JP2020504628A5 - - Google Patents
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- JP2020504628A5 JP2020504628A5 JP2019556411A JP2019556411A JP2020504628A5 JP 2020504628 A5 JP2020504628 A5 JP 2020504628A5 JP 2019556411 A JP2019556411 A JP 2019556411A JP 2019556411 A JP2019556411 A JP 2019556411A JP 2020504628 A5 JP2020504628 A5 JP 2020504628A5
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 89
- 102000004169 proteins and genes Human genes 0.000 claims 58
- 108090000623 proteins and genes Proteins 0.000 claims 58
- 150000001413 amino acids Chemical group 0.000 claims 49
- 229920001184 polypeptide Polymers 0.000 claims 46
- 102000004196 processed proteins & peptides Human genes 0.000 claims 46
- 239000000427 antigen Substances 0.000 claims 42
- 102000036639 antigens Human genes 0.000 claims 42
- 108091007433 antigens Proteins 0.000 claims 42
- 102000039446 nucleic acids Human genes 0.000 claims 18
- 108020004707 nucleic acids Proteins 0.000 claims 18
- 150000007523 nucleic acids Chemical class 0.000 claims 18
- 210000004027 cell Anatomy 0.000 claims 12
- 102000004127 Cytokines Human genes 0.000 claims 9
- 108090000695 Cytokines Proteins 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 101710145634 Antigen 1 Proteins 0.000 claims 8
- 241000701806 Human papillomavirus Species 0.000 claims 8
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 8
- -1 NY-ESO- 1 Proteins 0.000 claims 8
- 239000013598 vector Substances 0.000 claims 8
- 206010038389 Renal cancer Diseases 0.000 claims 7
- 241000700605 Viruses Species 0.000 claims 7
- 210000002865 immune cell Anatomy 0.000 claims 7
- 201000010982 kidney cancer Diseases 0.000 claims 7
- 102000005962 receptors Human genes 0.000 claims 7
- 108020003175 receptors Proteins 0.000 claims 7
- 239000000463 material Substances 0.000 claims 6
- 102000003812 Interleukin-15 Human genes 0.000 claims 5
- 108090000172 Interleukin-15 Proteins 0.000 claims 5
- 102000004388 Interleukin-4 Human genes 0.000 claims 5
- 206010025323 Lymphomas Diseases 0.000 claims 5
- 230000000813 microbial effect Effects 0.000 claims 5
- 208000003200 Adenoma Diseases 0.000 claims 4
- 206010005003 Bladder cancer Diseases 0.000 claims 4
- 208000003174 Brain Neoplasms Diseases 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 4
- 208000026310 Breast neoplasm Diseases 0.000 claims 4
- 206010008342 Cervix carcinoma Diseases 0.000 claims 4
- 101150029707 ERBB2 gene Proteins 0.000 claims 4
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 4
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 4
- 206010027480 Metastatic malignant melanoma Diseases 0.000 claims 4
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 4
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 4
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 4
- 206010039491 Sarcoma Diseases 0.000 claims 4
- 208000000453 Skin Neoplasms Diseases 0.000 claims 4
- 108010017842 Telomerase Proteins 0.000 claims 4
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 4
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 201000010881 cervical cancer Diseases 0.000 claims 4
- 208000032839 leukemia Diseases 0.000 claims 4
- 201000007270 liver cancer Diseases 0.000 claims 4
- 208000014018 liver neoplasm Diseases 0.000 claims 4
- 201000005202 lung cancer Diseases 0.000 claims 4
- 208000020816 lung neoplasm Diseases 0.000 claims 4
- 201000001441 melanoma Diseases 0.000 claims 4
- 208000021039 metastatic melanoma Diseases 0.000 claims 4
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims 4
- 101150047061 tag-72 gene Proteins 0.000 claims 4
- 210000000115 thoracic cavity Anatomy 0.000 claims 4
- 201000005112 urinary bladder cancer Diseases 0.000 claims 4
- 206010001233 Adenoma benign Diseases 0.000 claims 3
- 208000017604 Hodgkin disease Diseases 0.000 claims 3
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 3
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 3
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 3
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 3
- 206010029260 Neuroblastoma Diseases 0.000 claims 3
- 206010033128 Ovarian cancer Diseases 0.000 claims 3
- 206010060862 Prostate cancer Diseases 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 3
- 210000000822 natural killer cell Anatomy 0.000 claims 3
- 201000002528 pancreatic cancer Diseases 0.000 claims 3
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 3
- 201000000849 skin cancer Diseases 0.000 claims 3
- 210000004881 tumor cell Anatomy 0.000 claims 3
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims 2
- WEVYNIUIFUYDGI-UHFFFAOYSA-N 3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide Chemical compound NC(=O)C1=CC=CC(C=2N=CN=C(NC=3C=CC(OC(F)(F)F)=CC=3)C=2)=C1 WEVYNIUIFUYDGI-UHFFFAOYSA-N 0.000 claims 2
- 101710163573 5-hydroxyisourate hydrolase Proteins 0.000 claims 2
- 102100030840 AT-rich interactive domain-containing protein 4B Human genes 0.000 claims 2
- 102100023635 Alpha-fetoprotein Human genes 0.000 claims 2
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims 2
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims 2
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims 2
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 2
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 2
- 102000015735 Beta-catenin Human genes 0.000 claims 2
- 108060000903 Beta-catenin Proteins 0.000 claims 2
- 102100024423 Carbonic anhydrase 9 Human genes 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 claims 2
- 102100036252 Cyclin-dependent kinase 4 Human genes 0.000 claims 2
- 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 claims 2
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims 2
- 102100028073 Fibroblast growth factor 5 Human genes 0.000 claims 2
- 108090000380 Fibroblast growth factor 5 Proteins 0.000 claims 2
- 101710113436 GTPase KRas Proteins 0.000 claims 2
- 102100039554 Galectin-8 Human genes 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 101000792935 Homo sapiens AT-rich interactive domain-containing protein 4B Proteins 0.000 claims 2
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims 2
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 2
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 2
- 101100165850 Homo sapiens CA9 gene Proteins 0.000 claims 2
- 101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 claims 2
- 101000608769 Homo sapiens Galectin-8 Proteins 0.000 claims 2
- 101001103039 Homo sapiens Inactive tyrosine-protein kinase transmembrane receptor ROR1 Proteins 0.000 claims 2
- 101000998120 Homo sapiens Interleukin-3 receptor subunit alpha Proteins 0.000 claims 2
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 claims 2
- 101001014223 Homo sapiens MAPK/MAK/MRK overlapping kinase Proteins 0.000 claims 2
- 101000934372 Homo sapiens Macrosialin Proteins 0.000 claims 2
- 101001005719 Homo sapiens Melanoma-associated antigen 3 Proteins 0.000 claims 2
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 2
- 101001103036 Homo sapiens Nuclear receptor ROR-alpha Proteins 0.000 claims 2
- 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 claims 2
- 101001062222 Homo sapiens Receptor-binding cancer antigen expressed on SiSo cells Proteins 0.000 claims 2
- 101000671653 Homo sapiens U3 small nucleolar RNA-associated protein 14 homolog A Proteins 0.000 claims 2
- 101710123134 Ice-binding protein Proteins 0.000 claims 2
- 101710082837 Ice-structuring protein Proteins 0.000 claims 2
- 102100039615 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Human genes 0.000 claims 2
- 102000048143 Insulin-Like Growth Factor II Human genes 0.000 claims 2
- 108090001117 Insulin-Like Growth Factor II Proteins 0.000 claims 2
- 108010030506 Integrin alpha6beta4 Proteins 0.000 claims 2
- 102100033493 Interleukin-3 receptor subunit alpha Human genes 0.000 claims 2
- 102100031586 Leukocyte antigen CD37 Human genes 0.000 claims 2
- 102100031520 MAPK/MAK/MRK overlapping kinase Human genes 0.000 claims 2
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 claims 2
- 102100028123 Macrophage colony-stimulating factor 1 Human genes 0.000 claims 2
- 102100025136 Macrosialin Human genes 0.000 claims 2
- 102000000440 Melanoma-associated antigen Human genes 0.000 claims 2
- 108050008953 Melanoma-associated antigen Proteins 0.000 claims 2
- 102100025082 Melanoma-associated antigen 3 Human genes 0.000 claims 2
- 102000003735 Mesothelin Human genes 0.000 claims 2
- 108090000015 Mesothelin Proteins 0.000 claims 2
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 2
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 2
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 2
- 101710100968 Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 2
- 102100029165 Receptor-binding cancer antigen expressed on SiSo cells Human genes 0.000 claims 2
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 2
- 101150031162 TM4SF1 gene Proteins 0.000 claims 2
- 102100034902 Transmembrane 4 L6 family member 1 Human genes 0.000 claims 2
- 101710107540 Type-2 ice-structuring protein Proteins 0.000 claims 2
- 102100040099 U3 small nucleolar RNA-associated protein 14 homolog A Human genes 0.000 claims 2
- 102000040856 WT1 Human genes 0.000 claims 2
- 108700020467 WT1 Proteins 0.000 claims 2
- 101150084041 WT1 gene Proteins 0.000 claims 2
- 108010057085 cytokine receptors Proteins 0.000 claims 2
- 102000003675 cytokine receptors Human genes 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 108010087914 epidermal growth factor receptor VIII Proteins 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- 229940084986 human chorionic gonadotropin Drugs 0.000 claims 2
- 238000009169 immunotherapy Methods 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 238000012737 microarray-based gene expression Methods 0.000 claims 2
- 244000005700 microbiome Species 0.000 claims 2
- 238000012243 multiplex automated genomic engineering Methods 0.000 claims 2
- 206010038038 rectal cancer Diseases 0.000 claims 2
- 201000001275 rectum cancer Diseases 0.000 claims 2
- 206010046766 uterine cancer Diseases 0.000 claims 2
- 101100243447 Arabidopsis thaliana PER53 gene Proteins 0.000 claims 1
- 102100024003 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Human genes 0.000 claims 1
- 102100039510 Cancer/testis antigen 2 Human genes 0.000 claims 1
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 101000889345 Homo sapiens Cancer/testis antigen 2 Proteins 0.000 claims 1
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 1
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims 1
- 108010031794 IGF Type 1 Receptor Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 claims 1
- 102000000588 Interleukin-2 Human genes 0.000 claims 1
- 102100030704 Interleukin-21 Human genes 0.000 claims 1
- 102000000704 Interleukin-7 Human genes 0.000 claims 1
- 102000000585 Interleukin-9 Human genes 0.000 claims 1
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims 1
- 102100021768 Phosphoserine aminotransferase Human genes 0.000 claims 1
- 108010072866 Prostate-Specific Antigen Proteins 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 101150080074 TP53 gene Proteins 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 230000000112 colonic effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000012010 growth Effects 0.000 claims 1
- 239000000833 heterodimer Substances 0.000 claims 1
- 238000003018 immunoassay Methods 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 108010074108 interleukin-21 Proteins 0.000 claims 1
- 210000003757 neuroblast Anatomy 0.000 claims 1
- 108040000983 polyphosphate:AMP phosphotransferase activity proteins Proteins 0.000 claims 1
- 210000001236 prokaryotic cell Anatomy 0.000 claims 1
- 238000010839 reverse transcription Methods 0.000 claims 1
- 210000004291 uterus Anatomy 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611246592.0 | 2016-12-29 | ||
| CN201611246592.0A CN108250302A (zh) | 2016-12-29 | 2016-12-29 | 一种多功能蛋白质 |
| PCT/CN2017/118984 WO2018121605A1 (zh) | 2016-12-29 | 2017-12-27 | 一种多功能蛋白质 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020504628A JP2020504628A (ja) | 2020-02-13 |
| JP2020504628A5 true JP2020504628A5 (enExample) | 2021-07-26 |
| JP7221213B2 JP7221213B2 (ja) | 2023-02-13 |
Family
ID=62710858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019556411A Active JP7221213B2 (ja) | 2016-12-29 | 2017-12-27 | 多官能性タンパク質 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11530264B2 (enExample) |
| EP (1) | EP3578570A4 (enExample) |
| JP (1) | JP7221213B2 (enExample) |
| CN (2) | CN108250302A (enExample) |
| WO (1) | WO2018121605A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112016018100A2 (pt) | 2014-02-07 | 2018-02-20 | Univ Mcmaster | acoplador antigênico de células t trifuncional, métodos e usos do mesmo |
| CN111479925B (zh) | 2017-10-12 | 2024-03-08 | 麦克马斯特大学 | 具有y182t突变的t细胞-抗原偶联物及其方法和用途 |
| JP7404279B2 (ja) * | 2018-07-17 | 2023-12-25 | トリウムビラ イミュノロジクス ユーエスエー，インク． | 様々な構築物最適化を備えたｔ細胞抗原カプラ |
| US11110123B2 (en) | 2018-07-17 | 2021-09-07 | Triumvira Immunologics Usa, Inc. | T cell-antigen coupler with various construct optimizations |
| US10640562B2 (en) | 2018-07-17 | 2020-05-05 | Mcmaster University | T cell-antigen coupler with various construct optimizations |
| CN110862967A (zh) * | 2018-08-27 | 2020-03-06 | 天津天锐生物科技有限公司 | 一种不依赖细胞因子培养的自然杀伤细胞系silk-nk |
| KR20210091714A (ko) * | 2018-10-17 | 2021-07-22 | 이뮤놈 인코포레이티드 | 엑소좀-표적 이중 특이적 항체 |
| WO2020165374A1 (en) * | 2019-02-14 | 2020-08-20 | Ose Immunotherapeutics | Bifunctional molecule comprising il-15ra |
| US20220112258A1 (en) * | 2019-07-25 | 2022-04-14 | I-Mab Biopharma Us Limited | Bifunctional molecules with il-7 activity |
| CN113321738A (zh) * | 2020-02-27 | 2021-08-31 | 启愈生物技术(上海)有限公司 | 肿瘤靶向、抗cd3和t细胞激活三功能融合蛋白及其应用 |
| CN112110988A (zh) * | 2020-08-21 | 2020-12-22 | 温州医科大学 | 一种具有毛发生长作用的多肽类似物及制备方法和应用 |
| AU2022283819A1 (en) | 2021-06-01 | 2024-01-04 | Triumvira Immunologics Usa, Inc. | Claudin 18.2 t cell-antigen couplers and uses thereof |
| US11453723B1 (en) | 2021-06-25 | 2022-09-27 | Mcmaster University | BCMA T cell-antigen couplers and uses thereof |
| CN116102655A (zh) * | 2021-08-19 | 2023-05-12 | 南京吉盛澳玛生物医药有限公司 | 靶向pd-l1/pd-1的抗体及其应用 |
| JP2024534982A (ja) * | 2021-09-09 | 2024-09-26 | クレ バイオテクノロジ （シャンハイ） カンパニー リミテッド | 抗原ターゲティング、抗ｃｄ１６ａおよび免疫エフェクター細胞活性化の三機能性融合タンパク質ならびにその応用 |
| WO2025096770A1 (en) * | 2023-10-31 | 2025-05-08 | Immunitybio, Inc. | Multi-chain chimeric polypeptides and uses thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5986059A (en) * | 1996-06-14 | 1999-11-16 | Bayer Corporation | T-cell selective interleukin-4 agonists |
| CA2410551A1 (en) * | 2000-06-30 | 2002-01-10 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw (Vib) | Heterodimeric fusion proteins |
| CA2607954A1 (en) * | 2005-05-11 | 2006-11-16 | Philogen S.P.A. | Conjugate for targeting of drug |
| CN101743249B (zh) | 2007-05-11 | 2017-08-08 | 阿尔托生物科学有限公司 | 融合分子与il‑15变异体 |
| CN101830986A (zh) * | 2009-03-13 | 2010-09-15 | 北京表源生物技术有限公司 | 一种融合蛋白多聚体 |
| CN101550191B (zh) * | 2009-05-15 | 2011-08-24 | 无锡胜博生物技术有限公司 | 一种恶性黑素瘤t细胞纳米抗体、其编码序列及应用 |
| JP5764127B2 (ja) * | 2009-08-17 | 2015-08-12 | ロシュ グリクアート アーゲー | 標的化イムノコンジュゲート |
| US8507222B2 (en) * | 2010-09-21 | 2013-08-13 | Altor Bioscience Corporation | Multimeric IL-15 soluble fusion molecules and methods of making and using same |
| AU2012245116A1 (en) * | 2011-04-20 | 2013-11-07 | Genmab A/S | Bispecific antibodies against HER2 and CD3 |
| CN102559696A (zh) * | 2011-09-26 | 2012-07-11 | 无锡赛特基因生物科技有限公司 | 一种重组人白细胞介素-15的高效可溶性表达方法 |
| CN202239821U (zh) * | 2011-09-27 | 2012-05-30 | 上海宏功机械科技有限公司 | 偏心强力反刮锪组合刀具 |
| PL3489254T3 (pl) * | 2012-04-30 | 2023-01-30 | Biocon Limited | Ukierunkowujące/immunomodulujące białko fuzyjne i sposoby jego otrzymywania |
| US9682143B2 (en) * | 2012-08-14 | 2017-06-20 | Ibc Pharmaceuticals, Inc. | Combination therapy for inducing immune response to disease |
| EP2970985A1 (en) * | 2013-03-14 | 2016-01-20 | Fred Hutchinson Cancer Research Center | Compositions and methods to modify cells for therapeutic objectives |
| RU2689717C2 (ru) * | 2014-01-08 | 2019-05-28 | Шанхай Хэнжуй Фармасьютикал Ко., Лтд. | Гетеродимерный белок il-15 и его применения |
-
2016
- 2016-12-29 CN CN201611246592.0A patent/CN108250302A/zh active Pending
-
2017
- 2017-12-27 WO PCT/CN2017/118984 patent/WO2018121605A1/zh not_active Ceased
- 2017-12-27 US US16/475,060 patent/US11530264B2/en active Active
- 2017-12-27 EP EP17888600.8A patent/EP3578570A4/en active Pending
- 2017-12-27 JP JP2019556411A patent/JP7221213B2/ja active Active
- 2017-12-27 CN CN201780029217.7A patent/CN109153725B/zh active Active
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