JP2020503024A5 - - Google Patents
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- Publication number
- JP2020503024A5 JP2020503024A5 JP2019534344A JP2019534344A JP2020503024A5 JP 2020503024 A5 JP2020503024 A5 JP 2020503024A5 JP 2019534344 A JP2019534344 A JP 2019534344A JP 2019534344 A JP2019534344 A JP 2019534344A JP 2020503024 A5 JP2020503024 A5 JP 2020503024A5
- Authority
- JP
- Japan
- Prior art keywords
- gene
- transformed cell
- coa
- cell line
- isobutyryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 15
- 230000015572 biosynthetic process Effects 0.000 claims 11
- 108090000623 proteins and genes Proteins 0.000 claims 9
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 claims 8
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
- AEWHYWSPVRZHCT-NDZSKPAWSA-N isobutyryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C(C)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 AEWHYWSPVRZHCT-NDZSKPAWSA-N 0.000 claims 6
- 150000007523 nucleic acids Chemical group 0.000 claims 6
- 230000001851 biosynthetic effect Effects 0.000 claims 5
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 claims 4
- 108700021044 acyl-ACP thioesterase Proteins 0.000 claims 3
- 108010069175 acyl-CoA transferase Proteins 0.000 claims 3
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 claims 3
- JNSSVMGPTZYYIW-UHFFFAOYSA-N 2-chloro-6-methyl-1-oxidopyridin-1-ium Chemical compound CC1=CC=CC(Cl)=[N+]1[O-] JNSSVMGPTZYYIW-UHFFFAOYSA-N 0.000 claims 2
- 101100119780 Arabidopsis thaliana FATB gene Proteins 0.000 claims 2
- 101100119778 Cuphea viscosissima FATB2 gene Proteins 0.000 claims 2
- 241000196324 Embryophyta Species 0.000 claims 2
- 101100119784 Umbellularia californica FATB1 gene Proteins 0.000 claims 2
- 101150047711 acs gene Proteins 0.000 claims 2
- OAOABCKPVCUNKO-UHFFFAOYSA-N isodecanoic acid Natural products CC(C)CCCCCCC(O)=O OAOABCKPVCUNKO-UHFFFAOYSA-N 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 101150047126 CCL4 gene Proteins 0.000 claims 1
- 235000002566 Capsicum Nutrition 0.000 claims 1
- 240000008574 Capsicum frutescens Species 0.000 claims 1
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 108010078791 Carrier Proteins Proteins 0.000 claims 1
- 241000195493 Cryptophyta Species 0.000 claims 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 102000005488 Thioesterase Human genes 0.000 claims 1
- 108090000992 Transferases Proteins 0.000 claims 1
- 102000004357 Transferases Human genes 0.000 claims 1
- 229960002504 capsaicin Drugs 0.000 claims 1
- 235000017663 capsaicin Nutrition 0.000 claims 1
- 239000001390 capsicum minimum Substances 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 108020002982 thioesterase Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662437792P | 2016-12-22 | 2016-12-22 | |
| US62/437,792 | 2016-12-22 | ||
| PCT/US2017/068085 WO2018119343A1 (en) | 2016-12-22 | 2017-12-22 | Method for the microbial production of 8-methyl nonanoic acid |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020503024A JP2020503024A (ja) | 2020-01-30 |
| JP2020503024A5 true JP2020503024A5 (enExample) | 2020-12-17 |
| JP6986084B2 JP6986084B2 (ja) | 2021-12-22 |
Family
ID=62627726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019534344A Active JP6986084B2 (ja) | 2016-12-22 | 2017-12-22 | ８−メチルノナン酸の微生物生成方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10793881B2 (enExample) |
| EP (1) | EP3559219A4 (enExample) |
| JP (1) | JP6986084B2 (enExample) |
| CN (1) | CN110291194B (enExample) |
| WO (1) | WO2018119343A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017120473A1 (en) | 2016-01-07 | 2017-07-13 | Conagen Inc. | Methods of making capsinoids by biosynthetic processes |
| US11459591B2 (en) | 2016-07-19 | 2022-10-04 | Conagen Inc. | Method for the microbial production of specific natural capsaicinoids |
| CN114317555B (zh) * | 2021-12-29 | 2024-06-28 | 衡阳市蔬菜研究所 | 三樟黄贡椒叶绿体基因组及其应用 |
| CN115960736B (zh) * | 2023-03-01 | 2024-05-28 | 石河子大学 | 一种产香草胺和辣椒碱的酿酒酵母工程菌及其构建方法与应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4493848A (en) | 1983-07-14 | 1985-01-15 | The Procter & Gamble Company | Compositions and methods useful for producing analgesia |
| US5094782A (en) | 1990-12-24 | 1992-03-10 | National Science Council Of Republic Of China | Synthesis of capsacin derivatives and their use as an analgesic drug and vessel dilation drug |
| DE10000978A1 (de) * | 2000-01-12 | 2001-07-26 | Gvs Ges Fuer Erwerb Und Verwer | Verfahren zur Erhöhung des Gehalts an Fettsäuren in Pflanzen und Mikroorganismen |
| BRPI0821508B1 (pt) * | 2007-12-11 | 2018-12-26 | Synthetic Genomics Inc | cultura celular compreendendo uma cianobactéria recombinante da espécie synechococcus elongatus e método para converter carbono inorgânico em ácidos graxos. |
| US8951762B2 (en) * | 2011-07-27 | 2015-02-10 | Iowa State University Research Foundation, Inc. | Materials and methods for using an acyl—acyl carrier protein thioesterase and mutants and chimeras thereof in fatty acid synthesis |
| RU2723620C2 (ru) * | 2012-07-13 | 2020-06-16 | Калиста, Инк. | Система, способы и композиции для биопереработки |
| US10184140B2 (en) * | 2013-01-23 | 2019-01-22 | Iowa State University Research Foundation, Inc. | Materials and methods for production of bi-functional fatty acids in recombinant bacteria |
| EP3039151A2 (en) * | 2013-08-28 | 2016-07-06 | Invista Technologies S.A R.L. | Methods for biosynthesizing methacrylate |
| CN104404059B (zh) * | 2014-11-05 | 2017-05-24 | 中国科学院遗传与发育生物学研究所 | 用于制备β‑苦味酸的基因及其应用 |
| EP3020819A1 (en) * | 2014-11-17 | 2016-05-18 | Evonik Degussa GmbH | Fatty acid and derivatives production |
-
2017
- 2017-12-22 WO PCT/US2017/068085 patent/WO2018119343A1/en not_active Ceased
- 2017-12-22 CN CN201780079774.XA patent/CN110291194B/zh active Active
- 2017-12-22 EP EP17882749.9A patent/EP3559219A4/en active Pending
- 2017-12-22 JP JP2019534344A patent/JP6986084B2/ja active Active
-
2019
- 2019-06-18 US US16/444,305 patent/US10793881B2/en active Active
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