JP2020114842A5 - - Google Patents

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JP2020114842A5
JP2020114842A5 JP2020052658A JP2020052658A JP2020114842A5 JP 2020114842 A5 JP2020114842 A5 JP 2020114842A5 JP 2020052658 A JP2020052658 A JP 2020052658A JP 2020052658 A JP2020052658 A JP 2020052658A JP 2020114842 A5 JP2020114842 A5 JP 2020114842A5
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Japan
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compound
organic solvent
range
cuprous
temperature
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JP2020052658A
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Japanese (ja)
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JP6903785B2 (ja
JP2020114842A (ja
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JP2020052658A 2014-12-19 2020-03-24 ジアリールチオヒダントイン化合物を調製するためのプロセス Active JP6903785B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462094436P 2014-12-19 2014-12-19
US62/094,436 2014-12-19
JP2017532725A JP6681902B2 (ja) 2014-12-19 2015-12-17 ジアリールチオヒダントイン化合物を調製するためのプロセス

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2017532725A Division JP6681902B2 (ja) 2014-12-19 2015-12-17 ジアリールチオヒダントイン化合物を調製するためのプロセス

Publications (3)

Publication Number Publication Date
JP2020114842A JP2020114842A (ja) 2020-07-30
JP2020114842A5 true JP2020114842A5 (https=) 2020-11-12
JP6903785B2 JP6903785B2 (ja) 2021-07-14

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ID=55168400

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JP2017532725A Active JP6681902B2 (ja) 2014-12-19 2015-12-17 ジアリールチオヒダントイン化合物を調製するためのプロセス
JP2020052658A Active JP6903785B2 (ja) 2014-12-19 2020-03-24 ジアリールチオヒダントイン化合物を調製するためのプロセス

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JP2017532725A Active JP6681902B2 (ja) 2014-12-19 2015-12-17 ジアリールチオヒダントイン化合物を調製するためのプロセス

Country Status (33)

Country Link
US (1) US9688655B2 (https=)
EP (4) EP3372585B1 (https=)
JP (2) JP6681902B2 (https=)
KR (1) KR102586059B1 (https=)
CN (2) CN107108507B (https=)
AR (2) AR103228A1 (https=)
AU (1) AU2015364537B2 (https=)
BR (1) BR112017013113B1 (https=)
CY (3) CY1121684T1 (https=)
DK (3) DK3372584T5 (https=)
EA (4) EA201892485A1 (https=)
ES (3) ES2718539T3 (https=)
HR (3) HRP20190540T1 (https=)
HU (2) HUE042409T2 (https=)
IL (1) IL252843B2 (https=)
LT (3) LT3372585T (https=)
MA (1) MA41200B1 (https=)
MD (1) MD3233803T2 (https=)
ME (1) ME03420B (https=)
MX (1) MX375467B (https=)
NZ (1) NZ732766A (https=)
PH (1) PH12017501152B1 (https=)
PL (3) PL3233803T3 (https=)
PT (3) PT3233803T (https=)
RS (3) RS61060B9 (https=)
SG (4) SG10201912811QA (https=)
SI (3) SI3233803T1 (https=)
SM (3) SMT202000618T1 (https=)
TR (1) TR201904739T4 (https=)
TW (4) TWI703132B (https=)
UA (1) UA123201C2 (https=)
WO (1) WO2016100652A2 (https=)
ZA (1) ZA201704877B (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX383748B (es) 2014-12-19 2025-03-14 Aragon Pharmaceuticals Inc Procesos para la preparación de un compuesto de diariltiohidantoína.
EP3372585B1 (en) * 2014-12-19 2022-03-30 Aragon Pharmaceuticals, Inc. Process for the preparation of a diarylthiohydantoin compound
CN108069869B (zh) * 2016-11-09 2022-03-01 上海医药工业研究院 一种Apalutamide的制备方法及其中间体
TW201831461A (zh) * 2017-01-18 2018-09-01 台灣神隆股份有限公司 製備阿帕魯醯胺的方法
US10364245B2 (en) 2017-06-07 2019-07-30 Chiesi Farmaceutici S.P.A. Kinase inhibitors
CN107501237B (zh) * 2017-08-17 2022-03-22 上海西浦医药科技有限公司 一种Apalutamide的合成方法
CN108383749B (zh) * 2018-01-30 2021-03-09 杭州科巢生物科技有限公司 阿帕鲁胺的合成方法及其中间体
US10513504B2 (en) 2018-03-08 2019-12-24 Apotex Inc. Processes for the preparation of apalutamide and intermediates thereof
CN108314646B (zh) * 2018-04-11 2021-03-19 武汉慧敏科技中心 一种高分散双金属纳米材料制备泌尿生殖系统用药物中间体的方法
CN109651256A (zh) * 2018-11-20 2019-04-19 上海健康医学院 一种式（viii）的恩杂鲁胺的制备方法
CN110511206A (zh) * 2019-06-17 2019-11-29 扬子江药业集团江苏海慈生物药业有限公司 芳基-2-硫代海因类化合物中间体、其制备方法及应用
CN110511207A (zh) * 2019-06-17 2019-11-29 扬子江药业集团江苏海慈生物药业有限公司 芳基-2-硫代海因类化合物中间体、其制备方法及应用
CN113968815B (zh) * 2020-07-24 2025-11-18 苏州科伦药物研究有限公司 一种硫代二氮杂螺类化合物的合成方法、其中间体及其合成方法
EP4541786A3 (en) 2020-09-04 2025-08-06 Synthon B.V. Improved process for preparation of apalutamide
CN116507624A (zh) 2020-11-20 2023-07-28 美国安进公司 制备7-氯-6-氟-1-(2-异丙基-4-甲基吡啶-3-基)吡啶并f[2,3-d]嘧啶-2,4(1h,3h)-二酮的方法
CN113402466B (zh) * 2021-06-18 2022-08-16 南京方生和医药科技有限公司 一种阿帕鲁胺中间体及制备阿帕鲁胺的方法
CN113292535B (zh) * 2021-06-18 2022-07-01 南京方生和医药科技有限公司 一种制备阿帕鲁胺中间体及阿帕鲁胺的方法
CN115572264B (zh) * 2021-07-06 2025-12-05 山东新时代药业有限公司 一种恩杂鲁胺的制备方法
CN115850233B (zh) * 2021-09-24 2024-12-10 南京方生和医药科技有限公司 一种阿帕鲁胺的合成方法
CN116239536A (zh) * 2021-12-08 2023-06-09 山东新时代药业有限公司 一种阿帕鲁胺中间体化合物
CN117534652A (zh) * 2022-08-02 2024-02-09 黄冈人福药业有限责任公司 一种阿帕他胺的制备方法
CN115536634B (zh) * 2022-10-17 2024-06-11 上海博悦生物科技有限公司 一种阿帕他胺的合成方法
CN116332907A (zh) * 2023-03-16 2023-06-27 奥锐特药业股份有限公司 一种无定形阿帕他胺的制备方法
CN117645572A (zh) * 2023-11-23 2024-03-05 奥锐特药业股份有限公司 恩扎卢胺及其中间体的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040077605A1 (en) * 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
TWI263640B (en) * 2001-12-19 2006-10-11 Bristol Myers Squibb Co Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
LT2656842T (lt) 2006-03-27 2016-09-26 The Regents Of The University Of California Androgeno receptoriaus moduliatorius, skirtas prostatos vėžio ir su androgeno receptoriumi susijusių ligų gydymui
WO2008119015A2 (en) * 2007-03-27 2008-10-02 Sloan-Kettering Institute For Cancer Research Synthesis of thiohydantoins
BRPI0912802A2 (pt) * 2008-05-16 2015-10-13 Takeda San Diego Inc ativadores de glicoquinase
EP2509961B1 (en) 2009-12-11 2016-03-09 Autifony Therapeutics Limited Imidazolidinedione derivatives
WO2011103202A2 (en) * 2010-02-16 2011-08-25 Aragon Pharmaceuticals, Inc. Androgen receptor modulators and uses thereof
PL2538785T3 (pl) * 2010-02-24 2018-08-31 Medivation Prostate Therapeutics Llc Sposoby syntezy zwiazków diarylotiohydantoinowych i diarylohydantoinowych
DK2683694T3 (en) 2011-03-10 2016-07-18 Suzhou Kintor Pharmaceuticals Inc ANDROGEN RECEPTOR ANTAGONISTS AND APPLICATIONS THEREOF
WO2013029338A1 (en) 2011-09-01 2013-03-07 Glaxo Group Limited Novel compounds
CA2908236C (en) * 2012-03-29 2021-10-26 Schindler, William Diaspirin crosslinked pegylated hemoglobin
JP6469092B2 (ja) 2013-05-29 2019-02-13 ヒノバ ファーマシューティカルズ インコーポレイテッド イミダゾリジンジオン化合物及び薬物組成物
EP3372585B1 (en) * 2014-12-19 2022-03-30 Aragon Pharmaceuticals, Inc. Process for the preparation of a diarylthiohydantoin compound

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