JP2020186204A - External preparation for skin - Google Patents

Abstract

To provide an external functional material for skin with biological safety which exerts an effect of suppressing inflammation of skin (including scalp), and an effect of preventing and improving pigmentation, maintains or improves skin (including scalp) in a youthful and sound state.SOLUTION: An external preparation for skin has (1) extract from perilla of Lamiaceae family Perilla, (2) extract from plants that belong to Liliaceae family Hemerocallis, (3) juniper berry extract from Cupressaceae family Juniperus, and (4) extract from mulberry of Moraceae family Morus as active ingredients.SELECTED DRAWING: Figure 1

Description

The present invention relates to a functional material having an excellent anti-inflammatory effect and high safety, and an external preparation for skin (cosmetics, etc.) containing the same.

Skin aging, dryness, and rough skin are induced by internal factors such as inactivation of cell proliferation and differentiation with aging, decreased hormone secretion, and quantitative decrease of extracellular matrix components, and sunlight (ultraviolet rays). It is a phenomenon that occurs when external factors such as cell / tissue damage or inflammation caused by active oxygen are intricately intertwined.

Active oxygen, which is an external factor of skin aging, not only directly damages skin cells, but also denatures or cross-links extracellular matrix components, resulting in the formation of wrinkles and a decrease in skin elasticity, and further, melanin pigment. It induces abnormal deposition of melanin and causes various damages to the skin such as inflammation, age spots, and freckles.

In order to prevent this skin inflammation and keep the skin healthy and youthful, the use of various active ingredients has been proposed in the past, and these anti-aging ingredients, moisturizing ingredients and ingredients that improve spots are blended. Skin external preparations have been put on the market. For example, anti-inflammatory agents such as glycyrrhizic acid and allantoin are known and are widely used as components of external preparations for skin. Further, as described in Patent Documents 1 to 4, an external preparation for skin containing a plant-derived component has also been proposed.

However, these conventional ingredients have problems in terms of safety to the skin and the like, and effectiveness when actually applied to the skin. Therefore, there is a need for a natural product-derived anti-inflammatory component for external preparations for skin with improved such points.

Japanese Patent Application Laid-Open No. 2014-169253 JP 2006-143670 Japanese Patent Application Laid-Open No. 01-090131 Japanese Patent Application Laid-Open No. 50-135236

In view of the problems of the prior art, the present inventors have conducted diligent research to find new anti-inflammatory components derived from natural products and components for preventing and improving pigmentation from the viewpoint of skin safety. As a result, by using a plurality of plant extracts in combination, it is possible to provide an external preparation for skin that has an excellent anti-inflammatory effect, an effect of preventing and improving pigmentation, and has excellent skin safety. This has led to the completion of the present invention.

The present invention relates to (1) an extract of Labiatae (Lamiaceae) Labiatae (Perilla), (2) an extract of a plant belonging to the family Labiatae (Hemerocallis), and (3) Cupressaceae (Cupressaceae) Juniper. It is a skin external preparation containing (Juniperus) juniper berry extract and (4) Cupressaceae (Moraceae) mulberry extract (Morus) as active ingredients.

The present invention comprises (1) an extract of Labiatae (Lamiaceae) and a genus Juniper (Perilla), (2) an extract of a plant belonging to the genus Hemerocallis of the family Moraceae, and (3) an extract of a plant belonging to the genus Cupressaceae. An external skin preparation containing a juniper berry extract of the genus Juniperus and (4) an extract of the mulberry of the genus Moraceae (Moraceae) as an active ingredient, and the anti-inflammatory possessed by the active ingredient. It is possible to provide an external preparation for skin such as a cosmetic that exerts an effect and an effect of preventing and improving pigmentation.

FIG. 1 is a diagram showing a measurement result of the amount of change in erythema.

The "perilla" used in the present invention is a perilla of the Labiatae (Lamiaceae) genus Perilla (Perilla), and generally includes those described by the scientific name Perilla frutescensvar. Crispa or Perilla frutescensvar. Britton. For example, Aojiso, Chirimendiso, Akajiso, Madarajiso, Catamendiso, Chirimen Aojiso or variants or subspecies thereof, or hybrids thereof can be mentioned, but the present invention is not limited thereto. Further, any of the whole plant, leaves, flowers, stems, seeds, fruits, roots, etc. of perilla may be used, but it is preferable to use whole plants, leaves, flowers, stems and / or fruits, and particularly leaves. And / or the use of flower parts is preferred. Further, the collection time and size of the part where the perilla is used are not particularly limited, and any size and collection time may be used.

Examples of the daylily plant of the daylily family used in the present invention include the daylily (Hemerocallis fulva var. Fulva), the daylily (Hemerocallis fulva var. Kwanso), the daylily (Hemerocallis fulva var. Littorea), and the daylily (Hemerocallis fulva var. Littorea). , Daylily (Hemerocallis fulva var. Semipervirens) and other daylilies (Hemerocallis fulva), Ukonkanzo (Hemerocallis citrina Baroni), Himekanzo (Hemerocallis dumortieri var. Dumortieri), Manshuukisuge (Hemerocallis dumortieri var. Dumortieri), Manshuukisuge (Hemerocallis dumortieri var. ), Ezokisuge (Hemerocallis lilioasphodelus var. Yezoensis), Nikkokisuge (Hemerocallis dumortieri var. Esculenta), Yuusuge (Hemerocallis citrina var. Vespertina), or Daylily (Hemerocallis plicata).

The "juniper berry" used in the present invention is a juniper berry (scientific name: Juniperus communis) belonging to the genus Juniperus of the Cupressaceae family. Examples of sites that can be used in the present invention include whole plants, leaves, flowers, fruits, stems, seeds, roots, etc., but the use of whole plants or fruits is preferable.

The "mulberry" used in the present invention includes a mulberry (scientific name: Morus alba) of the Moraceae (Moraceae) genus Morus. Examples of the site that can be used in the present invention include whole plants, leaves, stems, seeds, roots and the like, but the use of whole plants or roots is preferable.

A method for preparing an extract using the above plants will be described below. Extracts are prepared by conventional methods such as dipping method, countercurrent extraction method, supercritical extraction method, etc. after washing the extraction target part of each plant with water in advance, drying, chopping or crushing as necessary. This can be done by contacting with the extraction solvent.

Extraction solvents include water; lower alcohols such as methanol, ethanol and propanol; polyhydric alcohols such as ethylene glycol, 1,3-propylene glycol, 1,3-butylene glycol and glycerin; ethyl acetate, butyl acetate and propion. Esters such as methyl acid; ketones such as acetone and methyl ethyl ketone; ethers such as ethyl ether and isopropyl ether; hydrocarbon solvents such as n-hexane, toluene and chloroform, etc., which may be used alone or in combination of two. The above is mixed and used.

Further, when preparing the extract of the present invention, it is generally preferable to set the pH in the range of 3 to 8, and in this sense, if necessary, the above-mentioned extraction solvent may be alkaline with sodium hydroxide, sodium carbonate, potassium hydroxide or the like. A regulator or an acid regulator such as citric acid, hydrochloric acid, phosphoric acid, or sulfuric acid may be added to adjust the pH to the desired level. The extraction conditions such as the extraction temperature and the extraction time differ depending on the type and pH of the solvent used, the fineness of the object to be extracted, the particle size, etc., but in the case of the immersion method using water as the extraction solvent, for example, The extraction temperature is generally in the range of 1-90 ° C. and the extraction time is in the range of 0.5-96 hours at room temperature, for example.

The extract prepared as described above may generally have a pH adjusted to 3 to 8 and then used as it is as a cosmetic compounding agent, or may be used as a desired concentration by concentration under reduced pressure or the like. You may. Further, the extract may be a dried product by a conventional method such as a spray drying method.

The mixture solution of the extract according to the present invention can be blended with an external preparation for skin (cosmetics, quasi-drugs, external medicines). Examples of external skin preparations include emulsions, creams, lotions, essences, packs, lipsticks, foundations, liquid foundations, makeup press powders, blushers, white powders, facial cleansers, body shampoos, packs and masks (cleansing packs, (Oil pack, cleansing mask, impregnated sheet mask, etc.), scalp, shampoo for hair, conditioner for hair, shampoo or tonic for hair growth and hair growth, cleansing cosmetics such as soap, and bathing agents. The present invention is not limited to these.

In addition to the extracts according to the present invention, external preparations for skin (cosmetics and quasi-drugs) include components usually used in external composition for skin, such as oily components and surfactants (synthetic and natural products). ), Moisturizer, thickener, preservative / bactericidal agent, powder component, ultraviolet absorber, antioxidant, chelating agent, pigment, fragrance and the like can be appropriately blended as needed. Further, as long as the effectiveness and characteristics of the extract, hydrolyzate or fermented product according to the present invention are not impaired, other physiologically active ingredients may be combined and blended at all.

Here, as the oily component, for example, paraffin oil, olive oil, jojoba oil, paraffin oil, soybean oil, rice oil, rice bran oil, rice germ oil, coconut oil, chamomile oil, palm oil, cacao oil, meadowfoam oil, etc. Plant-derived fats and oils such as bergamot oil, rosehip oil, Arabic coffee tree seed oil, lanbender oil, sheer butter, tea tree oil, avocado oil, macadamia nut oil, vanilla oil, and plant-derived squalane; mink oil, turtle oil, etc. Animal-derived fats and oils; waxes such as beeswax, carnauba wax, rice wax, and lanolin; hydrocarbons such as liquid paraffin, vaseline, paraffin wax, and squalane; myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid, and eikosen. Fatty acids such as acids; higher alcohols such as lauryl alcohol, cetanol, stearyl alcohol; isopropyl myristate, isopropyl palmitate, butyl oleate, cetyl isooctanoate, 2-ethylhexyl glyceride, higher fatty acid octyldodecyl (octyldodecyl stearate, etc.) ) And other synthetic esters and synthetic triglycerides and the like.

Examples of the surfactant include polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyethylene glycol fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, and poly. Nonionic surfactants such as oxyethylene hydrogenated castor oil, polyoxyethylene sorbitol fatty acid ester; fatty acid salt, alkyl sulfate, alkylbenzene sulfonate, polyoxyethylene alkyl ether sulfate, polyoxyethylene fatty amine sulfate, polyoxy Anionic surfactants such as ethylenealkylphenyl ether sulfate, polyoxyethylene alkyl ether phosphate, α-sulfonated fatty acid alkyl ester salt, polyoxyethylene alkyl phenyl ether phosphate; quaternary ammonium salt, primary to secondary Tertiary fatty amine salt, trialkylbenzylammonium salt, alkylpyridinium salt, 2-alkyl-1-alkyl-1-hydroxyethylimidazolinium salt, N, N-dialkylmorphonium salt, polyethylene polyamine fatty acid amide salt, etc. Cationic surfactants; N, N-dimethyl-N-alkyl-N-carboxymethylammoniobetaine, N, N, N-trialkyl-N-alkyleneammoniocarboxybetaine, N-acylamide propyl-N', N An amphoteric surfactant such as ′ -dimethyl-N ′ -β-hydroxypropylammoniosulfobetaine can be used.

The emulsifier or emulsifying aid is derived from stevia derivatives such as enzyme-treated stevia, saponins or derivatives thereof, casein or salts thereof (sodium, etc.), sugar-protein complexes, sucrose or its esters, lactose, and soybeans. Water-soluble polysaccharide, complex of soybean-derived protein and polysaccharide, lanolin or its derivative, cholesterol, stevia derivative (stevia enzyme fermented product, etc.), silicate (aluminum, magnesium, etc.), carbonate (calcium, sodium, etc.), saponin And its derivatives, lecithin and its derivatives (hydrogenated lecithin, etc.), lactic acid bacteria fermented rice, lactic acid bacteria fermented germinated rice, lactic acid bacteria fermented grains (wheat, beans, miscellaneous grains, etc.) and the like can also be blended.

Examples of the moisturizing agent include glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, polyethylene glycol, sorbitol, xylitol, sodium pyrrolidone carboxylate, and 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer solution. Etc., saccharides such as trehalose, mucopolysaccharides (eg, hyaluronic acid and its derivatives, chondroitin and its derivatives, heparin and its derivatives, etc.), tuberose polysaccharides, elastin and its derivatives, collagen and its derivatives, NMF-related Substances, hydrolyzed conchiolin, hydrolyzed silk, sphingomonas culture, spingoglycolipid, ceramide, lactic acid, urea, higher fatty acid octyldodecyl, seaweed extract, silane root (white and) extract, various amino acids and their derivatives Can be mentioned.

Examples of the thickener include components derived from brown algae, green algae or red algae such as alginic acid, agar, carrageenan, and fucoidan; silane root (white and) extract; pectin, locust bean gum, aloe polysaccharide, and alkaligenes-producing polysaccharide. Polysaccharides such as body; gums such as xanthan gum, tragant gum, roast bean gum, guar gum; cellulose derivatives such as carboxymethyl cellulose and hydroxyethyl cellulose; polyvinyl alcohol, polyvinyl pyrrolidone, carboxyvinyl polymer, mastic resin, alginic acid / methacrylic acid co-weight Synthetic polymers such as coalescence; hyaluronic acid and its derivatives; polyglutamic acid and its derivatives and the like.

Examples of preservatives and bactericides include urea; paraoxybenzoic acid esters such as methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, and butyl paraoxybenzoate; phenoxyethanol, dichlorophenol, hexachlorophene, and chlorhexidine hydrochloride. , Benzalconium chloride, salicylic acid, ethanol, undecyleneic acid, phenols, jamar (imidazodeinylurea), polyphosphate, propanediol, 1,2-pentanediol, various essential oils, dried bark, radish fermented liquid, sugar cane Etc., such as plant-derived ethanol or 1,3-butylene glycol.

Examples of the powder component include sericite, titanium oxide, talc, kaolin, bentonite, zinc oxide, magnesium carbonate, magnesium oxide, zirconium oxide, barium sulfate, silicic anhydride, mica, nylon powder, polyethylene powder, and silk. There are powders, cellulose-based powders, grains (rice, wheat, corn, millet, etc.) powders, beans (soybeans, red beans, etc.) powders, etc.

Examples of the ultraviolet absorber include ethyl paraaminobenzoate, ethylhexyl paradimethylaminobenzoate, amyl salicylate and its derivatives, 2-ethylhexyl paramethoxycinnamate, octyl silicate, oxybenzoyl, 2,4-dihydroxybenzophenone, 2-. Hydroxy-4-methoxybenzophenone-5-sulfonate, 4-tertiary butyl-4-methoxybenzoylmethane, 2- (2-hydroxy-5-methylphenyl) benzotriazole, urocanic acid, ethyl urocanate, aloe extract And so on.

Examples of the defoaming agent include ethanol, isopropanol, disiloxane, dimethylpolycyclosan, silica dimethicone silicate, trisiloxane, silylated silica, dimethicone, trimethylsiloxysilicate, and DPG isobornyl ether.

Examples of antioxidants include butylhydroxyanisole, butylhydroxytoluene, propyl gallate, beautyberry extract, silane root extract, shakuyaku extract, vitamin E and its derivatives (for example, vitamin E nicotinate and vitamins). E-renolate, etc.) etc.

Examples of the chelating agent include ethylenediamine hydroxyethyl triacetate trisodium, edetonic acid or salts thereof, gluconic acid, phytic acid, sodium polyphosphate, sodium metaphosphate, tetrasodium hydroxyethanediphosphonate and the like.

Examples of the pH adjuster include citric acid or salts thereof, lactic acid or salts thereof, glycolic acid, succinic acid, hydrochloric acid, monoethanolamine, diethanolamine, triethanolamine, sodium hydroxide, potassium hydroxide and the like.

The whitening agents include t-cycloamino acid derivatives, kodiic acid and its derivatives, ascorbic acid and its derivatives, hydroquinone or its derivatives, ellagic acid and its derivatives, nicotinic acid and its derivatives, resorcinol derivatives, tranexamic acid and its derivatives. , 4-methoxysalicylic acid potassium salt, magnolignan (5,5'-dipropyl-biphenyl-2,2'-diol), hydroxybenzoic acid and its derivatives, vitamin E and its derivatives, α-hydroxy acid, AMP (adenosine mono) Phosphate and adenosine monophosphate) can be mentioned, and these may be blended alone or in combination of two or more.

Examples of the above-mentioned chemistry derivative include chemistry esters such as chemistry monobutyrate, chemistry monocaplate, chemistry monopalmitate, and chemistry dibutyrate, chemistry ethers, and chemistry sugars such as glucoside chemistry. Examples of the ascorbic acid derivative include, for example, L-ascorbic acid-2-phosphate ester sodium, L-ascorbic acid-2-phosphate ester magnesium, L-ascorbic acid-2-sulfate sodium, L-ascorbic acid. Ascorbic acid ester salts such as -2-sulfate magnesium, L-ascorbic acid-2-glucoside, L-ascorbic acid-5-glucoside, ascorvirtocopheryl maleic acid, ascorvirtocopheryl phosphate K, myristyl 3-glyceryl ascorbic acid , Ascorbic acid sugar derivatives such as caprylyl 2-glyceryl ascorbic acid, 6-position acylated products of these ascorbic acid sugar derivatives (acyl groups are hexanoyl group, octanoyl group, decanoyl group, etc.), L-ascorbic acid tetraisopalmitic acid ester, L-ascorbic acid tetra fatty acid esters such as L-ascorbic acid tetralauric acid ester, 3-O-ethylascorbic acid, L-ascorbic acid-2-phosphate-6-O-palmitate sodium, glyceryl ascorbic acid or its Ascorylated derivatives, glycerin ascorbic acid derivatives such as bisglyceryl ascorbic acid, aminopropyl L-ascorbic acid phosphate, hyaluronic acid derivatives of L-ascorbic acid, 3-OD lactose-L-ascorbic acid, isostearly ascorvir phosphate Albutin (hydroquinone-β-D-glucopyranoside), α-arbutin (hydroquinone-α-D-glucopyranoside) and the like are used as hydroquinone derivatives, and tranexamic acid esters (for example, lauryl tranexamic acid) are used as tranexamic acid derivatives. Examples thereof include esters, hexadecyl esters of tranexamic acid, cetyl tranexamic acid esters or salts thereof), amides of tranexamic acid (for example, methylamide tranexamic acid), and examples of the resorcinol derivative include 4-n-butylresorcinol and 4-. Isoamylresorcinol and the like are examples of the 2,5-dihydroxybenzoic acid derivative such as 2,5-diacetoxybenzoic acid, 2-acetoxy-5-hydroxybenzoic acid, 2-hydroxy-5-propio. Nyloxybenzoic acid and the like are examples of nicotinic acid derivatives such as nicotinamide and benzyl nicotinate, and α-hydroxy acids include, for example, lactic acid, malic acid, succinic acid, citric acid and α-hydroxyoctanoic acid. ..

Examples of the physiologically active ingredient include placenta extract, yukinoshita extract, rice bran extract or its hydrolyzate, white potato extract or its hydrolyzate, fermented white potato, fermented white potato, or its hydrolysis. Fermented rice with lactic acid bacteria, Murasakikibu extract, Hass seed extract or its hydrolyzate, Hass seed fermented product, Hatomugi hydrolyzate, Hatomugi seed fermented product, Royal jelly fermented product, Sake lees extract or ceramide contained therein, Sake lees fermentation Examples include Pandanus amaryllifolius Roxb. Extract, Arcangelicia flava Merrilli extract, chamomile extract and the like. In addition, coral grass extract, rice leaf extract or its hydrolyzate, eggplant (has, long eggplant, Kamo eggplant, rice eggplant, etc.) extract or its hydrolyzate, apricot fruit extract, katamen giraffe, etc. Seaweed extract, marine flowering plant extract such as amamo, soymilk fermented product, jellyfish water, rice extract or its hydrolyzate, fermented rice extract, sprouted rice extract or its hydrolyzate, sprouted rice fermentation Amino acid, black bean extract or its hydrolyzate, brown sugar extract or its fermented product, damask rose flower extract, ylang ylang flower extract, bamboo shoot skin extract, linoleic acid and its derivatives or processed products (eg) Liposomal linoleic acid, etc.), animal or fish-derived collagen and its derivatives, elastin and its derivatives, glycyrrhizic acid and its derivatives (dipotassium salt, etc.), t-cycloamino acid derivatives, vitamin A and its derivatives, allantin, diisopropylamine dichloro Acetate, γ-amino-β-hydroxybutyric acid, gentian extract, licorice extract, carrot extract, otane carrot extract or fermented product thereof, camellia extract, red ginseng extract, honeybee extract, hechima extract, anaaosa extract Amino acid, peach extract, horse extract, peach seed extract, kiwi extract, sunflower extract, Zizyphus joazeiro extract, paudalco bark extract, hibiscus flower extract or fermented product, hagoromogusa extract, cherimoya extract Fermentation, mango extract, mangostin extract, funori extract, Karyu tea extract, Benifuki extract, silane extract, sweet potato extract, sansho peel or seed coat extract or hydrolyzate, Benibana flower extract, Casablanca extract Amino acid, sweet potato extract or fermented product thereof, Guava leaf extract, olive leaf extract, sardine extract, ginger extract, vanilla extract, dokudami extract, evening white yuzu extract, aloe extract, aloe vera extract , Fig flower extract, apple extract, white asparagus extract, etc.

Next, the present invention will be described in more detail with reference to Production Examples, Formulation Examples, Examples and Test Examples, but the present invention is not limited thereto. In the following, all parts mean parts by weight, and% means all parts by weight.

Production example 1. Preparation of Perilla Leaf Extract 200 g of purified water was added to 20 g of dried and coarsely pulverized perilla leaves and immersed at 4 ° C., and then 200 g of 1,3-butylene glycol was added. This was extracted at 4 ° C. and then filtered to obtain 352 g of a brown transparent filtrate (solid content concentration 1.01%). Then, 234 g of purified water was added to obtain 590 g of a perilla leaf extract solution (solid content concentration: 0.61%).

Production Example 2-1. Preparation of daylily extract 200 g of purified water was added to 10 g of shredded daylily flower parts that had been dried and crushed, and the mixture was immersed at 4 ° C., and then 200 g of 1,3-butylene glycol was added. This was extracted at 4 ° C. and then filtered to obtain 374 g of a brown transparent filtrate (solid content concentration: 1.24%). Then, 249 g of purified water was added to obtain 623 g of a daylily extract solution (solid content concentration 0.80%).

Production Example 2-2. Preparation of Hongkan Elephant Extract 618 g of Hong Kan Elephant Extract Solution was obtained in the same manner as in Production Example 2-1 except that the flower part of Hong Kan Elephant was used in place of the Yabu Kan Elephant of Production Example 2-1 (solid content concentration 0. 78%).

Production example 3. Preparation of juniper berry extract 200 g of purified water was added to 10 g of dried and crushed juniper berries, and the mixture was immersed at 4 ° C., and then 200 g of 1,3-butylene glycol was added. This was extracted at 4 ° C. and then filtered to obtain 360 g of a brown transparent filtrate (solid content concentration 1.01%). Then, 240 g of purified water was added to obtain 600 g of a juniper berry extract solution (solid content concentration 0.53%).

Production example 4. Preparation of mulberry root extract 200 g of purified water was added to 10 g of dried and chopped mulberry root and immersed at 4 ° C., and then 200 g of 1,3-butylene glycol was added. This was extracted at 4 ° C. and then filtered to obtain 374 g of a brown transparent filtrate (solid content concentration 0.51%). Then, 249 g of purified water was added to obtain 623 g of a mulberry root extract solution (solid content concentration 0.20%).

Example 1. Preparation of composition After mixing equal amounts of the four extract solutions obtained in Production Examples 1, 2-1 and Production Examples 3 and 4, the insoluble matter is filtered to obtain 2360 g of a brown transparent extract solution mixed solution. Obtained (solid content concentration 0.41%).

Example 2. Preparation of composition After mixing equal amounts of the four extract solutions obtained in Production Examples 1, 2-2 and Production Examples 3 and 4, the insoluble matter is filtered to obtain 2360 g of a brown transparent extract solution mixed solution. Obtained (solid content concentration 0.41%).

Test example 1. Primary skin irritation suppression test 10 subjects (men and women aged 20 to 60 years) were divided into 2 groups, a test part was provided on the medial side of each upper arm, and the amount of erythema in the test part of each subject was measured as an initial value after washing. It was measured by an apparatus (Mexameter (registered trademark) MX18, manufactured by Courage + Khazaka). Then, an aqueous solution containing laureth 5 (10% Polyoxyethylene 5 lauryl ether) known as a surfactant in the test part and the composition of Example 1 (final concentration of 1% as a solution) was used in one group. A 30-minute semi-occlusion patch was performed, and the other group was subjected to a 30-minute semi-occlusion patch using an aqueous solution containing the composition of Example 2 (final concentration of 1% as a solution). After the completion of the semi-occluded patch, the same semi-occluded patch was repeated 3 times at intervals of 30 minutes or more. The amount of erythema in the test part of each subject was measured by the above-mentioned measuring device, and the average value of 5 subjects for each group was calculated as the primary stimulation suppression amount for the value obtained by subtracting the value immediately after the treatment from the initial value. In addition, as a comparative control, 30% butylene glycol (30-BG) and 0.1% dipotassium glycyrrhizinate (GK2) were used in place of the composition of Example 1 or the composition of Example 2, respectively. Similarly, a 30-minute semi-occlusion patch was performed, and the amount of erythema in the test portion was measured by the above measuring device.

The result of Test Example 1 is shown in FIG.
As shown in FIG. 1, it was confirmed that the composition according to Example 1 or 2 of the present invention remarkably suppresses erythema, that is, suppresses skin inflammation, and the effect is glycyrrhizin. It was more remarkable than dipotassium acid. In addition, this result also suggests the effect of preventing and improving pigmentation caused by inflammation.

The following is a preferred formulation example of the present invention.
Prescription example 1. Toner [Ingredients] Part Olive oil 1.0
Polyoxyethylene (5.5) cetyl alcohol 5.0
Butylparaben 0.1
Composition of Example 1 3.0
Ethanol 5.0
Glycerin 5.0
1,3-butylene glycol 5.0
Potassium hydroxide Appropriate amount Purified water 100 parts in total Fragrance Appropriate amount

Prescription example 2. Toner Toner was obtained in the same manner as in Formulation 1 except that 3.0 parts of the composition of Example 2 was used instead of 3.0 parts of the composition of Example 1 among the components of Formulation Example 1.

Prescription example 3. Emulsion [Ingredients] Part Liquid paraffin 6.0
Hexalan 4.0
Jojoba oil 1.0
Polyoxyethylene (20) sorbitan monostearate 1.0
Lipophilic glyceryl stearate 1.0
Soy lecithin 1.5
Composition of Example 1 3.0
L-ascorbic acid-2-glucoside 2.0
Potassium hydroxide 0.5
Glycerin 3.0
1,3-butylene glycol 2.0
Carboxymethyl cellulose 0.3
Sodium hyaluronate 0.01
Amount that makes the total amount of purified water 100 copies Appropriate amount of fragrance

Prescription example 4. Emulsion Emulsion was obtained in the same manner as in Formulation 3 except that 3.0 parts of arbutin was used instead of 2.0 parts of L-ascorbic acid-2-glucoside and 0.5 part of potassium hydroxide among the components of Formulation Example 3. It was.

Prescription example 5. Emulsion Emulsion was prepared in the same manner as in Formulation 3 except that 2.0 parts of tranexamic acid was used instead of 2.0 parts of L-ascorbic acid-2-glucoside and 0.5 part of potassium hydroxide among the components of Formulation Example 3. Obtained.

Prescription example 6. Emulsion Emulsion in the same manner as in Formulation 3 except that 3.0 parts of nicotinamide is used instead of 2.0 parts of L-ascorbic acid-2-glucoside and 0.5 part of potassium hydroxide among the components of Formulation Example 3. Got

Prescription example 7. Lotion [Ingredients] Part The composition of Example 1 10.0
Ethanol 10.0
Glycerin 3.0
1,3-butylene glycol 2.0
Methylparaben 0.2
Citric acid 0.1
Sodium citrate 0.3
Carboxyvinyl polymer 0.1
Xanthan gum 0.1
Appropriate amount of fragrance Potassium hydroxide Appropriate amount Purified water 100 parts in total

Prescription example 8. Essence [Ingredients] Part Ethanol 2.0
Glycerin 5.0
1,3-butylene glycol 5.0
Methylparaben 0.1
Sodium hyaluronate 0.1
Composition of Example 1 5.0
Citric acid 0.3
Sodium citrate 0.6
Amount of purified water totaling 100 parts

Example 9. Liquid foundation [ingredients] part stearic acid 2.4
Propylene glycol monostearate 2.0
Setostearyl alcohol 0.2
Liquid lanolin 2.0
Liquid paraffin 3.0
Isopropyl myristate 8.5
Propylparaben 0.05
Composition of Example 2 5.0
Sodium Carboxymethyl Cellulose 0.2
Bentonite 0.5
Propylene glycol 4.0
Triethanolamine 1.1
Methylparaben 0.1
Amount of purified water totaling 100 parts Titanium oxide 8.0
Talc 4.0
Appropriate amount of coloring pigment

Prescription example 10. Body shampoo [Ingredients] Part N-lauroylmethylalanine sodium 25.0
Coconut oil fatty acid potassium solution (40%) 26.0
Coconut oil fatty acid diethanolamide 3.0
Methylparaben 0.1
Composition of Example 1 5.0
1,3-butylene glycol 2.0
Amount of purified water totaling 100 parts

Prescription example 11. Hair restorer [Ingredients] Part Dipotassium glycyrrhizinate 0.1
Mononitroguaiacol Sodium 0.02
Pyridoxine hydrochloride 0.03
l-Menthol 0.8
Menispermaceae root extract 0.3
Brown algae extract 0.3
Panax ginseng extract 0.3
Gentiana extract 2.0
Composition of Example 1 3.5
Trimethylglycine 0.5
Lactic acid 0.2
1,3-butylene glycol 10.0
Phenoxyethanol 0.2
Polyoxyethylene hardened castor oil 0.4
L-Arginine Appropriate amount Ethanol 20.0
Amount of purified water totaling 100 parts

Prescription example 12. Hair shampoo [Ingredients] Part N-coconut oil fatty acid methyl taurine sodium 10.0
Polyoxyethylene (3) Alkyl Ether Sodium Sulfate 20.0
Betaine Lauryldimethylaminoacetic Acid 10.0
Coconut oil fatty acid diethanolamide 4.0
Methylparaben 0.1
Citric acid 0.1
Composition of Example 1 2.0
1,3-butylene glycol 2.0
Amount of purified water totaling 100 parts

Example 13. Hair conditioner [Ingredients] Part Polyoxyethylene (10) Hardened castor oil 1.0
Distearyl dimethylammonium chloride 1.5
Stearyltrimethylammonium chloride 2.0
Glyceryl 2-ethylhexanoate 1.0
Cetanol 3.2
Stearyl alcohol 1.0
Methylparaben 0.1
Composition of Example 1 2.0
1,3-butylene glycol 5.0
Amount of purified water totaling 100 parts

Prescription example 14. Sheet mask A sheet mask is obtained by impregnating a non-woven fabric with the following components.
[Ingredients] Part The composition of Example 1 10.0
Ethanol 10.0
Glycerin 3.0
1,3-butylene glycol 2.0
Methylparaben 0.2
Citric acid 0.1
Sodium citrate 0.3
Xanthan gum 1.0
Water-soluble collagen 0.1
Sodium hyaluronate 0.1
Potassium hydroxide Appropriate amount Purified water The total amount is 100 parts

Claims (1)

(1) Extracts of Labiatae (Lamiaceae) Labiatae (Perilla), (2) Extracts of plants belonging to the family Labiatae (Hemerocallis), (3) Cupressaceae (Cupressaceae) Juniperus An external preparation for skin containing juniper berry extract and (4) Cupressaceae (Moraceae) mulberry extract (Morus) as active ingredients.