JP2020505350A5 - - Google Patents
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- Publication number
- JP2020505350A5 JP2020505350A5 JP2019538484A JP2019538484A JP2020505350A5 JP 2020505350 A5 JP2020505350 A5 JP 2020505350A5 JP 2019538484 A JP2019538484 A JP 2019538484A JP 2019538484 A JP2019538484 A JP 2019538484A JP 2020505350 A5 JP2020505350 A5 JP 2020505350A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- combination according
- acid sequence
- constant region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 102000003812 Interleukin-15 Human genes 0.000 claims description 24
- 108090000172 Interleukin-15 Proteins 0.000 claims description 24
- 150000001413 amino acids Chemical group 0.000 claims description 24
- 230000035772 mutation Effects 0.000 claims description 12
- AUXMWYRZQPIXCC-KNIFDHDWSA-N (2s)-2-amino-4-methylpentanoic acid;(2s)-2-aminopropanoic acid Chemical compound C[C@H](N)C(O)=O.CC(C)C[C@H](N)C(O)=O AUXMWYRZQPIXCC-KNIFDHDWSA-N 0.000 claims description 4
- 101001055157 Homo sapiens Interleukin-15 Proteins 0.000 claims description 4
- 102000056003 human IL15 Human genes 0.000 claims description 4
- PNBMXFUTFSFLNU-BXRBKJIMSA-N (2s)-2-aminobutanedioic acid;(2s)-2-aminopropanoic acid Chemical compound C[C@H](N)C(O)=O.OC(=O)[C@@H](N)CC(O)=O PNBMXFUTFSFLNU-BXRBKJIMSA-N 0.000 claims description 2
- 102000004556 Interleukin-15 Receptors Human genes 0.000 claims description 2
- 108010017535 Interleukin-15 Receptors Proteins 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 239000000833 heterodimer Substances 0.000 claims description 2
- 230000003442 weekly effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762448460P | 2017-01-20 | 2017-01-20 | |
| US62/448,460 | 2017-01-20 | ||
| PCT/IB2018/050348 WO2018134782A1 (en) | 2017-01-20 | 2018-01-19 | Combination therapy for the treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020505350A JP2020505350A (ja) | 2020-02-20 |
| JP2020505350A5 true JP2020505350A5 (OSRAM) | 2021-02-25 |
Family
ID=61168137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019538484A Ceased JP2020505350A (ja) | 2017-01-20 | 2018-01-19 | 癌の治療のための組合せ療法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20220356222A9 (OSRAM) |
| EP (1) | EP3570869A1 (OSRAM) |
| JP (1) | JP2020505350A (OSRAM) |
| KR (1) | KR20190105584A (OSRAM) |
| CN (1) | CN110177568A (OSRAM) |
| AU (2) | AU2018208883B2 (OSRAM) |
| CA (1) | CA3046120A1 (OSRAM) |
| IL (1) | IL266993A (OSRAM) |
| RU (1) | RU2019122408A (OSRAM) |
| WO (1) | WO2018134782A1 (OSRAM) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| JP2022512139A (ja) * | 2018-12-13 | 2022-02-02 | ジエンス ヘンルイ メデイシンカンパニー リミテッド | 腫瘍性疾患の治療のためのｐｄ－ｌ１抗体と組み合わせたｉｌ－１５タンパク質複合体の使用 |
| CN116574183A (zh) * | 2019-08-22 | 2023-08-11 | 盛禾(中国)生物制药有限公司 | 多功能抗体、其制备及其用途 |
| CA3168469A1 (en) * | 2020-02-05 | 2021-08-12 | Novartis Ag | Cho cell expressing il-15 heterodimers |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL71691A (en) | 1984-04-27 | 1991-04-15 | Yeda Res & Dev | Production of interferon-ypsilon |
| US6174666B1 (en) | 1992-03-27 | 2001-01-16 | The United States Of America As Represented By The Department Of Health And Human Services | Method of eliminating inhibitory/instability regions from mRNA |
| TW402639B (en) | 1992-12-03 | 2000-08-21 | Transkaryotic Therapies Inc | Protein production and protein delivery |
| US6569681B1 (en) | 2000-03-14 | 2003-05-27 | Transkaryotic Therapies, Inc. | Methods of improving homologous recombination |
| PL1899364T5 (pl) | 2005-05-17 | 2024-12-09 | University Of Connecticut | Kompozycje i sposoby immunomodulacji w organizmie |
| WO2007070488A2 (en) | 2005-12-12 | 2007-06-21 | The Cbr Institute For Biomedical Research, Inc. | Integrin alpha l i domain mutants with increased binding affinity |
| JP5709356B2 (ja) | 2006-01-13 | 2015-04-30 | アメリカ合衆国 | 哺乳動物細胞における発現のためのコドン最適化ＩＬ−１５およびＩＬ−１５Ｒ−α遺伝子 |
| CA2690825C (en) | 2007-05-11 | 2019-02-12 | Altor Bioscience Corporation | Fusion molecules and il-15 variants |
| KR101577849B1 (ko) | 2008-08-22 | 2015-12-15 | 마그나 시팅 인크. | 감소된 백래쉬를 갖는 디스크 리클라이너 |
| CN105017429B (zh) | 2010-09-21 | 2021-04-06 | 阿尔托生物科学有限公司 | 多聚体il-15可溶性融合分子与其制造与使用方法 |
| ES2747997T3 (es) * | 2012-10-24 | 2020-03-12 | Novartis Ag | Formas de IL-15R alfa, células que expresan formas de IL-15R alfa, y usos terapéuticos de IL-15R alfa y complejos IL-15/IL-15R alfa |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| EP3160498B1 (en) * | 2014-06-30 | 2021-10-06 | Altor BioScience Corporation | Il-15-based molecules and methods of use thereof |
| MX389663B (es) * | 2014-10-14 | 2025-03-20 | Novartis Ag | Moleculas de anticuerpo que se unen a pd-l1 y usos de las mismas. |
-
2018
- 2018-01-19 AU AU2018208883A patent/AU2018208883B2/en not_active Ceased
- 2018-01-19 EP EP18703630.6A patent/EP3570869A1/en not_active Withdrawn
- 2018-01-19 CN CN201880007116.4A patent/CN110177568A/zh active Pending
- 2018-01-19 CA CA3046120A patent/CA3046120A1/en active Pending
- 2018-01-19 US US16/479,089 patent/US20220356222A9/en not_active Abandoned
- 2018-01-19 RU RU2019122408A patent/RU2019122408A/ru unknown
- 2018-01-19 KR KR1020197020516A patent/KR20190105584A/ko not_active Ceased
- 2018-01-19 WO PCT/IB2018/050348 patent/WO2018134782A1/en not_active Ceased
- 2018-01-19 JP JP2019538484A patent/JP2020505350A/ja not_active Ceased
-
2019
- 2019-05-29 IL IL266993A patent/IL266993A/en unknown
-
2021
- 2021-05-04 AU AU2021202787A patent/AU2021202787A1/en not_active Abandoned
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