MA46887A - Sulfonation sélective de dérivés de benzodiazépine - Google Patents
Sulfonation sélective de dérivés de benzodiazépineInfo
- Publication number
- MA46887A MA46887A MA046887A MA46887A MA46887A MA 46887 A MA46887 A MA 46887A MA 046887 A MA046887 A MA 046887A MA 46887 A MA46887 A MA 46887A MA 46887 A MA46887 A MA 46887A
- Authority
- MA
- Morocco
- Prior art keywords
- sulphonation
- selective
- benzodiazepine derivatives
- benzodiazepine
- derivatives
- Prior art date
Links
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title 1
- 150000001557 benzodiazepines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/68035—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a pyrrolobenzodiazepine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662425761P | 2016-11-23 | 2016-11-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA46887A true MA46887A (fr) | 2019-10-02 |
Family
ID=60655118
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA046887A MA46887A (fr) | 2016-11-23 | 2017-11-22 | Sulfonation sélective de dérivés de benzodiazépine |
Country Status (11)
Country | Link |
---|---|
US (5) | US10287256B2 (fr) |
EP (1) | EP3544983A2 (fr) |
JP (2) | JP7203729B2 (fr) |
KR (2) | KR20230133935A (fr) |
CN (2) | CN116813690A (fr) |
AU (2) | AU2017363237B2 (fr) |
CA (1) | CA3044391A1 (fr) |
IL (2) | IL266743B (fr) |
MA (1) | MA46887A (fr) |
TW (2) | TW202235109A (fr) |
WO (1) | WO2018098258A2 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RS61452B9 (sr) | 2015-06-29 | 2021-12-31 | Immunogen Inc | Anti-cd123 antitela i njihovi konjugati i derivati |
WO2018098258A2 (fr) * | 2016-11-23 | 2018-05-31 | Immunogen, Inc. | Sulfonation sélective de dérivés de benzodiazépine |
CN113329768A (zh) | 2018-10-30 | 2021-08-31 | 伊缪诺金公司 | 使用抗cd123免疫缀合物的治疗方法 |
CA3133802A1 (fr) * | 2019-03-21 | 2020-09-24 | Immunogen, Inc. | Procedes de preparation de conjugues agent de liaison cellulaire-medicament |
AU2020265225A1 (en) | 2019-04-29 | 2021-10-28 | Immunogen, Inc. | Therapeutic combinations comprising anti-CD123 immunoconjugates |
AU2020347257A1 (en) | 2019-09-13 | 2022-04-28 | Mythic Therapeutics, Inc. | Antigen-binding protein constructs and uses thereof |
CN113189184B (zh) * | 2021-04-28 | 2022-09-09 | 浙江大学 | 含有半胱氨酸的毛细管凝胶电泳样品缓冲液 |
Family Cites Families (49)
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US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
ES2149768T3 (es) | 1992-03-25 | 2000-11-16 | Immunogen Inc | Conjugados de agentes enlazantes de celulas derivados de cc-1065. |
GB9422383D0 (en) | 1994-11-05 | 1995-01-04 | Wellcome Found | Antibodies |
ES2276708T3 (es) | 1999-11-24 | 2007-07-01 | Immunogen, Inc. | Agentes citotoxicos que comprenden taxanos y su uso terapeutico. |
US6441163B1 (en) | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
US6716821B2 (en) | 2001-12-21 | 2004-04-06 | Immunogen Inc. | Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same |
US6756397B2 (en) | 2002-04-05 | 2004-06-29 | Immunogen, Inc. | Prodrugs of CC-1065 analogs |
WO2004013093A2 (fr) | 2002-08-02 | 2004-02-12 | Immunogen, Inc. | Agents cytotoxiques renfermant des nouveaux taxanes puissants et utilisation therapeutique de ceux-ci |
AU2003259163B2 (en) | 2002-08-16 | 2008-07-03 | Immunogen, Inc. | Cross-linkers with high reactivity and solubility and their use in the preparation of conjugates for targeted delivery of small molecule drugs |
DK1578446T3 (en) | 2002-11-07 | 2015-06-29 | Immunogen Inc | ANTI-CD33 ANTIBODIES AND PROCEDURES FOR TREATING ACUTE MYELOID LEUKEMIA BY USING IT |
US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
US7276497B2 (en) | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
CA2558399C (fr) | 2004-03-02 | 2015-05-19 | Seattle Genetics, Inc. | Anticorps partiellement charges et procedes de conjugaison desdits anticorps |
BRPI0510883B8 (pt) | 2004-06-01 | 2021-05-25 | Genentech Inc | composto conjugado de droga e anticorpo, composição farmacêutica, método de fabricação de composto conjugado de droga e anticorpo e usos de uma formulação, de um conjugado de droga e anticorpo e um agente quimioterapêutico e de uma combinação |
RU2412947C2 (ru) | 2004-09-23 | 2011-02-27 | Дженентек, Инк. | Антитела, сконструированные на основе цистеинов, и их конъюгаты |
CA2587589A1 (fr) | 2004-11-29 | 2006-06-22 | Seattle Genetics, Inc. | Anticorps et immunoconjugues mis au point |
SI1879901T1 (sl) | 2005-04-21 | 2010-04-30 | Spirogen Ltd | Pirolobenzodiazepini |
US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
CA2652945C (fr) | 2006-05-30 | 2015-06-02 | Genentech, Inc. | Anticorps et immuno-conjugues, et leurs utilisations |
ES2593484T3 (es) | 2007-03-29 | 2016-12-09 | Genmab A/S | Anticuerpos biespecíficos y métodos de producción de los mismos |
PL2019104T3 (pl) | 2007-07-19 | 2014-03-31 | Sanofi Sa | Środki cytotoksyczne obejmujące nowe pochodne tomaymycyny i ich zastosowanie terapeutyczne |
DK2281006T3 (da) | 2008-04-30 | 2017-11-06 | Immunogen Inc | Tværbindingsmidler og anvendelser deraf |
WO2009134976A1 (fr) | 2008-04-30 | 2009-11-05 | Immunogen, Inc | Conjugués puissants et coupleurs hydrophiles |
GB0819095D0 (en) | 2008-10-17 | 2008-11-26 | Spirogen Ltd | Pyrrolobenzodiazepines |
KR101835033B1 (ko) | 2009-02-05 | 2018-03-08 | 이뮤노젠 아이엔씨 | 신규한 벤조디아제핀 유도체 |
CN102802661B (zh) | 2009-06-22 | 2016-01-13 | 米迪缪尼有限公司 | 用于位点特异性偶联的工程改造的Fc区 |
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NZ724971A (en) | 2010-02-24 | 2019-06-28 | Immunogen Inc | Folate receptor 1 antibodies and immunoconjugates and uses thereof |
ES2748347T3 (es) | 2010-03-12 | 2020-03-16 | Debiopharm Int Sa | Moléculas de unión a CD37 e inmunoconjugados de las mismas |
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NZ701825A (en) | 2010-04-20 | 2016-06-24 | Genmab As | Heterodimeric antibody fc-containing proteins and methods for production thereof |
CN105399831A (zh) | 2010-10-29 | 2016-03-16 | 伊缪诺金公司 | 非拮抗性egfr结合分子及其免疫偶联物 |
CN103298489A (zh) | 2010-10-29 | 2013-09-11 | 伊缪诺金公司 | 新型egfr结合分子及其免疫偶联物 |
CA2824864C (fr) | 2011-02-15 | 2019-04-09 | Immunogen, Inc. | Derives cytotoxiques de benzodiazepine |
WO2013177481A1 (fr) | 2012-05-25 | 2013-11-28 | Immunogen, Inc. | Benzodiazépines et leurs conjugués |
WO2014134457A2 (fr) | 2013-02-28 | 2014-09-04 | Immunogen, Inc. | Conjugués comprenant des agents de liaison cellulaire (cba) et des agents cytotoxiques |
EP2961435B1 (fr) | 2013-02-28 | 2019-05-01 | ImmunoGen, Inc. | Conjugués comprenant des agents de liaison cellulaire (cba) et des agents cytotoxiques |
EP2961434A2 (fr) | 2013-02-28 | 2016-01-06 | ImmunoGen, Inc. | Conjugués comprenant des agents de liaison cellulaire (cba) et des agents cytotoxiques |
NZ717003A (en) * | 2013-09-02 | 2019-05-31 | Hangzhou Dac Biotech Co Ltd | Novel cytotoxic agents for conjugation of drugs to cell binding molecule |
BR112016029860A2 (pt) | 2014-06-20 | 2017-10-24 | Abgenomics Int Inc | conjugados de anticorpo antirreceptor alfa de folato (fra)-fármaco e métodos de uso dos mesmos |
KR20170027774A (ko) | 2014-06-20 | 2017-03-10 | 바이오얼라이언스 씨.브이. | 항-cd22 항체-약물 컨쥬게이트 및 그것의 사용 방법 |
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TW201613930A (en) * | 2014-09-03 | 2016-04-16 | Immunogen Inc | Cytotoxic benzodiazepine derivatives |
TWI757759B (zh) | 2014-09-03 | 2022-03-11 | 美商免疫原公司 | 細胞毒性苯并二氮呯衍生物 |
MA41645A (fr) | 2015-03-04 | 2018-01-09 | Abbvie Stemcentrx Llc | Anticorps issus de génie génétique spécifiques au site et méthodes d'utilisation |
RS61452B9 (sr) | 2015-06-29 | 2021-12-31 | Immunogen Inc | Anti-cd123 antitela i njihovi konjugati i derivati |
CA2988806A1 (fr) * | 2015-06-29 | 2017-01-05 | Immunogen, Inc. | Conjugues d'anticorps a cysteine modifiee |
US20190038762A1 (en) | 2016-02-05 | 2019-02-07 | Millennium Pharmaceuticals, Inc. | Gcc-targeted antibody-drug conjugates |
WO2018098258A2 (fr) * | 2016-11-23 | 2018-05-31 | Immunogen, Inc. | Sulfonation sélective de dérivés de benzodiazépine |
-
2017
- 2017-11-22 WO PCT/US2017/062989 patent/WO2018098258A2/fr unknown
- 2017-11-22 TW TW111103323A patent/TW202235109A/zh unknown
- 2017-11-22 CN CN202310731029.6A patent/CN116813690A/zh active Pending
- 2017-11-22 CA CA3044391A patent/CA3044391A1/fr active Pending
- 2017-11-22 JP JP2019527831A patent/JP7203729B2/ja active Active
- 2017-11-22 AU AU2017363237A patent/AU2017363237B2/en active Active
- 2017-11-22 US US15/820,648 patent/US10287256B2/en active Active
- 2017-11-22 KR KR1020237030171A patent/KR20230133935A/ko not_active Application Discontinuation
- 2017-11-22 EP EP17812176.0A patent/EP3544983A2/fr active Pending
- 2017-11-22 MA MA046887A patent/MA46887A/fr unknown
- 2017-11-22 CN CN201780084278.3A patent/CN110392685B/zh active Active
- 2017-11-22 KR KR1020197017971A patent/KR102576550B1/ko active IP Right Grant
- 2017-11-22 TW TW106140599A patent/TWI755450B/zh active
-
2019
- 2019-03-26 US US16/364,801 patent/US10494348B2/en active Active
- 2019-05-20 IL IL266743A patent/IL266743B/en unknown
- 2019-10-30 US US16/669,121 patent/US10822313B2/en active Active
-
2020
- 2020-09-17 US US17/023,545 patent/US11572349B2/en active Active
-
2022
- 2022-03-22 IL IL291597A patent/IL291597A/en unknown
- 2022-06-15 AU AU2022204163A patent/AU2022204163A1/en active Pending
- 2022-12-26 JP JP2022207896A patent/JP2023036842A/ja active Pending
- 2022-12-30 US US18/091,653 patent/US20230391733A1/en active Pending
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