JP2020505038A5 - - Google Patents
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- JP2020505038A5 JP2020505038A5 JP2019539835A JP2019539835A JP2020505038A5 JP 2020505038 A5 JP2020505038 A5 JP 2020505038A5 JP 2019539835 A JP2019539835 A JP 2019539835A JP 2019539835 A JP2019539835 A JP 2019539835A JP 2020505038 A5 JP2020505038 A5 JP 2020505038A5
- Authority
- JP
- Japan
- Prior art keywords
- culture medium
- pluripotent stem
- stem cells
- acid
- mammalian pluripotent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000010367 cloning Methods 0.000 claims 18
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 16
- 239000013589 supplement Substances 0.000 claims 16
- 239000001963 growth medium Substances 0.000 claims 15
- 238000000034 method Methods 0.000 claims 8
- 150000002632 lipids Chemical class 0.000 claims 7
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 6
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 6
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims 6
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 6
- 210000002744 extracellular matrix Anatomy 0.000 claims 6
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 6
- 230000004083 survival effect Effects 0.000 claims 6
- 238000012258 culturing Methods 0.000 claims 5
- 239000003112 inhibitor Substances 0.000 claims 5
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 3
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 3
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 3
- 102000009027 Albumins Human genes 0.000 claims 3
- 108010088751 Albumins Proteins 0.000 claims 3
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 3
- 239000005642 Oleic acid Substances 0.000 claims 3
- 235000021314 Palmitic acid Nutrition 0.000 claims 3
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims 3
- 229940114079 arachidonic acid Drugs 0.000 claims 3
- 235000021342 arachidonic acid Nutrition 0.000 claims 3
- 230000002708 enhancing effect Effects 0.000 claims 3
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 3
- 229960004488 linolenic acid Drugs 0.000 claims 3
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 3
- 238000010899 nucleation Methods 0.000 claims 3
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 3
- 230000035755 proliferation Effects 0.000 claims 3
- 150000003384 small molecules Chemical class 0.000 claims 3
- 239000006143 cell culture medium Substances 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 238000001879 gelation Methods 0.000 claims 2
- VKOBVWXKNCXXDE-UHFFFAOYSA-N icosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCC(O)=O VKOBVWXKNCXXDE-UHFFFAOYSA-N 0.000 claims 2
- SECPZKHBENQXJG-FPLPWBNLSA-N palmitoleic acid Chemical compound CCCCCC\C=C/CCCCCCCC(O)=O SECPZKHBENQXJG-FPLPWBNLSA-N 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- 239000011435 rock Substances 0.000 claims 2
- 239000002356 single layer Substances 0.000 claims 2
- UNSRRHDPHVZAHH-YOILPLPUSA-N (5Z,8Z,11Z)-icosatrienoic acid Chemical compound CCCCCCCC\C=C/C\C=C/C\C=C/CCCC(O)=O UNSRRHDPHVZAHH-YOILPLPUSA-N 0.000 claims 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims 1
- XDHJBIYJRNFDKS-IBGZPJMESA-N 1-[(4-methoxyphenyl)methyl]-5-[(2s)-2-(pyridin-3-yloxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione Chemical compound C1=CC(OC)=CC=C1CN1C2=CC=C(S(=O)(=O)N3[C@@H](CCC3)COC=3C=NC=CC=3)C=C2C(=O)C1=O XDHJBIYJRNFDKS-IBGZPJMESA-N 0.000 claims 1
- KHZOJCQBHJUJFY-UHFFFAOYSA-N 2-[4-(2-methylpyridin-4-yl)phenyl]-n-(4-pyridin-3-ylphenyl)acetamide Chemical compound C1=NC(C)=CC(C=2C=CC(CC(=O)NC=3C=CC(=CC=3)C=3C=NC=CC=3)=CC=2)=C1 KHZOJCQBHJUJFY-UHFFFAOYSA-N 0.000 claims 1
- GNCZTZCPXFDPLI-UHFFFAOYSA-N 4-chloro-2-[[oxo-[3-(trifluoromethyl)anilino]methyl]amino]benzoic acid Chemical compound OC(=O)C1=CC=C(Cl)C=C1NC(=O)NC1=CC=CC(C(F)(F)F)=C1 GNCZTZCPXFDPLI-UHFFFAOYSA-N 0.000 claims 1
- UNSRRHDPHVZAHH-UHFFFAOYSA-N 6beta,11alpha-Dihydroxy-3alpha,5alpha-cyclopregnan-20-on Natural products CCCCCCCCC=CCC=CCC=CCCCC(O)=O UNSRRHDPHVZAHH-UHFFFAOYSA-N 0.000 claims 1
- AQGNHMOJWBZFQQ-UHFFFAOYSA-N CT 99021 Chemical compound CC1=CNC(C=2C(=NC(NCCNC=3N=CC(=CC=3)C#N)=NC=2)C=2C(=CC(Cl)=CC=2)Cl)=N1 AQGNHMOJWBZFQQ-UHFFFAOYSA-N 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 229920000858 Cyclodextrin Polymers 0.000 claims 1
- 102000016942 Elastin Human genes 0.000 claims 1
- 108010014258 Elastin Proteins 0.000 claims 1
- 108010067306 Fibronectins Proteins 0.000 claims 1
- 102000016359 Fibronectins Human genes 0.000 claims 1
- 229920002971 Heparan sulfate Polymers 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 108010085895 Laminin Proteins 0.000 claims 1
- 102000007547 Laminin Human genes 0.000 claims 1
- 102100037369 Nidogen-1 Human genes 0.000 claims 1
- 235000021319 Palmitoleic acid Nutrition 0.000 claims 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 1
- 108010067787 Proteoglycans Proteins 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- 108010031318 Vitronectin Proteins 0.000 claims 1
- 102100035140 Vitronectin Human genes 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 230000001070 adhesive effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- SECPZKHBENQXJG-UHFFFAOYSA-N cis-palmitoleic acid Natural products CCCCCCC=CCCCCCCCC(O)=O SECPZKHBENQXJG-UHFFFAOYSA-N 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 229920002549 elastin Polymers 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 210000001808 exosome Anatomy 0.000 claims 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- 239000011976 maleic acid Substances 0.000 claims 1
- 108010082117 matrigel Proteins 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 229940050561 matrix product Drugs 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 108010008217 nidogen Proteins 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- 229920001993 poloxamer 188 Polymers 0.000 claims 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762449413P | 2017-01-23 | 2017-01-23 | |
| US62/449,413 | 2017-01-23 | ||
| US201762518776P | 2017-06-13 | 2017-06-13 | |
| US62/518,776 | 2017-06-13 | ||
| US201762608875P | 2017-12-21 | 2017-12-21 | |
| US62/608,875 | 2017-12-21 | ||
| PCT/CA2018/050076 WO2018132926A1 (en) | 2017-01-23 | 2018-01-23 | Media and methods for enhancing the survival and proliferation of stem cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020505038A JP2020505038A (ja) | 2020-02-20 |
| JP2020505038A5 true JP2020505038A5 (https=) | 2021-07-26 |
| JP7049347B2 JP7049347B2 (ja) | 2022-04-06 |
Family
ID=62907538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019539835A Active JP7049347B2 (ja) | 2017-01-23 | 2018-01-23 | 幹細胞の生存および増殖を高めるための培地および方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11697796B2 (https=) |
| EP (2) | EP4361256A3 (https=) |
| JP (1) | JP7049347B2 (https=) |
| CN (1) | CN110462025B (https=) |
| AU (1) | AU2018209127B2 (https=) |
| CA (1) | CA3051141C (https=) |
| IL (1) | IL268194B (https=) |
| SG (1) | SG11201906731XA (https=) |
| WO (1) | WO2018132926A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201906731XA (en) | 2017-01-23 | 2019-08-27 | Stemcell Technologies Canada Inc | Media and methods for enhancing the survival and proliferation of stem cells |
| CN111808797A (zh) * | 2020-07-28 | 2020-10-23 | 湖南赛诺生物科技股份有限公司 | Necrostatin-1的应用及促进新生猪胰岛细胞成熟的制剂 |
| JP2022032793A (ja) * | 2020-08-14 | 2022-02-25 | アルブキュラ コーポレーション | アルブミン組成物並びにそれを製造及び使用する方法 |
| CA3191071A1 (en) | 2020-09-02 | 2022-03-10 | Yaacov Guy | Cellular composition for treatment of diseases, disorders or conditions and method of use |
| WO2022114724A1 (ko) * | 2020-11-27 | 2022-06-02 | (주)엑셀세라퓨틱스 | 고효율 및 고순도 엑소좀 생산용 배지 조성물 |
| US20240117313A1 (en) * | 2021-02-15 | 2024-04-11 | Toppan Inc. | Method for producing three-dimensional tissue body and method for promoting differentiation of adipose-derived stem cells |
| CN116121186A (zh) * | 2023-01-03 | 2023-05-16 | 内蒙古奥普赛生物科技有限公司 | 一种利用棕榈油酸培养脂肪间充质干细胞的方法 |
| EP4698630A1 (en) * | 2023-04-20 | 2026-02-25 | Stemcell Technologies Canada Inc. | Methods for large scale expansion of pluripotent stem cells (pscs) |
| CN116814532B (zh) * | 2023-07-10 | 2025-02-11 | 上海迈邦生物科技有限公司 | 一种用于哺乳动物细胞培养基的脂类复合物及其制备方法与应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2277278A1 (en) | 1997-01-10 | 1998-07-16 | Life Technologies, Inc. | Embryonic stem cell serum replacement |
| CN101052712A (zh) * | 2004-09-08 | 2007-10-10 | 威斯康星校友研究基金会 | 培养人胚胎干细胞 |
| JP4385076B2 (ja) * | 2006-01-13 | 2009-12-16 | 独立行政法人科学技術振興機構 | 動物細胞を無血清培養するための培地用添加剤、キット及びこれらの利用 |
| US8241908B2 (en) * | 2006-05-16 | 2012-08-14 | Becton, Dickinson And Company | Extracellular matrix coated surface for culturing cells |
| GB0613756D0 (en) | 2006-07-12 | 2006-08-23 | Univ Sheffield | Cell culture medium |
| ES2360782B1 (es) | 2009-07-28 | 2012-03-12 | Grifols, S.A. | Medios para cultivo de células de mamíferos que comprenden sobrenadante de etapas del fraccionamiento de Cohn y uso de los mismos. |
| FI20096288A0 (fi) * | 2009-12-04 | 2009-12-04 | Kristiina Rajala | Formulations and methods for culturing stem cells |
| US10323919B2 (en) | 2010-01-06 | 2019-06-18 | Ervin Industries, Inc. | Frangible, ceramic-metal composite objects and methods of making the same |
| JP6148429B2 (ja) | 2011-01-31 | 2017-06-14 | 協和発酵バイオ株式会社 | ヒト多能性幹細胞の培養方法 |
| US8497124B2 (en) * | 2011-12-05 | 2013-07-30 | Factor Bioscience Inc. | Methods and products for reprogramming cells to a less differentiated state |
| HK1206058A1 (en) | 2012-03-07 | 2015-12-31 | Janssen Biotech, Inc. | Defined media for expansion and maintenance of pluripotent stem cells |
| JP2016521971A (ja) * | 2013-04-23 | 2016-07-28 | イェダ リサーチ アンド ディベロップメント カンパニー リミテッド | 単離ナイーブ型多能性幹細胞およびそれを発生させる方法関連出願本出願は、米国特許法１１９条第（ｅ）項に基づき、２０１４年１月２９日出願の米国特許仮出願第６１／９３２，９３５号、２０１３年９月１７日出願の米国特許仮出願第６１／８７８，７６９号、および２０１３年４月２３日出願の米国特許仮出願第６１／８１４，９２０号の優先権を主張する。また、本出願は、同時に提出された同出願人による同時係属出願である、ＹａｑｕｂＨＡＮＮＡ、ＮｏａＮＯＶＥＲＳＨＴＥＲＮ、およびＹｏａｃｈＲＡＩＳによる米国特許出願（発明の名称「単離ナイーブ型多能性幹細胞およびそれを発生させる方法（ＩＳＯＬＡＴＥＤＮＡＩＶＥＰＬＵＲＩＰＯＴＥＮＴＳＴＥＭＣＥＬＬＳＡＮＤＭＥＴＨＯＤＳＯＦＧＥＮＥＲＡＴＩＮＧＳＡＭＥ）」）（代理人事件記録簿第５８８７０号）にも関する。上記出願の内容はその全体を参考として本明細書に組み込む。 |
| CN105283541B (zh) * | 2013-05-30 | 2019-02-19 | 味之素株式会社 | 干细胞培养用培养基 |
| WO2015042356A1 (en) | 2013-09-19 | 2015-03-26 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Chemically defined culture medium for stem cell maintenance and differentiation |
| EP3279318A4 (en) * | 2015-03-30 | 2018-08-29 | Ajinomoto Co., Inc. | Human serum albumin-containing culture medium for growth of neural stem cells |
| SG11201906731XA (en) | 2017-01-23 | 2019-08-27 | Stemcell Technologies Canada Inc | Media and methods for enhancing the survival and proliferation of stem cells |
-
2018
- 2018-01-23 SG SG11201906731XA patent/SG11201906731XA/en unknown
- 2018-01-23 US US16/480,025 patent/US11697796B2/en active Active
- 2018-01-23 EP EP24162728.0A patent/EP4361256A3/en active Pending
- 2018-01-23 CN CN201880019192.7A patent/CN110462025B/zh active Active
- 2018-01-23 CA CA3051141A patent/CA3051141C/en active Active
- 2018-01-23 JP JP2019539835A patent/JP7049347B2/ja active Active
- 2018-01-23 AU AU2018209127A patent/AU2018209127B2/en active Active
- 2018-01-23 WO PCT/CA2018/050076 patent/WO2018132926A1/en not_active Ceased
- 2018-01-23 EP EP18741389.3A patent/EP3571290B1/en active Active
-
2019
- 2019-07-21 IL IL268194A patent/IL268194B/en unknown
-
2023
- 2023-03-15 US US18/184,517 patent/US20230250392A1/en active Pending
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