JP2020510418A5 - - Google Patents

Download PDF

Info

Publication number
JP2020510418A5
JP2020510418A5 JP2019545322A JP2019545322A JP2020510418A5 JP 2020510418 A5 JP2020510418 A5 JP 2020510418A5 JP 2019545322 A JP2019545322 A JP 2019545322A JP 2019545322 A JP2019545322 A JP 2019545322A JP 2020510418 A5 JP2020510418 A5 JP 2020510418A5
Authority
JP
Japan
Prior art keywords
seq
tfr
animal
polypeptide
apical domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019545322A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020510418A (ja
JP7669113B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/018302 external-priority patent/WO2018152285A1/en
Publication of JP2020510418A publication Critical patent/JP2020510418A/ja
Publication of JP2020510418A5 publication Critical patent/JP2020510418A5/ja
Priority to JP2023085382A priority Critical patent/JP2023116513A/ja
Priority to JP2025036281A priority patent/JP2025087857A/ja
Application granted granted Critical
Publication of JP7669113B2 publication Critical patent/JP7669113B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019545322A 2017-02-17 2018-02-15 トランスフェリン受容体トランスジェニックモデル Active JP7669113B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023085382A JP2023116513A (ja) 2017-02-17 2023-05-24 トランスフェリン受容体トランスジェニックモデル
JP2025036281A JP2025087857A (ja) 2017-02-17 2025-03-07 トランスフェリン受容体トランスジェニックモデル

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201762460692P 2017-02-17 2017-02-17
US62/460,692 2017-02-17
US201762543658P 2017-08-10 2017-08-10
US201762543559P 2017-08-10 2017-08-10
US62/543,559 2017-08-10
US62/543,658 2017-08-10
US201762583314P 2017-11-08 2017-11-08
US62/583,314 2017-11-08
PCT/US2018/018302 WO2018152285A1 (en) 2017-02-17 2018-02-15 Transferrin receptor transgenic models

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023085382A Division JP2023116513A (ja) 2017-02-17 2023-05-24 トランスフェリン受容体トランスジェニックモデル

Publications (3)

Publication Number Publication Date
JP2020510418A JP2020510418A (ja) 2020-04-09
JP2020510418A5 true JP2020510418A5 (cg-RX-API-DMAC10.html) 2021-03-11
JP7669113B2 JP7669113B2 (ja) 2025-04-28

Family

ID=61628463

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2019545322A Active JP7669113B2 (ja) 2017-02-17 2018-02-15 トランスフェリン受容体トランスジェニックモデル
JP2023085382A Pending JP2023116513A (ja) 2017-02-17 2023-05-24 トランスフェリン受容体トランスジェニックモデル
JP2025036281A Pending JP2025087857A (ja) 2017-02-17 2025-03-07 トランスフェリン受容体トランスジェニックモデル

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2023085382A Pending JP2023116513A (ja) 2017-02-17 2023-05-24 トランスフェリン受容体トランスジェニックモデル
JP2025036281A Pending JP2025087857A (ja) 2017-02-17 2025-03-07 トランスフェリン受容体トランスジェニックモデル

Country Status (10)

Country Link
US (2) US10143187B2 (cg-RX-API-DMAC10.html)
EP (2) EP4628586A3 (cg-RX-API-DMAC10.html)
JP (3) JP7669113B2 (cg-RX-API-DMAC10.html)
KR (1) KR102637590B1 (cg-RX-API-DMAC10.html)
CN (1) CN110382526B (cg-RX-API-DMAC10.html)
AU (1) AU2018221704B2 (cg-RX-API-DMAC10.html)
CA (1) CA3053370A1 (cg-RX-API-DMAC10.html)
IL (1) IL268659A (cg-RX-API-DMAC10.html)
SG (1) SG11201907419PA (cg-RX-API-DMAC10.html)
WO (1) WO2018152285A1 (cg-RX-API-DMAC10.html)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4628586A3 (en) 2017-02-17 2026-01-14 Denali Therapeutics Inc. Transferrin receptor transgenic models
RS63818B1 (sr) 2017-02-17 2023-01-31 Denali Therapeutics Inc Konstruisani polipeptidi za vezivanje za receptor transferina
CA3053381A1 (en) 2017-02-17 2018-08-23 Denali Therapeutics Inc. Engineered polypeptides
JOP20190248A1 (ar) 2017-04-21 2019-10-20 Amgen Inc بروتينات ربط مولد ضد trem2 واستخداماته
BR112020005271A2 (pt) 2017-10-02 2020-09-15 Denali Therapeutics Inc. proteína, polipeptídeo, polinucleotídeo, vetor, célula hospedeira, método para produção de um polipeptídeo, métodos de tratamento de um distúrbio, de diminuição do acúmulo, de monitoramento, de transporte de um agente e de tratamento de um lsd e composição farmacêutica
WO2019246071A1 (en) 2018-06-18 2019-12-26 Denali Therapeutics Inc. Fusion proteins comprising progranulin
EP3894864A2 (en) 2018-12-10 2021-10-20 Denali Therapeutics Inc. Lysosomal storage disorder biomarkers and methods of use thereof
US12595310B2 (en) 2019-11-06 2026-04-07 The Regents Of The University Of California Compositions and methods for transferrin receptor 1 targeting
BR112022012230A2 (pt) 2019-12-23 2022-08-30 Denali Therapeutics Inc Variantes de progranulina
WO2021146256A1 (en) 2020-01-13 2021-07-22 Denali Therapeutics Inc. Anti-trem2 antibodies and methods of use thereof
JP7231745B2 (ja) * 2020-06-22 2023-03-01 中国科学院昆明▲動▼物研究所 抗SARS-CoV-2薬の調製における干渉ポリペプチドの応用
CN112243953B (zh) * 2020-07-15 2022-02-11 吉林医药学院 TfR1肺组织特异性敲除小鼠模型及其构建方法和应用
CR20230178A (es) 2020-10-14 2023-07-26 Denali Therapeutics Inc Proteínas de fusión que comprenden enzimas sulfoglucosamina sulfohidrolasa y métodos de estas
CN112501124A (zh) * 2020-11-27 2021-03-16 领诺(上海)医药科技有限公司 稳定表达人转铁蛋白受体1细胞株的制备方法及其应用
CN115785251B (zh) * 2021-07-16 2024-12-24 百奥赛图(北京)医药科技股份有限公司 Tfr1基因人源化非人动物及其构建方法和应用
US20250018015A1 (en) 2021-07-23 2025-01-16 Denali Therapeutics Inc. Methods for the treatment of hunter syndrome
IL311003A (en) 2021-08-25 2024-04-01 Denali Therapeutics Inc Anti-2HER antibodies and methods of using them
AR128003A1 (es) 2021-12-17 2024-03-20 Denali Therapeutics Inc PROTEÍNAS DE FUSIÓN QUE COMPRENDEN ENZIMAS DE a-L-IDURONIDASA Y MÉTODOS PARA LAS MISMAS
WO2023114499A1 (en) 2021-12-17 2023-06-22 Denali Therapeutics Inc. Polypeptide engineering, libraries, and engineered cd98 heavy chain and transferrin receptor binding polypeptides
EP4499693A1 (en) 2022-03-28 2025-02-05 Denali Therapeutics Inc. Monovalent anti-trem2 binding molecules and methods of use thereof
CN120112164A (zh) * 2022-07-29 2025-06-06 瑞泽恩制药公司 包含修饰的转铁蛋白受体基因座的非人动物
JP2026505005A (ja) 2023-01-30 2026-02-10 イーエスアーエル バイオサイエンス ゲゼルシャフト ミット ベシュレンクテル ハフツング 神経変性障害を治療するためのヒト抗trem2抗体
CN116784280B (zh) * 2023-08-10 2025-08-19 广东药康生物科技有限公司 一种tfrc人源化小鼠模型的构建方法及其应用
TW202542190A (zh) 2023-12-20 2025-11-01 美商戴納立製藥公司 包含酸性α—葡萄糖苷酶之融合蛋白及其方法
TW202617982A (zh) 2024-06-24 2026-05-01 美商戴納立製藥公司 包含經修飾之葡萄糖腦苷脂酶多肽之融合蛋白及其方法

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527527A (en) 1989-09-07 1996-06-18 Alkermes, Inc. Transferrin receptor specific antibody-neuropharmaceutical agent conjugates
US5260210A (en) 1989-09-27 1993-11-09 Rubin Lee L Blood-brain barrier model
US5254342A (en) 1991-09-30 1993-10-19 University Of Southern California Compositions and methods for enhanced transepithelial and transendothelial transport or active agents
FR2705194A1 (fr) 1993-05-21 1994-11-25 Transgene Sa Animal transgénique exprimant une transferrine d'origine humaine.
US5898094A (en) 1996-10-21 1999-04-27 University Of South Florida Transgenic mice expressing APPK670N,M671L and a mutant presenilin transgenes
WO1999000150A2 (en) 1997-06-27 1999-01-07 Regents Of The University Of California Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor
US6175057B1 (en) 1997-10-08 2001-01-16 The Regents Of The University Of California Transgenic mouse model of alzheimer's disease and cerebral amyloid angiopathy
US7241449B1 (en) 1999-04-12 2007-07-10 Aventis Pasteur Limited Transferrin receptor genes of moraxella
EP1285272A2 (en) 2000-02-08 2003-02-26 University of British Columbia Compositions and methods for screening therapeutic agents
JP2001238681A (ja) 2000-03-03 2001-09-04 Japan Science & Technology Corp 共培養による血液脳関門再構築モデル
AU2002236499A1 (en) 2000-11-30 2002-06-11 Uab Research Foundation Receptor-mediated uptake of peptides that bind the human transferrin receptor
AU2002315398A1 (en) 2001-06-29 2003-03-03 Wyeth Methods and compositions useful for the prediction of blood-brain barrier permeation
US20030074141A1 (en) 2001-10-15 2003-04-17 Camitro Corporation Meta-models for predicting blood brain barrier penetration based on simple physicochemical descriptors
US7592143B2 (en) * 2003-04-18 2009-09-22 Cytovia, Inc. Methods of treating diseases responsive to induction of apoptosis and screening assays
WO2005076011A2 (en) 2004-01-30 2005-08-18 Xenoport, Inc. Use of glut1 transporter expressed in blood brain barrier cells for screening for pharmacologically active substances
GB0403490D0 (en) 2004-02-17 2004-03-24 Daniolabs Ltd Screening methods
FR2871162B1 (fr) 2004-06-02 2007-06-29 Univ Paris 7 Denis Diderot Materiau de surface modifiee, son procede de preparation et ses utilisations
ES2473587T3 (es) 2004-08-03 2014-07-07 Transtech Pharma, Inc. Proteínas de fusión de RAGE y métodos de uso
WO2006056879A1 (en) 2004-11-29 2006-06-01 Institut National De La Sante Et De La Recherche Medicale (Inserm) Human blood brain barrier model
US8900865B2 (en) 2005-12-14 2014-12-02 The Invention Science Fund I, Llc Blood brain barrier device
JP5113332B2 (ja) 2005-12-19 2013-01-09 正美 丹羽 血液脳関門インヴィトロ・モデル、病態血液脳関門インヴィトロ・モデル、及びこれを用いた薬物スクリーニング方法、病態血液脳関門機能解析方法、病因解析方法
WO2007094926A2 (en) 2006-02-09 2007-08-23 Transtech Pharma, Inc. Rage fusion proteins and methods of use
WO2007143711A2 (en) 2006-06-07 2007-12-13 Wisconsin Alumni Research Foundation Blood-brain barrier targeting antibodies
US20080044847A1 (en) 2006-06-23 2008-02-21 Shusta Eric V Blood-Brain Barrier Model
AU2007285763B2 (en) 2006-08-18 2011-12-15 Armagen Technologies, Inc. Agents for blood-brain barrier delivery
JP2010533170A (ja) 2007-07-12 2010-10-21 プロセンサ テクノロジーズ ビー.ブイ. 化合物を種々の選択された臓器、組織又は腫瘍細胞に標的化するための分子
CA2720903C (en) 2008-04-14 2019-01-15 Sangamo Biosciences, Inc. Linear donor constructs for targeted integration
WO2010014622A2 (en) 2008-07-28 2010-02-04 Fondazione Istituto Firc Di Oncologica Molecolare (Ifom) In vitro model for modulating the blood brain barrier and methods of screening
DK3241435T3 (da) 2009-07-08 2021-08-23 Kymab Ltd Dyremodeller og terapeutiske molekyler
US8417465B2 (en) 2009-11-04 2013-04-09 Cfd Research Corporation Synthetic microfluidic blood-brain barrier
US9255259B2 (en) 2010-02-09 2016-02-09 Sangamo Biosciences, Inc. Targeted genomic modification with partially single-stranded donor molecules
US8476485B2 (en) 2010-06-24 2013-07-02 Academia Sinica Non-human animal model for amyotrophic lateral sclerosis (ALS) with loss-of-TDP-43 function
WO2012055891A1 (en) 2010-10-29 2012-05-03 F. Hoffmann-La Roche Ag Murine model of inflammation with il33 n-terminal domain deletion
CN103443125B (zh) 2010-11-30 2019-05-03 霍夫曼-拉罗奇有限公司 低亲和力血脑屏障受体抗体及其用途
KR20140026372A (ko) 2011-02-02 2014-03-05 이무노퓨처 아이앤씨. 혈액-뇌 장벽을 투과하는 약물 전달체, 펩티드 및 이의 용도
RU2013150331A (ru) 2011-04-20 2015-05-27 Рош Гликарт Аг СПОСОБ И УСТРОЙСТВА ДЛЯ рН-ЗАВИСИМОГО ПРОХОЖДЕНИЯ ГЕМАТОЭНЦЕФАЛИЧЕСКОГО БАРЬЕРА
EP2568051A1 (en) 2011-09-07 2013-03-13 Stallergenes S.A. Methods for identifying dendritic cell subsets, for determining if a patient is developing a regulatory or an effector immune response, and for determining response to immunotherapy
DK177327B1 (en) 2011-12-23 2013-01-14 Entomopharm Aps OPTIMIZED INSECT BASED EX VIVO MODEL FOR EXAMINATION OF BLOOD BRAIN BARRIER penetration and method of exposing the insect brain to chemical compounds
US9475840B2 (en) 2012-02-27 2016-10-25 Universitat De Barcelona Protease-resistant compounds useful as shuttles through the blood-brain barrier and shuttle-cargo constructs
WO2013177062A2 (en) 2012-05-21 2013-11-28 Genentech, Inc. Methods for improving safety of blood-brain barrier transport
US9232775B2 (en) 2012-08-03 2016-01-12 Industry-Academic Cooperation Foundation, Yonsei University Genetically engineered mouse model for autism spectrum disorder having deletion of Shank2 gene and use thereof
US9513280B2 (en) 2012-08-28 2016-12-06 University Of Utah Research Foundation Microfluidic biological barrier model and associated method
MX367126B (es) 2012-08-29 2019-08-06 Hoffmann La Roche Transporte para atravesar la barrera hematoencefálica.
US10590393B2 (en) 2012-11-08 2020-03-17 Wisconsin Alumni Research Foundation Retinoic acid enhanced human stem cell derived blood brain barrier model
US9932559B2 (en) 2012-11-16 2018-04-03 The Johns Hopkins University Platform for creating an artificial blood brain barrier
US8697359B1 (en) 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products
AU2014231768A1 (en) 2013-03-13 2015-09-24 Australian Nuclear Science And Technology Organisation Transgenic non-human organisms with non-functional TSPO genes
PT2978840T (pt) 2013-03-26 2021-01-06 Univ Of Artois Um modelo de barreira hematoencefálica humana derivado de células estaminais
TWI523945B (zh) 2013-03-29 2016-03-01 Nat Univ Chung Cheng Establishment of blood - brain barrier model in
SG11201509566RA (en) 2013-05-20 2015-12-30 Genentech Inc Anti-transferrin receptor antibodies and methods of use
EA201600141A1 (ru) 2013-08-02 2016-09-30 Ф. Хоффманн-Ля Рош Аг Терапевтический слитый белок
ES2681622T3 (es) 2013-09-18 2018-09-14 Kymab Limited Métodos, células y organismos
WO2015101586A1 (en) 2014-01-03 2015-07-09 F. Hoffmann-La Roche Ag Bispecific anti-hapten/anti-blood brain barrier receptor antibodies, complexes thereof and their use as blood brain barrier shuttles
US9629801B2 (en) 2014-01-10 2017-04-25 Wisconsin Alumni Research Foundation Blood-brain barrier targeting antibodies
CN103897033A (zh) * 2014-03-31 2014-07-02 中国药科大学 转铁蛋白受体TfR特异性结合肽及其应用
ES2913205T3 (es) 2014-05-13 2022-06-01 Bioatla Inc Proteínas biológicas activas condicionalmente
EP2995949A1 (en) 2014-09-09 2016-03-16 Institut Pasteur New in vitro blood brain barrier model
CA2967830A1 (en) 2014-11-14 2016-05-19 Ossianix, Inc. Tfr selective binding compounds and related methods
JP6779876B2 (ja) * 2014-11-19 2020-11-04 ジェネンテック, インコーポレイテッド 抗トランスフェリン受容体抗体及びその使用方法
EP3221361B1 (en) 2014-11-19 2021-04-21 Genentech, Inc. Anti-transferrin receptor / anti-bace1 multispecific antibodies and methods of use
WO2016090486A1 (en) 2014-12-09 2016-06-16 National Research Council Of Canada Human blood brain barrier model
US9988454B2 (en) 2015-05-20 2018-06-05 Immunwork Inc. Peptide core-based multi-arm linkers for treating central nervous system diseases
WO2016202343A1 (en) 2015-06-19 2016-12-22 Aalborg Universitet A triple co-culture model of the blood-brain barrier using primary porcine brain endothelial cells, porcine pericytes and porcine astrocytes
AU2016282334B2 (en) 2015-06-24 2022-07-21 F. Hoffmann-La Roche Ag Anti-transferrin receptor antibodies with tailored affinity
JP7021955B2 (ja) * 2015-06-24 2022-03-03 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト Her2及び血液脳関門受容体に特異的な三重特異性抗体及び使用方法
CA2990785C (en) 2015-06-24 2024-11-12 Jcr Pharmaceuticals Co., Ltd. ANTI-HUMAN TRANSFERRIN RECEPTOR ANTIBODIES CROSSING THE BLOOD-BRAIN BARRIER
HK1247933A1 (en) * 2015-06-24 2018-10-05 Jcr Pharmaceuticals Co., Ltd. Fusion protein containing bdnf
WO2017035119A1 (en) 2015-08-24 2017-03-02 National University Of Singapore Blood brain barrier model in a 3d co-culture microfluidic system
TWI833178B (zh) * 2016-12-26 2024-02-21 日商Jcr製藥股份有限公司 通過血腦障壁之新穎抗人類運鐵蛋白受體抗體
TWI791006B (zh) * 2016-12-26 2023-02-01 日商Jcr製藥股份有限公司 包含bdnf之融合蛋白質
EP4628586A3 (en) 2017-02-17 2026-01-14 Denali Therapeutics Inc. Transferrin receptor transgenic models
CA3053381A1 (en) 2017-02-17 2018-08-23 Denali Therapeutics Inc. Engineered polypeptides

Similar Documents

Publication Publication Date Title
US10945418B2 (en) Genetically modified non-human animal with human or chimeric PD-L1
US11317611B2 (en) Genetically modified non-human animal with human or chimeric PD-L1
US11279948B2 (en) Genetically modified non-human animal with human or chimeric OX40
US20200359610A1 (en) Humanized transgenic animal
EP0996707A4 (en) TRANSGENIC ANIMAL WITH RECOMBINANT VASCULAR ENDOTHEL CELL GROWTH FACTOR B (VEGF-B) DNA AND USES THEREFOR
JP7765403B2 (ja) ヒト化cxcl13遺伝子を有する非ヒト動物
WO2013185239A1 (en) Transgenic mouse models for mc4r
KR101348852B1 (ko) Mis18α 유전자 넉아웃 생쥐모델 및 그의 제조방법
JP2024539928A (ja) 改変cacng1遺伝子座を含む非ヒト動物
JP5645357B2 (ja) サイトグロビン遺伝子の機能が欠損している非ヒト疾患モデル動物
CN102203249A (zh) 一种突变基因导入方法、突变导入基因、突变导入盒和突变导入载体以及基因敲入非人类哺乳动物
JP2004267002A (ja) セネッセンスマーカープロテイン30欠損動物、抗体およびその作製方法
CN112841128B (zh) 基因敲除小鼠在制备限制型心肌病动物模型中的应用
US20220217956A1 (en) Rodent Model Of Increased Bone Mineral Density
JP5605718B2 (ja) アルツハイマー病モデル動物およびその用途
AU2023316646A1 (en) Non-human animals comprising a modified transferrin receptor locus
WO2002102143A1 (en) Transgenic animal transformed using green fluorescent protein gene
CN120290567A (zh) 构建先天性心脏病小鼠模型的方法
WO2015068411A1 (ja) 遺伝子組み換え非ヒト動物
JP5403536B2 (ja) ヒトmll/af4融合遺伝子導入トランスジェニック非ヒト動物
CN119120576A (zh) 一种c5ar1基因人源化动物模型的构建方法及应用
CN108085339A (zh) Mics1心脏特异表达转基因动物的制备方法及应用
JP2006325452A (ja) Tzf/tzf−l遺伝子ノックアウト非ヒト哺乳動物、その作製方法、およびその利用方法
JP2006042683A (ja) ニューログリカンc遺伝子の発現が抑制された非ヒト動物
JP2003116407A (ja) ラディキシンノックアウト動物