JP2020501516A5 - - Google Patents
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- Publication number
- JP2020501516A5 JP2020501516A5 JP2019522647A JP2019522647A JP2020501516A5 JP 2020501516 A5 JP2020501516 A5 JP 2020501516A5 JP 2019522647 A JP2019522647 A JP 2019522647A JP 2019522647 A JP2019522647 A JP 2019522647A JP 2020501516 A5 JP2020501516 A5 JP 2020501516A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- mouse
- gene segments
- light chain
- immunoglobulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000018358 Immunoglobulins Human genes 0.000 claims description 54
- 108060003951 Immunoglobulins Proteins 0.000 claims description 54
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims description 23
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims description 23
- 238000003780 insertion Methods 0.000 claims description 22
- 239000003623 enhancer Substances 0.000 claims description 19
- 230000002708 enhancing Effects 0.000 claims description 19
- 210000004602 germ cell Anatomy 0.000 claims description 14
- 229920002332 Noncoding DNA Polymers 0.000 claims description 10
- 108010002162 IGK Proteins 0.000 claims description 9
- 102100007034 Immunoglobulin kappa light chain Human genes 0.000 claims description 9
- 210000001671 Embryonic Stem Cells Anatomy 0.000 claims description 7
- 229920001850 Nucleic acid sequence Polymers 0.000 claims description 6
- 229920003013 deoxyribonucleic acid Polymers 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 210000002308 embryonic cell Anatomy 0.000 claims 1
- 241000283984 Rodentia Species 0.000 description 81
- 210000004027 cells Anatomy 0.000 description 5
- 241000700159 Rattus Species 0.000 description 3
- 239000000427 antigen Substances 0.000 description 3
- 102000038129 antigens Human genes 0.000 description 3
- 108091007172 antigens Proteins 0.000 description 3
- 238000011144 upstream manufacturing Methods 0.000 description 3
- 102000004965 antibodies Human genes 0.000 description 2
- 108090001123 antibodies Proteins 0.000 description 2
- 230000028993 immune response Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662417845P | 2016-11-04 | 2016-11-04 | |
| US62/417,845 | 2016-11-04 | ||
| US201762567932P | 2017-10-04 | 2017-10-04 | |
| US62/567,932 | 2017-10-04 | ||
| PCT/US2017/060006 WO2018128691A1 (en) | 2016-11-04 | 2017-11-03 | Non-human animals having an engineered immunoglobulin lambda light chain locus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021036180A Division JP2021090455A (ja) | 2016-11-04 | 2021-03-08 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020501516A JP2020501516A (ja) | 2020-01-23 |
| JP2020501516A5 true JP2020501516A5 (el) | 2020-12-10 |
| JP6884860B2 JP6884860B2 (ja) | 2021-06-09 |
Family
ID=62025924
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019522647A Active JP6884860B2 (ja) | 2016-11-04 | 2017-11-03 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
| JP2021036180A Withdrawn JP2021090455A (ja) | 2016-11-04 | 2021-03-08 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
| JP2022109658A Active JP7386292B2 (ja) | 2016-11-04 | 2022-07-07 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
| JP2023023312A Pending JP2023053400A (ja) | 2016-11-04 | 2023-02-17 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021036180A Withdrawn JP2021090455A (ja) | 2016-11-04 | 2021-03-08 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
| JP2022109658A Active JP7386292B2 (ja) | 2016-11-04 | 2022-07-07 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
| JP2023023312A Pending JP2023053400A (ja) | 2016-11-04 | 2023-02-17 | 操作されたイムノグロブリンラムダ軽鎖座位を有する非ヒト動物 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US10820582B2 (el) |
| EP (3) | EP3766343B1 (el) |
| JP (4) | JP6884860B2 (el) |
| KR (4) | KR102492433B1 (el) |
| CN (2) | CN109996441B (el) |
| AU (2) | AU2017391167B2 (el) |
| BR (1) | BR112019008675A2 (el) |
| CA (1) | CA3038720A1 (el) |
| CY (1) | CY1123491T1 (el) |
| DK (2) | DK3766343T3 (el) |
| ES (2) | ES2823305T3 (el) |
| HR (2) | HRP20220888T1 (el) |
| HU (2) | HUE061980T2 (el) |
| IL (2) | IL308197A (el) |
| LT (2) | LT3766343T (el) |
| MA (2) | MA53935A (el) |
| MX (2) | MX2019005256A (el) |
| PL (2) | PL3407709T3 (el) |
| PT (2) | PT3766343T (el) |
| RS (2) | RS63390B1 (el) |
| RU (2) | RU2021129958A (el) |
| SG (2) | SG11201903344XA (el) |
| SI (2) | SI3766343T1 (el) |
| WO (1) | WO2018128691A1 (el) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104202971B (zh) * | 2012-02-01 | 2016-07-06 | 瑞泽恩制药公司 | 表达包含vl结构域的重链的人源化啮齿动物的制备方法 |
| EP3384030A4 (en) | 2015-12-03 | 2019-07-03 | Trianni, Inc. | IMPROVED IMMUNOGLULINIVITY |
| LT3766343T (lt) | 2016-11-04 | 2022-06-10 | Regeneron Pharmaceuticals, Inc. | Gyvūnai, išskyrus žmogų, turintys sukonstruotą imunoglobulino lambda lengvosios grandinės lokusą |
| US20210051929A1 (en) | 2018-03-24 | 2021-02-25 | Regeneron Pharmaceuticals, Inc. | Genetically modified non-human animals for generating therapeutic antibodies against peptide-mhc complexes, methods of making and uses thereof |
| MA52177A (fr) | 2018-03-26 | 2021-02-17 | Regeneron Pharma | Rongeurs humanisés pour tester des agents thérapeutiques |
| AU2019287727B2 (en) | 2018-06-14 | 2022-12-01 | Regeneron Pharmaceuticals, Inc. | Non-human animals capable of DH-DH rearrangement in the immunoglobulin heavy chain coding sequences |
| KR20210129083A (ko) | 2019-02-22 | 2021-10-27 | 리제너론 파마슈티칼스 인코포레이티드 | 유전적으로 변형된 나트륨 채널을 갖는 설치류 및 이의 사용 방법 |
| CN114554841B (zh) * | 2019-07-01 | 2024-06-11 | 特里安尼公司 | 转基因哺乳动物及其使用方法 |
| AU2021342159A1 (en) | 2020-09-11 | 2023-03-02 | Regeneron Pharmaceuticals, Inc. | Identification and production of antigen-specific antibodies |
| IL303626A (en) | 2020-12-16 | 2023-08-01 | Regeneron Pharma | Mice expressing human FC alpha receptors |
| EP4267608A1 (en) | 2020-12-23 | 2023-11-01 | Regeneron Pharmaceuticals, Inc. | Methods for obtaining antibodies that bind transmembrane proteins and cells that produce the same |
| MX2023007401A (es) | 2020-12-23 | 2023-07-06 | Regeneron Pharma | Acidos nucleicos que codifican anticuerpos modificados por anclaje y usos de los mismos. |
| GB202217978D0 (en) * | 2022-11-30 | 2023-01-11 | Petmedix Ltd | Rodents expressing a common light chain |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0746609A4 (en) * | 1991-12-17 | 1997-12-17 | Genpharm Int | NON-HUMAN TRANSGENIC ANIMALS CAPABLE OF PRODUCING HETEROLOGOUS ANTIBODIES |
| US5670356A (en) | 1994-12-12 | 1997-09-23 | Promega Corporation | Modified luciferase |
| US5874304A (en) | 1996-01-18 | 1999-02-23 | University Of Florida Research Foundation, Inc. | Humanized green fluorescent protein genes and methods |
| GB9823930D0 (en) | 1998-11-03 | 1998-12-30 | Babraham Inst | Murine expression of human ig\ locus |
| US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| WO2003047336A2 (en) | 2001-11-30 | 2003-06-12 | Abgenix, Inc. | TRANSGENIC ANIMALS BEARING HUMAN Igμ LIGHT CHAIN GENES |
| WO2005007696A2 (en) * | 2003-07-15 | 2005-01-27 | Therapeutic Human Polyclonals, Inc. | Humanized immunoglobulin loci |
| SI2041177T1 (sl) | 2006-06-02 | 2012-03-30 | Regeneron Pharma | Visoko afinitetna protitelesa za humani IL receptor |
| CA2739038C (en) | 2008-09-30 | 2020-04-28 | Ablexis, Llc | Non-human mammals for the production of chimeric antibodies |
| BRPI0922479A2 (pt) * | 2008-12-18 | 2017-07-25 | Univ Erasmus Med Ct Rotterdam | Animais transgênicos não humanos que expressam os anticorpos humanizados e uso deles |
| HUE055817T2 (hu) * | 2009-07-08 | 2021-12-28 | Kymab Ltd | Állatmodellek és terápiás molekulák |
| US20120204278A1 (en) * | 2009-07-08 | 2012-08-09 | Kymab Limited | Animal models and therapeutic molecules |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| WO2011115476A1 (en) | 2010-03-17 | 2011-09-22 | N.V. Nutricia | Infant nutrition for improving fatty acid composition of brain membranes later in life |
| ES2576928T3 (es) | 2010-06-22 | 2016-07-12 | Regeneron Pharmaceuticals, Inc. | Ratones que expresan una cadena ligera con las regiones variable lambda humana y constante de ratón |
| EP2738258B2 (en) | 2011-02-25 | 2023-02-01 | Regeneron Pharmaceuticals, Inc. | ADAM6 mice |
| DK3216871T3 (da) | 2011-10-17 | 2022-02-21 | Regeneron Pharma | Mus med indskrænket tung immunoglobulinkæde |
| US9253965B2 (en) * | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| SG10201913164YA (en) * | 2011-12-20 | 2020-03-30 | Regeneron Pharma | Humanized light chain mice |
| KR20160025033A (ko) * | 2013-02-20 | 2016-03-07 | 리제너론 파마슈티칼스 인코포레이티드 | 변형된 면역글로불린 중쇄 서열을 갖는 비인간 동물 |
| RU2690352C2 (ru) | 2013-02-20 | 2019-05-31 | Регенерон Фармасютикалс, Инк. | Генетическая модификация крыс |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| DE112014004537T5 (de) * | 2013-10-01 | 2016-07-21 | Kymab Limited | Tiermodelle und therapeutische Moleküle |
| MX2016007654A (es) | 2013-12-11 | 2017-08-15 | Regeneron Pharma | Metodos y composiciones para la modificacion dirigida de un genoma. |
| CN106795521B (zh) | 2014-06-06 | 2021-06-04 | 瑞泽恩制药公司 | 用于修饰所靶向基因座的方法和组合物 |
| EP3354732B1 (en) | 2014-06-23 | 2020-01-08 | Regeneron Pharmaceuticals, Inc. | Nuclease-mediated dna assembly |
| ES2731437T3 (es) | 2014-11-21 | 2019-11-15 | Regeneron Pharma | Métodos y composiciones para la modificación genética dirigida mediante el uso de pares de ARN guías |
| EP3232774B1 (en) | 2014-12-19 | 2019-10-09 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for targeted genetic modification through single-step multiple targeting |
| LT3766343T (lt) | 2016-11-04 | 2022-06-10 | Regeneron Pharmaceuticals, Inc. | Gyvūnai, išskyrus žmogų, turintys sukonstruotą imunoglobulino lambda lengvosios grandinės lokusą |
-
2017
- 2017-11-03 LT LTEP20180508.2T patent/LT3766343T/lt unknown
- 2017-11-03 PT PT201805082T patent/PT3766343T/pt unknown
- 2017-11-03 KR KR1020217034468A patent/KR102492433B1/ko active IP Right Grant
- 2017-11-03 DK DK20180508.2T patent/DK3766343T3/da active
- 2017-11-03 MX MX2019005256A patent/MX2019005256A/es unknown
- 2017-11-03 RU RU2021129958A patent/RU2021129958A/ru unknown
- 2017-11-03 ES ES17863293T patent/ES2823305T3/es active Active
- 2017-11-03 HU HUE20180508A patent/HUE061980T2/hu unknown
- 2017-11-03 CN CN201780067880.6A patent/CN109996441B/zh active Active
- 2017-11-03 EP EP20180508.2A patent/EP3766343B1/en active Active
- 2017-11-03 SI SI201731147T patent/SI3766343T1/sl unknown
- 2017-11-03 PL PL17863293T patent/PL3407709T3/pl unknown
- 2017-11-03 HU HUE17863293A patent/HUE052087T2/hu unknown
- 2017-11-03 MA MA053935A patent/MA53935A/fr unknown
- 2017-11-03 JP JP2019522647A patent/JP6884860B2/ja active Active
- 2017-11-03 KR KR1020197015717A patent/KR102319069B1/ko active IP Right Grant
- 2017-11-03 LT LTEP17863293.1T patent/LT3407709T/lt unknown
- 2017-11-03 SG SG11201903344XA patent/SG11201903344XA/en unknown
- 2017-11-03 EP EP22164751.4A patent/EP4082334A1/en active Pending
- 2017-11-03 CN CN202210050898.8A patent/CN114369157A/zh active Pending
- 2017-11-03 PT PT178632931T patent/PT3407709T/pt unknown
- 2017-11-03 PL PL20180508.2T patent/PL3766343T3/pl unknown
- 2017-11-03 HR HRP20220888TT patent/HRP20220888T1/hr unknown
- 2017-11-03 IL IL308197A patent/IL308197A/en unknown
- 2017-11-03 AU AU2017391167A patent/AU2017391167B2/en active Active
- 2017-11-03 ES ES20180508T patent/ES2915609T3/es active Active
- 2017-11-03 BR BR112019008675A patent/BR112019008675A2/pt unknown
- 2017-11-03 MA MA044091A patent/MA44091A/fr unknown
- 2017-11-03 KR KR1020237002504A patent/KR102658529B1/ko active IP Right Grant
- 2017-11-03 EP EP17863293.1A patent/EP3407709B9/en active Active
- 2017-11-03 IL IL266282A patent/IL266282B2/en unknown
- 2017-11-03 US US15/803,513 patent/US10820582B2/en active Active
- 2017-11-03 RU RU2019112589A patent/RU2757665C2/ru active
- 2017-11-03 SG SG10201913483XA patent/SG10201913483XA/en unknown
- 2017-11-03 WO PCT/US2017/060006 patent/WO2018128691A1/en active Application Filing
- 2017-11-03 DK DK17863293.1T patent/DK3407709T3/da active
- 2017-11-03 RS RS20220669A patent/RS63390B1/sr unknown
- 2017-11-03 CA CA3038720A patent/CA3038720A1/en active Pending
- 2017-11-03 RS RS20201205A patent/RS60886B1/sr unknown
- 2017-11-03 SI SI201730381T patent/SI3407709T1/sl unknown
- 2017-11-03 KR KR1020247012338A patent/KR20240055863A/ko active Search and Examination
-
2019
- 2019-05-03 MX MX2021010556A patent/MX2021010556A/es unknown
-
2020
- 2020-09-03 HR HRP20201403TT patent/HRP20201403T1/hr unknown
- 2020-09-24 US US17/031,367 patent/US20210029978A1/en active Pending
- 2020-10-29 CY CY20201101022T patent/CY1123491T1/el unknown
-
2021
- 2021-03-08 JP JP2021036180A patent/JP2021090455A/ja not_active Withdrawn
-
2022
- 2022-07-07 JP JP2022109658A patent/JP7386292B2/ja active Active
-
2023
- 2023-02-17 JP JP2023023312A patent/JP2023053400A/ja active Pending
-
2024
- 2024-01-31 AU AU2024200582A patent/AU2024200582A1/en active Pending
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