JP2020512276A5 - - Google Patents
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- JP2020512276A5 JP2020512276A5 JP2019527831A JP2019527831A JP2020512276A5 JP 2020512276 A5 JP2020512276 A5 JP 2020512276A5 JP 2019527831 A JP2019527831 A JP 2019527831A JP 2019527831 A JP2019527831 A JP 2019527831A JP 2020512276 A5 JP2020512276 A5 JP 2020512276A5
- Authority
- JP
- Japan
- Prior art keywords
- carbon atoms
- branched
- substituted
- linear
- cyclic alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 *IN(C(C=C1)=O)C1=O Chemical compound *IN(C(C=C1)=O)C1=O 0.000 description 8
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022207896A JP2023036842A (ja) | 2016-11-23 | 2022-12-26 | ベンゾジアゼピン誘導体の選択的スルホン化 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662425761P | 2016-11-23 | 2016-11-23 | |
| US62/425,761 | 2016-11-23 | ||
| PCT/US2017/062989 WO2018098258A2 (en) | 2016-11-23 | 2017-11-22 | Selective sulfonation of benzodiazepine derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022207896A Division JP2023036842A (ja) | 2016-11-23 | 2022-12-26 | ベンゾジアゼピン誘導体の選択的スルホン化 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020512276A JP2020512276A (ja) | 2020-04-23 |
| JP2020512276A5 true JP2020512276A5 (https=) | 2021-01-07 |
| JP7203729B2 JP7203729B2 (ja) | 2023-01-13 |
Family
ID=60655118
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019527831A Active JP7203729B2 (ja) | 2016-11-23 | 2017-11-22 | ベンゾジアゼピン誘導体の選択的スルホン化 |
| JP2022207896A Pending JP2023036842A (ja) | 2016-11-23 | 2022-12-26 | ベンゾジアゼピン誘導体の選択的スルホン化 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022207896A Pending JP2023036842A (ja) | 2016-11-23 | 2022-12-26 | ベンゾジアゼピン誘導体の選択的スルホン化 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US10287256B2 (https=) |
| EP (1) | EP3544983A2 (https=) |
| JP (2) | JP7203729B2 (https=) |
| KR (2) | KR20230133935A (https=) |
| CN (2) | CN110392685B (https=) |
| AU (2) | AU2017363237B2 (https=) |
| CA (1) | CA3044391A1 (https=) |
| IL (2) | IL266743B (https=) |
| MA (1) | MA46887A (https=) |
| TW (2) | TWI845890B (https=) |
| WO (1) | WO2018098258A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3769787A1 (en) * | 2015-06-29 | 2021-01-27 | ImmunoGen, Inc. | Conjugates of cysteine engineered antibodies |
| ES2887273T3 (es) | 2015-06-29 | 2021-12-22 | Immunogen Inc | Anticuerpos anti-CD123 y conjugados y derivados de los mismos |
| TWI845890B (zh) * | 2016-11-23 | 2024-06-21 | 美商伊繆諾金公司 | 苯二氮平衍生物之選擇性磺化 |
| US20200157228A1 (en) * | 2018-10-30 | 2020-05-21 | Immunogen, Inc. | Methods of treatment using anti-cd123 immunoconjugates |
| WO2020092344A1 (en) * | 2018-10-31 | 2020-05-07 | Health Research, Inc. | Combination treatment with anti-cd123 antibody drug conjugate and parp inhibitor |
| US11833214B2 (en) | 2019-03-21 | 2023-12-05 | Immunogen, Inc. | Methods of preparing cell-binding agent-drug conjugates |
| CA3137454A1 (en) | 2019-04-29 | 2020-11-05 | Immunogen, Inc. | Therapeutic combinations comprising anti-cd123 immunoconjugates |
| US20220306751A1 (en) | 2019-09-13 | 2022-09-29 | Mythic Therapeutics, Inc. | Antigen-binding protein constructs and uses thereof |
| CN113189184B (zh) * | 2021-04-28 | 2022-09-09 | 浙江大学 | 含有半胱氨酸的毛细管凝胶电泳样品缓冲液 |
| KR20250031149A (ko) | 2022-06-30 | 2025-03-06 | 도레이 카부시키가이샤 | 암의 치료 및/또는 예방용 의약 조성물 |
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| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| ES2149768T3 (es) | 1992-03-25 | 2000-11-16 | Immunogen Inc | Conjugados de agentes enlazantes de celulas derivados de cc-1065. |
| GB9422383D0 (en) | 1994-11-05 | 1995-01-04 | Wellcome Found | Antibodies |
| ES2276708T3 (es) | 1999-11-24 | 2007-07-01 | Immunogen, Inc. | Agentes citotoxicos que comprenden taxanos y su uso terapeutico. |
| US6441163B1 (en) | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
| US6716821B2 (en) | 2001-12-21 | 2004-04-06 | Immunogen Inc. | Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same |
| US6756397B2 (en) | 2002-04-05 | 2004-06-29 | Immunogen, Inc. | Prodrugs of CC-1065 analogs |
| CN100522955C (zh) | 2002-08-02 | 2009-08-05 | 伊缪诺金公司 | 含有新型强效紫杉烷的细胞毒性剂及其治疗用途 |
| JP2006500364A (ja) | 2002-08-16 | 2006-01-05 | イムノージェン インコーポレーテッド | 高い反応性と溶解度を有する架橋剤および小分子薬物の標的化送達用コンジュゲートの調製におけるそれらの使用 |
| BR0316101A (pt) | 2002-11-07 | 2005-09-27 | Immunogen Inc | Anticorpos anticd33 e processo para tratamento de leucemia melóide aguda usando os mesmos |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| US7276497B2 (en) | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
| AU2005218642B2 (en) | 2004-03-02 | 2011-04-28 | Seagen Inc. | Partially loaded antibodies and methods of their conjugation |
| KR20120064120A (ko) | 2004-06-01 | 2012-06-18 | 제넨테크, 인크. | 항체 약물 접합체 및 방법 |
| KR101270829B1 (ko) | 2004-09-23 | 2013-06-07 | 제넨테크, 인크. | 시스테인 유전자조작 항체 및 접합체 |
| EP1817341A2 (en) | 2004-11-29 | 2007-08-15 | Seattle Genetics, Inc. | Engineered antibodies and immunoconjugates |
| PL1879901T3 (pl) | 2005-04-21 | 2010-06-30 | Medimmune Ltd | Pirolobenzodiazepiny |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| ES2567402T3 (es) | 2006-05-30 | 2016-04-22 | Genentech, Inc. | Anticuerpos anti CD22, sus inmunoconjugados y usos de los mismos |
| WO2008119353A1 (en) | 2007-03-29 | 2008-10-09 | Genmab A/S | Bispecific antibodies and methods for production thereof |
| PL2019104T3 (pl) | 2007-07-19 | 2014-03-31 | Sanofi Sa | Środki cytotoksyczne obejmujące nowe pochodne tomaymycyny i ich zastosowanie terapeutyczne |
| KR20200058590A (ko) | 2008-04-30 | 2020-05-27 | 이뮤노젠 아이엔씨 | 가교제 및 그 용도 |
| EP2276506A4 (en) | 2008-04-30 | 2014-05-07 | Immunogen Inc | EFFICIENT CONJUGATES AND HYDROPHILIC BINDER |
| GB0819095D0 (en) | 2008-10-17 | 2008-11-26 | Spirogen Ltd | Pyrrolobenzodiazepines |
| CN102365021B (zh) | 2009-02-05 | 2015-07-15 | 伊缪诺金公司 | 新型苯并二氮杂*衍生物 |
| AU2010270979B2 (en) | 2009-06-22 | 2015-04-23 | Medimmune, Llc | Engineered Fc regions for site-specific conjugation |
| WO2011092838A1 (ja) | 2010-01-29 | 2011-08-04 | 株式会社フォーサイド・ドット・コム | コンテンツ共有システム、およびコンテンツ共有方法 |
| CN103037900B (zh) | 2010-02-24 | 2016-04-06 | 伊缪诺金公司 | 叶酸受体1抗体与免疫缀合物以及其用途 |
| SG183542A1 (en) | 2010-03-12 | 2012-10-30 | Immunogen Inc | Cd37-binding molecules and immunoconjugates thereof |
| US8697688B2 (en) | 2010-04-15 | 2014-04-15 | Seattle Genetics Inc. | Pyrrolobenzodiazepines used to treat proliferative diseases |
| DK2560993T3 (da) | 2010-04-20 | 2024-10-14 | Genmab As | Heterodimeric antibody fc-containing proteins and methods for production thereof |
| CN103298489A (zh) | 2010-10-29 | 2013-09-11 | 伊缪诺金公司 | 新型egfr结合分子及其免疫偶联物 |
| CN105399831A (zh) | 2010-10-29 | 2016-03-16 | 伊缪诺金公司 | 非拮抗性egfr结合分子及其免疫偶联物 |
| JP6049642B2 (ja) | 2011-02-15 | 2016-12-21 | イミュノジェン・インコーポレーテッド | 複合体の調製方法 |
| WO2013177481A1 (en) | 2012-05-25 | 2013-11-28 | Immunogen, Inc. | Benzodiazepines and conjugates thereof |
| JP6494533B2 (ja) | 2013-02-28 | 2019-04-03 | イミュノジェン・インコーポレーテッド | 細胞結合剤及び細胞毒性剤としてのマイタンシノイドを含む複合体 |
| WO2014134457A2 (en) | 2013-02-28 | 2014-09-04 | Immunogen, Inc. | Conjugates comprising cell-binding agents and cytotoxic agents |
| WO2014134486A2 (en) | 2013-02-28 | 2014-09-04 | Immunogen, Inc. | Conjugates comprising cell-binding agents and cytotoxic agents |
| CN115124573A (zh) * | 2013-09-02 | 2022-09-30 | 杭州多禧生物科技有限公司 | 应用于细胞结合分子-药物共轭体的新型细胞毒性分子 |
| WO2015196089A1 (en) | 2014-06-20 | 2015-12-23 | Bioalliance C.V. | Anti-cd22 antibody-drug conjugates and methods of using thereof |
| SG11201610620UA (en) | 2014-06-20 | 2017-01-27 | Bioalliance Cv | Anti-folate receptor aplha (fra) antibody-drug conjugates and methods of using thereof |
| CN106999604B (zh) | 2014-09-02 | 2021-08-03 | 伊缪诺金公司 | 用于配制抗体药物缀合物组合物的方法 |
| EP3189057A1 (en) | 2014-09-03 | 2017-07-12 | ImmunoGen, Inc. | Cytotoxic benzodiazepine derivatives |
| ES2815353T3 (es) * | 2014-09-03 | 2021-03-29 | Immunogen Inc | Derivados de benzodiazepina citotóxicos |
| MA41645A (fr) | 2015-03-04 | 2018-01-09 | Abbvie Stemcentrx Llc | Anticorps issus de génie génétique spécifiques au site et méthodes d'utilisation |
| ES2887273T3 (es) | 2015-06-29 | 2021-12-22 | Immunogen Inc | Anticuerpos anti-CD123 y conjugados y derivados de los mismos |
| EP3769787A1 (en) | 2015-06-29 | 2021-01-27 | ImmunoGen, Inc. | Conjugates of cysteine engineered antibodies |
| MX2018009487A (es) | 2016-02-05 | 2019-01-31 | Millennium Pharm Inc | Conjugados de anticuerpo y fármaco dirigidos contra gcc. |
| TWI845890B (zh) | 2016-11-23 | 2024-06-21 | 美商伊繆諾金公司 | 苯二氮平衍生物之選擇性磺化 |
-
2017
- 2017-11-22 TW TW111103323A patent/TWI845890B/zh not_active IP Right Cessation
- 2017-11-22 EP EP17812176.0A patent/EP3544983A2/en not_active Withdrawn
- 2017-11-22 JP JP2019527831A patent/JP7203729B2/ja active Active
- 2017-11-22 TW TW106140599A patent/TWI755450B/zh not_active IP Right Cessation
- 2017-11-22 WO PCT/US2017/062989 patent/WO2018098258A2/en not_active Ceased
- 2017-11-22 AU AU2017363237A patent/AU2017363237B2/en not_active Ceased
- 2017-11-22 CA CA3044391A patent/CA3044391A1/en active Pending
- 2017-11-22 KR KR1020237030171A patent/KR20230133935A/ko not_active Ceased
- 2017-11-22 KR KR1020197017971A patent/KR102576550B1/ko active Active
- 2017-11-22 CN CN201780084278.3A patent/CN110392685B/zh not_active Expired - Fee Related
- 2017-11-22 US US15/820,648 patent/US10287256B2/en active Active
- 2017-11-22 CN CN202310731029.6A patent/CN116813690A/zh active Pending
- 2017-11-22 MA MA046887A patent/MA46887A/fr unknown
-
2019
- 2019-03-26 US US16/364,801 patent/US10494348B2/en active Active
- 2019-05-20 IL IL266743A patent/IL266743B/en unknown
- 2019-10-30 US US16/669,121 patent/US10822313B2/en active Active
-
2020
- 2020-09-17 US US17/023,545 patent/US11572349B2/en active Active
-
2022
- 2022-03-22 IL IL291597A patent/IL291597A/en unknown
- 2022-06-15 AU AU2022204163A patent/AU2022204163B2/en not_active Expired - Fee Related
- 2022-12-26 JP JP2022207896A patent/JP2023036842A/ja active Pending
- 2022-12-30 US US18/091,653 patent/US20230391733A1/en not_active Abandoned
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