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020512276A JP2020512276A (ja) | 2020-04-23 |
| JP2020512276A5 true JP2020512276A5 (https=) | 2021-01-07 |
| JP7203729B2 JP7203729B2 (ja) | 2023-01-13 |
Family
ID=60655118
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019527831A Active JP7203729B2 (ja) | 2016-11-23 | 2017-11-22 | ベンゾジアゼピン誘導体の選択的スルホン化 |
| JP2022207896A Pending JP2023036842A (ja) | 2016-11-23 | 2022-12-26 | ベンゾジアゼピン誘導体の選択的スルホン化 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022207896A Pending JP2023036842A (ja) | 2016-11-23 | 2022-12-26 | ベンゾジアゼピン誘導体の選択的スルホン化 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US10287256B2 (https=) |
| EP (1) | EP3544983A2 (https=) |
| JP (2) | JP7203729B2 (https=) |
| KR (2) | KR20230133935A (https=) |
| CN (2) | CN116813690A (https=) |
| AU (2) | AU2017363237B2 (https=) |
| CA (1) | CA3044391A1 (https=) |
| IL (2) | IL266743B (https=) |
| MA (1) | MA46887A (https=) |
| TW (2) | TWI755450B (https=) |
| WO (1) | WO2018098258A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SMT202000614T1 (it) * | 2015-06-29 | 2021-01-05 | Immunogen Inc | Coniugati di anticorpi ingegnerizzati con cisteina |
| AU2016285552B2 (en) * | 2015-06-29 | 2022-10-13 | Immunogen, Inc. | Anti-CD123 antibodies and conjugates and derivatives thereof |
| WO2018098258A2 (en) | 2016-11-23 | 2018-05-31 | Immunogen, Inc. | Selective sulfonation of benzodiazepine derivatives |
| MA54088A (fr) * | 2018-10-30 | 2022-03-16 | Immunogen Inc | Procédés de traitement faisant appel à des immunoconjugués anti-cd123 |
| WO2020092344A1 (en) * | 2018-10-31 | 2020-05-07 | Health Research, Inc. | Combination treatment with anti-cd123 antibody drug conjugate and parp inhibitor |
| KR20220022112A (ko) | 2019-03-21 | 2022-02-24 | 이뮤노젠 아이엔씨 | 세포-결합 제제-약물 콘쥬게이트를 준비하는 방법 |
| KR20220004669A (ko) | 2019-04-29 | 2022-01-11 | 이뮤노젠 아이엔씨 | 항-cd123 면역접합체를 포함하는 치료적 조합물 |
| US20220306751A1 (en) | 2019-09-13 | 2022-09-29 | Mythic Therapeutics, Inc. | Antigen-binding protein constructs and uses thereof |
| CN113189184B (zh) * | 2021-04-28 | 2022-09-09 | 浙江大学 | 含有半胱氨酸的毛细管凝胶电泳样品缓冲液 |
| EP4548932A1 (en) | 2022-06-30 | 2025-05-07 | Toray Industries, Inc. | Pharmaceutical composition for treating and/or preventing cancer |
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| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| EP0563475B1 (en) | 1992-03-25 | 2000-05-31 | Immunogen Inc | Cell binding agent conjugates of derivatives of CC-1065 |
| GB9422383D0 (en) | 1994-11-05 | 1995-01-04 | Wellcome Found | Antibodies |
| CA2388063C (en) | 1999-11-24 | 2010-06-08 | Immunogen, Inc. | Cytotoxic agents comprising taxanes and their therapeutic use |
| US6441163B1 (en) | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
| US6716821B2 (en) | 2001-12-21 | 2004-04-06 | Immunogen Inc. | Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same |
| US6756397B2 (en) | 2002-04-05 | 2004-06-29 | Immunogen, Inc. | Prodrugs of CC-1065 analogs |
| BR0313197A (pt) | 2002-08-02 | 2005-08-09 | Immunogen Inc | Agentes citotóxicos contendo potentes taxanos e seu uso terapêutico |
| DE60336149D1 (de) | 2002-08-16 | 2011-04-07 | Immunogen Inc | Vernetzer mit hoher reaktivität und löslichkeit und ihre verwendung bei der herstellung von konjugaten für die gezielte abgabe von kleinmolekularen arzneimitteln |
| ZA200503075B (en) | 2002-11-07 | 2006-09-27 | Immunogen Inc | Anti-CD33 antibodies and method for treatment of acute myeloid leukemia using the same |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| US7276497B2 (en) | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
| JP4942643B2 (ja) | 2004-03-02 | 2012-05-30 | シアトル ジェネティックス， インコーポレイテッド | 部分的に付加された抗体およびそれらの結合体化方法 |
| NZ579482A (en) | 2004-06-01 | 2011-02-25 | Genentech Inc | Antibody drug conjugates and methods |
| DK1791565T3 (en) | 2004-09-23 | 2016-08-01 | Genentech Inc | Cysteingensplejsede antibodies and conjugates |
| JP2008521828A (ja) | 2004-11-29 | 2008-06-26 | シアトル ジェネティックス， インコーポレイテッド | 操作された抗体およびイムノコンジュゲート |
| US7612062B2 (en) | 2005-04-21 | 2009-11-03 | Spirogen Limited | Pyrrolobenzodiazepines |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| EP2032606B1 (en) | 2006-05-30 | 2013-11-27 | Genentech, Inc. | Antibodies and immunoconjugates and uses therefor |
| ES2593484T3 (es) | 2007-03-29 | 2016-12-09 | Genmab A/S | Anticuerpos biespecíficos y métodos de producción de los mismos |
| SI2019104T1 (sl) | 2007-07-19 | 2013-12-31 | Sanofi | Citotoksična sredstva, ki obsegajo nove tomaimicinske derivate, in njihova terapevtska uporaba |
| NZ610239A (en) | 2008-04-30 | 2014-11-28 | Immunogen Inc | Cross-linkers and their uses |
| SG189817A1 (en) | 2008-04-30 | 2013-05-31 | Immunogen Inc | Potent conjugates and hydrophilic linkers |
| GB0819095D0 (en) | 2008-10-17 | 2008-11-26 | Spirogen Ltd | Pyrrolobenzodiazepines |
| RU2683325C2 (ru) | 2009-02-05 | 2019-03-28 | Иммьюноджен, Инк. | Новые производные бензодиазепина |
| EP2711018A1 (en) | 2009-06-22 | 2014-03-26 | MedImmune, LLC | Engineered Fc regions for site-specific conjugation |
| WO2011092838A1 (ja) | 2010-01-29 | 2011-08-04 | 株式会社フォーサイド・ドット・コム | コンテンツ共有システム、およびコンテンツ共有方法 |
| TWI622402B (zh) | 2010-02-24 | 2018-05-01 | 免疫遺傳股份有限公司 | 葉酸受體１抗體類和免疫共軛物類及彼等之用途 |
| SG10201501803YA (en) | 2010-03-12 | 2015-05-28 | Immunogen Inc | Cd37-binding molecules and immunoconjugates thereof |
| JP5875083B2 (ja) | 2010-04-15 | 2016-03-02 | メディミューン リミテッド | 増殖性疾患治療用ピロロベンゾジアゼピン |
| HRP20241208T1 (hr) | 2010-04-20 | 2024-11-22 | Genmab A/S | Heterodimerni proteini koji sadrže fc fragment protutijela i postupci za njihovu proizvodnju |
| EA201390472A1 (ru) | 2010-10-29 | 2014-02-28 | Иммьюноджен, Инк. | Новые молекулы, связывающиеся с egfr, и их иммуноконъюгаты |
| EA201390575A1 (ru) | 2010-10-29 | 2014-01-30 | Иммьюноджен, Инк. | Неантагонистические egfr-связывающие молекулы и их иммуноконъюгаты |
| JP5826863B2 (ja) | 2011-02-15 | 2015-12-02 | イミュノジェン・インコーポレーテッド | 細胞傷害性ベンゾジアゼピン誘導体 |
| WO2013177481A1 (en) | 2012-05-25 | 2013-11-28 | Immunogen, Inc. | Benzodiazepines and conjugates thereof |
| JP6423804B2 (ja) | 2013-02-28 | 2018-11-14 | イミュノジェン・インコーポレーテッド | 細胞結合剤及び細胞毒性剤を含む複合体 |
| EP3566750A3 (en) | 2013-02-28 | 2020-04-08 | ImmunoGen, Inc. | Conjugates comprising cell-binding agents and cytotoxic agents |
| WO2014134457A2 (en) | 2013-02-28 | 2014-09-04 | Immunogen, Inc. | Conjugates comprising cell-binding agents and cytotoxic agents |
| EP3041846B1 (en) | 2013-09-02 | 2018-11-07 | Hangzhou Dac Biotech Co., Ltd | Novel cytotoxic agents for conjugation of drugs to cell binding molecule |
| US9950077B2 (en) | 2014-06-20 | 2018-04-24 | Bioalliance C.V. | Anti-folate receptor alpha (FRA) antibody-drug conjugates and methods of using thereof |
| SG11201610624WA (en) | 2014-06-20 | 2017-01-27 | Bioalliance Cv | Anti-cd22 antibody-drug conjugates and methods of using thereof |
| SG11201701328XA (en) | 2014-09-02 | 2017-03-30 | Immunogen Inc | Methods for formulating antibody drug conjugate compositions |
| WO2016036804A1 (en) * | 2014-09-03 | 2016-03-10 | Immunogen, Inc. | Cytotoxic benzodiazepine derivatives |
| AU2015311987B2 (en) | 2014-09-03 | 2020-06-04 | Immunogen, Inc. | Cytotoxic benzodiazepine derivatives |
| MA41645A (fr) | 2015-03-04 | 2018-01-09 | Abbvie Stemcentrx Llc | Anticorps issus de génie génétique spécifiques au site et méthodes d'utilisation |
| AU2016285552B2 (en) | 2015-06-29 | 2022-10-13 | Immunogen, Inc. | Anti-CD123 antibodies and conjugates and derivatives thereof |
| SMT202000614T1 (it) | 2015-06-29 | 2021-01-05 | Immunogen Inc | Coniugati di anticorpi ingegnerizzati con cisteina |
| EA201891723A1 (ru) | 2016-02-05 | 2018-12-28 | Милленниум Фармасьютикалз, Инк. | Gcc-направленные конъюгаты антитело-лекарство |
| WO2018098258A2 (en) | 2016-11-23 | 2018-05-31 | Immunogen, Inc. | Selective sulfonation of benzodiazepine derivatives |
-
2017
- 2017-11-22 WO PCT/US2017/062989 patent/WO2018098258A2/en not_active Ceased
- 2017-11-22 JP JP2019527831A patent/JP7203729B2/ja active Active
- 2017-11-22 CN CN202310731029.6A patent/CN116813690A/zh active Pending
- 2017-11-22 KR KR1020237030171A patent/KR20230133935A/ko not_active Ceased
- 2017-11-22 AU AU2017363237A patent/AU2017363237B2/en not_active Ceased
- 2017-11-22 KR KR1020197017971A patent/KR102576550B1/ko active Active
- 2017-11-22 EP EP17812176.0A patent/EP3544983A2/en not_active Withdrawn
- 2017-11-22 MA MA046887A patent/MA46887A/fr unknown
- 2017-11-22 CN CN201780084278.3A patent/CN110392685B/zh not_active Expired - Fee Related
- 2017-11-22 CA CA3044391A patent/CA3044391A1/en active Pending
- 2017-11-22 US US15/820,648 patent/US10287256B2/en active Active
- 2017-11-22 TW TW106140599A patent/TWI755450B/zh not_active IP Right Cessation
- 2017-11-22 TW TW111103323A patent/TWI845890B/zh not_active IP Right Cessation
-
2019
- 2019-03-26 US US16/364,801 patent/US10494348B2/en active Active
- 2019-05-20 IL IL266743A patent/IL266743B/en unknown
- 2019-10-30 US US16/669,121 patent/US10822313B2/en active Active
-
2020
- 2020-09-17 US US17/023,545 patent/US11572349B2/en active Active
-
2022
- 2022-03-22 IL IL291597A patent/IL291597A/en unknown
- 2022-06-15 AU AU2022204163A patent/AU2022204163B2/en not_active Expired - Fee Related
- 2022-12-26 JP JP2022207896A patent/JP2023036842A/ja active Pending
- 2022-12-30 US US18/091,653 patent/US20230391733A1/en not_active Abandoned
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