AU2017376839B2 - Thrombin inhibitors for treatment of stroke and related coagulative disorders - Google Patents

Thrombin inhibitors for treatment of stroke and related coagulative disorders Download PDF

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Publication number
AU2017376839B2
AU2017376839B2 AU2017376839A AU2017376839A AU2017376839B2 AU 2017376839 B2 AU2017376839 B2 AU 2017376839B2 AU 2017376839 A AU2017376839 A AU 2017376839A AU 2017376839 A AU2017376839 A AU 2017376839A AU 2017376839 B2 AU2017376839 B2 AU 2017376839B2
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AU
Australia
Prior art keywords
peptide
thrombin
seq
inhibitor
amino acid
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AU2017376839A
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AU2017376839A1 (en
Inventor
Pedro Jose BARBOSA PEREIRA
Shaun Phillip Jackson
Richard J Payne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Heart Research Institute Ltd
University of Sydney
IBMC Instituto de Biologia Molecular e Celular
Original Assignee
Heart Res Institute Ltd
Heart Research Institute Ltd
University of Sydney
IBMC Instituto de Biologia Molecular e Celular
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Priority claimed from AU2016905231A external-priority patent/AU2016905231A0/en
Application filed by Heart Res Institute Ltd, Heart Research Institute Ltd, University of Sydney, IBMC Instituto de Biologia Molecular e Celular filed Critical Heart Res Institute Ltd
Publication of AU2017376839A1 publication Critical patent/AU2017376839A1/en
Assigned to THE UNIVERSITY OF SYDNEY, HEART RESEARCH INSTITUTE, IBMC (Instituto de Biologia Molecular e Cellular) reassignment THE UNIVERSITY OF SYDNEY Request for Assignment Assignors: THE UNIVERSITY OF SYDNEY
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Publication of AU2017376839B2 publication Critical patent/AU2017376839B2/en
Assigned to THE UNIVERSITY OF SYDNEY, IBMC (Instituto de Biologia Molecular e Cellular), THE HEART RESEARCH INSTITUTE LIMITED reassignment THE UNIVERSITY OF SYDNEY Amend patent request/document other than specification (104) Assignors: HEART RESEARCH INSTITUTE, IBMC (Instituto de Biologia Molecular e Cellular), THE UNIVERSITY OF SYDNEY
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
AU2017376839A 2016-12-16 2017-12-15 Thrombin inhibitors for treatment of stroke and related coagulative disorders Active AU2017376839B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2016905231A AU2016905231A0 (en) 2016-12-16 Thrombin inhibitors for treatment of stroke and related coagulative disorders
AU2016905231 2016-12-16
PCT/AU2017/051405 WO2018107247A1 (en) 2016-12-16 2017-12-15 Thrombin inhibitors for treatment of stroke and related coagulative disorders

Publications (2)

Publication Number Publication Date
AU2017376839A1 AU2017376839A1 (en) 2019-07-11
AU2017376839B2 true AU2017376839B2 (en) 2021-01-14

Family

ID=62557849

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017376839A Active AU2017376839B2 (en) 2016-12-16 2017-12-15 Thrombin inhibitors for treatment of stroke and related coagulative disorders

Country Status (8)

Country Link
US (1) US11091535B2 (https=)
EP (1) EP3555116A4 (https=)
JP (2) JP2020501561A (https=)
CN (1) CN110139871A (https=)
AU (1) AU2017376839B2 (https=)
CA (1) CA3047159A1 (https=)
NZ (1) NZ754781A (https=)
WO (1) WO2018107247A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110590911B (zh) * 2019-09-30 2021-10-22 华南理工大学 一种含酪氨酸硫酸化修饰的多肽合成方法及其应用
CN114887123B (zh) * 2022-04-18 2023-07-04 南通大学 水蛭素接枝纳米纤维血管支架材料、制备方法与应用
CN119462906A (zh) * 2024-11-11 2025-02-18 武汉元启合生科技有限公司 一种酪氨酸硫酸化的重组水蛭素、制备方法及其用途

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001000667A2 (en) * 1999-06-29 2001-01-04 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-thrombin peptide from anopheles albimanus salivary gland
WO2001038503A2 (en) * 1999-11-24 2001-05-31 Sugen, Inc. Novel human protein kinases and protein kinase-like enzymes
JP2003116573A (ja) * 2001-10-15 2003-04-22 Mie Univ 血液凝固阻害活性を有するハマダラカ由来のＡｓ−１蛋白質
WO2007067983A2 (en) * 2005-12-09 2007-06-14 Wyeth Sulfotyrosine specific antibodies and uses therefor
WO2010128285A2 (en) * 2009-05-05 2010-11-11 Natural Environment Research Council Method of modifying serine protease inhibitors
WO2012024543A1 (en) * 2010-08-18 2012-02-23 Caris Life Sciences Luxembourg Holdings Circulating biomarkers for disease
WO2014194361A1 (en) * 2013-06-04 2014-12-11 The University Of Sydney Peptide ligation
WO2016042093A1 (en) * 2014-09-17 2016-03-24 Novo Nordisk A/S Antibodies capable of binding two epitopes on tissue factor pathway inhibitor (1-161)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4323754C1 (de) 1993-07-15 1994-12-01 Gruenenthal Gmbh Bifunktionelle Urokinasevarianten mit verbesserten fibrinolytischen Eigenschaften und thrombinhemmender Wirkung
US6759384B1 (en) * 1994-04-26 2004-07-06 Aventis Pharmaceuticals Inc. Factor Xa inhibitors
EP1425296B1 (de) * 2001-09-10 2011-04-13 Novel Science International GmbH Organische verbindungen mit biologischer wirkung als thrombinhemmer und ihre verwendung
DE10301255A1 (de) 2003-01-15 2004-07-29 Cpi Creative Pharma International Gmbh Organische Verbindungen mit biologischer Wirkung als Thrombinhemmer und ihre Verwendung
JP2008532490A (ja) * 2005-02-15 2008-08-21 アポロ ライフ サイエンシズ リミテッド 分子およびそのキメラ分子
CN100595208C (zh) * 2006-07-31 2010-03-24 浙江中医药大学 硫酸化丝素蛋白的制备方法及其在抗凝血药物上的应用
GB0711779D0 (en) * 2007-06-18 2007-07-25 Univ Singapore Thrombin inhibitor
WO2014194015A1 (en) * 2013-05-30 2014-12-04 Virginia Commonwealth University Sulfated beta-o4 low molecular weight lignins
JP2023529993A (ja) * 2020-06-19 2023-07-12 ザ・ユニバーシティ・オブ・シドニー 血栓塞栓状態の治療のための改良されたトロンビン阻害剤

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001000667A2 (en) * 1999-06-29 2001-01-04 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-thrombin peptide from anopheles albimanus salivary gland
WO2001038503A2 (en) * 1999-11-24 2001-05-31 Sugen, Inc. Novel human protein kinases and protein kinase-like enzymes
JP2003116573A (ja) * 2001-10-15 2003-04-22 Mie Univ 血液凝固阻害活性を有するハマダラカ由来のＡｓ−１蛋白質
WO2007067983A2 (en) * 2005-12-09 2007-06-14 Wyeth Sulfotyrosine specific antibodies and uses therefor
WO2010128285A2 (en) * 2009-05-05 2010-11-11 Natural Environment Research Council Method of modifying serine protease inhibitors
WO2012024543A1 (en) * 2010-08-18 2012-02-23 Caris Life Sciences Luxembourg Holdings Circulating biomarkers for disease
WO2014194361A1 (en) * 2013-06-04 2014-12-11 The University Of Sydney Peptide ligation
WO2016042093A1 (en) * 2014-09-17 2016-03-24 Novo Nordisk A/S Antibodies capable of binding two epitopes on tissue factor pathway inhibitor (1-161)

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
LI, W. et al., "Thrombin Inhibition by Serpins Disrupts Exosite 1l", The Journal of Biological Chemistry, (2010), vol. 285, no. 49, pages 38621 - 38629 *
THOMPSON, R. E. ET AL., "Trifluoroethanethiol: An Additive for Efficient One-Pot Peptide Ligation- Desulfurization Chemistry", Journal of the American Chemical Society, 2014, Vol. 136 (23), pages 8161-8164 *
THOMPSON, R. E. ET AL., "Tyrosine sulfation modulates activity of tick-derived thrombin inhibitors", Nature Chemistry, 2017, Vol. 9(9), pages 909-917 *
VALENZUELA, J. G. et al., "Purification, Cloning, and Synthesis of a Novel Salivary Anti-thrombin from the Mosquito Anopheles albimanus", Biochemistry, (1999), vol. 38, pages 11209 - 11215 *

Also Published As

Publication number Publication date
WO2018107247A1 (en) 2018-06-21
AU2017376839A1 (en) 2019-07-11
JP2022130527A (ja) 2022-09-06
US11091535B2 (en) 2021-08-17
US20190367583A1 (en) 2019-12-05
EP3555116A4 (en) 2020-07-22
NZ754781A (en) 2021-12-24
JP2020501561A (ja) 2020-01-23
CA3047159A1 (en) 2018-06-21
EP3555116A1 (en) 2019-10-23
CN110139871A (zh) 2019-08-16

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Owner name: HEART RESEARCH INSTITUTE

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Free format text: FORMER NAME(S): IBMC (INSTITUTO DE BIOLOGIA MOLECULAR E CELLULAR); HEART RESEARCH INSTITUTE; THE UNIVERSITY OF SYDNEY

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