JP2020511501A5 - - Google Patents
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- Publication number
- JP2020511501A5 JP2020511501A5 JP2019551928A JP2019551928A JP2020511501A5 JP 2020511501 A5 JP2020511501 A5 JP 2020511501A5 JP 2019551928 A JP2019551928 A JP 2019551928A JP 2019551928 A JP2019551928 A JP 2019551928A JP 2020511501 A5 JP2020511501 A5 JP 2020511501A5
- Authority
- JP
- Japan
- Prior art keywords
- immune complex
- formula
- adjuvant
- antibody
- subscript
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- PNTFGHXPUNVBOE-UHFFFAOYSA-N CN(C)CCCN(C)CCCCN(C)CCCNC(CNC(c1ccc(C[n](c2n3)c(O)nc2c(N)nc3OCCOC)cc1)=O)=O Chemical compound CN(C)CCCN(C)CCCCN(C)CCCNC(CNC(c1ccc(C[n](c2n3)c(O)nc2c(N)nc3OCCOC)cc1)=O)=O PNTFGHXPUNVBOE-UHFFFAOYSA-N 0.000 description 1
- GHMJVFKDZOFLFG-UHFFFAOYSA-N CN(C)CCCNCCCCNCCCNC(CNC(c1ccc(CNc2nc(OCCOC)nc(N)c2N)cc1)=O)=O Chemical compound CN(C)CCCNCCCCNCCCNC(CNC(c1ccc(CNc2nc(OCCOC)nc(N)c2N)cc1)=O)=O GHMJVFKDZOFLFG-UHFFFAOYSA-N 0.000 description 1
- GIWFLYQNOGLFIT-UHFFFAOYSA-N CNCCCN(C)CCCCN(C)CCCNC(CNC(c1ccc(C[n](c2n3)c(O)nc2c(N)nc3OCCOC)cc1)=O)=O Chemical compound CNCCCN(C)CCCCN(C)CCCNC(CNC(c1ccc(C[n](c2n3)c(O)nc2c(N)nc3OCCOC)cc1)=O)=O GIWFLYQNOGLFIT-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662433742P | 2016-12-13 | 2016-12-13 | |
| US62/433,742 | 2016-12-13 | ||
| PCT/US2017/066220 WO2018112108A1 (en) | 2016-12-13 | 2017-12-13 | Antibody adjuvant conjugates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020511501A JP2020511501A (ja) | 2020-04-16 |
| JP2020511501A5 true JP2020511501A5 (https=) | 2021-01-28 |
Family
ID=60915669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019551928A Pending JP2020511501A (ja) | 2016-12-13 | 2017-12-13 | 抗体アジュバント複合体 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20190015516A1 (https=) |
| EP (1) | EP3554550A1 (https=) |
| JP (1) | JP2020511501A (https=) |
| KR (1) | KR20190095329A (https=) |
| CN (1) | CN110290810A (https=) |
| AU (1) | AU2017376460A1 (https=) |
| CA (1) | CA3046790A1 (https=) |
| WO (1) | WO2018112108A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109843327B (zh) | 2016-07-07 | 2022-05-13 | 小利兰·斯坦福大学托管委员会 | 抗体佐剂缀合物 |
| ES2951817T3 (es) | 2017-08-22 | 2023-10-25 | Dynavax Tech Corp | Derivados de imidazoquinolina de cadena alquílica modificada como agonistas de TLR7/8 y usos de los mismos |
| US10722591B2 (en) | 2017-11-14 | 2020-07-28 | Dynavax Technologies Corporation | Cleavable conjugates of TLR7/8 agonist compounds, methods for preparation, and uses thereof |
| CA3110510A1 (en) * | 2018-08-29 | 2020-03-05 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting egfr |
| MX2021002764A (es) | 2018-09-12 | 2021-05-12 | Silverback Therapeutics Inc | Composiciones para el tratamiento de enfermedades con conjugados inmunoestimuladores. |
| AU2020210506B2 (en) * | 2019-01-23 | 2025-02-13 | AbTis Co., Ltd. | Compound for preparation of antibody-payload conjugate and use thereof |
| WO2020190725A1 (en) * | 2019-03-15 | 2020-09-24 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting her2 |
| US20220152215A1 (en) * | 2019-03-15 | 2022-05-19 | Bolt Biotherapeutics, Inc. | Immunoconjugates Targeting CEA |
| WO2020190731A1 (en) * | 2019-03-15 | 2020-09-24 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting her2 |
| US20220226491A1 (en) * | 2019-03-15 | 2022-07-21 | Bolt Biotherapeutics, Inc. | Immunoconjugates Targeting PD-L1 |
| US20220143012A1 (en) * | 2019-03-15 | 2022-05-12 | Bolt Biotherapeutics, Inc. | Macromolecule-Supported TLR Agonists |
| CA3151662A1 (en) * | 2019-09-04 | 2021-03-11 | Bolt Biotherapeutics, Inc. | Immunoconjugate synthesis method |
| CA3151322A1 (en) | 2019-10-01 | 2021-04-08 | Silverback Therapeutics, Inc. | Combination therapy with immune stimulatory conjugates |
| CN113138273B (zh) * | 2020-01-17 | 2024-06-18 | 孟民杰 | 一种应用于肺癌快速筛查及免疫靶向治疗检测的试剂盒及其用途 |
| JP7735291B2 (ja) | 2020-02-21 | 2025-09-08 | エーアールエス ファーマシューティカルズ、インコーポレイテッド | ネクチン－４抗体コンジュゲートおよびその使用 |
| KR20230019889A (ko) | 2020-06-03 | 2023-02-09 | 아센디스 파마 온콜로지 디비전 에이/에스 | Il-2 서열 및 이의 용도 |
| JP2023532304A (ja) | 2020-07-01 | 2023-07-27 | エーアールエス ファーマシューティカルズ オペレーションズ，インク． | 抗ａｓｇｒ１抗体コンジュゲートおよびその使用 |
| IL300316A (en) * | 2020-08-13 | 2023-04-01 | Bolt Biotherapeutics Inc | Immune conjugates of pyrazolozapines and their uses |
| TW202219060A (zh) | 2020-08-28 | 2022-05-16 | 丹麥商阿森迪斯腫瘤製藥有限公司 | 醣基化il-2蛋白及其用途 |
| IL303350A (en) | 2020-12-04 | 2023-08-01 | Macrogenics Inc | Pharmaceutical compositions of a her2/neu antibody and use of the same |
| CN112603996B (zh) * | 2020-12-18 | 2024-05-07 | 江南大学 | 一种脂磷壁酸疫苗制剂及其应用 |
| CN113181353B (zh) * | 2021-04-09 | 2022-12-13 | 华中师范大学 | 一种抗病毒疫苗分子及其制备方法与应用 |
| JP2024539993A (ja) | 2021-10-29 | 2024-10-31 | ボルト バイオセラピューティクス、インコーポレーテッド | システイン変異抗体を含むｔｌｒアゴニスト免疫複合体、及びその使用 |
| CN121175071A (zh) | 2023-05-09 | 2025-12-19 | 阿森迪斯药物肿瘤股份有限公司 | 使用il-2缀合物的新型癌症治疗方法 |
| TW202540200A (zh) | 2023-12-01 | 2025-10-16 | 美商基利科學股份有限公司 | 抗ｆａｐ－ｌｉｇｈｔ融合蛋白及其用途 |
| WO2025259871A1 (en) | 2024-06-14 | 2025-12-18 | Gilead Sciences, Inc. | Anti-ccr8 antibodies and uses thereof |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・２・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| US5389640A (en) | 1991-03-01 | 1995-02-14 | Minnesota Mining And Manufacturing Company | 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
| US6069149A (en) | 1997-01-09 | 2000-05-30 | Terumo Kabushiki Kaisha | Amide derivatives and intermediates for the synthesis thereof |
| JP2003531149A (ja) | 2000-04-13 | 2003-10-21 | ザ・ロツクフエラー・ユニバーシテイ | 抗体由来の免疫応答の増強 |
| ES2312659T3 (es) | 2001-11-29 | 2009-03-01 | 3M Innovative Properties Company | Formulaciones farmaceuticas que comprenden un modificador de la respuesta inmune. |
| US20040101909A1 (en) | 2002-08-20 | 2004-05-27 | Hema-Quebec, 2535 Boul. Laurier, Ste-Foy, Quebec, Canada G1V 4M3 | Purification of polyreactive autoantibodies and uses thereof |
| DK1791565T3 (en) | 2004-09-23 | 2016-08-01 | Genentech Inc | Cysteingensplejsede antibodies and conjugates |
| WO2006073921A2 (en) | 2004-12-30 | 2006-07-13 | The Rockefeller University | Compositions and methods for enhanced dendritic cell maturation and function |
| US8354249B2 (en) | 2005-08-11 | 2013-01-15 | Omrix Biopharmaceuticals Ltd. | Intravenous immunoglobulin composition |
| CN101304748A (zh) | 2005-08-22 | 2008-11-12 | 加利福尼亚大学董事会 | Tlr激动剂 |
| US20080286819A1 (en) | 2005-11-07 | 2008-11-20 | Ravetch Jeffrey V | Reagents, Methods and Systems for Selecting a Cytotoxic Antibody or Variant Thereof |
| EP1988896A4 (en) * | 2006-02-22 | 2011-07-27 | 3M Innovative Properties Co | CONJUGATES TO MODIFY IMMUNE REACTIONS |
| US20100150942A1 (en) | 2008-12-03 | 2010-06-17 | Cantor Thomas L | Affinity purified human polyclonal antibodies and methods of making and using them |
| RS53347B (sr) * | 2008-12-09 | 2014-10-31 | Gilead Sciences, Inc. | Modulatori toll-sličnih receptora |
| CA2799540A1 (en) | 2010-06-08 | 2011-12-15 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| US20130108619A1 (en) | 2011-11-02 | 2013-05-02 | Isaac Melamed | Intravenous immunoglobulin processing, diagnostic, and treatment systems and methods |
| US20130177574A1 (en) | 2012-01-11 | 2013-07-11 | Paul I. Terasaki Foundation Laboratory | ANTI-HLA CLASS-Ib ANTIBODIES MIMIC IMMUNOREACTIVITY AND IMMUNOMODULATORY FUNCTIONS OF INTRAVENOUS IMMUNOGLOBULIN (IVIg) USEFUL AS THERAPEUTIC IVIg MIMETICS AND METHODS OF THEIR USE |
| WO2013166110A1 (en) * | 2012-05-02 | 2013-11-07 | Yale University | Tlr-agonist-conjugated antibody recruiting molecules (tlr_arms) |
| DK3092256T3 (da) * | 2014-01-10 | 2022-06-20 | Birdie Biopharmaceuticals Inc | Forbindelser og sammensætninger til immunterapi |
| AU2015270845B2 (en) * | 2014-06-02 | 2019-09-12 | Baylor Research Institute | Methods and compositions for treating allergy and inflammatory diseases |
| JP6522732B2 (ja) * | 2014-07-11 | 2019-05-29 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｉｖを治療するためのトール様受容体の調節因子 |
| AU2015349878A1 (en) | 2014-11-21 | 2017-05-25 | Bristol-Myers Squibb Company | Antibodies against CD73 and uses thereof |
| EP3368092B9 (en) * | 2015-10-29 | 2020-07-29 | Novartis AG | Antibody conjugates comprising toll-like receptor agonist |
| US20170158772A1 (en) | 2015-12-07 | 2017-06-08 | Opi Vi - Ip Holdco Llc | Compositions of antibody construct - agonist conjugates and methods of use thereof |
| CN109843327B (zh) * | 2016-07-07 | 2022-05-13 | 小利兰·斯坦福大学托管委员会 | 抗体佐剂缀合物 |
-
2017
- 2017-12-13 AU AU2017376460A patent/AU2017376460A1/en not_active Abandoned
- 2017-12-13 KR KR1020197019424A patent/KR20190095329A/ko not_active Ceased
- 2017-12-13 WO PCT/US2017/066220 patent/WO2018112108A1/en not_active Ceased
- 2017-12-13 CA CA3046790A patent/CA3046790A1/en not_active Abandoned
- 2017-12-13 EP EP17823323.5A patent/EP3554550A1/en not_active Withdrawn
- 2017-12-13 CN CN201780084571.XA patent/CN110290810A/zh active Pending
- 2017-12-13 JP JP2019551928A patent/JP2020511501A/ja active Pending
-
2018
- 2018-09-12 US US16/129,118 patent/US20190015516A1/en not_active Abandoned
-
2019
- 2019-12-20 US US16/723,276 patent/US20200108151A1/en not_active Abandoned
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