JP2020509767A5 - - Google Patents

Download PDF

Info

Publication number
JP2020509767A5
JP2020509767A5 JP2019550622A JP2019550622A JP2020509767A5 JP 2020509767 A5 JP2020509767 A5 JP 2020509767A5 JP 2019550622 A JP2019550622 A JP 2019550622A JP 2019550622 A JP2019550622 A JP 2019550622A JP 2020509767 A5 JP2020509767 A5 JP 2020509767A5
Authority
JP
Japan
Prior art keywords
seq
domain
amino acid
cdr2
cdr1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019550622A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020509767A (ja
JP7037577B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/022759 external-priority patent/WO2018170338A2/en
Publication of JP2020509767A publication Critical patent/JP2020509767A/ja
Publication of JP2020509767A5 publication Critical patent/JP2020509767A5/ja
Application granted granted Critical
Publication of JP7037577B2 publication Critical patent/JP7037577B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019550622A 2017-03-15 2018-03-15 高親和性mage-a1特異的tcr及びその使用 Expired - Fee Related JP7037577B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762471956P 2017-03-15 2017-03-15
US62/471,956 2017-03-15
PCT/US2018/022759 WO2018170338A2 (en) 2017-03-15 2018-03-15 High affinity mage-a1-specific tcrs and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021039957A Division JP2021090462A (ja) 2017-03-15 2021-03-12 高親和性mage−a1特異的tcr及びその使用

Publications (3)

Publication Number Publication Date
JP2020509767A JP2020509767A (ja) 2020-04-02
JP2020509767A5 true JP2020509767A5 (cg-RX-API-DMAC7.html) 2021-04-22
JP7037577B2 JP7037577B2 (ja) 2022-03-16

Family

ID=63523985

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019550622A Expired - Fee Related JP7037577B2 (ja) 2017-03-15 2018-03-15 高親和性mage-a1特異的tcr及びその使用
JP2021039957A Pending JP2021090462A (ja) 2017-03-15 2021-03-12 高親和性mage−a1特異的tcr及びその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2021039957A Pending JP2021090462A (ja) 2017-03-15 2021-03-12 高親和性mage−a1特異的tcr及びその使用

Country Status (13)

Country Link
US (2) US11034748B2 (cg-RX-API-DMAC7.html)
EP (1) EP3595708A4 (cg-RX-API-DMAC7.html)
JP (2) JP7037577B2 (cg-RX-API-DMAC7.html)
KR (1) KR102375033B1 (cg-RX-API-DMAC7.html)
CN (1) CN110582299A (cg-RX-API-DMAC7.html)
AU (1) AU2018234830B2 (cg-RX-API-DMAC7.html)
BR (1) BR112019018863A8 (cg-RX-API-DMAC7.html)
CA (1) CA3055983A1 (cg-RX-API-DMAC7.html)
EA (1) EA201992131A1 (cg-RX-API-DMAC7.html)
IL (1) IL269250A (cg-RX-API-DMAC7.html)
MX (1) MX2019010972A (cg-RX-API-DMAC7.html)
SG (1) SG11201908527SA (cg-RX-API-DMAC7.html)
WO (1) WO2018170338A2 (cg-RX-API-DMAC7.html)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116217703A (zh) 2016-04-08 2023-06-06 艾达普特免疫有限公司 T细胞受体
DE102016123847B3 (de) * 2016-12-08 2018-04-05 Immatics Biotechnologies Gmbh Neue T-Zellrezeptoren und deren Verwendung in Immuntherapie
DK3551221T3 (da) 2016-12-08 2022-01-24 Immatics Biotechnologies Gmbh Hidtil ukendte t-cellereceptorer og immunterapi med anvendelse deraf
SG11201908527SA (en) * 2017-03-15 2019-10-30 Hutchinson Fred Cancer Res High affinity mage-a1-specific tcrs and uses thereof
US12377147B2 (en) 2018-04-19 2025-08-05 Baylor College Of Medicine Reprogramming CD4 t cells into cytotoxic CD8 cells by forced expression of CD8ab and class 1 restricted t cell receptors
GB201819540D0 (en) * 2018-11-30 2019-01-16 Adaptimmune Ltd T cell modification
TWI850360B (zh) * 2019-04-04 2024-08-01 德商梅迪基因免疫治療公司 黑色素瘤相關抗原1(magea1)特異性t細胞受體及其用途
JP7717619B2 (ja) 2019-05-01 2025-08-04 パクト ファーマ インコーポレイテッド Cd8改変t細胞療法を使用するがんの治療のための組成物及び方法
UA129329C2 (uk) 2019-06-25 2025-03-19 Гіліад Сайєнсіз, Інк. ЗЛИТІ БІЛКИ FLT3L-Fc
GB201915282D0 (en) 2019-10-22 2019-12-04 Immunocore Ltd Specific binding molecules
PH12022552122A1 (en) 2020-02-14 2024-01-29 Jounce Therapeutics Inc Antibodies and fusion proteins that bind to ccr8 and uses thereof
CN111320703A (zh) * 2020-03-11 2020-06-23 北京双赢科创生物科技有限公司 靶向cd22的嵌合抗原受体及其应用
CN111499763A (zh) * 2020-03-31 2020-08-07 江苏省省级机关医院 一种靶向mage-a1的特异性全人源嵌合抗原受体及其应用
US20230190802A1 (en) * 2020-05-13 2023-06-22 Adaptimmune Limited Method of treatment of cancer or tumour
CN112194719A (zh) * 2020-09-01 2021-01-08 中日友好医院(中日友好临床医学研究所) Crt抗原和mage-a1抗原的制备及其应用
TW202222841A (zh) 2020-10-06 2022-06-16 福瑞德哈金森腫瘤研究中心 用於治療表現mage-a1之疾病的組成物及方法
TWI815194B (zh) 2020-10-22 2023-09-11 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法
WO2022132836A2 (en) 2020-12-14 2022-06-23 Fred Hutchinson Cancer Research Center Compositions and methods for cellular immunotherapy
US12234473B2 (en) 2020-12-31 2025-02-25 Immatics US, Inc. CD8 polypeptides, compositions, and methods of using thereof
CA3215276A1 (en) * 2021-04-14 2022-10-20 Tscan Therapeutics, Inc. Binding proteins recognizing ha-2 antigen and uses thereof
US20220389394A1 (en) 2021-05-18 2022-12-08 Gilead Sciences, Inc. METHODS OF USING FLT3L-Fc FUSION PROTEINS
AU2022375782A1 (en) 2021-10-28 2024-05-02 Gilead Sciences, Inc. Pyridizin-3(2h)-one derivatives
US11919869B2 (en) 2021-10-29 2024-03-05 Gilead Sciences, Inc. CD73 compounds
US20230310607A1 (en) 2021-11-09 2023-10-05 T-Knife Gmbh Methods of selecting a patient for treatment of a mage-a1 positive solid tumor, of predicting whether a patient being diagnosed with mage-a1 positive solid tumor will be responsive to treatment of this tumor and of treating a patient being diagnosed with such a mage-a1 positive solid tumor as well as corresponding pharmaceutical compositions and diagnostic kits
CA3237577A1 (en) 2021-12-22 2023-06-29 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
CN118488946A (zh) 2021-12-22 2024-08-13 吉利德科学公司 Ikaros锌指家族降解剂及其用途
TW202340168A (zh) 2022-01-28 2023-10-16 美商基利科學股份有限公司 Parp7抑制劑
ES2999273T3 (en) 2022-03-17 2025-02-25 Gilead Sciences Inc Ikaros zinc finger family degraders and uses thereof
KR20250004824A (ko) 2022-04-21 2025-01-08 길리애드 사이언시즈, 인코포레이티드 Kras g12d 조절 화합물
CN114539386B (zh) * 2022-04-27 2022-07-26 恒瑞源正(广州)生物科技有限公司 Mage-a1特异性t细胞受体及其用途
EP4534554A1 (en) * 2022-06-01 2025-04-09 Corregene Biotechnology Co., Ltd. Mage-a1 specific tcr and use thereof
NL2032130B1 (en) * 2022-06-10 2023-12-18 Academisch Ziekenhuis Leiden T cell receptors directed against melanoma-associated antigen and uses thereof
WO2024006929A1 (en) 2022-07-01 2024-01-04 Gilead Sciences, Inc. Cd73 compounds
AU2023409398A1 (en) 2022-12-22 2025-06-05 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
WO2024215754A1 (en) 2023-04-11 2024-10-17 Gilead Sciences, Inc. Kras modulating compounds
WO2024220917A1 (en) 2023-04-21 2024-10-24 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
WO2025006720A1 (en) 2023-06-30 2025-01-02 Gilead Sciences, Inc. Kras modulating compounds
US20250100998A1 (en) 2023-07-26 2025-03-27 Gilead Sciences, Inc. Parp7 inhibitors
WO2025024663A1 (en) 2023-07-26 2025-01-30 Gilead Sciences, Inc. Parp7 inhibitors
US20250101042A1 (en) 2023-09-08 2025-03-27 Gilead Sciences, Inc. Kras g12d modulating compounds
WO2025054530A1 (en) 2023-09-08 2025-03-13 Gilead Sciences, Inc. Pyrimidine-containing polycyclic derivatives as kras g12d modulating compounds
WO2025081123A1 (en) 2023-10-12 2025-04-17 Fred Hutchinson Cancer Center Methods and compositions for improving t cell immunotherapy
US20250154172A1 (en) 2023-11-03 2025-05-15 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
US20250230168A1 (en) 2023-12-22 2025-07-17 Gilead Sciences, Inc. Azaspiro wrn inhibitors
WO2025146286A1 (en) * 2024-01-04 2025-07-10 Immunoscape Pte. Ltd. Human t cell receptors and uses thereof
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof
US20250376484A1 (en) 2024-05-21 2025-12-11 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
WO2025245169A1 (en) 2024-05-21 2025-11-27 Fred Hutchinson Cancer Center Immunotherapy cells equipped with a collagen-targeting payload

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6596536B1 (en) * 1991-02-08 2003-07-22 Aventis Pharma S.A. Nucleotide sequences coding for variable regions of the alpha chains of human T lymphocyte receptors, corresponding peptide segments and the diagnostic and therapeutic uses
US5420032A (en) 1991-12-23 1995-05-30 Universitge Laval Homing endonuclease which originates from chlamydomonas eugametos and recognizes and cleaves a 15, 17 or 19 degenerate double stranded nucleotide sequence
US5792632A (en) 1992-05-05 1998-08-11 Institut Pasteur Nucleotide sequence encoding the enzyme I-SceI and the uses thereof
US7067318B2 (en) 1995-06-07 2006-06-27 The Regents Of The University Of Michigan Methods for transfecting T cells
GB9518220D0 (en) 1995-09-06 1995-11-08 Medical Res Council Checkpoint gene
US6410319B1 (en) 1998-10-20 2002-06-25 City Of Hope CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies
US7070995B2 (en) 2001-04-11 2006-07-04 City Of Hope CE7-specific redirected immune cells
US7514537B2 (en) 2001-04-30 2009-04-07 City Of Hope Chimeric immunoreceptor useful in treating human gliomas
US20030148973A1 (en) * 2001-05-23 2003-08-07 Peter Emtage MAGE-A1 peptides for treating or preventing cancer
WO2003078619A1 (en) 2002-03-15 2003-09-25 Cellectis Hybrid and single chain meganucleases and use thereof
US20060153826A1 (en) 2003-01-28 2006-07-13 Sylvain Arnould Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof
US20090304679A1 (en) 2004-05-27 2009-12-10 Weidanz Jon A Antibodies as T cell receptor mimics, methods of production and uses thereof
JP2008527001A (ja) 2005-01-13 2008-07-24 ザ ジョンズ ホプキンス ユニバーシティー 前立腺幹細胞抗原ワクチンおよびその使用
GB0511124D0 (en) * 2005-06-01 2005-07-06 Avidex Ltd High affinity melan-a t cell receptors
ES2533370T3 (es) 2005-10-18 2015-04-09 Precision Biosciences Meganucleasas diseñadas racionalmente con especificidad de secuencia y afinidad de unión a ADN alteradas
US20080064631A1 (en) * 2006-01-13 2008-03-13 Jeffrey Molldrem T-cell receptors for use in diagnosis and therapy of cancers and autoimmune disease
WO2008039969A2 (en) * 2006-09-28 2008-04-03 Cedars-Sinai Medical Center Cancer vaccines and vaccination methods
EP3173480A3 (en) * 2007-03-05 2017-08-16 International Institute of Cancer Immunology, Inc. Cancer antigen-specific t-cell receptor gene, peptide encoded by the gene, and use of them
KR101319499B1 (ko) 2008-02-22 2013-10-17 엘지디스플레이 주식회사 화학적 자기조립 방법을 이용한 나노선 혹은탄소나노튜브의 적층 및 패턴형성 방법과, 이를 적용한액정표시장치의 제조방법
JP2012501180A (ja) 2008-08-26 2012-01-19 シティ・オブ・ホープ T細胞の抗腫瘍エフェクター機能増進のための方法および組成物
EP2210903A1 (en) 2009-01-21 2010-07-28 Monoclonal Antibodies Therapeutics Anti-CD160 monoclonal antibodies and uses thereof
WO2010088160A1 (en) * 2009-01-28 2010-08-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors and related materials and methods of use
EP2258719A1 (en) 2009-05-19 2010-12-08 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Multiple target T cell receptor
GB0911566D0 (en) 2009-07-03 2009-08-12 Immunocore Ltd T cell receptors
US9228007B1 (en) * 2010-03-11 2016-01-05 The Regents Of The University Of California Recombinant human progenitor cells, engineered human thymocytes, and engineered human T cells
EP2571512B1 (en) 2010-05-17 2017-08-23 Sangamo BioSciences, Inc. Novel dna-binding proteins and uses thereof
CA3071740C (en) * 2010-09-20 2020-09-08 Biontech Ag Antigen-specific t cell receptors and t cell epitopes
WO2012054825A1 (en) 2010-10-22 2012-04-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-mage-a3 t cell receptors and related materials and methods of use
AU2012276908A1 (en) * 2011-06-28 2014-02-20 International Institute Of Cancer Immunology, Inc. Receptor gene for peptide cancer antigen-specific T cell
EP2756094B1 (en) 2011-08-15 2017-12-27 Medlmmune, LLC Anti-b7-h4 antibodies and their uses
CN102295702B (zh) * 2011-08-26 2014-01-29 中国科学院微生物研究所 一种针对t细胞受体可变区特异性单抗的制备方法
WO2013074916A1 (en) 2011-11-18 2013-05-23 Board Of Regents, The University Of Texas System Car+ t cells genetically modified to eliminate expression of t- cell receptor and/or hla
GB2537000C (en) 2012-05-25 2019-10-09 Univ California Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
SMT202100005T1 (it) 2012-08-20 2021-05-07 Hutchinson Fred Cancer Res Metodo e composizioni per immunoterapia cellulare
CA2886684C (en) 2012-10-10 2023-09-19 Sangamo Biosciences, Inc. T cell modifying compounds and uses thereof
EP2896697B1 (en) 2012-12-12 2015-09-02 The Broad Institute, Inc. Engineering of systems, methods and optimized guide compositions for sequence manipulation
US8697359B1 (en) 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products
AU2013361231A1 (en) 2012-12-19 2015-06-04 Amplimmune, Inc. B7-H4 specific antibodies, and compositions and methods of use thereof
CN105377886B (zh) * 2013-01-29 2020-07-28 马克思-德布鲁克-分子医学中心(Mdc)柏林-布赫 识别mage-a1的高亲和力结合分子
EP3404111A1 (en) * 2013-03-13 2018-11-21 Health Research, Inc. Compositions and methods for use of recombinant t cell receptors for direct recognition of tumor antigen
WO2015066262A1 (en) 2013-11-04 2015-05-07 Trustees Of Dartmouth College Methods for preventing toxicity of adoptive cell therapy
EP3071695A2 (en) 2013-11-18 2016-09-28 Crispr Therapeutics AG Crispr-cas system materials and methods
BR112016011567A2 (pt) * 2013-11-22 2017-10-24 Hutchinson Fred Cancer Res receptores de célula t humana de alta afinidade geneticamente modificados.
RS58627B2 (sr) * 2014-04-01 2022-06-30 Biontech Cell&Gene Therapies Gmbh Klaudin-6-specifični imuno receptori i t-ćelijski epitopi
US10202640B2 (en) 2014-05-07 2019-02-12 The Board Of Trustees Of The Leland Stanford Junior University Single cell analysis of T cells using high-throughput multiplex amplification and deep sequencing
EP2944652A1 (en) * 2014-05-13 2015-11-18 Technische Universität München Glypican-3-specific T-cell receptors and their uses for immunotherapy of hepatocellular carcinoma
JP6712261B2 (ja) * 2014-08-04 2020-06-24 フレッド ハッチンソン キャンサー リサーチ センター Wt−1に特異的なt細胞免疫治療
EP3191518B1 (en) 2014-09-12 2020-01-15 Genentech, Inc. Anti-b7-h4 antibodies and immunoconjugates
WO2016040900A1 (en) * 2014-09-14 2016-03-17 Washington University Personalized cancer vaccines and methods therefor
WO2016054638A1 (en) 2014-10-03 2016-04-07 Dana-Farber Cancer Institute, Inc. Glucocorticoid-induced tumor necrosis factor receptor (gitr) antibodies and methods of use thereof
PT3258951T (pt) 2015-02-19 2020-08-18 Compugen Ltd Anticorpos anti-pvrig e métodos de utilização
US10544392B2 (en) * 2015-05-01 2020-01-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of isolating T cells and T cell receptors having antigenic specificity for a cancer-specific mutation from peripheral blood
CN106188274A (zh) * 2015-05-06 2016-12-07 广州市香雪制药股份有限公司 识别rhamm抗原短肽的t细胞受体
CA2987857A1 (en) * 2015-06-01 2016-12-08 Medigene Immunotherapies Gmbh T cell receptor library
JO3620B1 (ar) 2015-08-05 2020-08-27 Amgen Res Munich Gmbh مثبطات نقطة فحص مناعية للاستخدام في علاج سرطانات محمولة عبر الدم
CN105316362B (zh) * 2015-08-19 2020-03-17 暨南大学 一种Dual-RMCE介导的TCR基因置换系统及其方法
CN106749620B (zh) * 2016-03-29 2020-09-25 广东香雪精准医疗技术有限公司 识别mage-a1抗原短肽的t细胞受体
EP3472208B9 (en) * 2016-06-17 2023-10-04 Medigene Immunotherapies GmbH T cell receptors and uses thereof
DE102016115246C5 (de) * 2016-08-17 2018-12-20 Immatics Biotechnologies Gmbh Neue t-zellrezeptoren und deren verwendung in immuntherapie
DE102016123847B3 (de) * 2016-12-08 2018-04-05 Immatics Biotechnologies Gmbh Neue T-Zellrezeptoren und deren Verwendung in Immuntherapie
SG11201908527SA (en) * 2017-03-15 2019-10-30 Hutchinson Fred Cancer Res High affinity mage-a1-specific tcrs and uses thereof

Similar Documents

Publication Publication Date Title
JP2020509767A5 (cg-RX-API-DMAC7.html)
Ben-Shmuel et al. Unleashing natural killer cells in the tumor microenvironment–the next generation of immunotherapy?
JP7781243B2 (ja) ガイダンス及びナビゲーションコントロール蛋白質並びにその生産及び使用方法
AU2014407539B2 (en) Methods of isolating T cell receptors having antigenic specificity for a cancer-specific mutation
Essand et al. Genetically engineered T cells for the treatment of cancer
JP2017523784A5 (cg-RX-API-DMAC7.html)
Shevtsov et al. Immunological and translational aspects of NK cell-based antitumor immunotherapies
Shi et al. Chimeric antigen receptor for adoptive immunotherapy of cancer: latest research and future prospects
JP2020517259A5 (cg-RX-API-DMAC7.html)
JP2017531687A5 (cg-RX-API-DMAC7.html)
JP6578604B2 (ja) 固形がんの治療剤
AU2016321256A1 (en) NY-ESO-1 specific TCRs and methods of use thereof
JP2020533962A5 (cg-RX-API-DMAC7.html)
CN114616337A (zh) 嵌合CD3融合蛋白与基于anti-CD3的双特异性T细胞激活元件的联合表达
JP2024519335A (ja) がん免疫療法のための投薬レジメン
JP2023548974A (ja) T細胞抗原カプラを含む細胞及びその使用
WO2021027785A1 (zh) 共表达趋化因子受体的免疫效应细胞
Heiblig et al. Adoptive immunotherapy for acute leukemia: new insights in chimeric antigen receptors
Handgretinger et al. Emerging role of immunotherapy for childhood cancers
WO2022033483A1 (zh) 多功能的免疫效应细胞及其应用
JPWO2019157524A5 (cg-RX-API-DMAC7.html)
Smits et al. Designing multivalent proteins based on natural killer cell receptors and their ligands as immunotherapy for cancer
Kebriaei et al. CARs: driving T-cell specificity to enhance anti-tumor immunity
JPWO2020194195A5 (cg-RX-API-DMAC7.html)
Hazboun Adoptive cellular immunotherapy for solid tumors