NZ754781A - Thrombin inhibitors for treatment of stroke and related coagulative disorders - Google Patents

Thrombin inhibitors for treatment of stroke and related coagulative disorders

Info

Publication number
NZ754781A
NZ754781A NZ754781A NZ75478117A NZ754781A NZ 754781 A NZ754781 A NZ 754781A NZ 754781 A NZ754781 A NZ 754781A NZ 75478117 A NZ75478117 A NZ 75478117A NZ 754781 A NZ754781 A NZ 754781A
Authority
NZ
New Zealand
Prior art keywords
stroke
treatment
seq
peptide
thrombin inhibitors
Prior art date
Application number
NZ754781A
Other languages
English (en)
Inventor
Richard J Payne
Shaun Phillip Jackson
Pereira Pedro Jose Barbosa
Original Assignee
Univ Sydney
The Heart Res Institute Limited
Ibmc Inst De Biologia Molecular E Celular
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2016905231A external-priority patent/AU2016905231A0/en
Application filed by Univ Sydney, The Heart Res Institute Limited, Ibmc Inst De Biologia Molecular E Celular filed Critical Univ Sydney
Publication of NZ754781A publication Critical patent/NZ754781A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
NZ754781A 2016-12-16 2017-12-15 Thrombin inhibitors for treatment of stroke and related coagulative disorders NZ754781A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2016905231A AU2016905231A0 (en) 2016-12-16 Thrombin inhibitors for treatment of stroke and related coagulative disorders
PCT/AU2017/051405 WO2018107247A1 (en) 2016-12-16 2017-12-15 Thrombin inhibitors for treatment of stroke and related coagulative disorders

Publications (1)

Publication Number Publication Date
NZ754781A true NZ754781A (en) 2021-12-24

Family

ID=62557849

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ754781A NZ754781A (en) 2016-12-16 2017-12-15 Thrombin inhibitors for treatment of stroke and related coagulative disorders

Country Status (8)

Country Link
US (1) US11091535B2 (https=)
EP (1) EP3555116A4 (https=)
JP (2) JP2020501561A (https=)
CN (1) CN110139871A (https=)
AU (1) AU2017376839B2 (https=)
CA (1) CA3047159A1 (https=)
NZ (1) NZ754781A (https=)
WO (1) WO2018107247A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110590911B (zh) * 2019-09-30 2021-10-22 华南理工大学 一种含酪氨酸硫酸化修饰的多肽合成方法及其应用
CN114887123B (zh) * 2022-04-18 2023-07-04 南通大学 水蛭素接枝纳米纤维血管支架材料、制备方法与应用
CN119462906A (zh) * 2024-11-11 2025-02-18 武汉元启合生科技有限公司 一种酪氨酸硫酸化的重组水蛭素、制备方法及其用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4323754C1 (de) * 1993-07-15 1994-12-01 Gruenenthal Gmbh Bifunktionelle Urokinasevarianten mit verbesserten fibrinolytischen Eigenschaften und thrombinhemmender Wirkung
US6759384B1 (en) * 1994-04-26 2004-07-06 Aventis Pharmaceuticals Inc. Factor Xa inhibitors
WO2001000667A2 (en) * 1999-06-29 2001-01-04 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-thrombin peptide from anopheles albimanus salivary gland
AU1926001A (en) 1999-11-24 2001-06-04 Sugen, Inc. Novel human protein kinases and protein kinase-like enzymes
WO2003022873A1 (de) * 2001-09-10 2003-03-20 Novel Science International Gmbh Organische verbindungen mit biologischer wirkung als thrombinhemmer und ihre verwendung
JP3648548B2 (ja) 2001-10-15 2005-05-18 国立大学法人三重大学 血液凝固阻害活性を有するハマダラカ由来のＡｓ−１蛋白質
DE10301255A1 (de) * 2003-01-15 2004-07-29 Cpi Creative Pharma International Gmbh Organische Verbindungen mit biologischer Wirkung als Thrombinhemmer und ihre Verwendung
WO2006086822A1 (en) 2005-02-15 2006-08-24 Apollo Life Sciences Limited A molecule and chimeric molecules thereof
US20070298034A9 (en) * 2005-12-09 2007-12-27 Angela Widom Sulfotyrosine specific antibodies and uses therefor
CN100595208C (zh) * 2006-07-31 2010-03-24 浙江中医药大学 硫酸化丝素蛋白的制备方法及其在抗凝血药物上的应用
GB0711779D0 (en) * 2007-06-18 2007-07-25 Univ Singapore Thrombin inhibitor
GB0907698D0 (en) 2009-05-05 2009-06-10 Univ Singapore Method of modifying serine protease inhibitors
CA2808417A1 (en) 2010-08-18 2012-02-23 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Circulating biomarkers for disease
WO2014194015A1 (en) * 2013-05-30 2014-12-04 Virginia Commonwealth University Sulfated beta-o4 low molecular weight lignins
US20160122383A1 (en) 2013-06-04 2016-05-05 The University Of Sydney Peptide Ligation
JP6783754B2 (ja) 2014-09-17 2020-11-11 ノヴォ ノルディスク アー／エス 組織因子経路インヒビター（１〜１６１）上の２つのエピトープに結合する能力がある抗体
JP2023529993A (ja) * 2020-06-19 2023-07-12 ザ・ユニバーシティ・オブ・シドニー 血栓塞栓状態の治療のための改良されたトロンビン阻害剤

Also Published As

Publication number Publication date
JP2020501561A (ja) 2020-01-23
EP3555116A1 (en) 2019-10-23
EP3555116A4 (en) 2020-07-22
WO2018107247A1 (en) 2018-06-21
CA3047159A1 (en) 2018-06-21
AU2017376839A1 (en) 2019-07-11
JP2022130527A (ja) 2022-09-06
US11091535B2 (en) 2021-08-17
US20190367583A1 (en) 2019-12-05
AU2017376839B2 (en) 2021-01-14
CN110139871A (zh) 2019-08-16

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Legal Events

Date Code Title Description
ASS Change of ownership

Owner name: IBMC (INSTITUTO DE BIOLOGIA MOLECULAR E CELULA, PT

Effective date: 20210813

Owner name: THE HEART RESEARCH INSTITUTE LIMITED, AU

Effective date: 20210813

Owner name: THE UNIVERSITY OF SYDNEY PARRAMATTA ROADTHE UN, AU

Effective date: 20210813

PSEA Patent sealed
RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 15 DEC 2023 BY DENNEMEYER + CO. S.A.R.L.

Effective date: 20221205

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 15 DEC 2024 BY DENNEMEYER + CO. SARL

Effective date: 20231204

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 15 DEC 2025 BY DENNEMEYER ET CO

Effective date: 20241202

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 15 DEC 2026 BY DENNEMEYER + CO. SARL

Effective date: 20251209