JP2020509052A5 - - Google Patents
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- Publication number
- JP2020509052A5 JP2020509052A5 JP2019547658A JP2019547658A JP2020509052A5 JP 2020509052 A5 JP2020509052 A5 JP 2020509052A5 JP 2019547658 A JP2019547658 A JP 2019547658A JP 2019547658 A JP2019547658 A JP 2019547658A JP 2020509052 A5 JP2020509052 A5 JP 2020509052A5
- Authority
- JP
- Japan
- Prior art keywords
- dispersible tablet
- orally dispersible
- lipase
- tablet according
- aqueous solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007919 dispersible tablet Substances 0.000 claims 14
- 102000004882 Lipase Human genes 0.000 claims 11
- 108090001060 Lipase Proteins 0.000 claims 11
- 239000004367 Lipase Substances 0.000 claims 8
- 235000019421 lipase Nutrition 0.000 claims 8
- 239000007864 aqueous solution Substances 0.000 claims 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 239000011230 binding agent Substances 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 229940127557 pharmaceutical product Drugs 0.000 claims 3
- 208000035467 Pancreatic insufficiency Diseases 0.000 claims 2
- 230000007812 deficiency Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 241000251468 Actinopterygii Species 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 229950002931 burlulipase Drugs 0.000 claims 1
- 230000001079 digestive effect Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000007884 disintegrant Substances 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 238000007710 freezing Methods 0.000 claims 1
- 230000008014 freezing Effects 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000011121 sodium hydroxide Nutrition 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022151344A JP2022184994A (ja) | 2017-03-03 | 2022-09-22 | ブルルリパーゼを含有する口腔内分散性錠剤、ブルルリパーゼを含む液体医薬組成物を調製する方法および口腔内分散性錠剤を生産するプロセス |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102017104472.8 | 2017-03-03 | ||
| DE102017104472.8A DE102017104472A1 (de) | 2017-03-03 | 2017-03-03 | Schmelztablette enthaltend Burlulipase und daraus hergestellte pharmazeutische Zusammensetzung |
| PCT/EP2018/055285 WO2018158459A1 (de) | 2017-03-03 | 2018-03-05 | Schmelztablette enthaltend burlulipase und daraus hergestellte pharmazeutische zusammensetzung |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022151344A Division JP2022184994A (ja) | 2017-03-03 | 2022-09-22 | ブルルリパーゼを含有する口腔内分散性錠剤、ブルルリパーゼを含む液体医薬組成物を調製する方法および口腔内分散性錠剤を生産するプロセス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020509052A JP2020509052A (ja) | 2020-03-26 |
| JP2020509052A5 true JP2020509052A5 (https=) | 2021-04-15 |
| JP7208146B2 JP7208146B2 (ja) | 2023-01-18 |
Family
ID=61628314
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019547658A Active JP7208146B2 (ja) | 2017-03-03 | 2018-03-05 | ブルルリパーゼを含有する口腔内分散性錠剤を生産する方法およびブルルリパーゼを含む液体医薬組成物を生産する方法。 |
| JP2022151344A Pending JP2022184994A (ja) | 2017-03-03 | 2022-09-22 | ブルルリパーゼを含有する口腔内分散性錠剤、ブルルリパーゼを含む液体医薬組成物を調製する方法および口腔内分散性錠剤を生産するプロセス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022151344A Pending JP2022184994A (ja) | 2017-03-03 | 2022-09-22 | ブルルリパーゼを含有する口腔内分散性錠剤、ブルルリパーゼを含む液体医薬組成物を調製する方法および口腔内分散性錠剤を生産するプロセス |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11464834B2 (https=) |
| EP (1) | EP3525769B1 (https=) |
| JP (2) | JP7208146B2 (https=) |
| CN (1) | CN110612098B (https=) |
| CA (1) | CA3055116C (https=) |
| DE (1) | DE102017104472A1 (https=) |
| ES (1) | ES2880602T3 (https=) |
| PL (1) | PL3525769T3 (https=) |
| WO (1) | WO2018158459A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102017104480A1 (de) * | 2017-03-03 | 2018-09-06 | Nordmark Arzneimittel Gmbh & Co. Kg | Wässrige Lösung von Burlulipase umfassend Kalziumionen |
| US20240000705A1 (en) * | 2020-09-17 | 2024-01-04 | Catalent U.K. Swindon Zydis Limited | Use of surfactant with high molecular weight fish gelatin based dosage formulations to improve flow characteristics |
| WO2022103639A1 (en) | 2020-11-16 | 2022-05-19 | Orcosa Inc. | Methods of treating autoimmune or inflammatory conditions with cannabidiol or its derivatives/analogs |
| US11672761B2 (en) | 2020-11-16 | 2023-06-13 | Orcosa Inc. | Rapidly infusing platform and compositions for therapeutic treatment in humans |
| DE102023200788A1 (de) | 2023-01-31 | 2024-08-01 | Technische Universität Braunschweig - Körperschaft des öffentlichen Rechts | Festes Lyophilisat und Verfahren zur Herstellung |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1642654C3 (de) | 1968-01-16 | 1979-11-29 | Centre Europeen De Recherches Mauvernay, C.E.R.M., Riom | Verfahren zur mikrobiologischen Herstellung eines stabilen gereinigten Lipase-Präparates und pharmazeutisches Mittel, welches dieses enthält |
| DE2638088C3 (de) | 1976-08-24 | 1979-06-21 | Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt | Verwendung von SuBmolkenpulver |
| DE69004301T2 (de) | 1989-03-08 | 1994-03-24 | Simon Lodewijk Scharpe | Mischung zur Behandlung der von exokrinen Insuffizienz der Bauchspeicheldrüse und die Verwendung der genannten Mischung. |
| CA2110497C (en) | 1991-07-01 | 2005-04-19 | Reinhard Braatz | Use of bacterial lipases for producing drugs for maldigestion therapy |
| GB9908014D0 (en) | 1999-04-08 | 1999-06-02 | Scherer Corp R P | Pharmaceutical compositions |
| CA2374760A1 (en) | 1999-06-18 | 2000-12-28 | Takeda Chemical Industries, Ltd. | Quickly disintegrating solid preparations |
| US6588180B2 (en) | 2001-02-02 | 2003-07-08 | R. P. Scherer Technologies, Inc. | Constricted neck blister pack and apparatus and method for making the same |
| HRP20041152B1 (hr) | 2002-05-07 | 2008-01-31 | Ferring B.V. | Farmaceutske formulacije |
| CN1394607A (zh) * | 2002-08-07 | 2003-02-05 | 王登之 | 治疗心绞痛的黄杨宁口腔崩解片及其制备方法 |
| CA2560613C (en) | 2004-03-22 | 2015-11-24 | Solvay Pharmaceuticals Gmbh | Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants |
| PT1809320E (pt) | 2004-10-14 | 2010-10-25 | Altus Pharmaceuticals Inc | Composições contendo lipase, protease e amilase para o tratamento de insuficiência pancreática |
| KR101379297B1 (ko) | 2004-10-28 | 2014-04-10 | 팬택 아게 | 고 다공성, 속해성 고형 투여 형태 및 분말 제조 및동결건조 단계를 포함하는 그의 제조 방법 |
| EP2328609A1 (en) | 2008-08-26 | 2011-06-08 | Cystic Fibrosis Foundation Therapeutics, Inc. | Rapidly disintegrating tablets comprising lipase, amylase, and protease |
| DE102009006594A1 (de) * | 2009-01-29 | 2010-08-05 | Nordmark Arzneimittel Gmbh & Co. Kg | Pharmazeutisches Präparat |
| BRPI0922653B8 (pt) | 2009-01-29 | 2021-05-25 | Nordmark Arzneimittel Gmbh & Co Kg | uso de uma lipase bacteriana do tipo pseudomonas em solução aquosa |
| WO2014166994A1 (en) | 2013-04-09 | 2014-10-16 | Danmarks Tekniske Universitet | Nano-microdelivery systems for oral delivery of an active ingredient |
| CN104109662B (zh) | 2014-06-23 | 2017-03-01 | 华中科技大学 | 一种固定化的洋葱伯克霍尔德菌脂肪酶及其制备方法 |
| DE102015114857A1 (de) | 2015-09-04 | 2017-03-09 | Nordmark Arzneimittel Gmbh & Co. Kg | Getränk, enthaltend eine pharmazeutische Zusammensetzung |
-
2017
- 2017-03-03 DE DE102017104472.8A patent/DE102017104472A1/de not_active Withdrawn
-
2018
- 2018-03-05 EP EP18711039.0A patent/EP3525769B1/de active Active
- 2018-03-05 WO PCT/EP2018/055285 patent/WO2018158459A1/de not_active Ceased
- 2018-03-05 ES ES18711039T patent/ES2880602T3/es active Active
- 2018-03-05 CN CN201880019225.8A patent/CN110612098B/zh active Active
- 2018-03-05 JP JP2019547658A patent/JP7208146B2/ja active Active
- 2018-03-05 CA CA3055116A patent/CA3055116C/en active Active
- 2018-03-05 PL PL18711039T patent/PL3525769T3/pl unknown
- 2018-03-05 US US16/490,549 patent/US11464834B2/en active Active
-
2022
- 2022-09-22 JP JP2022151344A patent/JP2022184994A/ja active Pending
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