JP2020510690A5 - - Google Patents
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- Publication number
- JP2020510690A5 JP2020510690A5 JP2019551307A JP2019551307A JP2020510690A5 JP 2020510690 A5 JP2020510690 A5 JP 2020510690A5 JP 2019551307 A JP2019551307 A JP 2019551307A JP 2019551307 A JP2019551307 A JP 2019551307A JP 2020510690 A5 JP2020510690 A5 JP 2020510690A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- group
- drug
- alkyl
- linear
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920000642 polymer Polymers 0.000 claims description 50
- 125000001931 aliphatic group Chemical group 0.000 claims description 32
- 239000001257 hydrogen Substances 0.000 claims description 31
- 229910052739 hydrogen Inorganic materials 0.000 claims description 31
- 125000000217 alkyl group Chemical group 0.000 claims description 23
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 23
- 229940079593 drug Drugs 0.000 claims description 22
- 239000003814 drug Substances 0.000 claims description 22
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 21
- 125000000623 heterocyclic group Chemical group 0.000 claims description 21
- 125000000524 functional group Chemical group 0.000 claims description 20
- 150000002431 hydrogen Chemical class 0.000 claims description 19
- 239000001301 oxygen Substances 0.000 claims description 19
- 229910052760 oxygen Inorganic materials 0.000 claims description 19
- 239000000470 constituent Substances 0.000 claims description 17
- 125000005647 linker group Chemical group 0.000 claims description 15
- 239000000178 monomer Substances 0.000 claims description 13
- 150000001345 alkine derivatives Chemical class 0.000 claims description 12
- 125000003545 alkoxy group Chemical group 0.000 claims description 12
- 239000002876 beta blocker Substances 0.000 claims description 12
- 229940097320 beta blocking agent Drugs 0.000 claims description 12
- 229910052757 nitrogen Inorganic materials 0.000 claims description 12
- 150000003180 prostaglandins Chemical class 0.000 claims description 11
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 9
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 8
- IVRMZWNICZWHMI-UHFFFAOYSA-N azide group Chemical group [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 claims description 8
- 125000004663 dialkyl amino group Chemical group 0.000 claims description 8
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 8
- 229930195733 hydrocarbon Natural products 0.000 claims description 8
- 150000002430 hydrocarbons Chemical class 0.000 claims description 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 6
- -1 ethylene, propylene Chemical group 0.000 claims description 6
- 125000005842 heteroatom Chemical group 0.000 claims description 5
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 5
- 229940094443 oxytocics prostaglandins Drugs 0.000 claims description 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 5
- 150000003852 triazoles Chemical group 0.000 claims description 5
- 239000004721 Polyphenylene oxide Substances 0.000 claims description 4
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims description 4
- 125000003282 alkyl amino group Chemical group 0.000 claims description 4
- 125000004103 aminoalkyl group Chemical group 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 4
- 150000001540 azides Chemical class 0.000 claims description 4
- 230000000295 complement effect Effects 0.000 claims description 4
- 125000001072 heteroaryl group Chemical group 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 229920000570 polyether Polymers 0.000 claims description 4
- 125000003107 substituted aryl group Chemical group 0.000 claims description 4
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims description 4
- 125000003158 alcohol group Chemical group 0.000 claims description 3
- 150000001408 amides Chemical class 0.000 claims description 3
- 125000002837 carbocyclic group Chemical group 0.000 claims description 3
- 150000002148 esters Chemical class 0.000 claims description 3
- 125000001153 fluoro group Chemical group F* 0.000 claims description 3
- 125000001183 hydrocarbyl group Chemical group 0.000 claims description 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 3
- 239000004215 Carbon black (E152) Substances 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 125000004104 aryloxy group Chemical group 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims description 2
- 125000003367 polycyclic group Chemical group 0.000 claims description 2
- 125000003259 prostaglandin group Chemical class 0.000 claims description 2
- 125000001424 substituent group Chemical group 0.000 claims description 2
- 125000005415 substituted alkoxy group Chemical group 0.000 claims description 2
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 239000000562 conjugate Substances 0.000 description 26
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 4
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 4
- 0 CC1*CCC1 Chemical compound CC1*CCC1 0.000 description 3
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 3
- 239000000580 polymer-drug conjugate Substances 0.000 description 3
- 229920001451 polypropylene glycol Polymers 0.000 description 3
- 229920001400 block copolymer Polymers 0.000 description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 125000006832 (C1-C10) alkylene group Chemical group 0.000 description 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- FHIVAFMUCKRCQO-UHFFFAOYSA-N diazinon Chemical compound CCOP(=S)(OCC)OC1=CC(C)=NC(C(C)C)=N1 FHIVAFMUCKRCQO-UHFFFAOYSA-N 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15/458,546 | 2017-03-14 | ||
| US15/458,546 US10113033B2 (en) | 2013-03-08 | 2017-03-14 | Polymer conjugate for delivery of a bioactive agent |
| AU2017900888A AU2017900888A0 (en) | 2017-03-14 | Biodegradable drug-polymer conjugate | |
| AU2017900888 | 2017-03-14 | ||
| PCT/AU2018/050234 WO2018165711A1 (en) | 2017-03-14 | 2018-03-14 | Biodegradable drug-polymer conjugate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020510690A JP2020510690A (ja) | 2020-04-09 |
| JP2020510690A5 true JP2020510690A5 (https=) | 2021-04-30 |
| JP7204661B2 JP7204661B2 (ja) | 2023-01-16 |
Family
ID=63521659
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019551318A Active JP7355649B2 (ja) | 2017-03-14 | 2018-03-14 | 薬物－ポリマーコンジュゲート |
| JP2019551307A Active JP7204661B2 (ja) | 2017-03-14 | 2018-03-14 | 生分解性薬物－ポリマーコンジュゲート |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019551318A Active JP7355649B2 (ja) | 2017-03-14 | 2018-03-14 | 薬物－ポリマーコンジュゲート |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11787906B2 (https=) |
| EP (2) | EP3595670A4 (https=) |
| JP (2) | JP7355649B2 (https=) |
| KR (2) | KR102642432B1 (https=) |
| CN (4) | CN110461336A (https=) |
| AU (2) | AU2018233158B2 (https=) |
| CA (1) | CA3054084A1 (https=) |
| CL (1) | CL2019002600A1 (https=) |
| IL (2) | IL269321B (https=) |
| MX (2) | MX2019010837A (https=) |
| NZ (2) | NZ756626A (https=) |
| SG (2) | SG11201907956UA (https=) |
| WO (2) | WO2018165710A1 (https=) |
| ZA (2) | ZA201905589B (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11696955B2 (en) | 2017-03-14 | 2023-07-11 | Polyactiva Pty Ltd | Drug-polymer conjugate |
| MX2019010837A (es) * | 2017-03-14 | 2019-12-19 | Polyactiva Pty Ltd | Conjugado biodegradable de farmaco-polimero. |
| WO2021024041A1 (en) | 2019-08-07 | 2021-02-11 | Ripple Therapeutics Corporation | Controlled release drug dimers |
| CA3154867A1 (en) * | 2019-09-19 | 2021-03-25 | Polyactiva Pty Ltd | Biodegradable drug-polymer conjugate |
| MX2022013665A (es) | 2020-05-01 | 2022-11-30 | Ripple Therapeutics Corp | Composiciones y metodos heterodimeros para el tratamiento de trastornos oculares. |
| WO2024084056A1 (en) * | 2022-10-21 | 2024-04-25 | Etherna Immunotherapies Nv | Ionizable lipids |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1044797B (it) | 1974-10-15 | 1980-04-21 | Ferruti Paolo | Alti polimeri contenenti radicali prostaglandinici processo per la loro preparazione e loro impiego |
| JPH03220201A (ja) | 1988-11-18 | 1991-09-27 | Eisai Co Ltd | プロスタグランジン類と多糖類の結合体 |
| JP4419368B2 (ja) | 2002-07-25 | 2010-02-24 | 小野薬品工業株式会社 | プロスタグランジン誘導体およびその誘導体を有効成分として含有する薬剤 |
| CA2617907A1 (en) | 2005-08-05 | 2007-02-15 | Syntarga B.V. | Triazole-containing releasable linkers and conjugates comprising the same |
| MY155629A (en) | 2008-10-10 | 2015-11-13 | Polyactiva Pty Ltd | Biodegradable polymer-bioactive moiety conjugates |
| SI2340271T1 (sl) | 2008-10-10 | 2019-08-30 | Polyactiva Pty Ltd. | Konjugati polimer-bioaktivnega sredstva |
| US8535655B2 (en) * | 2008-10-10 | 2013-09-17 | Polyactiva Pty Ltd. | Biodegradable polymer—bioactive moiety conjugates |
| US20100104654A1 (en) | 2008-10-27 | 2010-04-29 | Allergan, Inc. | Prostaglandin and prostamide drug delivery systems and intraocular therapeutic uses thereof |
| US20120130045A1 (en) | 2009-06-01 | 2012-05-24 | Ablitech, Inc. | Biomolecule-polymer conjugates and methods of making same |
| FR2961694B1 (fr) | 2010-06-29 | 2013-01-25 | Thea Lab | Systeme de delivrance polymerique d'une solution non visqueuse a base de prostaglandine sans conservateur |
| WO2012075117A2 (en) | 2010-12-01 | 2012-06-07 | Ablitech, Inc. | Small molecule-polymer conjugates and methods of making same |
| WO2012139164A1 (en) * | 2011-04-12 | 2012-10-18 | Polyactiva Pty Ltd | Polymer conjugated prostaglandin analogues |
| JP2013035802A (ja) | 2011-08-10 | 2013-02-21 | D Western Therapeutics Institute Inc | 緑内障又は高眼圧症の予防又は治療剤 |
| MY190370A (en) * | 2012-06-26 | 2022-04-18 | Polyactiva Pty Ltd | Polymer-nsaid conjugate |
| US10113033B2 (en) | 2013-03-08 | 2018-10-30 | Polyactiva Pty Ltd | Polymer conjugate for delivery of a bioactive agent |
| DK2964224T3 (en) * | 2013-03-08 | 2024-10-14 | Polyactiva Pty Ltd | Polymer conjugate for delivery of a bioactive agent |
| MX2019010837A (es) * | 2017-03-14 | 2019-12-19 | Polyactiva Pty Ltd | Conjugado biodegradable de farmaco-polimero. |
| US11696955B2 (en) | 2017-03-14 | 2023-07-11 | Polyactiva Pty Ltd | Drug-polymer conjugate |
| US11207417B2 (en) | 2017-03-14 | 2021-12-28 | Polyactiva Pty Ltd | Drug-polymer conjugate |
-
2018
- 2018-03-14 MX MX2019010837A patent/MX2019010837A/es unknown
- 2018-03-14 AU AU2018233158A patent/AU2018233158B2/en active Active
- 2018-03-14 EP EP18767240.7A patent/EP3595670A4/en active Pending
- 2018-03-14 JP JP2019551318A patent/JP7355649B2/ja active Active
- 2018-03-14 IL IL269321A patent/IL269321B/en unknown
- 2018-03-14 AU AU2018233159A patent/AU2018233159C1/en active Active
- 2018-03-14 US US16/493,252 patent/US11787906B2/en active Active
- 2018-03-14 SG SG11201907956UA patent/SG11201907956UA/en unknown
- 2018-03-14 SG SG11201907931WA patent/SG11201907931WA/en unknown
- 2018-03-14 EP EP18768053.3A patent/EP3595728A4/en active Pending
- 2018-03-14 JP JP2019551307A patent/JP7204661B2/ja active Active
- 2018-03-14 KR KR1020197027318A patent/KR102642432B1/ko active Active
- 2018-03-14 CN CN201880017971.3A patent/CN110461336A/zh active Pending
- 2018-03-14 NZ NZ756626A patent/NZ756626A/en unknown
- 2018-03-14 MX MX2019010904A patent/MX2019010904A/es unknown
- 2018-03-14 KR KR1020197029230A patent/KR102642433B1/ko active Active
- 2018-03-14 CN CN202511024390.0A patent/CN120919336A/zh active Pending
- 2018-03-14 WO PCT/AU2018/050233 patent/WO2018165710A1/en not_active Ceased
- 2018-03-14 WO PCT/AU2018/050234 patent/WO2018165711A1/en not_active Ceased
- 2018-03-14 IL IL269323A patent/IL269323B/en unknown
- 2018-03-14 CN CN201880029815.9A patent/CN110662561A/zh active Pending
- 2018-03-14 CN CN202511030510.8A patent/CN120919337A/zh active Pending
- 2018-03-14 NZ NZ757356A patent/NZ757356A/en unknown
- 2018-03-14 CA CA3054084A patent/CA3054084A1/en active Pending
-
2019
- 2019-08-23 ZA ZA2019/05589A patent/ZA201905589B/en unknown
- 2019-09-12 CL CL2019002600A patent/CL2019002600A1/es unknown
- 2019-09-17 ZA ZA2019/06133A patent/ZA201906133B/en unknown
-
2023
- 2023-07-26 US US18/226,713 patent/US12503553B2/en active Active
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