JP2020508671A5 - - Google Patents
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- Publication number
- JP2020508671A5 JP2020508671A5 JP2019546813A JP2019546813A JP2020508671A5 JP 2020508671 A5 JP2020508671 A5 JP 2020508671A5 JP 2019546813 A JP2019546813 A JP 2019546813A JP 2019546813 A JP2019546813 A JP 2019546813A JP 2020508671 A5 JP2020508671 A5 JP 2020508671A5
- Authority
- JP
- Japan
- Prior art keywords
- reductase
- dihydrodaidzein
- tetrahydrodaidzein
- hydroxy
- daidzein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004316 Oxidoreductases Human genes 0.000 claims 23
- 108090000854 Oxidoreductases Proteins 0.000 claims 23
- 238000000034 method Methods 0.000 claims 11
- JHYXBPPMXZIHKG-CYBMUJFWSA-N Dihydrodaidzein Natural products C1=CC(O)=CC=C1[C@@H]1C(=O)C2=CC=C(O)C=C2OC1 JHYXBPPMXZIHKG-CYBMUJFWSA-N 0.000 claims 10
- ZQSIJRDFPHDXIC-UHFFFAOYSA-N daidzein Chemical compound C1=CC(O)=CC=C1C1=COC2=CC(O)=CC=C2C1=O ZQSIJRDFPHDXIC-UHFFFAOYSA-N 0.000 claims 10
- JHYXBPPMXZIHKG-UHFFFAOYSA-N dihydrodaidzein Chemical compound C1=CC(O)=CC=C1C1C(=O)C2=CC=C(O)C=C2OC1 JHYXBPPMXZIHKG-UHFFFAOYSA-N 0.000 claims 10
- 235000007240 daidzein Nutrition 0.000 claims 5
- 102000004879 Racemases and epimerases Human genes 0.000 claims 4
- 108090001066 Racemases and epimerases Proteins 0.000 claims 4
- 239000000758 substrate Substances 0.000 claims 4
- 230000002194 synthesizing effect Effects 0.000 claims 4
- 241000588724 Escherichia coli Species 0.000 claims 3
- TZBJGXHYKVUXJN-UHFFFAOYSA-N genistein Natural products C1=CC(O)=CC=C1C1=COC2=CC(O)=CC(O)=C2C1=O TZBJGXHYKVUXJN-UHFFFAOYSA-N 0.000 claims 3
- 235000006539 genistein Nutrition 0.000 claims 3
- 229940045109 genistein Drugs 0.000 claims 3
- ZCOLJUOHXJRHDI-CMWLGVBASA-N genistein 7-O-beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 ZCOLJUOHXJRHDI-CMWLGVBASA-N 0.000 claims 3
- 229920003169 water-soluble polymer Polymers 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 239000002778 food additive Substances 0.000 claims 1
- 235000013373 food additive Nutrition 0.000 claims 1
- ADFCQWZHKCXPAJ-UHFFFAOYSA-N indofine Natural products C1=CC(O)=CC=C1C1CC2=CC=C(O)C=C2OC1 ADFCQWZHKCXPAJ-UHFFFAOYSA-N 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020170026774A KR102005237B1 (ko) | 2017-02-28 | 2017-02-28 | 에쿠올 유도체를 생산하는 재조합 대장균 및 이를 이용한 에쿠올 유도체 합성 방법 |
| KR10-2017-0026774 | 2017-02-28 | ||
| PCT/KR2018/002201 WO2018159957A1 (ko) | 2017-02-28 | 2018-02-22 | 에쿠올 유도체를 생산하는 재조합 대장균 및 이를 이용한 에쿠올 유도체 합성 방법 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020508671A JP2020508671A (ja) | 2020-03-26 |
| JP2020508671A5 true JP2020508671A5 (enExample) | 2020-05-07 |
| JP7002557B2 JP7002557B2 (ja) | 2022-02-10 |
Family
ID=63370438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019546813A Active JP7002557B2 (ja) | 2017-02-28 | 2018-02-22 | エクオール誘導体を生産する組換え大腸菌およびこれを利用したエクオール誘導体の合成方法 |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP7002557B2 (enExample) |
| KR (1) | KR102005237B1 (enExample) |
| CN (1) | CN110382701A (enExample) |
| WO (1) | WO2018159957A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102079003B1 (ko) * | 2018-08-10 | 2020-02-19 | 서울대학교산학협력단 | 활성이 증대된 테트라하이드로다이드제인 환원효소 및 에쿠올 유도체 생산에의 응용 |
| JP7449526B2 (ja) * | 2018-12-07 | 2024-03-14 | 学校法人東京理科大学 | エクオール誘導体の産生のための組成物 |
| KR102222517B1 (ko) | 2019-03-26 | 2021-03-03 | 서울대학교산학협력단 | 모노옥시게나아제를 포함하는 생촉매 조성물 및 이를 이용한 에쿠올 수산화 유도체의 제조 방법 |
| CN114806999B (zh) * | 2022-06-30 | 2022-09-27 | 华熙生物科技股份有限公司 | 一种基因工程菌及其在制备二氢大豆苷元中的应用 |
| CN115725614B (zh) * | 2022-08-05 | 2025-06-06 | 华熙生物科技股份有限公司 | 一种生产雌马酚的菌株及其应用 |
| WO2025181921A1 (ja) * | 2024-02-27 | 2025-09-04 | 株式会社ダイセル | エクオールおよび５－ヒドロキシエクオールの製造方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4256679B2 (ja) * | 2001-03-16 | 2009-04-22 | ノボゲン リサーチ ピーティーワイ リミテッド | 再狭窄の治療方法 |
| CN101123958A (zh) * | 2003-11-19 | 2008-02-13 | 诺沃根研究股份有限公司 | 联合放射疗法与化学疗法的组合物和方法 |
| DK2404995T3 (da) * | 2007-12-27 | 2013-10-14 | Otsuka Pharma Co Ltd | Enzym associeret med equolsyntese |
| CN103275884B (zh) | 2013-02-04 | 2014-08-20 | 河北农业大学 | 史雷克氏菌auh-jlc159及其转化制备(-)-5-oh-雌马酚的方法 |
| CN104031875B (zh) * | 2014-05-30 | 2016-04-20 | 浙江省农业科学院 | 一种s-雌马酚产生工程菌及应用 |
-
2017
- 2017-02-28 KR KR1020170026774A patent/KR102005237B1/ko active Active
-
2018
- 2018-02-22 CN CN201880014592.9A patent/CN110382701A/zh active Pending
- 2018-02-22 JP JP2019546813A patent/JP7002557B2/ja active Active
- 2018-02-22 WO PCT/KR2018/002201 patent/WO2018159957A1/ko not_active Ceased
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