JP2020505468A5 - - Google Patents
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- Publication number
- JP2020505468A5 JP2020505468A5 JP2019561389A JP2019561389A JP2020505468A5 JP 2020505468 A5 JP2020505468 A5 JP 2020505468A5 JP 2019561389 A JP2019561389 A JP 2019561389A JP 2019561389 A JP2019561389 A JP 2019561389A JP 2020505468 A5 JP2020505468 A5 JP 2020505468A5
- Authority
- JP
- Japan
- Prior art keywords
- branched
- linear
- alkyl
- halide
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(CC1)(CCC1(*)Nc1ccc(*)c(-c2c(*)[n](*)nc2*)n1)N(*)* Chemical compound CC(CC1)(CCC1(*)Nc1ccc(*)c(-c2c(*)[n](*)nc2*)n1)N(*)* 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762453192P | 2017-02-01 | 2017-02-01 | |
| US62/453,192 | 2017-02-01 | ||
| PCT/IL2018/050100 WO2018142393A1 (en) | 2017-02-01 | 2018-01-30 | N1 -(4-(5-(cyclopropylmethyl)-1 -methyl-1 h-pyrazol-4-yl)pyridin-2-yl)cyclohexane-1,4-diamine derivatives and related compounds as ck1 and/or iraki inhibitors for treating cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020505468A JP2020505468A (ja) | 2020-02-20 |
| JP2020505468A5 true JP2020505468A5 (enExample) | 2021-03-18 |
| JP7142646B2 JP7142646B2 (ja) | 2022-09-27 |
Family
ID=61198874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019561389A Expired - Fee Related JP7142646B2 (ja) | 2017-02-01 | 2018-01-30 | がんを治療するためのｃｋ１及び／又はｉｒａｋ１インヒビターとしてのｎ１－（４－（５－（シクロプロピルメチル）－１－メチル－１ｈ－ピラゾール－４－イル）ピリジン－２－イル）シクロヘキサン－１，４－ジアミン誘導体及び関連化合物 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US11072599B2 (enExample) |
| EP (1) | EP3577108B1 (enExample) |
| JP (1) | JP7142646B2 (enExample) |
| KR (1) | KR20190115017A (enExample) |
| CN (1) | CN110475771B (enExample) |
| AU (1) | AU2018215809B2 (enExample) |
| CA (1) | CA3052247A1 (enExample) |
| ES (1) | ES2902885T3 (enExample) |
| IL (1) | IL268128B2 (enExample) |
| MX (1) | MX394556B (enExample) |
| NZ (1) | NZ755447A (enExample) |
| RU (1) | RU2761457C2 (enExample) |
| SG (1) | SG11201906681PA (enExample) |
| TW (1) | TW201837027A (enExample) |
| WO (1) | WO2018142393A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS62728B1 (sr) * | 2015-08-04 | 2022-01-31 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | Derivat pirazol pirimidina i njegove upotrebe |
| KR20200130287A (ko) * | 2018-02-08 | 2020-11-18 | 이슘 리서치 디벨롭먼트 컴퍼니 오브 더 히브루 유니버시티 오브 예루살렘 엘티디. | 헤테로아릴 화합물, 이의 약학 조성물 및 이의 치료적 용도 |
| CN114127058B (zh) * | 2019-07-04 | 2024-06-25 | 深圳国顺康医药科技有限公司 | 一种杂环化合物、其药物组合物及用途 |
| KR20230069169A (ko) * | 2020-09-17 | 2023-05-18 | 얀센 파마슈티카 엔.브이. | 카제인 키나제 1 델타 조절제 |
| WO2022232259A1 (en) * | 2021-04-28 | 2022-11-03 | Cornell University | Soluble adenylyl cyclase (sac) inhibitors and uses thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007129195A2 (en) | 2006-05-04 | 2007-11-15 | Pfizer Products Inc. | 4-pyrimidine-5-amino-pyrazole compounds |
| JP5985473B2 (ja) | 2010-07-13 | 2016-09-06 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ＩＲＡＫ４モジュレーターとしてのピラゾロ［１，５ａ］ピリミジン及びチエノ［３，２ｂ］ピリミジン誘導体 |
| EP2651405A2 (en) | 2010-12-14 | 2013-10-23 | Electrophoretics Limited | Casein kinase 1 (ck1 ) inhibitors |
| BR112014010563B1 (pt) | 2011-11-04 | 2021-01-12 | Jasco Pharmaceuticals, LLC | compostos inibidores da aminopirimidina quinase |
| EP3049086A4 (en) | 2013-09-27 | 2017-02-22 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| AU2014337044A1 (en) * | 2013-10-18 | 2016-05-05 | Dana-Farber Cancer Institute, Inc. | Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7) |
| LT3221306T (lt) * | 2014-11-20 | 2020-03-10 | Merck Patent Gmbh | Heteroarilo junginiai, kaip irak inhibitoriai ir jų panaudojimas |
| WO2016149756A1 (en) * | 2015-03-23 | 2016-09-29 | The University Of Melbourne | Treatment of respiratory diseases |
| RS62728B1 (sr) | 2015-08-04 | 2022-01-31 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | Derivat pirazol pirimidina i njegove upotrebe |
-
2018
- 2018-01-30 WO PCT/IL2018/050100 patent/WO2018142393A1/en not_active Ceased
- 2018-01-30 RU RU2019127038A patent/RU2761457C2/ru active
- 2018-01-30 AU AU2018215809A patent/AU2018215809B2/en not_active Ceased
- 2018-01-30 IL IL268128A patent/IL268128B2/en unknown
- 2018-01-30 JP JP2019561389A patent/JP7142646B2/ja not_active Expired - Fee Related
- 2018-01-30 NZ NZ755447A patent/NZ755447A/en unknown
- 2018-01-30 US US16/482,199 patent/US11072599B2/en active Active
- 2018-01-30 MX MX2019009083A patent/MX394556B/es unknown
- 2018-01-30 EP EP18705024.0A patent/EP3577108B1/en active Active
- 2018-01-30 ES ES18705024T patent/ES2902885T3/es active Active
- 2018-01-30 CN CN201880022829.8A patent/CN110475771B/zh not_active Expired - Fee Related
- 2018-01-30 KR KR1020197025024A patent/KR20190115017A/ko not_active Ceased
- 2018-01-30 TW TW107103255A patent/TW201837027A/zh unknown
- 2018-01-30 CA CA3052247A patent/CA3052247A1/en active Pending
- 2018-01-30 SG SG11201906681PA patent/SG11201906681PA/en unknown
-
2021
- 2021-07-26 US US17/384,922 patent/US11999721B2/en active Active
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