JP2020508671A5 - - Google Patents
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- Publication number
- JP2020508671A5 JP2020508671A5 JP2019546813A JP2019546813A JP2020508671A5 JP 2020508671 A5 JP2020508671 A5 JP 2020508671A5 JP 2019546813 A JP2019546813 A JP 2019546813A JP 2019546813 A JP2019546813 A JP 2019546813A JP 2020508671 A5 JP2020508671 A5 JP 2020508671A5
- Authority
- JP
- Japan
- Prior art keywords
- reductase
- dihydrodaidzein
- tetrahydrodaidzein
- hydroxy
- daidzein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004316 Oxidoreductases Human genes 0.000 claims 23
- 108090000854 Oxidoreductases Proteins 0.000 claims 23
- JHYXBPPMXZIHKG-CYBMUJFWSA-N Dihydrodaidzein Natural products C1=CC(O)=CC=C1[C@@H]1C(=O)C2=CC=C(O)C=C2OC1 JHYXBPPMXZIHKG-CYBMUJFWSA-N 0.000 claims 20
- ZQSIJRDFPHDXIC-UHFFFAOYSA-N Daidzein Chemical compound C1=CC(O)=CC=C1C1=COC2=CC(O)=CC=C2C1=O ZQSIJRDFPHDXIC-UHFFFAOYSA-N 0.000 claims 10
- 235000007240 daidzein Nutrition 0.000 claims 5
- 239000000758 substrate Substances 0.000 claims 4
- 230000002194 synthesizing Effects 0.000 claims 4
- 241000588724 Escherichia coli Species 0.000 claims 3
- 229940045109 Genistein Drugs 0.000 claims 3
- ZCOLJUOHXJRHDI-CMWLGVBASA-N Genistin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 ZCOLJUOHXJRHDI-CMWLGVBASA-N 0.000 claims 3
- TZBJGXHYKVUXJN-UHFFFAOYSA-N genistein Natural products C1=CC(O)=CC=C1C1=COC2=CC(O)=CC(O)=C2C1=O TZBJGXHYKVUXJN-UHFFFAOYSA-N 0.000 claims 3
- 235000006539 genistein Nutrition 0.000 claims 3
- 229920003169 water-soluble polymer Polymers 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 239000002778 food additive Substances 0.000 claims 1
- 235000013373 food additive Nutrition 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
Claims (11)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020170026774A KR102005237B1 (en) | 2017-02-28 | 2017-02-28 | Recombinant e.coli producing equol derivatives and method for producing equol derivatives using thereof |
| KR10-2017-0026774 | 2017-02-28 | ||
| PCT/KR2018/002201 WO2018159957A1 (en) | 2017-02-28 | 2018-02-22 | Recombinant escherichia coli bacteria producing equol derivative and synthesis method of equol derivative using same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020508671A JP2020508671A (en) | 2020-03-26 |
| JP2020508671A5 true JP2020508671A5 (en) | 2020-05-07 |
| JP7002557B2 JP7002557B2 (en) | 2022-02-10 |
Family
ID=63370438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019546813A Active JP7002557B2 (en) | 2017-02-28 | 2018-02-22 | Recombinant Escherichia coli that produces equol derivatives and methods for synthesizing equol derivatives using these |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP7002557B2 (en) |
| KR (1) | KR102005237B1 (en) |
| CN (1) | CN110382701A (en) |
| WO (1) | WO2018159957A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102079003B1 (en) * | 2018-08-10 | 2020-02-19 | 서울대학교산학협력단 | Tetrahydrodaidzein reductase with improved activity, and application thereof for synthesis of equol derivatives |
| JP7449526B2 (en) * | 2018-12-07 | 2024-03-14 | 学校法人東京理科大学 | Composition for the production of equol derivatives |
| KR102222517B1 (en) | 2019-03-26 | 2021-03-03 | 서울대학교산학협력단 | Biocatalytic compositions comprising monooxygenases and method for the preparation of hydroxy-equol derivatives using the same |
| CN114806999B (en) * | 2022-06-30 | 2022-09-27 | 华熙生物科技股份有限公司 | Genetically engineered bacterium and application thereof in preparing dihydrodaidzein |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1368024A4 (en) * | 2001-03-16 | 2009-03-18 | Novogen Res Pty Ltd | Treatment of restenosis |
| EP1686981A4 (en) * | 2003-11-19 | 2011-02-23 | Novogen Res Pty Ltd | Combinational radiotherapy and chemotherapy compositions and methods |
| PT2404995E (en) | 2007-12-27 | 2013-09-26 | Otsuka Pharma Co Ltd | Enzyme associated with equol synthesis |
| CN103275884B (en) | 2013-02-04 | 2014-08-20 | 河北农业大学 | AUH-JLC159 and transforming method thereof for preparation of (-)-5-OH-equol |
| CN104031875B (en) | 2014-05-30 | 2016-04-20 | 浙江省农业科学院 | A kind of S-equol produces engineering bacteria and application |
-
2017
- 2017-02-28 KR KR1020170026774A patent/KR102005237B1/en active IP Right Grant
-
2018
- 2018-02-22 WO PCT/KR2018/002201 patent/WO2018159957A1/en active Application Filing
- 2018-02-22 CN CN201880014592.9A patent/CN110382701A/en active Pending
- 2018-02-22 JP JP2019546813A patent/JP7002557B2/en active Active
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