ES2855732T3 - Compuestos y composiciones para tratar afecciones asociadas con la actividad de NLRP - Google Patents

Compuestos y composiciones para tratar afecciones asociadas con la actividad de NLRP Download PDF

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ES2855732T3
ES2855732T3 ES17720928T ES17720928T ES2855732T3 ES 2855732 T3 ES2855732 T3 ES 2855732T3 ES 17720928 T ES17720928 T ES 17720928T ES 17720928 T ES17720928 T ES 17720928T ES 2855732 T3 ES2855732 T3 ES 2855732T3
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alkyl
hydroxy
membered
optionally substituted
ring
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Gary Glick
Shomir Ghosh
William R Roush
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Novartis AG
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Novartis AG
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Abstract

Un compuesto de Fórmula II, **(Ver fórmula)** o una sal farmacéuticamente aceptable del mismo, en donde la Fórmula II se selecciona de **(Ver fórmula)** se selecciona de **(Ver fórmula)** o **(Ver fórmula)** X2 es N o CR9; X3 es NH u O; X3' es O; o cuando X3 es NH, X3 y R2, tomados junto con los átomos que los conectan, forman un anillo heterocíclico de cuatro a siete miembros opcionalmente sustituido con uno o más R16; o cuando X3 es NH, X3 y R4, tomados junto con los átomos que los conectan, forman un anillo heterocíclico de cuatro a siete miembros opcionalmente sustituido con uno o más R16; Y es N o CR8; R8 se selecciona de H, CN, Cl, F, CO2alquilo C1-C6, CO2cicloalquilo C3-C8, CONR11R12, alquilo C1-C6, haloalcoxi C1-C6 y haloalquilo C1-C6; R8' se selecciona de CN, CO2alquilo C1-C6, CO2cicloalquilo C3-C8, CONR11R12 y haloalquilo C1-C6; R9 se selecciona de H, CN, Cl, F, CO2alquilo C1-C6, CO2cicloalquilo C3-C8, CONR11R12, alquilo C1-C6 y haloalquilo C1-C6; R2 es hidrógeno, alcoxi C1-C6, halo, haloalquilo C1-C6 o alquilo C1-C6 opcionalmente sustituido con hidroxi; R2' es hidrógeno, halo o alquilo C1-C6, opcionalmente sustituido con hidroxi; R2" es hidrógeno o alquilo C1-C6; R3 es hidrógeno, CN, alcoxi C1-C6, halo, haloalquilo C1-C6 o alquilo C1-C6 opcionalmente sustituido con hidroxi; R3' es hidrógeno, halo o alquilo C1-C6, opcionalmente sustituido con hidroxi; R3" es hidrógeno, CN o alquilo C1-C6; R4 es hidrógeno, alcoxi C1-C6, halo, haloalquilo C1-C6 o alquilo C1-C6 opcionalmente sustituido con hidroxi; R4' es hidrógeno, halo o alquilo C1-C6, opcionalmente sustituido con hidroxi; R4" es hidrógeno o alquilo C1-C6; R5 es hidrógeno, alcoxi C1-C6, halo, haloalquilo C1-C6 o alquilo C1-C6 opcionalmente sustituido con hidroxi; R5' es hidrógeno, halo o alquilo C1-C6, opcionalmente sustituido con hidroxi; R5" es hidrógeno, CN o alquilo C1-C6; o R2 y R3, tomados junto con los carbonos que los conectan, forman un anillo A de cuatro miembros a siete miembros, o R2' y R3', tomados junto con los carbonos que los conectan, forman un anillo A de cuatro miembros a siete miembros, o R4 y R5, tomados junto con los carbonos que los conectan, forman un anillo B de cuatro miembros a siete miembros, o R4' y R5', tomados junto con los carbonos que los conectan, forman un anillo B de cuatro miembros a siete miembros, o R2 y R3, tomados junto con los carbonos que los conectan, forman un anillo A de cuatro miembros a siete miembros y R4 y R5, tomados junto con los carbonos que los conectan, forman un anillo B de cuatro miembros a siete miembros, o R2' y R3', tomados junto con los carbonos que los conectan, forman un anillo A de cuatro miembros a siete miembros y R4' y R5', tomados junto con los carbonos que los conectan, forman un anillo B de cuatro miembros a siete miembros, en donde anillo A es **(Ver fórmula)** y anillo B es **(Ver fórmula)** en donde anillo A es un anillo carbocíclico saturado; n1 es de 2 a 5; m1 es de 1 a 10; en donde anillo B es un anillo carbocíclico saturado; n2 es de 2 a 5; m2 es de 1 a 10; en donde cada uno de los R6 en cada uno de los anillos es el mismo o diferente y se selecciona de H, alquilo C1-C6, alcoxi C1-C6, NR11R12, oxo y =NR13; o dos R6, tomados junto con el átomo o los átomos que los conectan, forman un anillo carbocíclico de 3 a 8 miembros o heterocíclico saturado que contiene 1 o 2 heteroátomos seleccionados independientemente de O, N, y S; R1 se selecciona de H, alquilo C1-C6 no sustituido, C(R19)2OH, C(O)alquilo C2-C6 y cicloalquilo C3-C6; en donde cada uno de los C(O)alquilo C2-C6 y cicloalquilo C3-C6 anteriores está opcionalmente sustituido con uno o más sustituyentes, cada uno independientemente seleccionado de hidroxi, alcoxi C1-C6, NR11R12, =NR13, COOalquilo C1-C6 y CONR11R12; R1' se selecciona de alquilo C1-C6 no sustituido, C(R19)2OH, C(O)alquilo C2-C6 y cicloalquilo C3-C6; en donde cada uno de los C(O)alquilo C2-C6 y cicloalquilo C3-C6 anteriores está opcionalmente sustituido con uno o más sustituyentes, cada uno independientemente seleccionado de hidroxi, alcoxi C1-C6, NR11R12, =NR13, COOalquilo C1-C6 y CONR11R12; R1" se selecciona de alquilo C1-C6 no sustituido, C(O)alquilo C2-C6 y cicloalquilo C3-C6, en donde cada uno de C(O)alquilo C2-C6 y cicloalquilo C3-C6 anteriores está opcionalmente sustituido con uno o más sustituyentes, cada uno independientemente seleccionado de hidroxi, oxo, alcoxi C1-C6, NR11R12, =NR13, COOalquilo C1-C6 y CONR11R12; R1"' se selecciona de C(R19)2OH; R10 se selecciona de H, Cl, alquilo C1-C6, cicloalquilo C3-C6 y heterocicloalquilo C3-C6, en donde R10 está opcionalmente sustituido con uno o más sustituyentes, cada uno independientemente seleccionado de hidroxi, alcoxi C1-C6, NR11R12, =NR13, COOalquilo C1-C6 y CONR11R12; R10' se selecciona de H, Cl, cicloalquilo C3-C6 y heterocicloalquilo C3-C6; en donde R10' está opcionalmente sustituido con uno o más sustituyentes, cada uno independientemente seleccionado de hidroxi, oxo, alcoxi C1-C6, NR11R12, =NR13, COOalquilo C1-C6 y CONR11R12; R10" se selecciona de Cl, alquilo C1-C6, cicloalquilo C3-C6 y heterocicloalquilo C3-C6; en donde R10" está opcionalmente sustituido con uno o más sustituyentes, cada uno independientemente seleccionado de hidroxi, alcoxi C1-C6, NR11R12, =NR13, COOalquilo C1-C6 y CONR11R12; R10"' se selecciona de Cl, alquilo C1-C6 sustituido con hidroxi, cicloalquilo C3-C6 y heterocicloalquilo C3-C6; en donde los cicloalquilo C3-C6 y heterocicloalquilo C3-C6 anteriores está opcionalmente sustituido con uno o más sustituyentes, cada uno independientemente seleccionado de hidroxi, oxo, alcoxi C1-C6, NR11R12, =NR13, COOalquilo C1- C6 y CONR11R12; o R1 y R10, tomados junto con los átomos que los conectan, forman un anillo carbocíclico o heterocíclico de 3 a 8 miembros que contiene 1 o 2 heteroátomos seleccionados independientemente de O, N y S, en donde el anillo está opcionalmente sustituido con uno o más sustituyentes, seleccionados cada uno independientemente de hidroxi, oxo, alcoxi C1-C6, NR11R12, =NR13, COOalquilo C1-C6 y CONR11R12; R13 es alquilo C1-C6; cada uno de los R11 y R12, en cada aparición, se selecciona independientemente de hidrógeno, alquilo C1-C6, CO2R15 y CONR17R18; R15 es alquilo C1-C6; cada uno de R17 y R18 en cada aparición se selecciona independientemente de hidrógeno y alquilo C1-C6; cada uno de los R16 es el mismo o diferente y se selecciona de H, alquilo C1-C6, alcoxi C1-C6, NR11R12, oxo y =NR13; cada uno de los R19 es el mismo y es alquilo C1-C6. R20 se selecciona de H, halo o alquilo C1-C6, opcionalmente sustituido con hidroxi; R21 se selecciona de H, halo o alquilo C1-C6 sustituido con hidroxi; con la condición de que si (1) en la Fórmula II es **(Ver fórmula)** y si (2) R10' es H o heterociclilo C3-C6, entonces **(Ver fórmula)** no es **(Ver fórmula)** y con la condición de que si: (1) Fórmula II es **(Ver fórmula)** o **(Ver fórmula)** y (2) cualquiera de R1 o R1', cuando está presente, es C(R19)2OH; y (3) cualquiera de R10' o R10"', cuando está presente, no es Cl; entonces **(Ver fórmula)** no es **(Ver fórmula)** y con la condición de que si: (1) Fórmula II es **(Ver fórmula)** y (2) R10'" es alquilo C1-C6 sustituido con hidroxi; entonces **(Ver fórmula)** no es **(Ver fórmula)**
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Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3046933B1 (fr) * 2016-01-25 2018-03-02 Galderma Research & Development Inhibiteurs nlrp3 pour le traitement des pathologies cutanees inflammatoires
JP7050751B2 (ja) 2016-04-18 2022-04-08 ノバルティス アーゲー Ｎｌｒｐ活性に関連する状態を処置するための化合物および組成物
JP7163293B2 (ja) 2017-01-23 2022-10-31 ジェネンテック， インコーポレイテッド インターロイキン－１活性の阻害剤としての化学化合物
US11840543B2 (en) 2017-05-24 2023-12-12 The University Of Queensland Compounds and uses
WO2019008029A1 (en) * 2017-07-07 2019-01-10 Inflazome Limited SULFONYLURATES AND SULFONYLTHIOURES AS INHIBITORS OF NLRP3
HRP20220195T1 (hr) 2017-07-07 2022-04-15 Inflazome Limited Novi spojevi sulfonamid karboksamida
EP3658538B1 (en) * 2017-07-24 2023-04-19 Novartis AG Compounds and compositions for treating conditions associated with nlrp activity
CN117209447A (zh) 2017-07-24 2023-12-12 诺华股份有限公司 用于治疗与nlrp活性相关的病症的化合物和组合物
PE20200758A1 (es) 2017-08-15 2020-07-27 Inflazome Ltd Sulfonilureas y sulfoniltioureas como inhibidores de nlrp3
EP3668843A1 (en) 2017-08-15 2020-06-24 Inflazome Limited Sulfonylureas and sulfonylthioureas as nlrp3 inhibitors
TW201910317A (zh) 2017-08-15 2019-03-16 愛爾蘭商英弗雷佐姆有限公司 新穎化合物
WO2019043610A1 (en) 2017-08-31 2019-03-07 Cadila Healthcare Limited NEW SUBSTITUTED SULFONYLUREA DERIVATIVES
CA3078195A1 (en) * 2017-11-09 2019-05-16 Inflazome Limited Novel sulfonamide carboxamide compounds
WO2019092171A1 (en) 2017-11-09 2019-05-16 Inflazome Limited Novel sulfonamide carboxamide compounds
GB201803394D0 (en) * 2018-03-02 2018-04-18 Inflazome Ltd Novel compounds
GB201803393D0 (en) * 2018-03-02 2018-04-18 Inflazome Ltd Novel compounds
US11905252B2 (en) 2018-03-02 2024-02-20 Inflazome Limited Compounds
WO2019166627A1 (en) 2018-03-02 2019-09-06 Inflazome Limited Novel compounds
WO2019166633A1 (en) 2018-03-02 2019-09-06 Inflazome Limited Sulfonamide derivates as nlrp3 inhibitors
GB201806578D0 (en) 2018-04-23 2018-06-06 Inflazome Ltd Novel compound
US20210261512A1 (en) 2018-05-04 2021-08-26 Inflazome Limited Novel compounds
CA3103664A1 (en) 2018-07-03 2020-01-09 Novartis Ag Methods of treating or selecting a treatment for a subject resistant to tnf inhibitor using a nlrp3 antagonist
US20210395241A1 (en) * 2018-07-03 2021-12-23 Novartis Ag Nlrp modulators
JP2021529187A (ja) * 2018-07-03 2021-10-28 ノバルティス アーゲー Ｎｌｒｐモジュレータ
PE20211811A1 (es) 2018-07-20 2021-09-14 Hoffmann La Roche Compuestos de sulfonimidamida como inhibidores de la actividad de interleucina-1
CA3104199A1 (en) 2018-07-20 2020-01-23 F. Hoffmann-La Roche Ag Sulfonylurea compounds as inhibitors of interleukin-1 activity
GB201902327D0 (en) 2019-02-20 2019-04-03 Inflazome Ltd Novel compounds
PE20211333A1 (es) 2018-08-15 2021-07-22 Inflazome Ltd Compuestos de sulfonamidaurea novedosos
JP2022505525A (ja) * 2018-10-24 2022-01-14 ノバルティス アーゲー Ｎｌｒｐ活性に関連する状態を治療するための化合物及び組成物
ES2974842T3 (es) * 2018-11-13 2024-07-01 Novartis Ag Compuestos y composiciones para el tratamiento de afecciones asociadas a la actividad de nlrp
US12134611B2 (en) 2018-11-13 2024-11-05 Novartis Ag Compounds and compositions for treating conditions associated with NLRP activity
CN120531732A (zh) * 2018-11-13 2025-08-26 诺华股份有限公司 用于治疗与nlrp活性相关的病症的化合物和组合物
CN113227055A (zh) * 2018-11-16 2021-08-06 诺华股份有限公司 用于治疗与nlrp活性相关的病症的化合物和组合物
GB201819083D0 (en) * 2018-11-23 2019-01-09 Inflazome Ltd Novel compounds
CN113474333B (zh) 2019-01-14 2025-06-13 载度思生命科学有限公司 新的经取代的磺酰脲类衍生物
GB201905265D0 (en) 2019-04-12 2019-05-29 Inflazome Ltd Inflammasome inhibition
CN111848461A (zh) * 2019-04-29 2020-10-30 苏州大学 Nlrp3炎症小体抑制剂及其制备方法和应用
CA3141407A1 (en) * 2019-06-17 2020-12-24 Charles A. Dinarello Method for treating asthma
US20220378801A1 (en) 2019-06-21 2022-12-01 Ac Immune Sa Novel compounds
WO2021002887A1 (en) * 2019-07-02 2021-01-07 Novartis Inflammasome Research, Inc. Gut-targeted nlrp3 antagonists and their use in therapy
JP7595642B2 (ja) 2019-07-17 2024-12-06 ズーマゲン バイオサイエンシーズ エルティーディー Ｎｌｒｐ３モジュレーター
CA3151865A1 (en) * 2019-07-17 2021-01-21 Zomagen Biosciences Ltd N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4,5,6,7-tetrahydrobenzofuran -2-sulfonamide derivatives and related compounds as nlpr3 modulators for the treatment of multiple sclerosis (ms)
JP2022545400A (ja) 2019-08-16 2022-10-27 インフレイゾーム リミテッド Ｎｌｒｐ３阻害剤として有用な大環状スルホニル尿素誘導体
JP2022547882A (ja) 2019-09-06 2022-11-16 インフレイゾーム リミテッド Ｎｌｒｐ３阻害剤
CN111100042B (zh) * 2019-11-18 2022-05-31 苏州诚和医药化学有限公司 一种2-甲氧基-5-磺酰胺基苯甲酸的制备方法
CN111018750B (zh) * 2019-12-19 2022-05-27 苏州诚和医药化学有限公司 一种2,3-二甲氧基-5-磺酰胺基苯甲酸的制备新方法
US11618751B1 (en) 2022-03-25 2023-04-04 Ventus Therapeutics U.S., Inc. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives
JP2023513935A (ja) 2020-02-18 2023-04-04 インフレイゾーム リミテッド 化合物
JP2023518044A (ja) * 2020-03-16 2023-04-27 ズーマゲン バイオサイエンシーズ エルティーディー Ｎｌｒｐ３モジュレーター
CN115297855A (zh) 2020-03-19 2022-11-04 索芙特海尔公司 治疗nlrp3相关的疾病的方法
WO2021249337A1 (zh) * 2020-06-11 2021-12-16 南京明德新药研发有限公司 二甲基亚磺酰亚胺衍生物
CA3178361A1 (en) 2020-06-19 2021-12-23 Emanuele Gabellieri Dihydrooxazole and thiourea derivatives modulating the nlrp3 inflammasome pathway
WO2022023907A1 (en) 2020-07-31 2022-02-03 Novartis Ag Methods of selecting and treating patients at elevated risk of major adverse cardiac events
JP7825294B2 (ja) * 2021-02-10 2026-03-06 ハンジョウ イノゲート ファーマ カンパニー リミテッド Ｎｌｒｐ３阻害剤としての化合物
US11319319B1 (en) 2021-04-07 2022-05-03 Ventus Therapeutics U.S., Inc. Compounds for inhibiting NLRP3 and uses thereof
US11932630B2 (en) 2021-04-16 2024-03-19 Novartis Ag Heteroaryl aminopropanol derivatives
CN116635374B (zh) * 2021-05-10 2025-05-06 康百达（四川）生物医药科技有限公司 酰胺衍生物及其应用
CN118355000A (zh) * 2021-12-03 2024-07-16 辰欣药业股份有限公司 二甲基亚磺酰亚胺衍生物的盐型及晶型
US20250109126A1 (en) 2021-12-22 2025-04-03 Ac Immune Sa Dihydro-oxazol derivative compounds
JP2025524640A (ja) 2022-07-14 2025-07-30 エーシー・イミューン・エス・アー Ｎｌｒｐ３インフラマソーム経路の調節剤としてのピロロトリアジン及びイミダゾトリアジン誘導体
CN119998284A (zh) 2022-07-28 2025-05-13 Ac免疫有限公司 新化合物
US12331048B2 (en) 2022-10-31 2025-06-17 Ventus Therapeutics U.S., Inc. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors
WO2024249539A1 (en) 2023-06-02 2024-12-05 Merck Sharp & Dohme Llc 5,6 unsaturated bicyclic heterocyles useful as inhibitors of nod-like receptor protein 3
WO2025133307A1 (en) 2023-12-22 2025-06-26 Ac Immune Sa Heterocyclic modulators of the nlrp3 inflammasome pathway
TW202545527A (zh) 2024-01-16 2025-12-01 英商諾得瑟拉公司 Ｎｌｒｐ３及ｇｌｐ－１ａ組合療法
WO2025153624A1 (en) 2024-01-17 2025-07-24 Ac Immune Sa Imidazo[1,2-d][1,2,4]triazine derivatives for use as inhibitors of the nlrp3 inflammasome pathway
WO2025153625A1 (en) 2024-01-17 2025-07-24 Ac Immune Sa Imidazo[1,2-d][1,2,4]triazine derivatives for use as inhibitors of the nlrp3 inflammasome pathway
WO2025163069A1 (en) 2024-01-31 2025-08-07 Ac Immune Sa Novel compounds

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL98784A0 (en) 1990-07-17 1992-07-15 Lilly Co Eli Heterocyclyl sulfonamide derivatives,process for their preparation and pharmaceutical compositions containing them
US5169860A (en) 1992-03-13 1992-12-08 Eli Lilly And Company Antitumor compositions and methods of treatment
CA2110524A1 (en) 1992-12-10 1994-06-11 Gerald Burr Grindey Antitumor compositions and methods of treatment
BR9714328A (pt) 1997-01-29 2000-03-21 Pfizer da atividade de interleucina-1
EP0987552A3 (en) 1998-08-31 2000-06-07 Pfizer Products Inc. Diarylsulfonylurea binding proteins
CA2383026A1 (en) 1999-09-14 2001-03-22 Pfizer Products Inc. Combination treatment with il-1ra and compounds that inhibit il-1 processing and release
CA2369967A1 (en) 2001-02-12 2002-08-12 Joseph Anthony Cornicelli Methods of treating nuclear factor-kappa b mediated diseases and disorders
WO2003045400A1 (en) * 2001-11-30 2003-06-05 Pfizer Products Inc. Combination of an il-1/18 inhibitor with a tnf inhibitor for the treatment of inflammation
DK200600313A (da) * 2006-03-03 2006-03-13 Novo Nordisk As Treating type 2 diabetes or metabolic syndrome with an interleukin 1beta inhibitor or an interleukin 1beta synthesis or release inhibitor
WO2014190015A1 (en) 2013-05-21 2014-11-27 Virginia Commonwealth University Cryopyrin inhibitors for preventing and treating inflammation
MY193765A (en) * 2015-02-16 2022-10-27 Univ Queensland Sulfonylureas and related compounds and use of same
JP7050751B2 (ja) 2016-04-18 2022-04-08 ノバルティス アーゲー Ｎｌｒｐ活性に関連する状態を処置するための化合物および組成物

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