JP2020501561A - 脳卒中および関係する凝固性障害の処置のためのトロンビン阻害剤 - Google Patents

脳卒中および関係する凝固性障害の処置のためのトロンビン阻害剤 Download PDF

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Publication number
JP2020501561A
JP2020501561A JP2019531876A JP2019531876A JP2020501561A JP 2020501561 A JP2020501561 A JP 2020501561A JP 2019531876 A JP2019531876 A JP 2019531876A JP 2019531876 A JP2019531876 A JP 2019531876A JP 2020501561 A JP2020501561 A JP 2020501561A
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Japan
Prior art keywords
thrombin
peptide
seq
inhibitor
exosite
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JP2019531876A
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English (en)
Japanese (ja)
Inventor
リチャード ジェイ ペイン
リチャード ジェイ ペイン
ショーン フィリップ ジャクソン
ショーン フィリップ ジャクソン
ペレイラ ペドロ ホセ バルボサ
ペレイラ ペドロ ホセ バルボサ
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University of Sydney
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University of Sydney
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Filing date
Publication date
Priority claimed from AU2016905231A external-priority patent/AU2016905231A0/en
Application filed by University of Sydney filed Critical University of Sydney
Publication of JP2020501561A publication Critical patent/JP2020501561A/ja
Priority to JP2022100650A priority Critical patent/JP2022130527A/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2019531876A 2016-12-16 2017-12-15 脳卒中および関係する凝固性障害の処置のためのトロンビン阻害剤 Pending JP2020501561A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022100650A JP2022130527A (ja) 2016-12-16 2022-06-22 脳卒中および関係する凝固性障害の処置のためのトロンビン阻害剤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2016905231A AU2016905231A0 (en) 2016-12-16 Thrombin inhibitors for treatment of stroke and related coagulative disorders
AU2016905231 2016-12-16
PCT/AU2017/051405 WO2018107247A1 (en) 2016-12-16 2017-12-15 Thrombin inhibitors for treatment of stroke and related coagulative disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022100650A Division JP2022130527A (ja) 2016-12-16 2022-06-22 脳卒中および関係する凝固性障害の処置のためのトロンビン阻害剤

Publications (1)

Publication Number Publication Date
JP2020501561A true JP2020501561A (ja) 2020-01-23

Family

ID=62557849

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019531876A Pending JP2020501561A (ja) 2016-12-16 2017-12-15 脳卒中および関係する凝固性障害の処置のためのトロンビン阻害剤
JP2022100650A Pending JP2022130527A (ja) 2016-12-16 2022-06-22 脳卒中および関係する凝固性障害の処置のためのトロンビン阻害剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022100650A Pending JP2022130527A (ja) 2016-12-16 2022-06-22 脳卒中および関係する凝固性障害の処置のためのトロンビン阻害剤

Country Status (8)

Country Link
US (1) US11091535B2 (https=)
EP (1) EP3555116A4 (https=)
JP (2) JP2020501561A (https=)
CN (1) CN110139871A (https=)
AU (1) AU2017376839B2 (https=)
CA (1) CA3047159A1 (https=)
NZ (1) NZ754781A (https=)
WO (1) WO2018107247A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110590911B (zh) * 2019-09-30 2021-10-22 华南理工大学 一种含酪氨酸硫酸化修饰的多肽合成方法及其应用
CN114887123B (zh) * 2022-04-18 2023-07-04 南通大学 水蛭素接枝纳米纤维血管支架材料、制备方法与应用
CN119462906A (zh) * 2024-11-11 2025-02-18 武汉元启合生科技有限公司 一种酪氨酸硫酸化的重组水蛭素、制备方法及其用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008532490A (ja) * 2005-02-15 2008-08-21 アポロ ライフ サイエンシズ リミテッド 分子およびそのキメラ分子
JP2012525836A (ja) * 2009-05-05 2012-10-25 ナチュラル・エンバイロンメント・リサーチ・カウンシル セリンプロテアーゼインヒビターの改変方法

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DE4323754C1 (de) 1993-07-15 1994-12-01 Gruenenthal Gmbh Bifunktionelle Urokinasevarianten mit verbesserten fibrinolytischen Eigenschaften und thrombinhemmender Wirkung
US6759384B1 (en) * 1994-04-26 2004-07-06 Aventis Pharmaceuticals Inc. Factor Xa inhibitors
WO2001000667A2 (en) * 1999-06-29 2001-01-04 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-thrombin peptide from anopheles albimanus salivary gland
CA2394803A1 (en) * 1999-11-24 2001-05-31 Sugen, Inc. Novel human protein kinases and protein kinase-like enzymes
EP1425296B1 (de) * 2001-09-10 2011-04-13 Novel Science International GmbH Organische verbindungen mit biologischer wirkung als thrombinhemmer und ihre verwendung
JP3648548B2 (ja) * 2001-10-15 2005-05-18 国立大学法人三重大学 血液凝固阻害活性を有するハマダラカ由来のＡｓ−１蛋白質
DE10301255A1 (de) 2003-01-15 2004-07-29 Cpi Creative Pharma International Gmbh Organische Verbindungen mit biologischer Wirkung als Thrombinhemmer und ihre Verwendung
WO2007067983A2 (en) * 2005-12-09 2007-06-14 Wyeth Sulfotyrosine specific antibodies and uses therefor
CN100595208C (zh) * 2006-07-31 2010-03-24 浙江中医药大学 硫酸化丝素蛋白的制备方法及其在抗凝血药物上的应用
GB0711779D0 (en) * 2007-06-18 2007-07-25 Univ Singapore Thrombin inhibitor
JP2013540995A (ja) * 2010-08-18 2013-11-07 カリス ライフ サイエンシズ ルクセンブルク ホールディングス エス．アー．エール．エル． 疾患に対する循環バイオマーカー
WO2014194015A1 (en) * 2013-05-30 2014-12-04 Virginia Commonwealth University Sulfated beta-o4 low molecular weight lignins
WO2014194361A1 (en) * 2013-06-04 2014-12-11 The University Of Sydney Peptide ligation
CN106687482B (zh) * 2014-09-17 2022-01-25 诺和诺德股份有限公司 能够结合组织因子途径抑制剂(1-161)上的两个表位的抗体
JP2023529993A (ja) * 2020-06-19 2023-07-12 ザ・ユニバーシティ・オブ・シドニー 血栓塞栓状態の治療のための改良されたトロンビン阻害剤

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008532490A (ja) * 2005-02-15 2008-08-21 アポロ ライフ サイエンシズ リミテッド 分子およびそのキメラ分子
JP2012525836A (ja) * 2009-05-05 2012-10-25 ナチュラル・エンバイロンメント・リサーチ・カウンシル セリンプロテアーゼインヒビターの改変方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PNAS, 2012, VOL. 109, NO. 52, PP. E3649-E3658, JPN6020027735, ISSN: 0004844207 *
PNAS, 2012, VOL. 109, NO. 52, PP. E3649-E3658, JPN6021033133, ISSN: 0004844206 *

Also Published As

Publication number Publication date
WO2018107247A1 (en) 2018-06-21
AU2017376839A1 (en) 2019-07-11
JP2022130527A (ja) 2022-09-06
US11091535B2 (en) 2021-08-17
US20190367583A1 (en) 2019-12-05
EP3555116A4 (en) 2020-07-22
NZ754781A (en) 2021-12-24
CA3047159A1 (en) 2018-06-21
EP3555116A1 (en) 2019-10-23
CN110139871A (zh) 2019-08-16
AU2017376839B2 (en) 2021-01-14

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