JP2020500909A5 - - Google Patents
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- Publication number
- JP2020500909A5 JP2020500909A5 JP2019530790A JP2019530790A JP2020500909A5 JP 2020500909 A5 JP2020500909 A5 JP 2020500909A5 JP 2019530790 A JP2019530790 A JP 2019530790A JP 2019530790 A JP2019530790 A JP 2019530790A JP 2020500909 A5 JP2020500909 A5 JP 2020500909A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- heteroaryl
- heterocyclyl
- alkynyl
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022070763A JP2022090051A (ja) | 2016-12-07 | 2022-04-22 | ＰＩ３Ｋδ阻害剤としてのイミダゾ［１，５－ａ］ピラジン誘導体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2016108897 | 2016-12-07 | ||
| CNPCT/CN2016/108897 | 2016-12-07 | ||
| PCT/CN2017/114970 WO2018103688A1 (en) | 2016-12-07 | 2017-12-07 | IMIDAZO [1,5-A] PYRAZINE DERIVATIVES AS PI3Kdelta INHIBITORS |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022070763A Division JP2022090051A (ja) | 2016-12-07 | 2022-04-22 | ＰＩ３Ｋδ阻害剤としてのイミダゾ［１，５－ａ］ピラジン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020500909A JP2020500909A (ja) | 2020-01-16 |
| JP2020500909A5 true JP2020500909A5 (https=) | 2021-01-21 |
| JP7064495B2 JP7064495B2 (ja) | 2022-05-10 |
Family
ID=62491736
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019530790A Expired - Fee Related JP7064495B2 (ja) | 2016-12-07 | 2017-12-07 | ＰＩ３Ｋδ阻害剤としてのイミダゾ［１，５－ａ］ピラジン誘導体 |
| JP2022070763A Pending JP2022090051A (ja) | 2016-12-07 | 2022-04-22 | ＰＩ３Ｋδ阻害剤としてのイミダゾ［１，５－ａ］ピラジン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022070763A Pending JP2022090051A (ja) | 2016-12-07 | 2022-04-22 | ＰＩ３Ｋδ阻害剤としてのイミダゾ［１，５－ａ］ピラジン誘導体 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11136323B2 (https=) |
| EP (1) | EP3551630A4 (https=) |
| JP (2) | JP7064495B2 (https=) |
| KR (1) | KR20190091339A (https=) |
| CN (2) | CN110267959B (https=) |
| AU (2) | AU2017372377B2 (https=) |
| BR (1) | BR112019011847A2 (https=) |
| CA (1) | CA3045959A1 (https=) |
| EA (1) | EA201991355A1 (https=) |
| IL (2) | IL266986B (https=) |
| MX (1) | MX394882B (https=) |
| NZ (1) | NZ754944A (https=) |
| SG (1) | SG10201912192RA (https=) |
| TW (2) | TW202233190A (https=) |
| WO (1) | WO2018103688A1 (https=) |
| ZA (1) | ZA201903286B (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3045959A1 (en) | 2016-12-07 | 2018-06-14 | Beigene, Ltd. | Imidazo [1,5-a] pyrazine derivatives as pi3kdelta inhibitors |
| BR112020004500A2 (pt) * | 2017-09-08 | 2020-12-01 | Beigene, Ltd. | derivados de imidazo [1,5-a] pirazina como inibidores de pi3kdelta |
| US20230011916A1 (en) * | 2019-11-21 | 2023-01-12 | Beigene, Ltd. | Methods of cancer treatment using anti-ox40 antibodies in combination with pi3 kinase delta inhibitors |
| KR102344185B1 (ko) * | 2020-02-26 | 2021-12-27 | 계명대학교 산학협력단 | 신규한 Pim 키나아제 억제제 및 이의 용도 |
| AU2022280905A1 (en) * | 2021-05-27 | 2024-01-18 | Beigene Switzerland Gmbh | SALTS OF A PI3Kdelta INHIBITOR, CRYSTALLINE FORMS, METHODS OF PREPARATION, AND USES THEREFORE |
| WO2023040810A1 (en) * | 2021-09-14 | 2023-03-23 | Beigene, Ltd. | Methods of cancer treatment using a combination of btk inhibitors and pi3 kinase inhibitors |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA83509C2 (en) | 2003-10-15 | 2008-07-25 | Оси Фармасьютикалз, Инк. | Imidazopyrazines as tyrosine kinase inhibitors |
| BRPI1014572B8 (pt) | 2009-04-16 | 2022-07-19 | Fundacion Centro Nac De Investigaciones Oncologicas Carlos Iii | Imidazopirazinas para uso como inibidores de cinase |
| RU2013138835A (ru) | 2011-02-09 | 2015-03-20 | Ф. Хоффманн-Ля Рош Аг | Гетероциклические соединения в качестве ингибиторов pi3 киназы |
| ES2588186T3 (es) * | 2012-01-10 | 2016-10-31 | Bayer Intellectual Property Gmbh | Imidazopirazinas sustituidas como inhibidores de la quinasa Akt |
| AU2013337717B2 (en) | 2012-11-01 | 2018-10-25 | Infinity Pharmaceuticals, Inc. | Treatment of cancers using PI3 kinase isoform modulators |
| CA2914284A1 (en) | 2013-05-30 | 2014-12-04 | Infinity Pharmaceuticals, Inc. | Treatment of cancers using pi3 kinase isoform modulators |
| CA2922058A1 (en) * | 2013-10-18 | 2015-04-23 | Medivation Technologies, Inc. | Heterocyclic compounds and methods of use |
| PL3179991T3 (pl) | 2014-08-11 | 2022-02-14 | Acerta Pharma B.V. | Kombinacje terapeutyczne inhibitora btk i inhibitora bcl-2 |
| CA3045959A1 (en) * | 2016-12-07 | 2018-06-14 | Beigene, Ltd. | Imidazo [1,5-a] pyrazine derivatives as pi3kdelta inhibitors |
| BR112020004500A2 (pt) | 2017-09-08 | 2020-12-01 | Beigene, Ltd. | derivados de imidazo [1,5-a] pirazina como inibidores de pi3kdelta |
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2017
- 2017-12-07 CA CA3045959A patent/CA3045959A1/en active Pending
- 2017-12-07 EP EP17877406.3A patent/EP3551630A4/en not_active Withdrawn
- 2017-12-07 TW TW111114434A patent/TW202233190A/zh unknown
- 2017-12-07 AU AU2017372377A patent/AU2017372377B2/en not_active Ceased
- 2017-12-07 CN CN201780076039.3A patent/CN110267959B/zh not_active Expired - Fee Related
- 2017-12-07 US US16/466,621 patent/US11136323B2/en active Active
- 2017-12-07 TW TW106143023A patent/TWI762534B/zh not_active IP Right Cessation
- 2017-12-07 MX MX2019006612A patent/MX394882B/es unknown
- 2017-12-07 BR BR112019011847-0A patent/BR112019011847A2/pt not_active IP Right Cessation
- 2017-12-07 EA EA201991355A patent/EA201991355A1/ru unknown
- 2017-12-07 JP JP2019530790A patent/JP7064495B2/ja not_active Expired - Fee Related
- 2017-12-07 CN CN202210507333.8A patent/CN114805366A/zh active Pending
- 2017-12-07 WO PCT/CN2017/114970 patent/WO2018103688A1/en not_active Ceased
- 2017-12-07 NZ NZ754944A patent/NZ754944A/en not_active IP Right Cessation
- 2017-12-07 KR KR1020197019710A patent/KR20190091339A/ko not_active Ceased
- 2017-12-07 SG SG10201912192RA patent/SG10201912192RA/en unknown
-
2019
- 2019-05-24 ZA ZA2019/03286A patent/ZA201903286B/en unknown
- 2019-05-29 IL IL266986A patent/IL266986B/en unknown
-
2021
- 2021-07-08 US US17/370,728 patent/US11725012B2/en active Active
-
2022
- 2022-02-07 IL IL290419A patent/IL290419B2/en unknown
- 2022-04-22 JP JP2022070763A patent/JP2022090051A/ja active Pending
- 2022-05-31 AU AU2022203737A patent/AU2022203737A1/en not_active Abandoned