JP2020508685A - サプレッサーｔＲＮＡ及びデアミナーゼによる変異のＲＮＡターゲティング - Google Patents

サプレッサーｔＲＮＡ及びデアミナーゼによる変異のＲＮＡターゲティング Download PDF

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JP2020508685A
JP2020508685A JP2019547704A JP2019547704A JP2020508685A JP 2020508685 A JP2020508685 A JP 2020508685A JP 2019547704 A JP2019547704 A JP 2019547704A JP 2019547704 A JP2019547704 A JP 2019547704A JP 2020508685 A JP2020508685 A JP 2020508685A
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rna
adar
trna
protein
vector
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Japanese (ja)
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JP2020508685A5 (cg-RX-API-DMAC7.html
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マリ，プラシャント
カトレカール，ドゥルヴァ
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University of California
University of California Berkeley
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University of California San Diego UCSD
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Priority to JP2023023308A priority Critical patent/JP2023075118A/ja
Priority to JP2025008232A priority patent/JP2025066771A/ja
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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    • C12N9/14—Hydrolases (3)
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    • C12Y603/05—Carbon-nitrogen ligases with glutamine as amido-N-donor (6.3.5)
    • C12Y603/05007—Glutaminyl-tRNA synthase (glutamine-hydrolyzing) (6.3.5.7)
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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JP2019547704A 2017-03-03 2018-03-02 サプレッサーｔＲＮＡ及びデアミナーゼによる変異のＲＮＡターゲティング Pending JP2020508685A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023023308A JP2023075118A (ja) 2017-03-03 2023-02-17 サプレッサーｔＲＮＡ及びデアミナーゼによる変異のＲＮＡターゲティング
JP2025008232A JP2025066771A (ja) 2017-03-03 2025-01-21 サプレッサーｔＲＮＡ及びデアミナーゼによる変異のＲＮＡターゲティング

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762466961P 2017-03-03 2017-03-03
US62/466,961 2017-03-03
US201762551732P 2017-08-29 2017-08-29
US62/551,732 2017-08-29
PCT/US2018/020762 WO2018161032A1 (en) 2017-03-03 2018-03-02 RNA TARGETING OF MUTATIONS VIA SUPPRESSOR tRNAs AND DEAMINASES

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JP2023023308A Division JP2023075118A (ja) 2017-03-03 2023-02-17 サプレッサーｔＲＮＡ及びデアミナーゼによる変異のＲＮＡターゲティング

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JP2020508685A true JP2020508685A (ja) 2020-03-26
JP2020508685A5 JP2020508685A5 (cg-RX-API-DMAC7.html) 2021-07-26

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JP2019547704A Pending JP2020508685A (ja) 2017-03-03 2018-03-02 サプレッサーｔＲＮＡ及びデアミナーゼによる変異のＲＮＡターゲティング
JP2023023308A Pending JP2023075118A (ja) 2017-03-03 2023-02-17 サプレッサーｔＲＮＡ及びデアミナーゼによる変異のＲＮＡターゲティング
JP2025008232A Pending JP2025066771A (ja) 2017-03-03 2025-01-21 サプレッサーｔＲＮＡ及びデアミナーゼによる変異のＲＮＡターゲティング

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JP2023023308A Pending JP2023075118A (ja) 2017-03-03 2023-02-17 サプレッサーｔＲＮＡ及びデアミナーゼによる変異のＲＮＡターゲティング
JP2025008232A Pending JP2025066771A (ja) 2017-03-03 2025-01-21 サプレッサーｔＲＮＡ及びデアミナーゼによる変異のＲＮＡターゲティング

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US (8) US11932856B2 (cg-RX-API-DMAC7.html)
EP (1) EP3589751A4 (cg-RX-API-DMAC7.html)
JP (3) JP2020508685A (cg-RX-API-DMAC7.html)
CN (2) CN118416088A (cg-RX-API-DMAC7.html)
GB (1) GB2574769A (cg-RX-API-DMAC7.html)
IL (1) IL268763A (cg-RX-API-DMAC7.html)
WO (1) WO2018161032A1 (cg-RX-API-DMAC7.html)

Cited By (3)

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JP2023075118A (ja) * 2017-03-03 2023-05-30 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア サプレッサーｔＲＮＡ及びデアミナーゼによる変異のＲＮＡターゲティング
JP2023552037A (ja) * 2020-10-12 2023-12-14 エバーハルト カール ウニヴェルジテート テュービンゲン Ｒｎａ編集のための人工核酸
JP2024504608A (ja) * 2021-01-12 2024-02-01 北京大学 遺伝子操作ｒｎａを使用した内因性ａｄａｒの活用による標的化ｒｎａの編集

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US12390514B2 (en) 2017-03-09 2025-08-19 President And Fellows Of Harvard College Cancer vaccine
JP2020510439A (ja) 2017-03-10 2020-04-09 プレジデント アンド フェローズ オブ ハーバード カレッジ シトシンからグアニンへの塩基編集因子
EP3658573A1 (en) 2017-07-28 2020-06-03 President and Fellows of Harvard College Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace)
US20200332272A1 (en) * 2017-10-23 2020-10-22 The Broad Institute, Inc. Systems, methods, and compositions for targeted nucleic acid editing
WO2019090154A1 (en) 2017-11-02 2019-05-09 University Of Iowa Research Foundation Methods of rescuing stop codons via genetic reassignment with ace-trna
EP3724214A4 (en) 2017-12-15 2021-09-01 The Broad Institute Inc. SYSTEMS AND METHODS FOR PREDICTING REPAIR RESULTS IN GENETIC ENGINEERING
WO2019126709A1 (en) * 2017-12-22 2019-06-27 The Broad Institute, Inc. Cas12b systems, methods, and compositions for targeted dna base editing
WO2020001793A1 (en) * 2018-06-29 2020-01-02 Eberhard-Karls-Universität Tübingen Artificial nucleic acids for rna editing
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JP2021536239A (ja) 2018-08-28 2021-12-27 ロシュ イノベーション センター コペンハーゲン エーエス スプライス調節化合物を使用したネオアンチゲン操作
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JP2022501055A (ja) * 2018-09-26 2022-01-06 ケース ウエスタン リザーブ ユニバーシティ 未成熟終止コドン媒介性障害を治療するための方法および組成物
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WO2021142343A1 (en) * 2020-01-09 2021-07-15 The Regents Of The University Of California Targeting transfer rna for the suppression of nonsense mutations in messenger rna
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