CA3046120A1 - Combination therapy for the treatment of cancer - Google Patents

Info

Publication number

CA3046120A1

CA3046120A1 CA3046120A CA3046120A CA3046120A1 CA 3046120 A1 CA3046120 A1 CA 3046120A1 CA 3046120 A CA3046120 A CA 3046120A CA 3046120 A CA3046120 A CA 3046120A CA 3046120 A1 CA3046120 A1 CA 3046120A1

Authority

CA

Canada

Prior art keywords

dose

complex

antibody molecule

seq

amino acid

Prior art date

2017-01-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 206010028980 Neoplasm Diseases 0.000 title claims abstract description 176
• 201000011510 cancer Diseases 0.000 title claims abstract description 101
• 238000011282 treatment Methods 0.000 title description 79
• 238000002648 combination therapy Methods 0.000 title description 13
• 102000003812 Interleukin-15 Human genes 0.000 claims abstract description 449
• 108090000172 Interleukin-15 Proteins 0.000 claims abstract description 449
• 238000000034 method Methods 0.000 claims description 126
• 150000001413 amino acids Chemical group 0.000 claims description 72
• 101001055157 Homo sapiens Interleukin-15 Proteins 0.000 claims description 30
• 102000056003 human IL15 Human genes 0.000 claims description 30
• 230000035772 mutation Effects 0.000 claims description 16
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 8
• 108010017535 Interleukin-15 Receptors Proteins 0.000 claims description 7
• 102000004556 Interleukin-15 Receptors Human genes 0.000 claims description 7
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 7
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 6
• 235000004279 alanine Nutrition 0.000 claims description 6
• DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims description 4
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 4
• ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims description 3
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 3
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims description 3
• DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims description 2
• 235000009582 asparagine Nutrition 0.000 claims description 2
• 229960001230 asparagine Drugs 0.000 claims description 2
• 229940009098 aspartate Drugs 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 63
• 150000007523 nucleic acids Chemical class 0.000 description 150
• 210000004027 cell Anatomy 0.000 description 126
• 125000003275 alpha amino acid group Chemical group 0.000 description 98
• 108090000765 processed proteins & peptides Proteins 0.000 description 96
• 102000004196 processed proteins & peptides Human genes 0.000 description 90
• 229920001184 polypeptide Polymers 0.000 description 86
• 102000039446 nucleic acids Human genes 0.000 description 81
• 108020004707 nucleic acids Proteins 0.000 description 81
• 235000001014 amino acid Nutrition 0.000 description 63
• 101001003140 Homo sapiens Interleukin-15 receptor subunit alpha Proteins 0.000 description 61
• 101100519207 Mus musculus Pdcd1 gene Proteins 0.000 description 61
• 108091028043 Nucleic acid sequence Proteins 0.000 description 61
• 229940024606 amino acid Drugs 0.000 description 59
• 238000006467 substitution reaction Methods 0.000 description 59
• 210000001744 T-lymphocyte Anatomy 0.000 description 52
• 125000003729 nucleotide group Chemical group 0.000 description 48
• 208000035475 disorder Diseases 0.000 description 46
• NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 description 45
• 239000002773 nucleotide Substances 0.000 description 45
• 239000000203 mixture Substances 0.000 description 44
• 238000003556 assay Methods 0.000 description 42
• 230000001404 mediated effect Effects 0.000 description 40
• 108090000623 proteins and genes Proteins 0.000 description 40
• 108010047041 Complementarity Determining Regions Proteins 0.000 description 39
• 230000036737 immune function Effects 0.000 description 36
• 238000002560 therapeutic procedure Methods 0.000 description 35
• 229950007213 spartalizumab Drugs 0.000 description 34
• 239000003795 chemical substances by application Substances 0.000 description 32
• 231100000371 dose-limiting toxicity Toxicity 0.000 description 31
• 230000000694 effects Effects 0.000 description 30
• 230000006870 function Effects 0.000 description 26
• 238000002965 ELISA Methods 0.000 description 25
• 102000004169 proteins and genes Human genes 0.000 description 25
• 230000004075 alteration Effects 0.000 description 24
• 230000007423 decrease Effects 0.000 description 24
• 230000014509 gene expression Effects 0.000 description 24
• 231100000682 maximum tolerated dose Toxicity 0.000 description 24
• 235000018102 proteins Nutrition 0.000 description 24
• 230000001965 increasing effect Effects 0.000 description 23
• 230000027455 binding Effects 0.000 description 21
• 230000028993 immune response Effects 0.000 description 21
• 239000003814 drug Substances 0.000 description 20
• 208000015181 infectious disease Diseases 0.000 description 20
• 210000000822 natural killer cell Anatomy 0.000 description 19
• 238000012217 deletion Methods 0.000 description 18
• 230000037430 deletion Effects 0.000 description 18
• 239000012634 fragment Substances 0.000 description 18
• 201000001441 melanoma Diseases 0.000 description 18
• 125000000539 amino acid group Chemical group 0.000 description 17
• 210000004698 lymphocyte Anatomy 0.000 description 17
• 102000005962 receptors Human genes 0.000 description 17
• 108020003175 receptors Proteins 0.000 description 17
• 230000001225 therapeutic effect Effects 0.000 description 17
• 238000001802 infusion Methods 0.000 description 16
• 239000003446 ligand Substances 0.000 description 16
• 230000035755 proliferation Effects 0.000 description 16
• 102000004127 Cytokines Human genes 0.000 description 15
• 108090000695 Cytokines Proteins 0.000 description 15
• 108010002350 Interleukin-2 Proteins 0.000 description 15
• 102000000588 Interleukin-2 Human genes 0.000 description 15
• 239000000427 antigen Substances 0.000 description 15
• 201000010099 disease Diseases 0.000 description 15
• 238000009396 hybridization Methods 0.000 description 15
• 208000002154 non-small cell lung carcinoma Diseases 0.000 description 15
• 241001529936 Murinae Species 0.000 description 14
• 108091007433 antigens Proteins 0.000 description 14
• 102000036639 antigens Human genes 0.000 description 14
• 239000008194 pharmaceutical composition Substances 0.000 description 14
• 108020004414 DNA Proteins 0.000 description 13
• 238000003776 cleavage reaction Methods 0.000 description 13
• 238000006206 glycosylation reaction Methods 0.000 description 13
• 238000007726 management method Methods 0.000 description 13
• 206010061289 metastatic neoplasm Diseases 0.000 description 13
• 108091033319 polynucleotide Proteins 0.000 description 13
• 102000040430 polynucleotide Human genes 0.000 description 13
• 239000002157 polynucleotide Substances 0.000 description 13
• 239000002243 precursor Substances 0.000 description 13
• 230000002265 prevention Effects 0.000 description 13
• 230000007017 scission Effects 0.000 description 13
• 208000035473 Communicable disease Diseases 0.000 description 12
• 230000009286 beneficial effect Effects 0.000 description 12
• 238000003780 insertion Methods 0.000 description 12
• 230000037431 insertion Effects 0.000 description 12
• 210000000265 leukocyte Anatomy 0.000 description 12
• 239000002609 medium Substances 0.000 description 12
• 230000019491 signal transduction Effects 0.000 description 12
• 239000013598 vector Substances 0.000 description 12
• 108010076504 Protein Sorting Signals Proteins 0.000 description 11
• 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 description 11
• 210000004899 c-terminal region Anatomy 0.000 description 11
• 230000013595 glycosylation Effects 0.000 description 11
• 230000001394 metastastic effect Effects 0.000 description 11
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 11
• 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 description 11
• 230000002411 adverse Effects 0.000 description 10
• 210000000612 antigen-presenting cell Anatomy 0.000 description 10
• -1 e.g. Proteins 0.000 description 10
• 230000002708 enhancing effect Effects 0.000 description 10
• 238000009472 formulation Methods 0.000 description 10
• 238000002347 injection Methods 0.000 description 10
• 239000007924 injection Substances 0.000 description 10
• 210000004962 mammalian cell Anatomy 0.000 description 10
• 230000002829 reductive effect Effects 0.000 description 10
• 230000004044 response Effects 0.000 description 10
• 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 description 9
• 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 description 9
• 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 description 9
• 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 description 9
• 206010060862 Prostate cancer Diseases 0.000 description 9
• 208000000236 Prostatic Neoplasms Diseases 0.000 description 9
• 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 description 9
• 238000002591 computed tomography Methods 0.000 description 9
• 230000012010 growth Effects 0.000 description 9
• 230000003463 hyperproliferative effect Effects 0.000 description 9
• 230000004083 survival effect Effects 0.000 description 9
• 229940124597 therapeutic agent Drugs 0.000 description 9
• 108010053727 Interleukin-15 Receptor alpha Subunit Proteins 0.000 description 8
• 108091005804 Peptidases Proteins 0.000 description 8
• 239000004365 Protease Substances 0.000 description 8
• 208000006265 Renal cell carcinoma Diseases 0.000 description 8
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 8
• 108700029229 Transcriptional Regulatory Elements Proteins 0.000 description 8
• 210000004369 blood Anatomy 0.000 description 8
• 239000008280 blood Substances 0.000 description 8
• 230000002401 inhibitory effect Effects 0.000 description 8
• 230000003902 lesion Effects 0.000 description 8
• 230000036210 malignancy Effects 0.000 description 8
• 210000000581 natural killer T-cell Anatomy 0.000 description 8
• 239000013642 negative control Substances 0.000 description 8
• 230000005855 radiation Effects 0.000 description 8
• 230000009467 reduction Effects 0.000 description 8
• 230000001105 regulatory effect Effects 0.000 description 8
• 208000024891 symptom Diseases 0.000 description 8
• 238000013518 transcription Methods 0.000 description 8
• 230000035897 transcription Effects 0.000 description 8
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 7
• 229940045513 CTLA4 antagonist Drugs 0.000 description 7
• 206010061598 Immunodeficiency Diseases 0.000 description 7
• 206010025327 Lymphopenia Diseases 0.000 description 7
• 206010035226 Plasma cell myeloma Diseases 0.000 description 7
• 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 description 7
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
• 239000002253 acid Substances 0.000 description 7
• 230000004913 activation Effects 0.000 description 7
• 210000004443 dendritic cell Anatomy 0.000 description 7
• 229940079593 drug Drugs 0.000 description 7
• 239000012636 effector Substances 0.000 description 7
• 238000003018 immunoassay Methods 0.000 description 7
• 239000003112 inhibitor Substances 0.000 description 7
• 230000005764 inhibitory process Effects 0.000 description 7
• 231100001023 lymphopenia Toxicity 0.000 description 7
• 238000004519 manufacturing process Methods 0.000 description 7
• 230000003285 pharmacodynamic effect Effects 0.000 description 7
• 229920000642 polymer Polymers 0.000 description 7
• 210000004881 tumor cell Anatomy 0.000 description 7
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
• 108010021064 CTLA-4 Antigen Proteins 0.000 description 6
• 102000008203 CTLA-4 Antigen Human genes 0.000 description 6
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
• 208000008839 Kidney Neoplasms Diseases 0.000 description 6
• 206010058467 Lung neoplasm malignant Diseases 0.000 description 6
• 241000699666 Mus <mouse, genus> Species 0.000 description 6
• 108091008874 T cell receptors Proteins 0.000 description 6
• 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 6
• 238000011374 additional therapy Methods 0.000 description 6
• 239000002671 adjuvant Substances 0.000 description 6
• 230000000259 anti-tumor effect Effects 0.000 description 6
• 230000006907 apoptotic process Effects 0.000 description 6
• 238000013459 approach Methods 0.000 description 6
• 210000003719 b-lymphocyte Anatomy 0.000 description 6
• 239000006143 cell culture medium Substances 0.000 description 6
• 238000001516 cell proliferation assay Methods 0.000 description 6
• 230000001684 chronic effect Effects 0.000 description 6
• 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 6
• 230000003993 interaction Effects 0.000 description 6
• 125000005647 linker group Chemical group 0.000 description 6
• 239000003550 marker Substances 0.000 description 6
• 244000052769 pathogen Species 0.000 description 6
• 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 6
• 238000009097 single-agent therapy Methods 0.000 description 6
• 239000000243 solution Substances 0.000 description 6
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 6
• 201000010000 Agranulocytosis Diseases 0.000 description 5
• 108010074708 B7-H1 Antigen Proteins 0.000 description 5
• 206010006187 Breast cancer Diseases 0.000 description 5
• 208000026310 Breast neoplasm Diseases 0.000 description 5
• 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 description 5
• 238000011510 Elispot assay Methods 0.000 description 5
• 101000867232 Escherichia coli Heat-stable enterotoxin II Proteins 0.000 description 5
• 206010018687 Granulocytopenia Diseases 0.000 description 5
• 208000029462 Immunodeficiency disease Diseases 0.000 description 5
• 206010038389 Renal cancer Diseases 0.000 description 5
• 238000007792 addition Methods 0.000 description 5
• 239000000654 additive Substances 0.000 description 5
• 230000000996 additive effect Effects 0.000 description 5
• 208000009956 adenocarcinoma Diseases 0.000 description 5
• 238000010171 animal model Methods 0.000 description 5
• 239000002246 antineoplastic agent Substances 0.000 description 5
• 230000004663 cell proliferation Effects 0.000 description 5
• 238000002512 chemotherapy Methods 0.000 description 5
• DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Natural products CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 5
• 230000003028 elevating effect Effects 0.000 description 5
• 231100000655 enterotoxin Toxicity 0.000 description 5
• 210000003630 histaminocyte Anatomy 0.000 description 5
• 239000012642 immune effector Substances 0.000 description 5
• 210000000987 immune system Anatomy 0.000 description 5
• 230000007813 immunodeficiency Effects 0.000 description 5
• 229940121354 immunomodulator Drugs 0.000 description 5
• 238000009169 immunotherapy Methods 0.000 description 5
• 238000000338 in vitro Methods 0.000 description 5
• 201000010982 kidney cancer Diseases 0.000 description 5
• 206010024378 leukocytosis Diseases 0.000 description 5
• 210000004185 liver Anatomy 0.000 description 5
• 201000007270 liver cancer Diseases 0.000 description 5
• 208000014018 liver neoplasm Diseases 0.000 description 5
• 201000005202 lung cancer Diseases 0.000 description 5
• 208000020816 lung neoplasm Diseases 0.000 description 5
• 210000002540 macrophage Anatomy 0.000 description 5
• 239000011159 matrix material Substances 0.000 description 5
• 210000003071 memory t lymphocyte Anatomy 0.000 description 5
• 208000037819 metastatic cancer Diseases 0.000 description 5
• 208000011575 metastatic malignant neoplasm Diseases 0.000 description 5
• 210000000440 neutrophil Anatomy 0.000 description 5
• 230000004768 organ dysfunction Effects 0.000 description 5
• 210000005259 peripheral blood Anatomy 0.000 description 5
• 239000011886 peripheral blood Substances 0.000 description 5
• 238000002360 preparation method Methods 0.000 description 5
• 238000001959 radiotherapy Methods 0.000 description 5
• 230000028327 secretion Effects 0.000 description 5
• 230000011664 signaling Effects 0.000 description 5
• 239000011780 sodium chloride Substances 0.000 description 5
• 150000003431 steroids Chemical class 0.000 description 5
• 238000001356 surgical procedure Methods 0.000 description 5
• 230000008685 targeting Effects 0.000 description 5
• 206010043554 thrombocytopenia Diseases 0.000 description 5
• 210000001519 tissue Anatomy 0.000 description 5
• 230000001988 toxicity Effects 0.000 description 5
• 231100000419 toxicity Toxicity 0.000 description 5
• 230000014616 translation Effects 0.000 description 5
• 230000003442 weekly effect Effects 0.000 description 5
• MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 4
• 201000009030 Carcinoma Diseases 0.000 description 4
• 108091026890 Coding region Proteins 0.000 description 4
• 108020004705 Codon Proteins 0.000 description 4
• 206010009944 Colon cancer Diseases 0.000 description 4
• 206010061818 Disease progression Diseases 0.000 description 4
• 102000004190 Enzymes Human genes 0.000 description 4
• 108090000790 Enzymes Proteins 0.000 description 4
• 102000037982 Immune checkpoint proteins Human genes 0.000 description 4
• 108091008036 Immune checkpoint proteins Proteins 0.000 description 4
• 102000003814 Interleukin-10 Human genes 0.000 description 4
• 108090000174 Interleukin-10 Proteins 0.000 description 4
• 206010025280 Lymphocytosis Diseases 0.000 description 4
• 241000124008 Mammalia Species 0.000 description 4
• 241001465754 Metazoa Species 0.000 description 4
• 208000034578 Multiple myelomas Diseases 0.000 description 4
• 230000004988 N-glycosylation Effects 0.000 description 4
• 206010061902 Pancreatic neoplasm Diseases 0.000 description 4
• 239000002202 Polyethylene glycol Substances 0.000 description 4
• 206010062237 Renal impairment Diseases 0.000 description 4
• 230000006044 T cell activation Effects 0.000 description 4
• MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 4
• 108010022394 Threonine synthase Proteins 0.000 description 4
• IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 4
• 102000009618 Transforming Growth Factors Human genes 0.000 description 4
• 108010009583 Transforming Growth Factors Proteins 0.000 description 4
• 241000700605 Viruses Species 0.000 description 4
• 206010052428 Wound Diseases 0.000 description 4
• 208000027418 Wounds and injury Diseases 0.000 description 4
• RJURFGZVJUQBHK-UHFFFAOYSA-N actinomycin D Natural products CC1OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)NC4C(=O)NC(C(N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-UHFFFAOYSA-N 0.000 description 4
• 230000004071 biological effect Effects 0.000 description 4
• 238000000749 co-immunoprecipitation Methods 0.000 description 4
• 208000029742 colonic neoplasm Diseases 0.000 description 4
• 230000021615 conjugation Effects 0.000 description 4
• 239000003246 corticosteroid Substances 0.000 description 4
• 229940127089 cytotoxic agent Drugs 0.000 description 4
• 102000004419 dihydrofolate reductase Human genes 0.000 description 4
• 230000005750 disease progression Effects 0.000 description 4
• 239000002552 dosage form Substances 0.000 description 4
• 239000003937 drug carrier Substances 0.000 description 4
• 229940088598 enzyme Drugs 0.000 description 4
• 108020001507 fusion proteins Proteins 0.000 description 4
• 102000037865 fusion proteins Human genes 0.000 description 4
• 210000002443 helper t lymphocyte Anatomy 0.000 description 4
• 239000000833 heterodimer Substances 0.000 description 4
• 230000016784 immunoglobulin production Effects 0.000 description 4
• 238000001727 in vivo Methods 0.000 description 4
• 230000001939 inductive effect Effects 0.000 description 4
• 230000000977 initiatory effect Effects 0.000 description 4
• 230000004073 interleukin-2 production Effects 0.000 description 4
• 230000005977 kidney dysfunction Effects 0.000 description 4
• 208000019423 liver disease Diseases 0.000 description 4
• 230000005976 liver dysfunction Effects 0.000 description 4
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 4
• 210000001806 memory b lymphocyte Anatomy 0.000 description 4
• 201000002528 pancreatic cancer Diseases 0.000 description 4
• 208000008443 pancreatic carcinoma Diseases 0.000 description 4
• 229960002621 pembrolizumab Drugs 0.000 description 4
• 210000004180 plasmocyte Anatomy 0.000 description 4
• 229920001223 polyethylene glycol Polymers 0.000 description 4
• 230000006641 stabilisation Effects 0.000 description 4
• 238000011105 stabilization Methods 0.000 description 4
• 230000002195 synergetic effect Effects 0.000 description 4
• 238000013519 translation Methods 0.000 description 4
• 229960005486 vaccine Drugs 0.000 description 4
• 102100025230 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial Human genes 0.000 description 3
• 108010087522 Aeromonas hydrophilia lipase-acyltransferase Proteins 0.000 description 3
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
• 208000017897 Carcinoma of esophagus Diseases 0.000 description 3
• 108010092160 Dactinomycin Proteins 0.000 description 3
• 208000000461 Esophageal Neoplasms Diseases 0.000 description 3
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
• 102000008070 Interferon-gamma Human genes 0.000 description 3
• 108010074328 Interferon-gamma Proteins 0.000 description 3
• 102000003815 Interleukin-11 Human genes 0.000 description 3
• 108090000177 Interleukin-11 Proteins 0.000 description 3
• 206010025323 Lymphomas Diseases 0.000 description 3
• 241000282560 Macaca mulatta Species 0.000 description 3
• NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 3
• 239000012270 PD-1 inhibitor Substances 0.000 description 3
• 239000012668 PD-1-inhibitor Substances 0.000 description 3
• 206010037660 Pyrexia Diseases 0.000 description 3
• 241000700157 Rattus norvegicus Species 0.000 description 3
• 208000015634 Rectal Neoplasms Diseases 0.000 description 3
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
• 206010039491 Sarcoma Diseases 0.000 description 3
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
• 208000000453 Skin Neoplasms Diseases 0.000 description 3
• 230000024932 T cell mediated immunity Effects 0.000 description 3
• 230000006052 T cell proliferation Effects 0.000 description 3
• AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 3
• 239000004473 Threonine Substances 0.000 description 3
• 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 description 3
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 3
• 230000002378 acidificating effect Effects 0.000 description 3
• NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 3
• 230000001093 anti-cancer Effects 0.000 description 3
• 230000005809 anti-tumor immunity Effects 0.000 description 3
• 238000011319 anticancer therapy Methods 0.000 description 3
• 230000030741 antigen processing and presentation Effects 0.000 description 3
• 230000008901 benefit Effects 0.000 description 3
• 238000001574 biopsy Methods 0.000 description 3
• 239000011575 calcium Substances 0.000 description 3
• 229910052791 calcium Inorganic materials 0.000 description 3
• 238000004113 cell culture Methods 0.000 description 3
• 230000005889 cellular cytotoxicity Effects 0.000 description 3
• 210000003169 central nervous system Anatomy 0.000 description 3
• 238000005119 centrifugation Methods 0.000 description 3
• 238000004587 chromatography analysis Methods 0.000 description 3
• 229960001334 corticosteroids Drugs 0.000 description 3
• 229940109239 creatinine Drugs 0.000 description 3
• 230000017188 evasion or tolerance of host immune response Effects 0.000 description 3
• 230000003394 haemopoietic effect Effects 0.000 description 3
• 208000014829 head and neck neoplasm Diseases 0.000 description 3
• 230000002489 hematologic effect Effects 0.000 description 3
• 230000002519 immonomodulatory effect Effects 0.000 description 3
• 238000010348 incorporation Methods 0.000 description 3
• 229960003130 interferon gamma Drugs 0.000 description 3
• 238000001990 intravenous administration Methods 0.000 description 3
• 238000002372 labelling Methods 0.000 description 3
• 208000032839 leukemia Diseases 0.000 description 3
• 239000007788 liquid Substances 0.000 description 3
• 210000004072 lung Anatomy 0.000 description 3
• 239000000463 material Substances 0.000 description 3
• 239000012528 membrane Substances 0.000 description 3
• 108020004999 messenger RNA Proteins 0.000 description 3
• 201000000050 myeloid neoplasm Diseases 0.000 description 3
• 210000003739 neck Anatomy 0.000 description 3
• 230000006654 negative regulation of apoptotic process Effects 0.000 description 3
• 229960003301 nivolumab Drugs 0.000 description 3
• 229940121655 pd-1 inhibitor Drugs 0.000 description 3
• 239000000546 pharmaceutical excipient Substances 0.000 description 3
• 230000036470 plasma concentration Effects 0.000 description 3
• 239000013612 plasmid Substances 0.000 description 3
• 230000001124 posttranscriptional effect Effects 0.000 description 3
• 230000002062 proliferating effect Effects 0.000 description 3
• 230000006337 proteolytic cleavage Effects 0.000 description 3
• 238000000746 purification Methods 0.000 description 3
• 230000002285 radioactive effect Effects 0.000 description 3
• 206010038038 rectal cancer Diseases 0.000 description 3
• 201000001275 rectum cancer Diseases 0.000 description 3
• 229960002052 salbutamol Drugs 0.000 description 3
• 210000002966 serum Anatomy 0.000 description 3
• 210000000813 small intestine Anatomy 0.000 description 3
• 241000894007 species Species 0.000 description 3
• 206010041823 squamous cell carcinoma Diseases 0.000 description 3
• 238000010561 standard procedure Methods 0.000 description 3
• 238000007920 subcutaneous administration Methods 0.000 description 3
• 239000000126 substance Substances 0.000 description 3
• 239000006228 supernatant Substances 0.000 description 3
• 239000000725 suspension Substances 0.000 description 3
• 230000009885 systemic effect Effects 0.000 description 3
• 230000004797 therapeutic response Effects 0.000 description 3
• 230000000699 topical effect Effects 0.000 description 3
• 230000009466 transformation Effects 0.000 description 3
• 208000022679 triple-negative breast carcinoma Diseases 0.000 description 3
• XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 description 2
• VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
• JTTIOYHBNXDJOD-UHFFFAOYSA-N 2,4,6-triaminopyrimidine Chemical compound NC1=CC(N)=NC(N)=N1 JTTIOYHBNXDJOD-UHFFFAOYSA-N 0.000 description 2
• IOOMXAQUNPWDLL-UHFFFAOYSA-N 2-[6-(diethylamino)-3-(diethyliminiumyl)-3h-xanthen-9-yl]-5-sulfobenzene-1-sulfonate Chemical group C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=C(S(O)(=O)=O)C=C1S([O-])(=O)=O IOOMXAQUNPWDLL-UHFFFAOYSA-N 0.000 description 2
• WOVKYSAHUYNSMH-RRKCRQDMSA-N 5-bromodeoxyuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(Br)=C1 WOVKYSAHUYNSMH-RRKCRQDMSA-N 0.000 description 2
• FVFVNNKYKYZTJU-UHFFFAOYSA-N 6-chloro-1,3,5-triazine-2,4-diamine Chemical compound NC1=NC(N)=NC(Cl)=N1 FVFVNNKYKYZTJU-UHFFFAOYSA-N 0.000 description 2
• 108091007505 ADAM17 Proteins 0.000 description 2
• 102000043279 ADAM17 Human genes 0.000 description 2
• 206010061424 Anal cancer Diseases 0.000 description 2
• 244000105975 Antidesma platyphyllum Species 0.000 description 2
• 208000007860 Anus Neoplasms Diseases 0.000 description 2
• 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 description 2
• 241000894006 Bacteria Species 0.000 description 2
• DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 2
• BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
• 206010005003 Bladder cancer Diseases 0.000 description 2
• 208000003174 Brain Neoplasms Diseases 0.000 description 2
• 206010008342 Cervix carcinoma Diseases 0.000 description 2
• 208000030808 Clear cell renal carcinoma Diseases 0.000 description 2
• 208000001333 Colorectal Neoplasms Diseases 0.000 description 2
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 2
• ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
• GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 2
• 108090001126 Furin Proteins 0.000 description 2
• 102100040004 Gamma-glutamylcyclotransferase Human genes 0.000 description 2
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
• 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 2
• 208000005176 Hepatitis C Diseases 0.000 description 2
• 241000238631 Hexapoda Species 0.000 description 2
• 241000282412 Homo Species 0.000 description 2
• 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 description 2
• 101000886680 Homo sapiens Gamma-glutamylcyclotransferase Proteins 0.000 description 2
• 101000746373 Homo sapiens Granulocyte-macrophage colony-stimulating factor Proteins 0.000 description 2
• 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 description 2
• 101000724418 Homo sapiens Neutral amino acid transporter B(0) Proteins 0.000 description 2
• 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 description 2
• 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 description 2
• 206010020772 Hypertension Diseases 0.000 description 2
• XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 2
• 108060003951 Immunoglobulin Proteins 0.000 description 2
• 102000013462 Interleukin-12 Human genes 0.000 description 2
• 108010065805 Interleukin-12 Proteins 0.000 description 2
• 108010002616 Interleukin-5 Proteins 0.000 description 2
• 102000000743 Interleukin-5 Human genes 0.000 description 2
• ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 2
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 2
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 2
• 102000003855 L-lactate dehydrogenase Human genes 0.000 description 2
• 108700023483 L-lactate dehydrogenases Proteins 0.000 description 2
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 2
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 2
• AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 2
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 2
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 2
• 241000713666 Lentivirus Species 0.000 description 2
• 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 description 2
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
• 239000004472 Lysine Substances 0.000 description 2
• 241000282553 Macaca Species 0.000 description 2
• 206010027476 Metastases Diseases 0.000 description 2
• 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 description 2
• 102100028267 Neutral amino acid transporter B(0) Human genes 0.000 description 2
• 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 2
• 108700026244 Open Reading Frames Proteins 0.000 description 2
• 206010033128 Ovarian cancer Diseases 0.000 description 2
• 206010061535 Ovarian neoplasm Diseases 0.000 description 2
• 101710173835 Penton protein Proteins 0.000 description 2
• 208000037581 Persistent Infection Diseases 0.000 description 2
• 206010057249 Phagocytosis Diseases 0.000 description 2
• 241000288906 Primates Species 0.000 description 2
• 206010040047 Sepsis Diseases 0.000 description 2
• 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 description 2
• 206010068771 Soft tissue neoplasm Diseases 0.000 description 2
• 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 description 2
• 230000005867 T cell response Effects 0.000 description 2
• 206010042971 T-cell lymphoma Diseases 0.000 description 2
• 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 description 2
• 208000024770 Thyroid neoplasm Diseases 0.000 description 2
• 238000008050 Total Bilirubin Reagent Methods 0.000 description 2
• GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 description 2
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 2
• VGQOVCHZGQWAOI-UHFFFAOYSA-N UNPD55612 Natural products N1C(O)C2CC(C=CC(N)=O)=CN2C(=O)C2=CC=C(C)C(O)=C12 VGQOVCHZGQWAOI-UHFFFAOYSA-N 0.000 description 2
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 2
• 208000002495 Uterine Neoplasms Diseases 0.000 description 2
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 2
• 208000036142 Viral infection Diseases 0.000 description 2
• RJURFGZVJUQBHK-IIXSONLDSA-N actinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-IIXSONLDSA-N 0.000 description 2
• 239000013543 active substance Substances 0.000 description 2
• 239000000556 agonist Substances 0.000 description 2
• 239000003708 ampul Substances 0.000 description 2
• 208000007502 anemia Diseases 0.000 description 2
• VGQOVCHZGQWAOI-HYUHUPJXSA-N anthramycin Chemical compound N1[C@@H](O)[C@@H]2CC(\C=C\C(N)=O)=CN2C(=O)C2=CC=C(C)C(O)=C12 VGQOVCHZGQWAOI-HYUHUPJXSA-N 0.000 description 2
• 239000002260 anti-inflammatory agent Substances 0.000 description 2
• 229940121363 anti-inflammatory agent Drugs 0.000 description 2
• 230000000692 anti-sense effect Effects 0.000 description 2
• 239000003443 antiviral agent Substances 0.000 description 2
• 201000011165 anus cancer Diseases 0.000 description 2
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
• IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 2
• 238000001815 biotherapy Methods 0.000 description 2
• 210000000481 breast Anatomy 0.000 description 2
• 238000002619 cancer immunotherapy Methods 0.000 description 2
• 230000003915 cell function Effects 0.000 description 2
• 230000006037 cell lysis Effects 0.000 description 2
• 230000003833 cell viability Effects 0.000 description 2
• 208000025997 central nervous system neoplasm Diseases 0.000 description 2
• 201000010881 cervical cancer Diseases 0.000 description 2
• 238000006243 chemical reaction Methods 0.000 description 2
• 230000000973 chemotherapeutic effect Effects 0.000 description 2
• 210000004978 chinese hamster ovary cell Anatomy 0.000 description 2
• 230000002759 chromosomal effect Effects 0.000 description 2
• 206010073251 clear cell renal cell carcinoma Diseases 0.000 description 2
• 210000001072 colon Anatomy 0.000 description 2
• 150000001875 compounds Chemical class 0.000 description 2
• 238000007796 conventional method Methods 0.000 description 2
• 230000000139 costimulatory effect Effects 0.000 description 2
• 230000001461 cytolytic effect Effects 0.000 description 2
• 239000002254 cytotoxic agent Substances 0.000 description 2
• 231100000599 cytotoxic agent Toxicity 0.000 description 2
• 230000001472 cytotoxic effect Effects 0.000 description 2
• 238000002784 cytotoxicity assay Methods 0.000 description 2
• 231100000263 cytotoxicity test Toxicity 0.000 description 2
• 229960000640 dactinomycin Drugs 0.000 description 2
• 230000003247 decreasing effect Effects 0.000 description 2
• 230000007123 defense Effects 0.000 description 2
• 230000002950 deficient Effects 0.000 description 2
• CFCUWKMKBJTWLW-UHFFFAOYSA-N deoliosyl-3C-alpha-L-digitoxosyl-MTM Natural products CC=1C(O)=C2C(O)=C3C(=O)C(OC4OC(C)C(O)C(OC5OC(C)C(O)C(OC6OC(C)C(O)C(C)(O)C6)C5)C4)C(C(OC)C(=O)C(O)C(C)O)CC3=CC2=CC=1OC(OC(C)C1O)CC1OC1CC(O)C(O)C(C)O1 CFCUWKMKBJTWLW-UHFFFAOYSA-N 0.000 description 2
• 230000001419 dependent effect Effects 0.000 description 2
• 238000003745 diagnosis Methods 0.000 description 2
• 238000004520 electroporation Methods 0.000 description 2
• 239000000839 emulsion Substances 0.000 description 2
• 230000002255 enzymatic effect Effects 0.000 description 2
• 238000003114 enzyme-linked immunosorbent spot assay Methods 0.000 description 2
• 230000003203 everyday effect Effects 0.000 description 2
• 238000007667 floating Methods 0.000 description 2
• 238000000684 flow cytometry Methods 0.000 description 2
• 238000001943 fluorescence-activated cell sorting Methods 0.000 description 2
• 229960002949 fluorouracil Drugs 0.000 description 2
• 238000013467 fragmentation Methods 0.000 description 2
• 238000006062 fragmentation reaction Methods 0.000 description 2
• 230000005714 functional activity Effects 0.000 description 2
• 230000004927 fusion Effects 0.000 description 2
• 230000002496 gastric effect Effects 0.000 description 2
• 238000001502 gel electrophoresis Methods 0.000 description 2
• 239000003862 glucocorticoid Substances 0.000 description 2
• 235000009424 haa Nutrition 0.000 description 2
• 210000003128 head Anatomy 0.000 description 2
• 201000000459 head and neck squamous cell carcinoma Diseases 0.000 description 2
• 208000019622 heart disease Diseases 0.000 description 2
• 208000006454 hepatitis Diseases 0.000 description 2
• 231100000283 hepatitis Toxicity 0.000 description 2
• 208000010710 hepatitis C virus infection Diseases 0.000 description 2
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 2
• 238000001794 hormone therapy Methods 0.000 description 2
• 102000048362 human PDCD1 Human genes 0.000 description 2
• JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
• 230000002209 hydrophobic effect Effects 0.000 description 2
• 230000007124 immune defense Effects 0.000 description 2
• 208000026278 immune system disease Diseases 0.000 description 2
• 230000036039 immunity Effects 0.000 description 2
• 102000018358 immunoglobulin Human genes 0.000 description 2
• 230000003259 immunoinhibitory effect Effects 0.000 description 2
• 230000001506 immunosuppresive effect Effects 0.000 description 2
• 230000001976 improved effect Effects 0.000 description 2
• 206010022000 influenza Diseases 0.000 description 2
• 230000010354 integration Effects 0.000 description 2
• 230000002601 intratumoral effect Effects 0.000 description 2
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 2
• 229960000310 isoleucine Drugs 0.000 description 2
• 230000002045 lasting effect Effects 0.000 description 2
• 230000000670 limiting effect Effects 0.000 description 2
• 238000012423 maintenance Methods 0.000 description 2
• 230000003211 malignant effect Effects 0.000 description 2
• 239000000594 mannitol Substances 0.000 description 2
• 238000005259 measurement Methods 0.000 description 2
• 230000007246 mechanism Effects 0.000 description 2
• 229960000485 methotrexate Drugs 0.000 description 2
• 238000000520 microinjection Methods 0.000 description 2
• CFCUWKMKBJTWLW-BKHRDMLASA-N mithramycin Chemical compound O([C@@H]1C[C@@H](O[C@H](C)[C@H]1O)OC=1C=C2C=C3C[C@H]([C@@H](C(=O)C3=C(O)C2=C(O)C=1C)O[C@@H]1O[C@H](C)[C@@H](O)[C@H](O[C@@H]2O[C@H](C)[C@H](O)[C@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@@](C)(O)C3)C2)C1)[C@H](OC)C(=O)[C@@H](O)[C@@H](C)O)[C@H]1C[C@@H](O)[C@H](O)[C@@H](C)O1 CFCUWKMKBJTWLW-BKHRDMLASA-N 0.000 description 2
• 229960004857 mitomycin Drugs 0.000 description 2
• 230000004048 modification Effects 0.000 description 2
• 238000012986 modification Methods 0.000 description 2
• 238000010369 molecular cloning Methods 0.000 description 2
• 208000004235 neutropenia Diseases 0.000 description 2
• 201000011330 nonpapillary renal cell carcinoma Diseases 0.000 description 2
• 210000000056 organ Anatomy 0.000 description 2
• 210000004789 organ system Anatomy 0.000 description 2
• 238000007911 parenteral administration Methods 0.000 description 2
• 230000037361 pathway Effects 0.000 description 2
• 210000005105 peripheral blood lymphocyte Anatomy 0.000 description 2
• 230000008782 phagocytosis Effects 0.000 description 2
• 210000003800 pharynx Anatomy 0.000 description 2
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 2
• ZJAOAACCNHFJAH-UHFFFAOYSA-N phosphonoformic acid Chemical compound OC(=O)P(O)(O)=O ZJAOAACCNHFJAH-UHFFFAOYSA-N 0.000 description 2
• 229960003171 plicamycin Drugs 0.000 description 2
• 239000000843 powder Substances 0.000 description 2
• 238000001556 precipitation Methods 0.000 description 2
• 229960004618 prednisone Drugs 0.000 description 2
• XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 2
• 230000008569 process Effects 0.000 description 2
• 230000002035 prolonged effect Effects 0.000 description 2
• 230000000069 prophylactic effect Effects 0.000 description 2
• AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 2
• 210000002307 prostate Anatomy 0.000 description 2
• 210000001938 protoplast Anatomy 0.000 description 2
• RXWNCPJZOCPEPQ-NVWDDTSBSA-N puromycin Chemical compound C1=CC(OC)=CC=C1C[C@H](N)C(=O)N[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(=C3N=C2)N(C)C)O[C@@H]1CO RXWNCPJZOCPEPQ-NVWDDTSBSA-N 0.000 description 2
• 238000011084 recovery Methods 0.000 description 2
• 210000003289 regulatory T cell Anatomy 0.000 description 2
• 238000011160 research Methods 0.000 description 2
• 239000012679 serum free medium Substances 0.000 description 2
• PCMORTLOPMLEFB-ONEGZZNKSA-N sinapic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC(OC)=C1O PCMORTLOPMLEFB-ONEGZZNKSA-N 0.000 description 2
• 210000003491 skin Anatomy 0.000 description 2
• 201000000849 skin cancer Diseases 0.000 description 2
• 150000003384 small molecules Chemical class 0.000 description 2
• DAEPDZWVDSPTHF-UHFFFAOYSA-M sodium pyruvate Chemical compound [Na+].CC(=O)C([O-])=O DAEPDZWVDSPTHF-UHFFFAOYSA-M 0.000 description 2
• 239000007787 solid Substances 0.000 description 2
• 230000010473 stable expression Effects 0.000 description 2
• 230000004936 stimulating effect Effects 0.000 description 2
• 230000000638 stimulation Effects 0.000 description 2
• 239000001797 sucrose acetate isobutyrate Substances 0.000 description 2
• 229940037128 systemic glucocorticoids Drugs 0.000 description 2
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 2
• 229960000195 terbutaline Drugs 0.000 description 2
• 229960003604 testosterone Drugs 0.000 description 2
• 229940104230 thymidine Drugs 0.000 description 2
• 231100000765 toxin Toxicity 0.000 description 2
• 239000003053 toxin Substances 0.000 description 2
• 108700012359 toxins Proteins 0.000 description 2
• 238000001890 transfection Methods 0.000 description 2
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
• 241000701161 unidentified adenovirus Species 0.000 description 2
• 241001430294 unidentified retrovirus Species 0.000 description 2
• 201000005112 urinary bladder cancer Diseases 0.000 description 2
• 206010046766 uterine cancer Diseases 0.000 description 2
• 239000004474 valine Substances 0.000 description 2
• 239000003981 vehicle Substances 0.000 description 2
• GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 2
• 229960002066 vinorelbine Drugs 0.000 description 2
• 230000009385 viral infection Effects 0.000 description 2
• 239000013603 viral vector Substances 0.000 description 2
• 238000005406 washing Methods 0.000 description 2
• 229960002555 zidovudine Drugs 0.000 description 2
• HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 description 2
• LJRDOKAZOAKLDU-UDXJMMFXSA-N (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-[(2r,3s,4r,5s)-5-[(1r,2r,3s,5r,6s)-3,5-diamino-2-[(2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric ac Chemical compound OS(O)(=O)=O.N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)O[C@@H]1CO LJRDOKAZOAKLDU-UDXJMMFXSA-N 0.000 description 1
• IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 description 1
• NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
• UBCHPRBFMUDMNC-UHFFFAOYSA-N 1-(1-adamantyl)ethanamine Chemical compound C1C(C2)CC3CC2CC1(C(N)C)C3 UBCHPRBFMUDMNC-UHFFFAOYSA-N 0.000 description 1
• 102000010400 1-phosphatidylinositol-3-kinase activity proteins Human genes 0.000 description 1
• JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
• UZOVYGYOLBIAJR-UHFFFAOYSA-N 4-isocyanato-4'-methyldiphenylmethane Chemical compound C1=CC(C)=CC=C1CC1=CC=C(N=C=O)C=C1 UZOVYGYOLBIAJR-UHFFFAOYSA-N 0.000 description 1
• LSLYOANBFKQKPT-DIFFPNOSSA-N 5-[(1r)-1-hydroxy-2-[[(2r)-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diol Chemical compound C([C@@H](C)NC[C@H](O)C=1C=C(O)C=C(O)C=1)C1=CC=C(O)C=C1 LSLYOANBFKQKPT-DIFFPNOSSA-N 0.000 description 1
• VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 description 1
• STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 description 1
• RTAPDZBZLSXHQQ-UHFFFAOYSA-N 8-methyl-3,7-dihydropurine-2,6-dione Chemical class N1C(=O)NC(=O)C2=C1N=C(C)N2 RTAPDZBZLSXHQQ-UHFFFAOYSA-N 0.000 description 1
• XGWFJBFNAQHLEF-UHFFFAOYSA-N 9-anthroic acid Chemical compound C1=CC=C2C(C(=O)O)=C(C=CC=C3)C3=CC2=C1 XGWFJBFNAQHLEF-UHFFFAOYSA-N 0.000 description 1
• 206010000830 Acute leukaemia Diseases 0.000 description 1
• 208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 1
• 208000014697 Acute lymphocytic leukaemia Diseases 0.000 description 1
• 208000031261 Acute myeloid leukaemia Diseases 0.000 description 1
• 206010001367 Adrenal insufficiency Diseases 0.000 description 1
• 102100035767 Adrenocortical dysplasia protein homolog Human genes 0.000 description 1
• 108010088751 Albumins Proteins 0.000 description 1
• 102000009027 Albumins Human genes 0.000 description 1
• 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
• 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
• 101100366892 Anopheles gambiae Stat gene Proteins 0.000 description 1
• 239000004475 Arginine Substances 0.000 description 1
• BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
• 208000023275 Autoimmune disease Diseases 0.000 description 1
• 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 1
• 208000003950 B-cell lymphoma Diseases 0.000 description 1
• 108010045634 B7 Antigens Proteins 0.000 description 1
• 102000005738 B7 Antigens Human genes 0.000 description 1
• 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 1
• 229940125431 BRAF inhibitor Drugs 0.000 description 1
• 208000035143 Bacterial infection Diseases 0.000 description 1
• 229940122361 Bisphosphonate Drugs 0.000 description 1
• 108010006654 Bleomycin Proteins 0.000 description 1
• 206010005949 Bone cancer Diseases 0.000 description 1
• 208000018084 Bone neoplasm Diseases 0.000 description 1
• 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
• 206010006143 Brain stem glioma Diseases 0.000 description 1
• VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 description 1
• 241000282465 Canis Species 0.000 description 1
• 208000009458 Carcinoma in Situ Diseases 0.000 description 1
• 208000020446 Cardiac disease Diseases 0.000 description 1
• 206010007559 Cardiac failure congestive Diseases 0.000 description 1
• 206010007953 Central nervous system lymphoma Diseases 0.000 description 1
• 241000282693 Cercopithecidae Species 0.000 description 1
• 208000000419 Chronic Hepatitis B Diseases 0.000 description 1
• 208000006154 Chronic hepatitis C Diseases 0.000 description 1
• 208000010833 Chronic myeloid leukaemia Diseases 0.000 description 1
• 208000032862 Clinical Deterioration Diseases 0.000 description 1
• 108091033380 Coding strand Proteins 0.000 description 1
• 208000028698 Cognitive impairment Diseases 0.000 description 1
• 108010069514 Cyclic Peptides Proteins 0.000 description 1
• 102000001189 Cyclic Peptides Human genes 0.000 description 1
• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
• 229930105110 Cyclosporin A Natural products 0.000 description 1
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
• 108010036949 Cyclosporine Proteins 0.000 description 1
• 101150074155 DHFR gene Proteins 0.000 description 1
• 229940123780 DNA topoisomerase I inhibitor Drugs 0.000 description 1
• MQJKPEGWNLWLTK-UHFFFAOYSA-N Dapsone Chemical compound C1=CC(N)=CC=C1S(=O)(=O)C1=CC=C(N)C=C1 MQJKPEGWNLWLTK-UHFFFAOYSA-N 0.000 description 1
• 206010012735 Diarrhoea Diseases 0.000 description 1
• 102100031111 Disintegrin and metalloproteinase domain-containing protein 17 Human genes 0.000 description 1
• 102100031250 Disks large-associated protein 1 Human genes 0.000 description 1
• 101100366894 Drosophila melanogaster Stat92E gene Proteins 0.000 description 1
• 101150029707 ERBB2 gene Proteins 0.000 description 1
• 206010014418 Electrolyte imbalance Diseases 0.000 description 1
• 241000196324 Embryophyta Species 0.000 description 1
• MBYXEBXZARTUSS-QLWBXOBMSA-N Emetamine Natural products O(C)c1c(OC)cc2c(c(C[C@@H]3[C@H](CC)CN4[C@H](c5c(cc(OC)c(OC)c5)CC4)C3)ncc2)c1 MBYXEBXZARTUSS-QLWBXOBMSA-N 0.000 description 1
• YQYJSBFKSSDGFO-UHFFFAOYSA-N Epihygromycin Natural products OC1C(O)C(C(=O)C)OC1OC(C(=C1)O)=CC=C1C=C(C)C(=O)NC1C(O)C(O)C2OCOC2C1O YQYJSBFKSSDGFO-UHFFFAOYSA-N 0.000 description 1
• 102100038595 Estrogen receptor Human genes 0.000 description 1
• 208000010201 Exanthema Diseases 0.000 description 1
• 206010015958 Eye pain Diseases 0.000 description 1
• 108091006020 Fc-tagged proteins Proteins 0.000 description 1
• 108700012941 GNRH1 Proteins 0.000 description 1
• 206010062878 Gastrooesophageal cancer Diseases 0.000 description 1
• 108010010803 Gelatin Proteins 0.000 description 1
• 241000224466 Giardia Species 0.000 description 1
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
• RJIVPOXLQFJRTG-LURJTMIESA-N Gly-Arg-Gly Chemical compound OC(=O)CNC(=O)[C@@H](NC(=O)CN)CCCN=C(N)N RJIVPOXLQFJRTG-LURJTMIESA-N 0.000 description 1
• 239000004471 Glycine Substances 0.000 description 1
• 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 description 1
• 108010026389 Gramicidin Proteins 0.000 description 1
• 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 1
• 102100039619 Granulocyte colony-stimulating factor Human genes 0.000 description 1
• 239000007995 HEPES buffer Substances 0.000 description 1
• 208000031886 HIV Infections Diseases 0.000 description 1
• 208000037357 HIV infectious disease Diseases 0.000 description 1
• 206010019280 Heart failures Diseases 0.000 description 1
• 102000001554 Hemoglobins Human genes 0.000 description 1
• 108010054147 Hemoglobins Proteins 0.000 description 1
• 208000032843 Hemorrhage Diseases 0.000 description 1
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
• 206010019799 Hepatitis viral Diseases 0.000 description 1
• 208000017604 Hodgkin disease Diseases 0.000 description 1
• 208000021519 Hodgkin lymphoma Diseases 0.000 description 1
• 208000010747 Hodgkins lymphoma Diseases 0.000 description 1
• 101000929940 Homo sapiens Adrenocortical dysplasia protein homolog Proteins 0.000 description 1
• 101000844784 Homo sapiens Disks large-associated protein 1 Proteins 0.000 description 1
• 206010020751 Hypersensitivity Diseases 0.000 description 1
• HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
• 229940076838 Immune checkpoint inhibitor Drugs 0.000 description 1
• 206010061218 Inflammation Diseases 0.000 description 1
• 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 description 1
• 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 description 1
• 102000014150 Interferons Human genes 0.000 description 1
• 108010050904 Interferons Proteins 0.000 description 1
• 108010066719 Interleukin Receptor Common gamma Subunit Proteins 0.000 description 1
• 102000018682 Interleukin Receptor Common gamma Subunit Human genes 0.000 description 1
• 108010038453 Interleukin-2 Receptors Proteins 0.000 description 1
• 102000010789 Interleukin-2 Receptors Human genes 0.000 description 1
• 230000004163 JAK-STAT signaling pathway Effects 0.000 description 1
• 208000007766 Kaposi sarcoma Diseases 0.000 description 1
• XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
• ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
• 229930182816 L-glutamine Natural products 0.000 description 1
• KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
• 241000222722 Leishmania <genus> Species 0.000 description 1
• NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
• 208000028018 Lymphocytic leukaemia Diseases 0.000 description 1
• 206010052178 Lymphocytic lymphoma Diseases 0.000 description 1
• 102000008072 Lymphokines Human genes 0.000 description 1
• 108010074338 Lymphokines Proteins 0.000 description 1
• 208000030289 Lymphoproliferative disease Diseases 0.000 description 1
• 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
• 102100028123 Macrophage colony-stimulating factor 1 Human genes 0.000 description 1
• 206010025671 Malignant melanoma stage IV Diseases 0.000 description 1
• 208000002030 Merkel cell carcinoma Diseases 0.000 description 1
• 206010027406 Mesothelioma Diseases 0.000 description 1
• 206010027480 Metastatic malignant melanoma Diseases 0.000 description 1
• FQISKWAFAHGMGT-SGJOWKDISA-M Methylprednisolone sodium succinate Chemical compound [Na+].C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(=O)CCC([O-])=O)CC[C@H]21 FQISKWAFAHGMGT-SGJOWKDISA-M 0.000 description 1
• 229930192392 Mitomycin Natural products 0.000 description 1
• UCHDWCPVSPXUMX-TZIWLTJVSA-N Montelukast Chemical compound CC(C)(O)C1=CC=CC=C1CC[C@H](C=1C=C(\C=C\C=2N=C3C=C(Cl)C=CC3=CC=2)C=CC=1)SCC1(CC(O)=O)CC1 UCHDWCPVSPXUMX-TZIWLTJVSA-N 0.000 description 1
• 241000699670 Mus sp. Species 0.000 description 1
• 229940121948 Muscarinic receptor antagonist Drugs 0.000 description 1
• 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 description 1
• 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 1
• GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
• 230000006042 NK cell recruitment Effects 0.000 description 1
• 206010028851 Necrosis Diseases 0.000 description 1
• 229930193140 Neomycin Natural products 0.000 description 1
• 108091005461 Nucleic proteins Chemical group 0.000 description 1
• 240000007594 Oryza sativa Species 0.000 description 1
• 235000007164 Oryza sativa Nutrition 0.000 description 1
• 108091007960 PI3Ks Proteins 0.000 description 1
• 229930012538 Paclitaxel Natural products 0.000 description 1
• 208000000821 Parathyroid Neoplasms Diseases 0.000 description 1
• 235000019483 Peanut oil Nutrition 0.000 description 1
• 229930182555 Penicillin Natural products 0.000 description 1
• JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
• 208000002471 Penile Neoplasms Diseases 0.000 description 1
• 206010034972 Photosensitivity reaction Diseases 0.000 description 1
• 108010004729 Phycoerythrin Proteins 0.000 description 1
• VQDBNKDJNJQRDG-UHFFFAOYSA-N Pirbuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=N1 VQDBNKDJNJQRDG-UHFFFAOYSA-N 0.000 description 1
• 208000007913 Pituitary Neoplasms Diseases 0.000 description 1
• 201000005746 Pituitary adenoma Diseases 0.000 description 1
• 206010061538 Pituitary tumour benign Diseases 0.000 description 1
• 206010035664 Pneumonia Diseases 0.000 description 1
• 206010035742 Pneumonitis Diseases 0.000 description 1
• 229920000805 Polyaspartic acid Polymers 0.000 description 1
• 239000004743 Polypropylene Substances 0.000 description 1
• 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 1
• 108010029485 Protein Isoforms Proteins 0.000 description 1
• 102000001708 Protein Isoforms Human genes 0.000 description 1
• 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
• 108091030071 RNAI Proteins 0.000 description 1
• 101000881112 Rattus norvegicus Dual specificity protein phosphatase 12 Proteins 0.000 description 1
• 108020004511 Recombinant DNA Proteins 0.000 description 1
• 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
• 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
• IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 description 1
• 108091028664 Ribonucleotide Proteins 0.000 description 1
• NCDNCNXCDXHOMX-UHFFFAOYSA-N Ritonavir Natural products C=1C=CC=CC=1CC(NC(=O)OCC=1SC=NC=1)C(O)CC(CC=1C=CC=CC=1)NC(=O)C(C(C)C)NC(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-UHFFFAOYSA-N 0.000 description 1
• 241000283984 Rodentia Species 0.000 description 1
• 238000011579 SCID mouse model Methods 0.000 description 1
• AUVVAXYIELKVAI-UHFFFAOYSA-N SJ000285215 Natural products N1CCC2=CC(OC)=C(OC)C=C2C1CC1CC2C3=CC(OC)=C(OC)C=C3CCN2CC1CC AUVVAXYIELKVAI-UHFFFAOYSA-N 0.000 description 1
• GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 description 1
• 102100023085 Serine/threonine-protein kinase mTOR Human genes 0.000 description 1
• 208000033749 Small cell carcinoma of the bladder Diseases 0.000 description 1
• 206010041067 Small cell lung cancer Diseases 0.000 description 1
• 208000021712 Soft tissue sarcoma Diseases 0.000 description 1
• 241000191967 Staphylococcus aureus Species 0.000 description 1
• 229920002472 Starch Polymers 0.000 description 1
• 208000005718 Stomach Neoplasms Diseases 0.000 description 1
• 229930006000 Sucrose Natural products 0.000 description 1
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
• 230000006043 T cell recruitment Effects 0.000 description 1
• 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 description 1
• 229940123237 Taxane Drugs 0.000 description 1
• BPEGJWRSRHCHSN-UHFFFAOYSA-N Temozolomide Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 description 1
• 208000024313 Testicular Neoplasms Diseases 0.000 description 1
• 206010057644 Testis cancer Diseases 0.000 description 1
• 108090000190 Thrombin Proteins 0.000 description 1
• 239000000365 Topoisomerase I Inhibitor Substances 0.000 description 1
• 229940122429 Tubulin inhibitor Drugs 0.000 description 1
• 108091005906 Type I transmembrane proteins Proteins 0.000 description 1
• GBOGMAARMMDZGR-UHFFFAOYSA-N UNPD149280 Natural products N1C(=O)C23OC(=O)C=CC(O)CCCC(C)CC=CC3C(O)C(=C)C(C)C2C1CC1=CC=CC=C1 GBOGMAARMMDZGR-UHFFFAOYSA-N 0.000 description 1
• 208000007814 Unstable Angina Diseases 0.000 description 1
• 208000023915 Ureteral Neoplasms Diseases 0.000 description 1
• 206010046458 Urethral neoplasms Diseases 0.000 description 1
• 241000700618 Vaccinia virus Species 0.000 description 1
• 206010046865 Vaccinia virus infection Diseases 0.000 description 1
• 201000003761 Vaginal carcinoma Diseases 0.000 description 1
• OIRDTQYFTABQOQ-UHTZMRCNSA-N Vidarabine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O OIRDTQYFTABQOQ-UHTZMRCNSA-N 0.000 description 1
• JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 description 1
• 229940122803 Vinca alkaloid Drugs 0.000 description 1
• 206010047700 Vomiting Diseases 0.000 description 1
• YEEZWCHGZNKEEK-UHFFFAOYSA-N Zafirlukast Chemical compound COC1=CC(C(=O)NS(=O)(=O)C=2C(=CC=CC=2)C)=CC=C1CC(C1=C2)=CN(C)C1=CC=C2NC(=O)OC1CCCC1 YEEZWCHGZNKEEK-UHFFFAOYSA-N 0.000 description 1
• 230000001594 aberrant effect Effects 0.000 description 1
• 230000021736 acetylation Effects 0.000 description 1
• 238000006640 acetylation reaction Methods 0.000 description 1
• 229960001138 acetylsalicylic acid Drugs 0.000 description 1
• 229960004150 aciclovir Drugs 0.000 description 1
• MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 description 1
• 229930183665 actinomycin Natural products 0.000 description 1
• 230000003213 activating effect Effects 0.000 description 1
• 239000012190 activator Substances 0.000 description 1
• 239000004480 active ingredient Substances 0.000 description 1
• 230000001154 acute effect Effects 0.000 description 1
• 206010000891 acute myocardial infarction Diseases 0.000 description 1
• 210000005006 adaptive immune system Anatomy 0.000 description 1
• 230000001464 adherent effect Effects 0.000 description 1
• 238000009098 adjuvant therapy Methods 0.000 description 1
• 208000024447 adrenal gland neoplasm Diseases 0.000 description 1
• 208000017515 adrenocortical insufficiency Diseases 0.000 description 1
• 238000001042 affinity chromatography Methods 0.000 description 1
• 125000000217 alkyl group Chemical group 0.000 description 1
• 229940100198 alkylating agent Drugs 0.000 description 1
• 239000002168 alkylating agent Substances 0.000 description 1
• DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 description 1
• 229960003805 amantadine Drugs 0.000 description 1
• 238000012870 ammonium sulfate precipitation Methods 0.000 description 1
• 230000003321 amplification Effects 0.000 description 1
• 239000002269 analeptic agent Substances 0.000 description 1
• 238000004458 analytical method Methods 0.000 description 1
• 210000004102 animal cell Anatomy 0.000 description 1
• 239000003957 anion exchange resin Substances 0.000 description 1
• 150000001450 anions Chemical class 0.000 description 1
• 208000022531 anorexia Diseases 0.000 description 1
• 239000005557 antagonist Substances 0.000 description 1
• MWPLVEDNUUSJAV-UHFFFAOYSA-N anthracene Chemical compound C1=CC=CC2=CC3=CC=CC=C3C=C21 MWPLVEDNUUSJAV-UHFFFAOYSA-N 0.000 description 1
• 229940045799 anthracyclines and related substance Drugs 0.000 description 1
• 239000003242 anti bacterial agent Substances 0.000 description 1
• 229940124675 anti-cancer drug Drugs 0.000 description 1
• 229940124650 anti-cancer therapies Drugs 0.000 description 1
• 230000001773 anti-convulsant effect Effects 0.000 description 1
• 230000001142 anti-diarrhea Effects 0.000 description 1
• 230000003474 anti-emetic effect Effects 0.000 description 1
• 230000000340 anti-metabolite Effects 0.000 description 1
• 229940044684 anti-microtubule agent Drugs 0.000 description 1
• 230000006023 anti-tumor response Effects 0.000 description 1
• 229940088710 antibiotic agent Drugs 0.000 description 1
• 230000005875 antibody response Effects 0.000 description 1
• 239000001961 anticonvulsive agent Substances 0.000 description 1
• 239000002111 antiemetic agent Substances 0.000 description 1
• 229960003965 antiepileptics Drugs 0.000 description 1
• 229940125715 antihistaminic agent Drugs 0.000 description 1
• 239000000739 antihistaminic agent Substances 0.000 description 1
• 239000013059 antihormonal agent Substances 0.000 description 1
• 239000003430 antimalarial agent Substances 0.000 description 1
• 229940100197 antimetabolite Drugs 0.000 description 1
• 239000002256 antimetabolite Substances 0.000 description 1
• 229940045719 antineoplastic alkylating agent nitrosoureas Drugs 0.000 description 1
• 230000005975 antitumor immune response Effects 0.000 description 1
• 210000000436 anus Anatomy 0.000 description 1
• 230000001640 apoptogenic effect Effects 0.000 description 1
• 238000003782 apoptosis assay Methods 0.000 description 1
• 239000008135 aqueous vehicle Substances 0.000 description 1
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
• 230000006793 arrhythmia Effects 0.000 description 1
• 206010003119 arrhythmia Diseases 0.000 description 1
• 210000004507 artificial chromosome Anatomy 0.000 description 1
• 125000003118 aryl group Chemical group 0.000 description 1
• 239000010425 asbestos Substances 0.000 description 1
• 235000003704 aspartic acid Nutrition 0.000 description 1
• 208000006673 asthma Diseases 0.000 description 1
• 230000001580 bacterial effect Effects 0.000 description 1
• 208000022362 bacterial infectious disease Diseases 0.000 description 1
• 210000000270 basal cell Anatomy 0.000 description 1
• 229940092705 beclomethasone Drugs 0.000 description 1
• NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 description 1
• 229940124748 beta 2 agonist Drugs 0.000 description 1
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
• 230000000975 bioactive effect Effects 0.000 description 1
• 230000033228 biological regulation Effects 0.000 description 1
• 230000015572 biosynthetic process Effects 0.000 description 1
• 150000004663 bisphosphonates Chemical class 0.000 description 1
• 210000003443 bladder cell Anatomy 0.000 description 1
• 230000000740 bleeding effect Effects 0.000 description 1
• 229960001561 bleomycin Drugs 0.000 description 1
• OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 description 1
• 230000000903 blocking effect Effects 0.000 description 1
• 230000036772 blood pressure Effects 0.000 description 1
• 210000001124 body fluid Anatomy 0.000 description 1
• 239000010839 body fluid Substances 0.000 description 1
• 230000036760 body temperature Effects 0.000 description 1
• RSIHSRDYCUFFLA-DYKIIFRCSA-N boldenone Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 RSIHSRDYCUFFLA-DYKIIFRCSA-N 0.000 description 1
• 238000006664 bond formation reaction Methods 0.000 description 1
• 238000010322 bone marrow transplantation Methods 0.000 description 1
• 238000002725 brachytherapy Methods 0.000 description 1
• 210000004958 brain cell Anatomy 0.000 description 1
• 229960004436 budesonide Drugs 0.000 description 1
• 230000000981 bystander Effects 0.000 description 1
• 238000004364 calculation method Methods 0.000 description 1
• 230000009702 cancer cell proliferation Effects 0.000 description 1
• 208000035269 cancer or benign tumor Diseases 0.000 description 1
• 239000002775 capsule Substances 0.000 description 1
• 239000000969 carrier Substances 0.000 description 1
• 239000003729 cation exchange resin Substances 0.000 description 1
• 230000010261 cell growth Effects 0.000 description 1
• 239000013592 cell lysate Substances 0.000 description 1
• 239000006285 cell suspension Substances 0.000 description 1
• 230000004700 cellular uptake Effects 0.000 description 1
• 208000019065 cervical carcinoma Diseases 0.000 description 1
• 210000003679 cervix uteri Anatomy 0.000 description 1
• NDAYQJDHGXTBJL-MWWSRJDJSA-N chembl557217 Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](NC=O)C(C)C)CC(C)C)C(=O)NCCO)=CNC2=C1 NDAYQJDHGXTBJL-MWWSRJDJSA-N 0.000 description 1
• BFPSDSIWYFKGBC-UHFFFAOYSA-N chlorotrianisene Chemical compound C1=CC(OC)=CC=C1C(Cl)=C(C=1C=CC(OC)=CC=1)C1=CC=C(OC)C=C1 BFPSDSIWYFKGBC-UHFFFAOYSA-N 0.000 description 1
• 239000000812 cholinergic antagonist Substances 0.000 description 1
• 238000011098 chromatofocusing Methods 0.000 description 1
• 208000024207 chronic leukemia Diseases 0.000 description 1
• 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 1
• 229960001265 ciclosporin Drugs 0.000 description 1
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 1
• 229960004316 cisplatin Drugs 0.000 description 1
• 208000009060 clear cell adenocarcinoma Diseases 0.000 description 1
• 238000010367 cloning Methods 0.000 description 1
• 238000012761 co-transfection Methods 0.000 description 1
• ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 1
• 208000010877 cognitive disease Diseases 0.000 description 1
• 230000002281 colonystimulating effect Effects 0.000 description 1
• 238000007398 colorimetric assay Methods 0.000 description 1
• 238000011284 combination treatment Methods 0.000 description 1
• 230000000295 complement effect Effects 0.000 description 1
• 239000002299 complementary DNA Substances 0.000 description 1
• 239000012141 concentrate Substances 0.000 description 1
• 239000000039 congener Substances 0.000 description 1
• 229940028617 conventional vaccine Drugs 0.000 description 1
• 229940111134 coxibs Drugs 0.000 description 1
• 238000007821 culture assay Methods 0.000 description 1
• 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 description 1
• 208000017763 cutaneous neuroendocrine carcinoma Diseases 0.000 description 1
• 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 description 1
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
• 235000018417 cysteine Nutrition 0.000 description 1
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 1
• GBOGMAARMMDZGR-TYHYBEHESA-N cytochalasin B Chemical compound C([C@H]1[C@@H]2[C@@H](C([C@@H](O)[C@@H]3/C=C/C[C@H](C)CCC[C@@H](O)/C=C/C(=O)O[C@@]23C(=O)N1)=C)C)C1=CC=CC=C1 GBOGMAARMMDZGR-TYHYBEHESA-N 0.000 description 1
• GBOGMAARMMDZGR-JREHFAHYSA-N cytochalasin B Natural products C[C@H]1CCC[C@@H](O)C=CC(=O)O[C@@]23[C@H](C=CC1)[C@H](O)C(=C)[C@@H](C)[C@@H]2[C@H](Cc4ccccc4)NC3=O GBOGMAARMMDZGR-JREHFAHYSA-N 0.000 description 1
• 230000016396 cytokine production Effects 0.000 description 1
• 102000003675 cytokine receptors Human genes 0.000 description 1
• 108010057085 cytokine receptors Proteins 0.000 description 1
• 230000009089 cytolysis Effects 0.000 description 1
• 230000001086 cytosolic effect Effects 0.000 description 1
• 231100000433 cytotoxic Toxicity 0.000 description 1
• 230000003013 cytotoxicity Effects 0.000 description 1
• 231100000135 cytotoxicity Toxicity 0.000 description 1
• 229960002465 dabrafenib Drugs 0.000 description 1
• BFSMGDJOXZAERB-UHFFFAOYSA-N dabrafenib Chemical compound S1C(C(C)(C)C)=NC(C=2C(=C(NS(=O)(=O)C=3C(=CC=CC=3F)F)C=CC=2)F)=C1C1=CC=NC(N)=N1 BFSMGDJOXZAERB-UHFFFAOYSA-N 0.000 description 1
• 229960000860 dapsone Drugs 0.000 description 1
• 229960000975 daunorubicin Drugs 0.000 description 1
• STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 description 1
• 206010061428 decreased appetite Diseases 0.000 description 1
• RSIHSRDYCUFFLA-UHFFFAOYSA-N dehydrotestosterone Natural products O=C1C=CC2(C)C3CCC(C)(C(CC4)O)C4C3CCC2=C1 RSIHSRDYCUFFLA-UHFFFAOYSA-N 0.000 description 1
• 238000000326 densiometry Methods 0.000 description 1
• 239000005547 deoxyribonucleotide Substances 0.000 description 1
• 125000002637 deoxyribonucleotide group Chemical group 0.000 description 1
• 238000013461 design Methods 0.000 description 1
• 238000011161 development Methods 0.000 description 1
• 239000008121 dextrose Substances 0.000 description 1
• 238000000502 dialysis Methods 0.000 description 1
• 229960001259 diclofenac Drugs 0.000 description 1
• DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 description 1
• 238000007865 diluting Methods 0.000 description 1
• 239000003085 diluting agent Substances 0.000 description 1
• 238000010790 dilution Methods 0.000 description 1
• 239000012895 dilution Substances 0.000 description 1
• 230000008034 disappearance Effects 0.000 description 1
• 239000002270 dispersing agent Substances 0.000 description 1
• 239000003534 dna topoisomerase inhibitor Substances 0.000 description 1
• 231100000673 dose–response relationship Toxicity 0.000 description 1
• 229960004679 doxorubicin Drugs 0.000 description 1
• 239000003596 drug target Substances 0.000 description 1
• 230000009977 dual effect Effects 0.000 description 1
• 210000003162 effector t lymphocyte Anatomy 0.000 description 1
• AUVVAXYIELKVAI-CKBKHPSWSA-N emetine Chemical compound N1CCC2=CC(OC)=C(OC)C=C2[C@H]1C[C@H]1C[C@H]2C3=CC(OC)=C(OC)C=C3CCN2C[C@@H]1CC AUVVAXYIELKVAI-CKBKHPSWSA-N 0.000 description 1
• 229960002694 emetine Drugs 0.000 description 1
• AUVVAXYIELKVAI-UWBTVBNJSA-N emetine Natural products N1CCC2=CC(OC)=C(OC)C=C2[C@H]1C[C@H]1C[C@H]2C3=CC(OC)=C(OC)C=C3CCN2C[C@H]1CC AUVVAXYIELKVAI-UWBTVBNJSA-N 0.000 description 1
• 239000003995 emulsifying agent Substances 0.000 description 1
• 230000002124 endocrine Effects 0.000 description 1
• 210000000750 endocrine system Anatomy 0.000 description 1
• 201000003914 endometrial carcinoma Diseases 0.000 description 1
• 238000005516 engineering process Methods 0.000 description 1
• 230000008029 eradication Effects 0.000 description 1
• 230000000925 erythroid effect Effects 0.000 description 1
• 229960003276 erythromycin Drugs 0.000 description 1
• 210000003238 esophagus Anatomy 0.000 description 1
• 239000003797 essential amino acid Substances 0.000 description 1
• 235000020776 essential amino acid Nutrition 0.000 description 1
• 108010038795 estrogen receptors Proteins 0.000 description 1
• 238000012869 ethanol precipitation Methods 0.000 description 1
• VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 description 1
• 229960005420 etoposide Drugs 0.000 description 1
• 238000011156 evaluation Methods 0.000 description 1
• 201000005884 exanthem Diseases 0.000 description 1
• 230000007717 exclusion Effects 0.000 description 1
• 239000013604 expression vector Substances 0.000 description 1
• 201000001343 fallopian tube carcinoma Diseases 0.000 description 1
• 208000015700 familial long QT syndrome Diseases 0.000 description 1
• 229960001022 fenoterol Drugs 0.000 description 1
• 239000012091 fetal bovine serum Substances 0.000 description 1
• 235000013312 flour Nutrition 0.000 description 1
• 229960000676 flunisolide Drugs 0.000 description 1
• MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
• 229960002714 fluticasone Drugs 0.000 description 1
• MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 description 1
• VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 description 1
• 235000008191 folinic acid Nutrition 0.000 description 1
• 239000011672 folinic acid Substances 0.000 description 1
• 229960002848 formoterol Drugs 0.000 description 1
• BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 description 1
• 229960005102 foscarnet Drugs 0.000 description 1
• 238000005194 fractionation Methods 0.000 description 1
• 230000037433 frameshift Effects 0.000 description 1
• 229960002963 ganciclovir Drugs 0.000 description 1
• IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 description 1
• 206010017758 gastric cancer Diseases 0.000 description 1
• 201000006974 gastroesophageal cancer Diseases 0.000 description 1
• 239000000499 gel Substances 0.000 description 1
• 239000008273 gelatin Substances 0.000 description 1
• 229920000159 gelatin Polymers 0.000 description 1
• 235000019322 gelatine Nutrition 0.000 description 1
• 235000011852 gelatine desserts Nutrition 0.000 description 1
• 238000002523 gelfiltration Methods 0.000 description 1
• SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 description 1
• 229960005277 gemcitabine Drugs 0.000 description 1
• 230000009368 gene silencing by RNA Effects 0.000 description 1
• 238000010363 gene targeting Methods 0.000 description 1
• 238000001415 gene therapy Methods 0.000 description 1
• 210000004392 genitalia Anatomy 0.000 description 1
• 239000008103 glucose Substances 0.000 description 1
• 235000013922 glutamic acid Nutrition 0.000 description 1
• 239000004220 glutamic acid Substances 0.000 description 1
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
• YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 1
• SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
• 239000003102 growth factor Substances 0.000 description 1
• 201000010536 head and neck cancer Diseases 0.000 description 1
• 230000004217 heart function Effects 0.000 description 1
• 239000003481 heat shock protein 90 inhibitor Substances 0.000 description 1
• 229960002897 heparin Drugs 0.000 description 1
• 229920000669 heparin Polymers 0.000 description 1
• 208000002672 hepatitis B Diseases 0.000 description 1
• 230000003118 histopathologic effect Effects 0.000 description 1
• 229940088597 hormone Drugs 0.000 description 1
• 239000005556 hormone Substances 0.000 description 1
• 102000052224 human IL15RA Human genes 0.000 description 1
• 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 1
• 230000028996 humoral immune response Effects 0.000 description 1
• 230000008348 humoral response Effects 0.000 description 1
• 210000004408 hybridoma Anatomy 0.000 description 1
• 229960000890 hydrocortisone Drugs 0.000 description 1
• WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
• XXSMGPRMXLTPCZ-UHFFFAOYSA-N hydroxychloroquine Chemical compound ClC1=CC=C2C(NC(C)CCCN(CCO)CC)=CC=NC2=C1 XXSMGPRMXLTPCZ-UHFFFAOYSA-N 0.000 description 1
• 229960004171 hydroxychloroquine Drugs 0.000 description 1
• 238000012872 hydroxylapatite chromatography Methods 0.000 description 1
• 229960001680 ibuprofen Drugs 0.000 description 1
• 229960004716 idoxuridine Drugs 0.000 description 1
• 229960001101 ifosfamide Drugs 0.000 description 1
• HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 description 1
• 210000001822 immobilized cell Anatomy 0.000 description 1
• 230000008004 immune attack Effects 0.000 description 1
• 230000001900 immune effect Effects 0.000 description 1
• 230000008629 immune suppression Effects 0.000 description 1
• 239000012274 immune-checkpoint protein inhibitor Substances 0.000 description 1
• 231100001158 immune-related toxicity Toxicity 0.000 description 1
• 230000000984 immunochemical effect Effects 0.000 description 1
• 230000005847 immunogenicity Effects 0.000 description 1
• 230000001771 impaired effect Effects 0.000 description 1
• 230000006872 improvement Effects 0.000 description 1
• 201000004933 in situ carcinoma Diseases 0.000 description 1
• 238000011065 in-situ storage Methods 0.000 description 1
• 229960001936 indinavir Drugs 0.000 description 1
• CBVCZFGXHXORBI-PXQQMZJSSA-N indinavir Chemical compound C([C@H](N(CC1)C[C@@H](O)C[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H]2C3=CC=CC=C3C[C@H]2O)C(=O)NC(C)(C)C)N1CC1=CC=CN=C1 CBVCZFGXHXORBI-PXQQMZJSSA-N 0.000 description 1
• 230000006698 induction Effects 0.000 description 1
• 230000004054 inflammatory process Effects 0.000 description 1
• 239000004615 ingredient Substances 0.000 description 1
• 210000005007 innate immune system Anatomy 0.000 description 1
• 238000007689 inspection Methods 0.000 description 1
• 238000009434 installation Methods 0.000 description 1
• 239000000138 intercalating agent Substances 0.000 description 1
• 230000002452 interceptive effect Effects 0.000 description 1
• 229940079322 interferon Drugs 0.000 description 1
• 108040002039 interleukin-15 receptor activity proteins Proteins 0.000 description 1
• 102000008616 interleukin-15 receptor activity proteins Human genes 0.000 description 1
• 230000003834 intracellular effect Effects 0.000 description 1
• 238000007918 intramuscular administration Methods 0.000 description 1
• 238000005342 ion exchange Methods 0.000 description 1
• 229960005386 ipilimumab Drugs 0.000 description 1
• 229960001361 ipratropium bromide Drugs 0.000 description 1
• KEWHKYJURDBRMN-ZEODDXGYSA-M ipratropium bromide hydrate Chemical compound O.[Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 KEWHKYJURDBRMN-ZEODDXGYSA-M 0.000 description 1
• UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 description 1
• 238000002955 isolation Methods 0.000 description 1
• 230000002147 killing effect Effects 0.000 description 1
• 239000008101 lactose Substances 0.000 description 1
• 229960000681 leflunomide Drugs 0.000 description 1
• VHOGYURTWQBHIL-UHFFFAOYSA-N leflunomide Chemical compound O1N=CC(C(=O)NC=2C=CC(=CC=2)C(F)(F)F)=C1C VHOGYURTWQBHIL-UHFFFAOYSA-N 0.000 description 1
• 229960001691 leucovorin Drugs 0.000 description 1
• 201000002364 leukopenia Diseases 0.000 description 1
• 231100001022 leukopenia Toxicity 0.000 description 1
• 239000003199 leukotriene receptor blocking agent Substances 0.000 description 1
• 229960004194 lidocaine Drugs 0.000 description 1
• 238000000670 ligand binding assay Methods 0.000 description 1
• 230000029226 lipidation Effects 0.000 description 1
• 230000007774 longterm Effects 0.000 description 1
• 201000005296 lung carcinoma Diseases 0.000 description 1
• RVFGKBWWUQOIOU-NDEPHWFRSA-N lurtotecan Chemical compound O=C([C@]1(O)CC)OCC(C(N2CC3=4)=O)=C1C=C2C3=NC1=CC=2OCCOC=2C=C1C=4CN1CCN(C)CC1 RVFGKBWWUQOIOU-NDEPHWFRSA-N 0.000 description 1
• 210000004324 lymphatic system Anatomy 0.000 description 1
• 208000003747 lymphoid leukemia Diseases 0.000 description 1
• 239000008176 lyophilized powder Substances 0.000 description 1
• 201000004792 malaria Diseases 0.000 description 1
• 208000026037 malignant tumor of neck Diseases 0.000 description 1
• 238000001254 matrix assisted laser desorption--ionisation time-of-flight mass spectrum Methods 0.000 description 1
• 238000002483 medication Methods 0.000 description 1
• 230000002503 metabolic effect Effects 0.000 description 1
• LMOINURANNBYCM-UHFFFAOYSA-N metaproterenol Chemical compound CC(C)NCC(O)C1=CC(O)=CC(O)=C1 LMOINURANNBYCM-UHFFFAOYSA-N 0.000 description 1
• 208000011645 metastatic carcinoma Diseases 0.000 description 1
• 208000021039 metastatic melanoma Diseases 0.000 description 1
• 229930182817 methionine Natural products 0.000 description 1
• 229960004584 methylprednisolone Drugs 0.000 description 1
• 244000005700 microbiome Species 0.000 description 1
• 238000013508 migration Methods 0.000 description 1
• 230000005012 migration Effects 0.000 description 1
• 235000010446 mineral oil Nutrition 0.000 description 1
• 239000002480 mineral oil Substances 0.000 description 1
• 230000000394 mitotic effect Effects 0.000 description 1
• 229960001156 mitoxantrone Drugs 0.000 description 1
• KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 description 1
• 210000001616 monocyte Anatomy 0.000 description 1
• 239000000178 monomer Substances 0.000 description 1
• 229960005127 montelukast Drugs 0.000 description 1
• 238000010172 mouse model Methods 0.000 description 1
• 210000000214 mouth Anatomy 0.000 description 1
• 208000025113 myeloid leukemia Diseases 0.000 description 1
• 230000017074 necrotic cell death Effects 0.000 description 1
• 230000001338 necrotic effect Effects 0.000 description 1
• 230000017066 negative regulation of growth Effects 0.000 description 1
• 238000009099 neoadjuvant therapy Methods 0.000 description 1
• 229960004927 neomycin Drugs 0.000 description 1
• 210000003061 neural cell Anatomy 0.000 description 1
• 230000001537 neural effect Effects 0.000 description 1
• 210000004498 neuroglial cell Anatomy 0.000 description 1
• PGSADBUBUOPOJS-UHFFFAOYSA-N neutral red Chemical compound Cl.C1=C(C)C(N)=CC2=NC3=CC(N(C)C)=CC=C3N=C21 PGSADBUBUOPOJS-UHFFFAOYSA-N 0.000 description 1
• 231100000062 no-observed-adverse-effect level Toxicity 0.000 description 1
• 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
• 238000003199 nucleic acid amplification method Methods 0.000 description 1
• 238000007899 nucleic acid hybridization Methods 0.000 description 1
• 239000002777 nucleoside Substances 0.000 description 1
• 150000003833 nucleoside derivatives Chemical class 0.000 description 1
• 239000003921 oil Substances 0.000 description 1
• 235000019198 oils Nutrition 0.000 description 1
• 238000002515 oligonucleotide synthesis Methods 0.000 description 1
• 231100000590 oncogenic Toxicity 0.000 description 1
• 230000002246 oncogenic effect Effects 0.000 description 1
• 230000014207 opsonization Effects 0.000 description 1
• 238000011369 optimal treatment Methods 0.000 description 1
• 229960002657 orciprenaline Drugs 0.000 description 1
• 230000002611 ovarian Effects 0.000 description 1
• DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 description 1
• 229960001756 oxaliplatin Drugs 0.000 description 1
• 229960001609 oxitropium bromide Drugs 0.000 description 1
• LCELQERNWLBPSY-KHSTUMNDSA-M oxitropium bromide Chemical compound [Br-].C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3[N+]([C@H](C2)[C@@H]2[C@H]3O2)(C)CC)=CC=CC=C1 LCELQERNWLBPSY-KHSTUMNDSA-M 0.000 description 1
• 239000006179 pH buffering agent Substances 0.000 description 1
• 229960001592 paclitaxel Drugs 0.000 description 1
• 229940124641 pain reliever Drugs 0.000 description 1
• 210000000496 pancreas Anatomy 0.000 description 1
• 210000002990 parathyroid gland Anatomy 0.000 description 1
• 230000001575 pathological effect Effects 0.000 description 1
• 239000000312 peanut oil Substances 0.000 description 1
• 229960001639 penicillamine Drugs 0.000 description 1
• 229940049954 penicillin Drugs 0.000 description 1
• 239000000816 peptidomimetic Substances 0.000 description 1
• 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 1
• 210000001322 periplasm Anatomy 0.000 description 1
• 239000003208 petroleum Substances 0.000 description 1
• 210000001539 phagocyte Anatomy 0.000 description 1
• 229940124531 pharmaceutical excipient Drugs 0.000 description 1
• 230000000144 pharmacologic effect Effects 0.000 description 1
• 230000026731 phosphorylation Effects 0.000 description 1
• 238000006366 phosphorylation reaction Methods 0.000 description 1
• 230000036211 photosensitivity Effects 0.000 description 1
• 239000006187 pill Substances 0.000 description 1
• 229960005414 pirbuterol Drugs 0.000 description 1
• 208000021310 pituitary gland adenoma Diseases 0.000 description 1
• 230000010287 polarization Effects 0.000 description 1
• 108010064470 polyaspartate Proteins 0.000 description 1
• 238000006116 polymerization reaction Methods 0.000 description 1
• 229920001155 polypropylene Polymers 0.000 description 1
• 208000017805 post-transplant lymphoproliferative disease Diseases 0.000 description 1
• 230000003389 potentiating effect Effects 0.000 description 1
• 229960005205 prednisolone Drugs 0.000 description 1
• OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
• 230000035935 pregnancy Effects 0.000 description 1
• 239000003755 preservative agent Substances 0.000 description 1
• 230000002335 preservative effect Effects 0.000 description 1
• 208000016800 primary central nervous system lymphoma Diseases 0.000 description 1
• 210000001948 pro-b lymphocyte Anatomy 0.000 description 1
• 229960004919 procaine Drugs 0.000 description 1
• MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
• 238000012545 processing Methods 0.000 description 1
• 239000000047 product Substances 0.000 description 1
• 102000003998 progesterone receptors Human genes 0.000 description 1
• 108090000468 progesterone receptors Proteins 0.000 description 1
• 229960003712 propranolol Drugs 0.000 description 1
• QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
• 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
• 201000005825 prostate adenocarcinoma Diseases 0.000 description 1
• 238000001742 protein purification Methods 0.000 description 1
• 208000020016 psychiatric disease Diseases 0.000 description 1
• 238000009613 pulmonary function test Methods 0.000 description 1
• 229950010131 puromycin Drugs 0.000 description 1
• MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 description 1
• 206010037844 rash Diseases 0.000 description 1
• 238000001525 receptor binding assay Methods 0.000 description 1
• 238000010188 recombinant method Methods 0.000 description 1
• 230000000306 recurrent effect Effects 0.000 description 1
• 238000004064 recycling Methods 0.000 description 1
• 208000016691 refractory malignant neoplasm Diseases 0.000 description 1
• 201000007444 renal pelvis carcinoma Diseases 0.000 description 1
• 238000004007 reversed phase HPLC Methods 0.000 description 1
• 238000012552 review Methods 0.000 description 1
• 229960000329 ribavirin Drugs 0.000 description 1
• HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 description 1
• 239000002336 ribonucleotide Substances 0.000 description 1
• 125000002652 ribonucleotide group Chemical group 0.000 description 1
• 235000009566 rice Nutrition 0.000 description 1
• 229910052895 riebeckite Inorganic materials 0.000 description 1
• 229960000888 rimantadine Drugs 0.000 description 1
• 229960000311 ritonavir Drugs 0.000 description 1
• NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 description 1
• 231100000279 safety data Toxicity 0.000 description 1
• 229960004017 salmeterol Drugs 0.000 description 1
• 229960001852 saquinavir Drugs 0.000 description 1
• QWAXKHKRTORLEM-UGJKXSETSA-N saquinavir Chemical compound C([C@@H]([C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)C=1N=C2C=CC=CC2=CC=1)C1=CC=CC=C1 QWAXKHKRTORLEM-UGJKXSETSA-N 0.000 description 1
• 238000012216 screening Methods 0.000 description 1
• 239000006152 selective media Substances 0.000 description 1
• 239000008159 sesame oil Substances 0.000 description 1
• 235000011803 sesame oil Nutrition 0.000 description 1
• 239000000741 silica gel Substances 0.000 description 1
• 229910002027 silica gel Inorganic materials 0.000 description 1
• 239000000377 silicon dioxide Substances 0.000 description 1
• PCMORTLOPMLEFB-UHFFFAOYSA-N sinapinic acid Natural products COC1=CC(C=CC(O)=O)=CC(OC)=C1O PCMORTLOPMLEFB-UHFFFAOYSA-N 0.000 description 1
• 235000020183 skimmed milk Nutrition 0.000 description 1
• 208000000587 small cell lung carcinoma Diseases 0.000 description 1
• 239000001509 sodium citrate Substances 0.000 description 1
• NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
• 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
• RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
• 239000001488 sodium phosphate Substances 0.000 description 1
• 229910000162 sodium phosphate Inorganic materials 0.000 description 1
• 229940054269 sodium pyruvate Drugs 0.000 description 1
• 239000003549 soybean oil Substances 0.000 description 1
• 235000012424 soybean oil Nutrition 0.000 description 1
• 230000009870 specific binding Effects 0.000 description 1
• 208000017572 squamous cell neoplasm Diseases 0.000 description 1
• 239000003381 stabilizer Substances 0.000 description 1
• 230000000087 stabilizing effect Effects 0.000 description 1
• 238000010186 staining Methods 0.000 description 1
• 239000008107 starch Substances 0.000 description 1
• 235000019698 starch Nutrition 0.000 description 1
• 239000008227 sterile water for injection Substances 0.000 description 1
• 238000003756 stirring Methods 0.000 description 1
• 201000011549 stomach cancer Diseases 0.000 description 1
• 201000009032 substance abuse Diseases 0.000 description 1
• 231100000736 substance abuse Toxicity 0.000 description 1
• 208000011117 substance-related disease Diseases 0.000 description 1
• 125000000547 substituted alkyl group Chemical group 0.000 description 1
• 239000005720 sucrose Substances 0.000 description 1
• VLYWMPOKSSWJAL-UHFFFAOYSA-N sulfamethoxypyridazine Chemical compound N1=NC(OC)=CC=C1NS(=O)(=O)C1=CC=C(N)C=C1 VLYWMPOKSSWJAL-UHFFFAOYSA-N 0.000 description 1
• NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 description 1
• 229960001940 sulfasalazine Drugs 0.000 description 1
• 229960000894 sulindac Drugs 0.000 description 1
• MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 description 1
• 239000013589 supplement Substances 0.000 description 1
• 230000009469 supplementation Effects 0.000 description 1
• 238000009120 supportive therapy Methods 0.000 description 1
• 239000000375 suspending agent Substances 0.000 description 1
• 238000013268 sustained release Methods 0.000 description 1
• 239000012730 sustained-release form Substances 0.000 description 1
• 208000011580 syndromic disease Diseases 0.000 description 1
• 239000003826 tablet Substances 0.000 description 1
• 239000000454 talc Substances 0.000 description 1
• 229910052623 talc Inorganic materials 0.000 description 1
• 229960004964 temozolomide Drugs 0.000 description 1
• NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 description 1
• 229960001278 teniposide Drugs 0.000 description 1
• 201000003120 testicular cancer Diseases 0.000 description 1
• 229960002372 tetracaine Drugs 0.000 description 1
• GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 description 1
• 125000003831 tetrazolyl group Chemical group 0.000 description 1
• 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
• 201000002510 thyroid cancer Diseases 0.000 description 1
• 210000001685 thyroid gland Anatomy 0.000 description 1
• 238000012090 tissue culture technique Methods 0.000 description 1
• 238000004448 titration Methods 0.000 description 1
• 229940044693 topoisomerase inhibitor Drugs 0.000 description 1
• 229960000303 topotecan Drugs 0.000 description 1
• UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 description 1
• 231100000440 toxicity profile Toxicity 0.000 description 1
• 238000012546 transfer Methods 0.000 description 1
• 230000010474 transient expression Effects 0.000 description 1
• 229960005294 triamcinolone Drugs 0.000 description 1
• GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
• 229960003962 trifluridine Drugs 0.000 description 1
• VSQQQLOSPVPRAZ-RRKCRQDMSA-N trifluridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(C(F)(F)F)=C1 VSQQQLOSPVPRAZ-RRKCRQDMSA-N 0.000 description 1
• RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
• 230000005747 tumor angiogenesis Effects 0.000 description 1
• 230000004222 uncontrolled growth Effects 0.000 description 1
• 241000701447 unidentified baculovirus Species 0.000 description 1
• 241001515965 unidentified phage Species 0.000 description 1
• 210000000626 ureter Anatomy 0.000 description 1
• 201000007710 urinary bladder small cell neuroendocrine carcinoma Diseases 0.000 description 1
• 208000007089 vaccinia Diseases 0.000 description 1
• 235000013311 vegetables Nutrition 0.000 description 1
• 229960003862 vemurafenib Drugs 0.000 description 1
• GPXBXXGIAQBQNI-UHFFFAOYSA-N vemurafenib Chemical compound CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C=2C3=CC(=CN=C3NC=2)C=2C=CC(Cl)=CC=2)=C1F GPXBXXGIAQBQNI-UHFFFAOYSA-N 0.000 description 1
• 230000035899 viability Effects 0.000 description 1
• 229960003636 vidarabine Drugs 0.000 description 1
• 229960003048 vinblastine Drugs 0.000 description 1
• JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
• 229960004528 vincristine Drugs 0.000 description 1
• OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
• OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
• 201000001862 viral hepatitis Diseases 0.000 description 1
• 230000003612 virological effect Effects 0.000 description 1
• 208000013013 vulvar carcinoma Diseases 0.000 description 1
• 238000009736 wetting Methods 0.000 description 1
• 239000000080 wetting agent Substances 0.000 description 1
• 210000005253 yeast cell Anatomy 0.000 description 1
• 229960004764 zafirlukast Drugs 0.000 description 1
• MWLSOWXNZPKENC-SSDOTTSWSA-N zileuton Chemical compound C1=CC=C2SC([C@H](N(O)C(N)=O)C)=CC2=C1 MWLSOWXNZPKENC-SSDOTTSWSA-N 0.000 description 1
• 229960005332 zileuton Drugs 0.000 description 1